palmitic acid has been researched along with Metabolic Syndrome in 25 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Metabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After 4 wk of treatment, alveolar bone loss was determined by micro-computed tomography." | 5.40 | Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome. ( Huang, Y; Jin, J; Kirkwood, KL; Li, Y; Lopes-Virella, MF; Lu, Z; Machado, ER; Yu, H; Zhang, X, 2014) |
| " The effects of vitamin D, alone or in combination with niacin, on endothelial cell (EC) angiogenic function and on revascularization in obese animals with peripheral ischemia are unknown." | 3.91 | Vitamin D intervention does not improve vascular regeneration in diet-induced obese male mice with peripheral ischemia. ( Borradaile, NM; Nong, Z; Park, C; Peters, KM; Pickering, JG; Sawyez, CG; Sutherland, BG; Wilson, RB; Yin, H; Zhang, R, 2019) |
| "Scly KO mice were more susceptible to diet-induced obesity than their wild-type counterparts after feeding a high-fat selenium-adequate diet." | 3.81 | Diet-induced obesity in the selenocysteine lyase knockout mouse. ( Berry, MJ; Gilman, CL; Hashimoto, AC; Ogawa-Wong, AN; Seale, LA, 2015) |
| "MetS and periodontitis were induced in mice by HFD and periodontal injection of LPS, respectively." | 1.46 | CD36 is upregulated in mice with periodontitis and metabolic syndrome and involved in macrophage gene upregulation by palmitate. ( Brinson, CW; Huang, Y; Kirkwood, KL; Li, Y; Lopes-Virella, MF; Lu, Z, 2017) |
| "Palmitic acid was one of the saturated fatty acids found to be significantly elevated in patients compared with control subjects (P = 0." | 1.42 | Increased RhoA/Rho-Kinase Activity and Markers of Endothelial Dysfunction in Young Adult Subjects with Metabolic Syndrome. ( Leguina-Ruzzi, A; Mezzano, D; Pereira, J; Pereira-Flores, K; Sáez, CG; Valderas, JP; Velarde, V, 2015) |
| "After 4 wk of treatment, alveolar bone loss was determined by micro-computed tomography." | 1.40 | Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome. ( Huang, Y; Jin, J; Kirkwood, KL; Li, Y; Lopes-Virella, MF; Lu, Z; Machado, ER; Yu, H; Zhang, X, 2014) |
| " The palmitate and drug coincubation potentiated toxicity, which when combined with the plasma maximum concentration (C(max)), allowed us to identify idiosyncratic toxic drugs that were not flagged in previously deployed cytotoxicity assays." | 1.38 | Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. ( Luo, Y; Rana, P; Will, Y, 2012) |
| "Insulin sensitivity was assessed by the minimal model analysis." | 1.36 | Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. ( Avogaro, A; Bortoluzzi, A; Ceolotto, G; Cobelli, C; Dalla Man, C; de Kreutzenberg, SV; Fadini, GP; Papparella, I; Semplicini, A, 2010) |
| "The metabolic syndrome is accompanied by an elevated level of serum insulin, which is known to enhance the synthesis of saturated and monounsaturated fatty acids, such as 16:0 and 18:1, and to stimulate the activity delta-6 desaturase, decreasing the concentration of linoleic acid." | 1.33 | Serum fatty acids in postinfarction middle-aged men. ( Alho, H; Kunnas, T; Leskinen, MH; Nikkari, ST; Solakivi, T, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 17 (68.00) | 24.3611 |
| 2020's | 5 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, Z | 4 |
| Li, Y | 4 |
| Chowdhury, N | 1 |
| Yu, H | 3 |
| Syn, WK | 1 |
| Lopes-Virella, M | 1 |
| Yilmaz, Ö | 1 |
| Huang, Y | 4 |
| Ghezzal, S | 1 |
| Postal, BG | 1 |
| Quevrain, E | 1 |
| Brot, L | 1 |
| Seksik, P | 1 |
| Leturque, A | 1 |
| Thenet, S | 1 |
| Carrière, V | 1 |
| Brezinova, M | 1 |
| Cajka, T | 1 |
| Oseeva, M | 1 |
| Stepan, M | 1 |
| Dadova, K | 1 |
| Rossmeislova, L | 1 |
| Matous, M | 1 |
| Siklova, M | 1 |
| Rossmeisl, M | 1 |
| Kuda, O | 1 |
| van Rooijen, MA | 1 |
| Mensink, RP | 1 |
| Kornicka-Garbowska, K | 1 |
| Bourebaba, L | 1 |
| Röcken, M | 1 |
| Marycz, K | 1 |
| Sekar, S | 1 |
| Shafie, SR | 1 |
| Prasadam, I | 1 |
| Crawford, R | 1 |
| Panchal, SK | 1 |
| Brown, L | 1 |
| Xiao, Y | 1 |
| Hilvo, M | 1 |
| Salonurmi, T | 1 |
| Havulinna, AS | 1 |
| Kauhanen, D | 1 |
| Pedersen, ER | 1 |
| Tell, GS | 1 |
| Meyer, K | 1 |
| Teeriniemi, AM | 1 |
| Laatikainen, T | 1 |
| Jousilahti, P | 1 |
| Savolainen, MJ | 1 |
| Nygård, O | 1 |
| Salomaa, V | 1 |
| Laaksonen, R | 1 |
| Suiter, C | 1 |
| Singha, SK | 1 |
| Khalili, R | 1 |
| Shariat-Madar, Z | 1 |
| Fatima, S | 1 |
| Hu, X | 1 |
| Gong, RH | 1 |
| Huang, C | 1 |
| Chen, M | 1 |
| Wong, HLX | 1 |
| Bian, Z | 1 |
| Kwan, HY | 1 |
| Peters, KM | 1 |
| Zhang, R | 1 |
| Park, C | 1 |
| Nong, Z | 1 |
| Yin, H | 1 |
| Wilson, RB | 1 |
| Sutherland, BG | 1 |
| Sawyez, CG | 1 |
| Pickering, JG | 1 |
| Borradaile, NM | 1 |
| Titov, VN | 1 |
| Vostrov, IA | 1 |
| Kaba, SI | 1 |
| Ameliushkina, VA | 1 |
| Shiriaeva, IuK | 1 |
| Jin, J | 1 |
| Machado, ER | 1 |
| Zhang, X | 2 |
| Lopes-Virella, MF | 3 |
| Kirkwood, KL | 3 |
| Gattu, AK | 1 |
| Birkenfeld, AL | 1 |
| Iwakiri, Y | 1 |
| Jay, S | 1 |
| Saltzman, M | 1 |
| Doll, J | 1 |
| Protiva, P | 1 |
| Samuel, VT | 1 |
| Crawford, SE | 1 |
| Chung, C | 1 |
| Mukwevho, E | 1 |
| Joseph, JS | 1 |
| Seale, LA | 1 |
| Gilman, CL | 1 |
| Hashimoto, AC | 1 |
| Ogawa-Wong, AN | 1 |
| Berry, MJ | 1 |
| Favre, J | 1 |
| Yildirim, C | 1 |
| Leyen, TA | 1 |
| Chen, WJ | 1 |
| van Genugten, RE | 1 |
| van Golen, LW | 1 |
| Garcia-Vallejo, JJ | 1 |
| Musters, R | 1 |
| Baggen, J | 1 |
| Fontijn, R | 1 |
| van der Pouw Kraan, T | 1 |
| Serné, E | 1 |
| Koolwijk, P | 1 |
| Diamant, M | 1 |
| Horrevoets, AJ | 1 |
| Leguina-Ruzzi, A | 1 |
| Pereira, J | 1 |
| Pereira-Flores, K | 1 |
| Valderas, JP | 1 |
| Mezzano, D | 1 |
| Velarde, V | 1 |
| Sáez, CG | 1 |
| Brinson, CW | 1 |
| Kishino, T | 1 |
| Watanabe, K | 1 |
| Urata, T | 1 |
| Takano, M | 1 |
| Uemura, T | 1 |
| Nishikawa, K | 1 |
| Mine, Y | 1 |
| Matsumoto, M | 1 |
| Ohtsuka, K | 1 |
| Ohnishi, H | 1 |
| Mori, H | 1 |
| Takahashi, S | 1 |
| Ishida, H | 1 |
| Watanabe, T | 1 |
| de Kreutzenberg, SV | 1 |
| Ceolotto, G | 1 |
| Papparella, I | 1 |
| Bortoluzzi, A | 1 |
| Semplicini, A | 1 |
| Dalla Man, C | 1 |
| Cobelli, C | 1 |
| Fadini, GP | 1 |
| Avogaro, A | 1 |
| Thörn, K | 1 |
| Hovsepyan, M | 1 |
| Bergsten, P | 1 |
| Luo, Y | 1 |
| Rana, P | 1 |
| Will, Y | 1 |
| Leskinen, MH | 1 |
| Solakivi, T | 1 |
| Kunnas, T | 1 |
| Alho, H | 1 |
| Nikkari, ST | 1 |
| Allagnat, F | 1 |
| Alonso, F | 1 |
| Martin, D | 1 |
| Abderrahmani, A | 1 |
| Waeber, G | 1 |
| Haefliger, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Exercise Training and Omega-3 Fatty Acids on Metabolic Health and Dysfunction of Adipose Tissue in Elderly[NCT03386461] | 55 participants (Actual) | Interventional | 2017-01-05 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for palmitic acid and Metabolic Syndrome
| Article | Year |
|---|---|
Palmitic Acid Versus Stearic Acid: Effects of Interesterification and Intakes on Cardiometabolic Risk Markers - A Systematic Review.
Topics: Biomarkers; Cardiovascular Diseases; Esterification; Humans; Metabolic Syndrome; Palmitic Acid; Risk | 2020 |
Free Fatty Acids: Circulating Contributors of Metabolic Syndrome.
Topics: Fatty Acids, Nonesterified; Humans; Metabolic Syndrome; Oleic Acid; Palmitic Acid; Risk Factors | 2018 |
Palmitic acid is an intracellular signaling molecule involved in disease development.
Topics: Animals; Autophagy; Cardiovascular Diseases; Humans; Inflammation; Metabolic Syndrome; Neoplasms; Ne | 2019 |
[Low and very low density lipoproteins: pathogenetic and clinical significance].
Topics: Atherosclerosis; Humans; Lipoproteins, LDL; Lipoproteins, VLDL; Metabolic Syndrome; Palmitic Acid | 2013 |
1 trial available for palmitic acid and Metabolic Syndrome
| Article | Year |
|---|---|
Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women.
Topics: Adipose Tissue; Aged; Aged, 80 and over; Aging; Combined Modality Therapy; Dietary Supplements; Este | 2020 |
20 other studies available for palmitic acid and Metabolic Syndrome
| Article | Year |
|---|---|
The Presence of Periodontitis Exacerbates Non-Alcoholic Fatty Liver Disease via Sphingolipid Metabolism-Associated Insulin Resistance and Hepatic Inflammation in Mice with Metabolic Syndrome.
Topics: Animals; Ceramides; Diet, High-Fat; Imipramine; Inflammation; Insulin Resistance; Lipopolysaccharide | 2023 |
Palmitic acid damages gut epithelium integrity and initiates inflammatory cytokine production.
Topics: Administration, Oral; Animals; Caco-2 Cells; Cytokines; Disease Models, Animal; Endoplasmic Reticulu | 2020 |
Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes In Vitro and Ex Vivo.
Topics: Animals; Endoplasmic Reticulum Stress; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Horses | 2021 |
Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats.
Topics: Animals; Cattle; Cells, Cultured; Chondrocytes; Disease Models, Animal; Fatty Acids; Heparan Sulfate | 2017 |
Ceramide stearic to palmitic acid ratio predicts incident diabetes.
Topics: Aged; Angina Pectoris; Body Mass Index; Ceramides; Cohort Studies; Coronary Angiography; Diabetes Me | 2018 |
Vitamin D intervention does not improve vascular regeneration in diet-induced obese male mice with peripheral ischemia.
Topics: Animals; Cell Movement; Cell Proliferation; Diet; Endothelial Cells; Gene Expression Profiling; Hind | 2019 |
Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Blood | 2014 |
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
Topics: Adipocytes; Animals; Eye Proteins; Gene Expression Regulation; Glucose Tolerance Test; Hepatocytes; | 2014 |
Calmodulin dependent protein kinase II activation by exercise regulates saturated & unsaturated fatty acids and improves some metabolic syndrome markers.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Enzyme Activation; Fatty Acids; Fatty A | 2014 |
Metabolic syndrome exacerbates inflammation and bone loss in periodontitis.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Chemokine CCL2; Cytokines; Diet, | 2015 |
Diet-induced obesity in the selenocysteine lyase knockout mouse.
Topics: Animals; Cell Line, Tumor; Diet, High-Fat; Energy Metabolism; Heat-Shock Proteins; Lyases; Metabolic | 2015 |
Palmitic acid increases pro-oxidant adaptor protein p66Shc expression and affects vascularization factors in angiogenic mononuclear cells: Action of resveratrol.
Topics: Antioxidants; Case-Control Studies; Cell Movement; Cells, Cultured; Diabetes Mellitus, Type 2; Gene | 2015 |
Increased RhoA/Rho-Kinase Activity and Markers of Endothelial Dysfunction in Young Adult Subjects with Metabolic Syndrome.
Topics: Adult; Age Factors; Biomarkers; Case-Control Studies; Cholesterol, HDL; Cross-Sectional Studies; Dys | 2015 |
CD36 is upregulated in mice with periodontitis and metabolic syndrome and involved in macrophage gene upregulation by palmitate.
Topics: Alveolar Bone Loss; Animals; CD36 Antigens; Cells, Cultured; Gene Silencing; Lipopolysaccharides; Ma | 2017 |
Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition.
Topics: Adiposity; Adult; Aged; Alcohol Drinking; Body Mass Index; Chromatography, Gas; Diabetes Mellitus; F | 2008 |
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.
Topics: Angiogenesis Inhibitors; Atherosclerosis; Carotid Arteries; Down-Regulation; Glucose; Glucose Tolera | 2010 |
Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells.
Topics: Animals; Apoptosis; Cell Line; Endoplasmic Reticulum; Eukaryotic Initiation Factor-2; Fatty Acids; G | 2010 |
Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease.
Topics: Drug Synergism; Hep G2 Cells; Humans; Metabolic Syndrome; Palmitic Acid | 2012 |
Serum fatty acids in postinfarction middle-aged men.
Topics: Aged; Body Mass Index; Cholesterol, HDL; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dietary | 2005 |
ICER-1gamma overexpression drives palmitate-mediated connexin36 down-regulation in insulin-secreting cells.
Topics: Animals; Cell Line, Tumor; Connexins; Cyclic AMP; Cyclic AMP Response Element Modulator; Cyclic AMP- | 2008 |