palmitic acid has been researched along with Neoplasms in 28 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent reports suggest that weight loss in cachectic cancer patients may be inhibited by supplementation of the n-3 fatty acid eicosapentaenoic acid (20:5n-3; EPA), presumably due to inhibition of lipolysis." | 5.09 | Eicosapentaenoic acid ethyl ester supplementation in cachectic cancer patients and healthy subjects: effects on lipolysis and lipid oxidation. ( Dagnelie, PC; Swart, GR; Van den Berg, JW; Van der Gaast, A; Wattimena, JL; Wilson, JH; Zuijdgeest-Van Leeuwen, SD, 2000) |
| " Few studies have investigated the effects of palm oil per se, and the main reason why it has been associated with negative health effects is the relatively high content of saturated fatty acids (SFAs), particularly palmitic acid, which in turn have been associated with increased risk of coronary heart disease and some tumours." | 4.89 | Palm oil and palmitic acid: a review on cardiovascular effects and carcinogenicity. ( Fanelli, R; Fattore, E, 2013) |
| "While the role of ras in malignancy is unclear, it is well-established that the association of ras protein with the inner surface of the plasma membrane is critical for triggering ras oncogenicity." | 2.38 | The ras/cholesterol connection: implications for ras oncogenicity. ( Cox, AD; Der, CJ, 1992) |
| "Although new strategies for breast cancer treatment have yielded promising results, most drugs can lead to serious side effects when applied systemically." | 1.91 | Effective breast cancer therapy based on palmitic acid-loaded PLGA nanoparticles. ( Cavalcante, RS; Cruz, LJ; de Araújo Júnior, RF; Eich, C; Gu, Z; He, Y; Schomann, T; Yu, Z, 2023) |
| "This allows cancer cells to activate extracellular matrix secretion from Schwann cells of the tumor microenvironment, which ultimately potentiates metastasis initiation." | 1.72 | Palmitic acid: Enabling the tumor's nerves. ( Alkan, HF; Altea-Manzano, P; Fendt, SM, 2022) |
| " In vivo in a murine model, the circulation half-life of intravenously-injected siPA-NPs was double that of si-NPs, resulting in a >2-fold increase in siRNA biodistribution to orthotopic MDA-MB-231 mammary tumors." | 1.43 | Hydrophobic interactions between polymeric carrier and palmitic acid-conjugated siRNA improve PEGylated polyplex stability and enhance in vivo pharmacokinetics and tumor gene silencing. ( Chandra, I; Duvall, CL; Giorgio, TD; Hattaway, ME; Jackson, MA; Kavanaugh, TE; Sarett, SM; Werfel, TA, 2016) |
| "Candidate biomarkers for selecting tumors highly sensitive to FASN inhibition are identified." | 1.42 | Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression. ( Buckley, D; Fridlib, M; Heuer, TS; Kemble, G; Lai, J; Mordec, K; Ventura, R; Wang, Z; Waszczuk, J, 2015) |
| "We show that cancer cells and tumors robustly incorporate and remodel exogenous palmitate into structural and oncogenic glycerophospholipids, sphingolipids, and ether lipids." | 1.39 | Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids. ( Louie, SM; Luo, K; Mulvihill, MM; Nomura, DK; Roberts, LS, 2013) |
| "Development and progression of cancer is accompanied by marked changes in the expression and activity of enzymes involved in the cellular homeostasis of fatty acids." | 1.34 | Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells. ( Beckers, A; Brusselmans, K; Organe, S; Peeters, A; Scheys, K; Swinnen, JV; Timmermans, L; Verhoeven, G, 2007) |
| " Interestingly, in both prostate and breast cancer cells, a remarkable dose-response parallelism was observed between flavonoid-induced inhibition of fatty acid synthesis, inhibition of cell growth, and induction of apoptosis." | 1.33 | Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. ( Brusselmans, K; Swinnen, JV; Verhoeven, G; Vrolix, R, 2005) |
| "Sixteen healthy subjects and 18 cancer patients with different tumor types and a weight loss of at least 5% in the previous 6 months were included in the study." | 1.31 | Lipolysis and lipid oxidation in weight-losing cancer patients and healthy subjects. ( Dagnelie, PC; Swart, GR; van den Berg, JW; van der Gaast, A; Wattimena, JL; Wilson, JH; Zuijdgeest-van Leeuwen, SD, 2000) |
| " A 24-h dose-response experiment showed that at 1." | 1.30 | SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells. ( Cabot, MC; Giuliano, AE; Han, TY; Liu, YY, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 4 (14.29) | 18.2507 |
| 2000's | 10 (35.71) | 29.6817 |
| 2010's | 9 (32.14) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
| Authors | Studies |
|---|---|
| Alkan, HF | 1 |
| Altea-Manzano, P | 1 |
| Fendt, SM | 1 |
| He, Y | 1 |
| de Araújo Júnior, RF | 1 |
| Cavalcante, RS | 1 |
| Yu, Z | 1 |
| Schomann, T | 1 |
| Gu, Z | 1 |
| Eich, C | 1 |
| Cruz, LJ | 1 |
| Kaur, S | 1 |
| Balakrishnan, B | 1 |
| Mallia, MB | 1 |
| Keshari, R | 1 |
| Hassan, PA | 1 |
| Banerjee, R | 1 |
| Fatima, S | 1 |
| Hu, X | 1 |
| Gong, RH | 1 |
| Huang, C | 1 |
| Chen, M | 1 |
| Wong, HLX | 1 |
| Bian, Z | 1 |
| Kwan, HY | 1 |
| Fattore, E | 1 |
| Fanelli, R | 1 |
| Louie, SM | 1 |
| Roberts, LS | 1 |
| Mulvihill, MM | 1 |
| Luo, K | 1 |
| Nomura, DK | 1 |
| Shen, KY | 1 |
| Song, YC | 1 |
| Chen, IH | 1 |
| Chong, P | 1 |
| Liu, SJ | 1 |
| Mancini, A | 1 |
| Imperlini, E | 1 |
| Nigro, E | 1 |
| Montagnese, C | 1 |
| Daniele, A | 1 |
| Orrù, S | 1 |
| Buono, P | 1 |
| Ventura, R | 1 |
| Mordec, K | 1 |
| Waszczuk, J | 1 |
| Wang, Z | 1 |
| Lai, J | 1 |
| Fridlib, M | 1 |
| Buckley, D | 1 |
| Kemble, G | 1 |
| Heuer, TS | 1 |
| Ashraf, A | 1 |
| Sarfraz, RA | 1 |
| Rashid, MA | 1 |
| Mahmood, A | 1 |
| Shahid, M | 1 |
| Noor, N | 1 |
| Sarett, SM | 1 |
| Werfel, TA | 1 |
| Chandra, I | 1 |
| Jackson, MA | 1 |
| Kavanaugh, TE | 1 |
| Hattaway, ME | 1 |
| Giorgio, TD | 1 |
| Duvall, CL | 1 |
| Little, JL | 1 |
| Kridel, SJ | 1 |
| Wang, C | 1 |
| Xu, C | 1 |
| Sun, M | 1 |
| Luo, D | 1 |
| Liao, DF | 1 |
| Cao, D | 1 |
| Lum, L | 1 |
| Clevers, H | 1 |
| PIETROPAOLO, C | 1 |
| PISANO, L | 1 |
| CALI, G | 1 |
| FIORENTINO, E | 1 |
| SATO, S | 1 |
| AMIZUKA, T | 1 |
| SATO, K | 1 |
| Kadenbach, B | 1 |
| Arnold, S | 1 |
| Lee, I | 1 |
| Hüttemann, M | 1 |
| Brusselmans, K | 2 |
| Vrolix, R | 1 |
| Verhoeven, G | 2 |
| Swinnen, JV | 2 |
| Yao, D | 1 |
| Shi, W | 1 |
| Gou, Y | 1 |
| Zhou, X | 1 |
| Yee Aw, T | 1 |
| Zhou, Y | 1 |
| Liu, Z | 1 |
| Beckers, A | 1 |
| Organe, S | 1 |
| Timmermans, L | 1 |
| Scheys, K | 1 |
| Peeters, A | 1 |
| Barbieri, B | 1 |
| Alvelius, G | 1 |
| Papadogiannakis, N | 1 |
| Cabot, MC | 1 |
| Giuliano, AE | 1 |
| Han, TY | 1 |
| Liu, YY | 1 |
| Zuijdgeest-van Leeuwen, SD | 2 |
| van den Berg, JW | 2 |
| Wattimena, JL | 2 |
| van der Gaast, A | 2 |
| Swart, GR | 2 |
| Wilson, JH | 2 |
| Dagnelie, PC | 2 |
| Du, X | 1 |
| Beloussow, K | 1 |
| Shen, WC | 1 |
| Poloso, N | 1 |
| Nagarajan, S | 1 |
| Bumgarner, GW | 1 |
| Zampell, JC | 1 |
| Selvaraj, P | 1 |
| Cairella, M | 1 |
| Cox, AD | 1 |
| Der, CJ | 1 |
7 reviews available for palmitic acid and Neoplasms
| Article | Year |
|---|---|
Palmitic acid is an intracellular signaling molecule involved in disease development.
Topics: Animals; Autophagy; Cardiovascular Diseases; Humans; Inflammation; Metabolic Syndrome; Neoplasms; Ne | 2019 |
Palm oil and palmitic acid: a review on cardiovascular effects and carcinogenicity.
Topics: Cardiovascular Diseases; Coronary Disease; Dietary Fats; Humans; Hypercholesterolemia; Neoplasms; Pa | 2013 |
Biological and Nutritional Properties of Palm Oil and Palmitic Acid: Effects on Health.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dietary Fats; Humans; Mice; Neoplasms; | 2015 |
Fatty acid synthase activity in tumor cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Enzyme Inhibitors; Fatty Acid Synthases; Gene Expression | 2008 |
The possible role of cytochrome c oxidase in stress-induced apoptosis and degenerative diseases.
Topics: Animals; Apoptosis; Calcium; Electron Transport; Electron Transport Complex IV; fas Receptor; Humans | 2004 |
Designer cancer vaccines made easy: protein transfer of immunostimulatory molecules for use in therapeutic tumor vaccines.
Topics: Animals; B7-1 Antigen; Cancer Vaccines; Chelating Agents; Cytokines; Genetic Therapy; Glycosylphosph | 2001 |
The ras/cholesterol connection: implications for ras oncogenicity.
Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cholesterol; Dimethylallyltranstransf | 1992 |
1 trial available for palmitic acid and Neoplasms
| Article | Year |
|---|---|
Eicosapentaenoic acid ethyl ester supplementation in cachectic cancer patients and healthy subjects: effects on lipolysis and lipid oxidation.
Topics: Aged; Cachexia; Double-Blind Method; Eicosapentaenoic Acid; Female; Humans; Lipid Peroxidation; Lipo | 2000 |
20 other studies available for palmitic acid and Neoplasms
| Article | Year |
|---|---|
Palmitic acid: Enabling the tumor's nerves.
Topics: Epigenomics; Humans; Methylation; Neoplasms; Palmitic Acid; Tumor Microenvironment | 2022 |
Effective breast cancer therapy based on palmitic acid-loaded PLGA nanoparticles.
Topics: Animals; Doxorubicin; Lactic Acid; Mice; Nanoparticles; Neoplasms; Palmitic Acid; Tumor Microenviron | 2023 |
Technetium-99m labeled core shell hyaluronate nanoparticles as tumor responsive, metastatic skeletal lesion targeted combinatorial theranostics.
Topics: Alendronate; Cell Line, Tumor; Glycosaminoglycans; Humans; Nanoparticles; Neoplasms; Palmitic Acid; | 2023 |
Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids.
Topics: Cell Line, Tumor; Humans; Lipid Metabolism; Metabolomics; Molecular Structure; Neoplasms; Oncogenes; | 2013 |
Depletion of tumor-associated macrophages enhances the anti-tumor immunity induced by a Toll-like receptor agonist-conjugated peptide.
Topics: Animals; Antibodies, Blocking; Clodronic Acid; Cyclooxygenase 2 Inhibitors; Dendritic Cells; Immuniz | 2014 |
Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression.
Topics: Apoptosis; Cell Line, Tumor; Cell Membrane; Enzyme Inhibitors; Fatty Acid Synthase, Type I; Gene Exp | 2015 |
Chemical composition, antioxidant, antitumor, anticancer and cytotoxic effects of Psidium guajava leaf extracts.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Artemia; Bipheny | 2016 |
Hydrophobic interactions between polymeric carrier and palmitic acid-conjugated siRNA improve PEGylated polyplex stability and enhance in vivo pharmacokinetics and tumor gene silencing.
Topics: Animals; Cell Line, Tumor; Drug Carriers; Female; Gene Silencing; Humans; Hydrophobic and Hydrophili | 2016 |
Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis.
Topics: Acetyl-CoA Carboxylase; Apoptosis; Cytotoxins; Enzyme Inhibitors; Furans; Humans; Neoplasms; Palmiti | 2009 |
Cell biology. The unusual case of Porcupine.
Topics: Acyltransferases; AMP-Activated Protein Kinase Kinases; Antineoplastic Agents; Clinical Trials, Phas | 2012 |
FATTY ACID COMPOSITION OF PATHOLOGICAL BODY FLUIDS.
Topics: Body Fluids; Chromatography; Exudates and Transudates; Fatty Acids; Heart Failure; Linoleic Acid; Li | 1964 |
THE INTERRELATIONSHIP BETWEEN GLUCOSE AND PALMITIC ACID OXIDATION IN VITRO BY ASCITES HEPATOMA, AH 130.
Topics: Ascites; Carbohydrate Metabolism; Carcinoma, Hepatocellular; Glucose; Glycolysis; In Vitro Technique | 1964 |
Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; fas Receptor; Fatty Acid | 2005 |
Fatty acid-mediated intracellular iron translocation: a synergistic mechanism of oxidative injury.
Topics: Animals; Antioxidants; Apoptosis; Biological Transport; Cardiovascular Diseases; Cell Death; Cell Su | 2005 |
Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells.
Topics: Acetyl-CoA Carboxylase; Apoptosis; Autophagy; Cell Death; Cell Proliferation; Drug Evaluation, Precl | 2007 |
Lower arachidonic acid content and preferential beta-oxidation of arachidonic acid over palmitic acid in tumour cell lines as compared to normal lymphoid cells.
Topics: Arachidonic Acid; Humans; Infant, Newborn; Lymphocytes; Neoplasms; Oxidation-Reduction; Palmitic Aci | 1998 |
SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells.
Topics: Cell Survival; Ceramides; Cyclosporins; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug S | 1999 |
Lipolysis and lipid oxidation in weight-losing cancer patients and healthy subjects.
Topics: Aged; Energy Intake; Female; Humans; Lipolysis; Male; Middle Aged; Neoplasms; Oxidation-Reduction; P | 2000 |
Bowman-Birk protease inhibitor and its palmitic acid conjugate prevent 7,12-dimethylbenz[a]anthracene-induced transformation in cultured mouse mammary glands.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast; Carcinogens; Cells, Cultured; Female; Mice; Mice, | 2001 |
[Strategies for maintaining health: dietetic aspects].
Topics: Adolescent; Adult; Child; Cholesterol; Coronary Disease; Diet; Dietary Fats; Dietary Fiber; Female; | 1992 |