palmitic acid has been researched along with Liver Steatosis in 107 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that high blood levels of palmitic acid (PA) strongly triggered neutrophil autophagy activation, leading to adhesion deficiency in dairy cows with fatty liver." | 8.02 | Autophagy Induced by Palmitic Acid Regulates Neutrophil Adhesion Through the Granule-Dependent Degradation of αMβ2 Integrin in Dairy Cows With Fatty Liver. ( Du, X; Fang, B; Li, X; Li, Y; Liu, G; Peng, Z; Qin, X; Song, Y; Wang, Z; Yang, Y; Zhang, Y; Zhao, C, 2021) |
| " This study examined the effect of a novel neuroprotective curcuminoid, CNB-001 [4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl)vinyl)-2-methoxy-phenol], on glucose intolerance and insulin signaling in high-fat diet (HFD)-fed mice." | 7.80 | Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. ( Hua, Y; Lapchak, PA; Lehmann, TE; Nair, S; Panzhinskiy, E; Ren, J; Topchiy, E, 2014) |
| "Melatonin plays an important role in regulating circadian rhythms." | 5.48 | Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. ( Baik, SH; Choi, DS; Choi, KM; Heo, JI; Kim, NH; Kim, SG; Seo, JA; Yoo, HJ; Yoon, DW; Yu, JH, 2018) |
| "The aging rats showed hyperinsulinemia and hyperlipidemia, and insulin resistance as examined by the decreased glucose decay constant rate during insulin tolerance test (kITT)." | 5.39 | Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction. ( Cai, L; Feng, H; Gong, D; Guan, L; Wu, Q; Yang, M; Yuan, B; Zhao, J; Zhao, X; Zou, Y, 2013) |
| " Here, we show that high blood levels of palmitic acid (PA) strongly triggered neutrophil autophagy activation, leading to adhesion deficiency in dairy cows with fatty liver." | 4.02 | Autophagy Induced by Palmitic Acid Regulates Neutrophil Adhesion Through the Granule-Dependent Degradation of αMβ2 Integrin in Dairy Cows With Fatty Liver. ( Du, X; Fang, B; Li, X; Li, Y; Liu, G; Peng, Z; Qin, X; Song, Y; Wang, Z; Yang, Y; Zhang, Y; Zhao, C, 2021) |
| "To investigate whether ezetimibe ameliorates hepatic steatosis and induces autophagy in a rat model of obesity and type 2 diabetes." | 3.81 | Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. ( Chang, E; Kim, L; Lee, WY; Oh, KW; Park, CY; Park, SE; Park, SW; Rhee, EJ, 2015) |
| " This study examined the effect of a novel neuroprotective curcuminoid, CNB-001 [4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl)vinyl)-2-methoxy-phenol], on glucose intolerance and insulin signaling in high-fat diet (HFD)-fed mice." | 3.80 | Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. ( Hua, Y; Lapchak, PA; Lehmann, TE; Nair, S; Panzhinskiy, E; Ren, J; Topchiy, E, 2014) |
| "In this study, we aimed to study the role of growth factor receptor-bound protein 2 (Grb2) in palmitic acid-induced steatosis and other "fatty liver" symptoms in vitro." | 3.79 | Suppression of Grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration. ( Chen, Y; Fan, R; Miao, Y; Mu, X; Shan, X; Song, C; Sun, G; Wan, Z; Wu, G; Zha, W; Zhou, G; Zhu, J, 2013) |
| "To quantify the various components of splanchnic free fatty acid and very-low-density lipoprotein-triacylglycerol (VLDL-TAG) metabolism in order to gain insight into the mechanisms responsible for the development of fatty liver in severely burned patients, and to determine if decreasing free fatty acid availability by use of propranolol could potentially reduce hepatic fatty acid accumulation." | 3.71 | Propranolol decreases splanchnic triacylglycerol storage in burn patients receiving a high-carbohydrate diet. ( Herndon, DN; Irtun, O; Morio, B; Wolfe, RR, 2002) |
| "These results provide a new potential treatment for obesity in the future." | 1.51 | Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice. ( Chen, CC; Lee, TY; Leu, YL; Wang, SH, 2019) |
| "Melatonin plays an important role in regulating circadian rhythms." | 1.48 | Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. ( Baik, SH; Choi, DS; Choi, KM; Heo, JI; Kim, NH; Kim, SG; Seo, JA; Yoo, HJ; Yoon, DW; Yu, JH, 2018) |
| "Treatment with palmitic acid (PA) or HFD significantly increased the expression of miR-33a in hepatocytes or liver tissues." | 1.48 | Hepatocyte miR-33a mediates mitochondrial dysfunction and hepatosteatosis by suppressing NDUFA5. ( Chen, Z; Dai, X; He, H; Huang, H; Li, Q; Nie, H; Ren, T; Song, C; Wang, D; Yu, X; Zhou, L; Zhou, Y, 2018) |
| "The pathogenesis of nonalcoholic steatohepatitis is primarily an immune-driven disease and a known factor associated with treatment failure of chronic hepatitis C with interferon (IFN) and ribavirin." | 1.42 | Fatty Acids Induce a Pro-Inflammatory Gene Expression Profile in Huh-7 Cells That Attenuates the Anti-HCV Action of Interferon. ( Beard, MR; George, J; Helbig, KJ; McCartney, EM; Tse, E; Van der Hoek, K; Van der Hoek, M, 2015) |
| "Liver steatosis is characterised by lipid droplet deposition in hepatocytes that can leads to an inflammatory and fibrotic phenotype." | 1.42 | The activation of peroxisome proliferator-activated receptor γ is regulated by Krüppel-like transcription factors 6 & 9 under steatotic conditions. ( Escalona-Nandez, I; Estanes-Hernández, A; Guerrero-Escalera, D; Ortíz-Ortega, V; Pérez-Monter, C; Tovar, AR, 2015) |
| " In wild type and CHOP(-/-) mice treated with EtOH and high fat diet (HFD), EtOH worsened the HFD-induced liver injury and dyslipidemia, while CHOP knockout blocked toxic effects of EtOH and PA." | 1.42 | Ethanol promotes saturated fatty acid-induced hepatoxicity through endoplasmic reticulum (ER) stress response. ( Cao, W; Lu, J; Ma, YX; Wang, CF; Wang, XN; Wu, XD; Yi, HW, 2015) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in parallel with the prevalence of obesity." | 1.42 | GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance. ( Isobe, K; Nishio, N, 2015) |
| "Treatment with dronedarone 200mg/kg/day had no effect on body weight, serum transaminases and bilirubin, and hepatic mitochondrial function in both wild-type and jvs(+/-) mice." | 1.40 | Hepatic toxicity of dronedarone in mice: role of mitochondrial β-oxidation. ( Bouitbir, J; Donzelli, M; Felser, A; Krähenbühl, S; Morand, R; Schnell, D; Stoller, A; Terracciano, L, 2014) |
| "The aging rats showed hyperinsulinemia and hyperlipidemia, and insulin resistance as examined by the decreased glucose decay constant rate during insulin tolerance test (kITT)." | 1.39 | Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction. ( Cai, L; Feng, H; Gong, D; Guan, L; Wu, Q; Yang, M; Yuan, B; Zhao, J; Zhao, X; Zou, Y, 2013) |
| "Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent, chronic liver diseases, worldwide." | 1.39 | EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD. ( Alisi, A; Ceccarelli, S; Crudele, A; De Stefanis, C; Gaspari, S; Gnani, D; Locatelli, F; Marquez, VE; Nobili, V; Rota, R; Vella, S, 2013) |
| "Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome and type 2 diabetes." | 1.38 | Increased erythrocytes n-3 and n-6 polyunsaturated fatty acids is significantly associated with a lower prevalence of steatosis in patients with type 2 diabetes. ( Athias, A; Bouillet, B; Brindisi, MC; Cercueil, JP; Cottet, V; Duvillard, L; Gambert, P; Guiu, B; Habchi, M; Hillon, P; Jooste, V; Petit, JM; Verges, B, 2012) |
| "Exendin-4 treatment decreased body weight, serum free fatty acid (FA), and triglyceride levels in HF-induced obese C57BL/6J mice." | 1.38 | Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice. ( Bae, JC; Chae, SW; Choi, JH; Hong, SW; Kim, DH; Kim, SW; Lee, J; Lee, WY; Oh, KW; Park, CY; Park, SE; Park, SW; Rhee, EJ, 2012) |
| "Nonalcoholic steatohepatitis (NASH) is associated with obesity and type 2 diabetes, and an increased risk for liver cirrhosis and cancer." | 1.38 | Elovl6 promotes nonalcoholic steatohepatitis. ( Atsumi, A; Ishii, K; Kobayashi, K; Kuba, M; Matsumori, R; Matsuzaka, T; Murata, S; Nakagawa, Y; Nakamuta, M; Nie, T; Shimada, M; Shimano, H; Shinozaki, H; Sone, H; Suzuki, H; Suzuki-Kemuriyama, N; Takahashi, A; Takekoshi, K; Yahagi, N; Yamada, N; Yatoh, S, 2012) |
| "The treatment with palmitic acid produced a significant increase in cell death." | 1.37 | Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. ( Bai, J; Dong, L; Shi, H; Yang, X; Zhang, Y, 2011) |
| "Nonalcoholic steatohepatitis is characterized by hepatic steatosis, elevated levels of circulating free fatty acids (FFA), endoplasmic reticulum (ER) stress, and hepatocyte lipoapoptosis." | 1.37 | Death receptor 5 signaling promotes hepatocyte lipoapoptosis. ( Bronk, SF; Cazanave, SC; El-Deiry, WS; Fingas, CD; Finnberg, N; Gores, GJ; Kaufmann, SH; Meng, XW; Mott, JL; Werneburg, NW, 2011) |
| "With progression from steatosis to steatohepatitis, there was activation and increased PKCδ protein content coincident with hepatic endoplasmic reticulum (ER) stress parameters." | 1.36 | PKC{delta} is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death. ( Burrington, CM; Chongkrairatanakul, T; Greene, MW; Johnson, AK; Kangwanpornsiri, A; Ruhoff, MS, 2010) |
| "The pathogenesis of nonalcoholic steatohepatitis (NASH) is unclear, despite epidemiological data implicating FFAs." | 1.35 | Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. ( Chung, KW; Chung, WJ; Han, MS; Hwang, JS; Kim, S; Kwon, CH; Lee, JH; Lee, KW; Lee, MS; Park, CK; Park, SY; Shinzawa, K; Song, DK; Tsujimoto, Y; Yan, JJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (14.02) | 18.7374 |
| 1990's | 3 (2.80) | 18.2507 |
| 2000's | 12 (11.21) | 29.6817 |
| 2010's | 65 (60.75) | 24.3611 |
| 2020's | 12 (11.21) | 2.80 |
| Authors | Studies |
|---|---|
| Cioffi, CL | 1 |
| Racz, B | 1 |
| Varadi, A | 1 |
| Freeman, EE | 1 |
| Conlon, MP | 1 |
| Chen, P | 1 |
| Zhu, L | 1 |
| Kitchen, DB | 1 |
| Barnes, KD | 1 |
| Martin, WH | 1 |
| Pearson, PG | 1 |
| Johnson, G | 1 |
| Blaner, WS | 1 |
| Petrukhin, K | 1 |
| Peng, Z | 1 |
| Zhao, C | 1 |
| Du, X | 1 |
| Yang, Y | 2 |
| Li, Y | 1 |
| Song, Y | 1 |
| Fang, B | 1 |
| Zhang, Y | 4 |
| Qin, X | 1 |
| Li, X | 2 |
| Wang, Z | 1 |
| Liu, G | 1 |
| Baddela, VS | 1 |
| Sharma, A | 1 |
| Plinski, C | 1 |
| Vanselow, J | 1 |
| Wang, G | 1 |
| Li, J | 3 |
| Bojmar, L | 1 |
| Chen, H | 1 |
| Li, Z | 1 |
| Tobias, GC | 1 |
| Hu, M | 1 |
| Homan, EA | 1 |
| Lucotti, S | 1 |
| Zhao, F | 1 |
| Posada, V | 1 |
| Oxley, PR | 1 |
| Cioffi, M | 1 |
| Kim, HS | 1 |
| Wang, H | 2 |
| Lauritzen, P | 1 |
| Boudreau, N | 1 |
| Shi, Z | 1 |
| Burd, CE | 1 |
| Zippin, JH | 1 |
| Lo, JC | 1 |
| Pitt, GS | 1 |
| Hernandez, J | 1 |
| Zambirinis, CP | 1 |
| Hollingsworth, MA | 1 |
| Grandgenett, PM | 1 |
| Jain, M | 1 |
| Batra, SK | 1 |
| DiMaio, DJ | 1 |
| Grem, JL | 1 |
| Klute, KA | 1 |
| Trippett, TM | 1 |
| Egeblad, M | 1 |
| Paul, D | 1 |
| Bromberg, J | 1 |
| Kelsen, D | 1 |
| Rajasekhar, VK | 1 |
| Healey, JH | 1 |
| Matei, IR | 1 |
| Jarnagin, WR | 1 |
| Schwartz, RE | 1 |
| Zhang, H | 1 |
| Lyden, D | 1 |
| Jiang, L | 1 |
| Liu, Y | 3 |
| Zhou, Y | 3 |
| Xu, Q | 1 |
| Cheng, S | 1 |
| Yan, J | 1 |
| Xiao, Y | 1 |
| Han, L | 1 |
| Wang, Y | 1 |
| Cai, W | 1 |
| Zheng, Y | 1 |
| Chen, X | 1 |
| Lu, T | 1 |
| Lin, Z | 2 |
| Liu, C | 1 |
| Yuan, D | 1 |
| Yuan, C | 1 |
| Schilcher, K | 1 |
| Dayoub, R | 1 |
| Kubitza, M | 1 |
| Riepl, J | 1 |
| Klein, K | 1 |
| Buechler, C | 1 |
| Melter, M | 1 |
| Weiss, TS | 2 |
| Yang, W | 1 |
| Liu, R | 2 |
| Xia, C | 1 |
| Chen, Y | 3 |
| Dong, Z | 1 |
| Huang, B | 1 |
| Li, R | 1 |
| Li, M | 1 |
| Xu, C | 1 |
| Zhong, L | 1 |
| Yu, S | 1 |
| Shen, W | 4 |
| Cai, C | 2 |
| Yu, H | 1 |
| Mittal, S | 1 |
| Inamdar, S | 1 |
| Acharya, J | 1 |
| Pekhale, K | 1 |
| Kalamkar, S | 1 |
| Boppana, R | 1 |
| Ghaskadbi, S | 1 |
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| Zhong, XB | 1 |
| Ku, WW | 1 |
| Schultz Moreira, AR | 1 |
| Rüschenbaum, S | 1 |
| Schefczyk, S | 1 |
| Hendgen-Cotta, U | 1 |
| Rassaf, T | 1 |
| Broering, R | 1 |
| Hardtke-Wolenski, M | 1 |
| Buitrago-Molina, LE | 1 |
| Liu, PY | 1 |
| Chen, CC | 2 |
| Chin, CY | 1 |
| Liu, TJ | 1 |
| Tsai, WC | 1 |
| Chou, JL | 1 |
| Huang, CY | 1 |
| Chen, YG | 1 |
| Chen, YC | 1 |
| He, K | 1 |
| Zhu, X | 1 |
| Miao, C | 1 |
| Wang, T | 1 |
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| Gong, J | 2 |
| Li, S | 2 |
| Ruan, XZ | 1 |
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| Schulz, T | 1 |
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| Seehofer, D | 1 |
| Borlak, J | 1 |
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| Berndt, N | 1 |
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| Yiu, JHC | 1 |
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| Wu, WH | 1 |
| Lee, JH | 3 |
| Jun, DW | 1 |
| Kim, J | 1 |
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| Lee, TB | 1 |
| Jun, JH | 1 |
| Chen, T | 1 |
| Yan, D | 1 |
| Cheng, X | 1 |
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| Yin, W | 1 |
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| Kim, SY | 1 |
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| Park, YB | 1 |
| Lee, KT | 1 |
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| Yu, JH | 1 |
| Kim, NH | 2 |
| Yoo, HJ | 1 |
| Seo, JA | 1 |
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| Choi, KM | 1 |
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| Nie, H | 1 |
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| Yang, ZX | 2 |
| Fang, DL | 1 |
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| Gnani, D | 1 |
| Crudele, A | 1 |
| Ceccarelli, S | 1 |
| De Stefanis, C | 1 |
| Gaspari, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1B, Single-Blinded, Linear Two Period, Placebo-controlled Study to Evaluate the Effects of 10 mg/Day of PF-05221304, Liver Targeted Acetyl-CoA Carboxylase Inhibitor (ACCi) on Very Low Density Lipoprotein ApoB100 and TG Secretion[NCT04395950] | Phase 1 | 0 participants (Actual) | Interventional | 2020-12-31 | Withdrawn (stopped due to Poor enrollment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
107 other studies available for palmitic acid and Liver Steatosis
| Article | Year |
|---|---|
Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.
Topics: Animals; Chemistry Techniques, Synthetic; Disease Models, Animal; Drug Design; Fatty Liver; Male; Mi | 2019 |
Autophagy Induced by Palmitic Acid Regulates Neutrophil Adhesion Through the Granule-Dependent Degradation of αMβ2 Integrin in Dairy Cows With Fatty Liver.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Cattle; CD11b Antigen; CD18 Antigens; Cell Adhesion | 2021 |
Palmitic acid protects granulosa cells from oleic acid induced steatosis and rescues progesterone production via cAMP dependent mechanism.
Topics: Fatty Liver; Female; Granulosa Cells; Humans; Oleic Acid; Palmitic Acid; Progesterone | 2022 |
Tumour extracellular vesicles and particles induce liver metabolic dysfunction.
Topics: Animals; Cytochrome P-450 Enzyme System; Extracellular Vesicles; Fatty Acids; Fatty Liver; Humans; I | 2023 |
Targeted metabolomics unravels altered phenylalanine levels in piglets receiving total parenteral nutrition.
Topics: Animals; Animals, Newborn; Fatty Liver; Liver; Liver Diseases; Metabolomics; Palmitic Acid; Parenter | 2023 |
miR-871-5p/PGC1α Regulates Aging-Induced Lipid Deposition in Hepatocytes Through Fatty Acid β-Oxidation.
Topics: Animals; Fatty Liver; Hepatocytes; Lipid Metabolism; Liver; Mice; MicroRNAs; Palmitic Acid; Peroxiso | 2023 |
Saturated Fat-Mediated Upregulation of IL-32 and CCL20 in Hepatocytes Contributes to Higher Expression of These Fibrosis-Driving Molecules in MASLD.
Topics: Carcinoma, Hepatocellular; Chemokine CCL20; Chemokines; Fats, Unsaturated; Fatty Liver; Hepatocytes; | 2023 |
Effects of different fatty acids on BRL3A rat liver cell damage.
Topics: Acetyl-CoA Carboxylase; alpha-Linolenic Acid; Animals; Cells, Cultured; Endoplasmic Reticulum Stress | 2020 |
Inhibition of stearoyl-coenzyme A desaturase 1 ameliorates hepatic steatosis by inducing AMPK-mediated lipophagy.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Enzyme Inhibitors; Fatty | 2020 |
miR-3666 inhibits development of hepatic steatosis by negatively regulating PPARγ.
Topics: 3' Untranslated Regions; Animals; Fatty Liver; Gene Expression Regulation; Hep G2 Cells; Humans; Liv | 2020 |
Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis.
Topics: Cell Line, Tumor; Culture Media; Cytochrome P-450 Enzyme System; DNA Methylation; Epigenesis, Geneti | 2020 |
9-PAHSA Prevents Mitochondrial Dysfunction and Increases the Viability of Steatotic Hepatocytes.
Topics: Animals; Cell Survival; Cells, Cultured; Cytoprotection; Fatty Liver; Hep G2 Cells; Hepatocytes; Hum | 2020 |
E3 ubiquitin ligase Grail promotes hepatic steatosis through Sirt1 inhibition.
Topics: Animals; Fatty Liver; Hepatocytes; Humans; Male; Mice; Mice, Knockout; Palmitic Acid; Sirtuin 1; Ubi | 2021 |
Inhibition of NLRP3 inflammasome by thioredoxin-interacting protein in mouse Kupffer cells as a regulatory mechanism for non-alcoholic fatty liver disease development.
Topics: Adult; Animals; Carrier Proteins; Cells, Cultured; Diet, High-Fat; Disease Progression; Fatty Liver; | 2017 |
Oxidative and ER stress-dependent ASK1 activation in steatotic hepatocytes and Kupffer cells sensitizes mice fatty liver to ischemia/reperfusion injury.
Topics: Animals; Diet, High-Fat; Endoplasmic Reticulum Stress; Fatty Liver; Gene Expression Regulation; Hepa | 2017 |
A unifying mathematical model of lipid droplet metabolism reveals key molecular players in the development of hepatic steatosis.
Topics: Cell Line, Tumor; Cholesterol Esters; Diacylglycerol O-Acyltransferase; Fatty Liver; Gene Expression | 2017 |
TRIF-dependent Toll-like receptor signaling suppresses
Topics: Adaptor Proteins, Vesicular Transport; Animals; Diet, High-Fat; Fatty Liver; HEK293 Cells; Hepatocyt | 2017 |
Fermented Soymilk Alleviates Lipid Accumulation by Inhibition of SREBP-1 and Activation of NRF-2 in the Hepatocellular Steatosis Model.
Topics: Bioreactors; Carcinoma, Hepatocellular; Cell Proliferation; Estrogens; Fatty Liver; Fermentation; Ge | 2018 |
miR-1224-5p Enhances Hepatic Lipogenesis by Targeting Adenosine Monophosphate-Activated Protein Kinase α1 in Male Mice.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Down-Regulation; Fatty Liver; Gene Expressio | 2018 |
Euodia daniellii Hemsl. (Bee-Bee Tree) Oil Attenuates Palmitate-Induced Lipid Accumulation and Apoptosis in Hepatocytes.
Topics: Animals; Apoptosis; Cells, Cultured; Dose-Response Relationship, Drug; Evodia; Fatty Liver; Hepatocy | 2018 |
Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein.
Topics: alpha-2-HS-Glycoprotein; Animals; Dietary Fats; Endoplasmic Reticulum Stress; Fatty Liver; Hep G2 Ce | 2018 |
Hepatocyte miR-33a mediates mitochondrial dysfunction and hepatosteatosis by suppressing NDUFA5.
Topics: Adenosine Triphosphate; Animals; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Gene Expressio | 2018 |
Permethrin and ivermectin modulate lipid metabolism in steatosis-induced HepG2 hepatocyte.
Topics: Endoplasmic Reticulum Stress; Fatty Acids; Fatty Liver; Hep G2 Cells; Hepatocytes; Humans; Insectici | 2019 |
Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Cell Proliferation; Clone Cells; Di | 2019 |
Palmitic Acid-Enriched Diet Induces Hepatic Steatosis and Injury in Adult Zebrafish.
Topics: Animal Feed; Animals; Chemical and Drug Induced Liver Injury; Diet; Endoplasmic Reticulum Stress; Fa | 2019 |
Metabolomic signatures in lipid-loaded HepaRGs reveal pathways involved in steatotic progression.
Topics: Bile Acids and Salts; Diglycerides; Disease Progression; Fatty Liver; HEK293 Cells; Hep G2 Cells; Hu | 2013 |
Suppression of Grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration.
Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Caspase 3; Cell Survival; Fatty Liver; Gene E | 2013 |
Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Diabetes Mellitus, Experimental; Down-Regulation; Dy | 2013 |
Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Age Factors; Aging; Animals; Antioxidants; Cell Line; Dose-Response Relation | 2013 |
Accumulation of lipids and oxidatively damaged DNA in hepatocytes exposed to particles.
Topics: Animals; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Fatty Acid Synthase, Type I; Fatty Liver; | 2014 |
Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3β activation in human liver cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Shape; Endoplasmic Reticulum Stress; Enzyme A | 2014 |
EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD.
Topics: Adenosine; Animals; Disease Models, Animal; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Fa | 2013 |
3,5-diiodo-L-thyronine modifies the lipid droplet composition in a model of hepatosteatosis.
Topics: Animals; Cell Line, Tumor; Diiodothyronines; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fatty | 2014 |
Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance.
Topics: Adiposity; Animals; Catalytic Domain; Cell Line; Cell Survival; Curcumin; Dietary Fats; Endoplasmic | 2014 |
Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARα pathways in L02 cells and HepG2 cells.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Antioxidants; Cell Line; Drugs, Chinese Herbal; | 2014 |
Overexpression of juxtaposed with another zinc finger gene 1 reduces proinflammatory cytokine release via inhibition of stress-activated protein kinases and nuclear factor-κB.
Topics: Animals; Chemokine CCL2; Co-Repressor Proteins; Cytokines; Diet, High-Fat; DNA-Binding Proteins; Fat | 2014 |
Hepatic toxicity of dronedarone in mice: role of mitochondrial β-oxidation.
Topics: Alanine Transaminase; Amiodarone; Animals; Anti-Arrhythmia Agents; bcl-2-Associated X Protein; Disea | 2014 |
Decreasing mitochondrial fission alleviates hepatic steatosis in a murine model of nonalcoholic fatty liver disease.
Topics: Animals; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; Disease Progression; Energy Metabo | 2014 |
Fatty Acids Induce a Pro-Inflammatory Gene Expression Profile in Huh-7 Cells That Attenuates the Anti-HCV Action of Interferon.
Topics: Cell Line; Cluster Analysis; Drug Synergism; Fatty Acids; Fatty Liver; Gene Expression Profiling; Ge | 2015 |
The activation of peroxisome proliferator-activated receptor γ is regulated by Krüppel-like transcription factors 6 & 9 under steatotic conditions.
Topics: Fatty Liver; Gene Expression Regulation; Hep G2 Cells; Humans; Kruppel-Like Factor 6; Kruppel-Like T | 2015 |
Radiolabeled BMIPP for imaging hepatic fatty acid metabolism: evaluation of hepatic distribution and metabolism in mice at various metabolic statuses induced by fasting in comparison with palmitic acid.
Topics: Animals; Area Under Curve; Body Weight; Fatty Acids; Fatty Liver; Food Deprivation; Iodine Radioisot | 2015 |
Ethanol promotes saturated fatty acid-induced hepatoxicity through endoplasmic reticulum (ER) stress response.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Caspase 3; Chemical and Drug Induced Liver In | 2015 |
New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro.
Topics: Animals; Cell Line; Cytokines; Fatty Liver; Fibronectins; Hepatocytes; Liver X Receptors; Mice; Orph | 2015 |
[Role of PI3K/Akt pathway in endoplasmic reticulum stress and apoptosis induced by saturated fatty acid in human steatotic hepatocytes].
Topics: Animals; Apoptosis; Cell Line; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Fa | 2015 |
Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats.
Topics: Animals; Anticholesteremic Agents; Autophagy; Biomarkers; Blood Glucose; Cells, Cultured; Diabetes M | 2015 |
Saturated fatty acids induce post-transcriptional regulation of HAMP mRNA via AU-rich element-binding protein, human antigen R (HuR).
Topics: 3' Untranslated Regions; Animals; Cell Line, Tumor; Cell Nucleus; Cytoplasm; ELAV-Like Protein 1; Fa | 2015 |
GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance.
Topics: Adipogenesis; Aging; Animals; Body Weight; Carcinoma, Hepatocellular; CHO Cells; Cricetinae; Cricetu | 2015 |
[Effects of JAZF1 overexpression on proinflammatory cytokines in hepatocytes induced by palmitic acid].
Topics: Cell Survival; Chemokine CCL2; Co-Repressor Proteins; Cytokines; DNA-Binding Proteins; Fatty Liver; | 2015 |
Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53.
Topics: Animals; Benzothiazoles; Caloric Restriction; Cell Survival; Diet; Endoplasmic Reticulum Stress; Fat | 2016 |
Protective Effect of Gomisin N against Endoplasmic Reticulum Stress-Induced Hepatic Steatosis.
Topics: Acetyl-CoA Carboxylase; Animals; Cyclooctanes; Cytokines; Endoplasmic Reticulum Chaperone BiP; Endop | 2016 |
The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca(2+) signalling in steatotic hepatocytes.
Topics: Animals; Bucladesine; Calcium; Calcium Signaling; Cyclic AMP; Exenatide; Fatty Liver; Glucagon-Like | 2016 |
Supplementing dietary sugar promotes endoplasmic reticulum stress-independent insulin resistance and fatty liver in goose.
Topics: Animals; Cells, Cultured; Dietary Carbohydrates; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Re | 2016 |
LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes.
Topics: Animals; Endoplasmic Reticulum Stress; Fatty Liver; Hepatocytes; Low Density Lipoprotein Receptor-Re | 2016 |
Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line.
Topics: Apoptosis; Cell Line; Cell Proliferation; Enzyme Inhibitors; Fatty Liver; Gene Expression Regulation | 2016 |
Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration.
Topics: Animals; Apolipoprotein A-I; Apoptosis; Bile Acids and Salts; Cell Line; Diet, High-Fat; Endoplasmic | 2017 |
Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content.
Topics: Abdomen; Adipose Tissue; Adolescent; Body Composition; Body Mass Index; Fatty Liver; Female; Glucose | 2009 |
Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes.
Topics: Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Fatty Liver; Gene Expression Regulati | 2009 |
Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway.
Topics: Animals; Caloric Restriction; Cell Line, Tumor; Cell Survival; Fatty Liver; Forkhead Box Protein O1; | 2009 |
Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it?
Topics: Apoptosis; Cytoprotection; Fatty Liver; Hepatocytes; Humans; Oleic Acid; Palmitic Acid; PPAR alpha; | 2009 |
Cholesterol metabolism and expression of its relevant genes in cultured steatotic hepatocytes.
Topics: Cell Line, Tumor; Cholesterol; Enzyme Inhibitors; Fatty Liver; Gene Expression; Hepatocytes; Humans; | 2009 |
Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death.
Topics: Animals; Blood Glucose; Cell Death; Cells, Cultured; Choline Deficiency; Diet; Dose-Response Relatio | 2010 |
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model.
Topics: Adipose Tissue; Animals; Azo Compounds; Body Composition; Disease Models, Animal; Energy Intake; Fat | 2010 |
CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Binding Sites; Cell Line, Tumo | 2010 |
PKC{delta} is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death.
Topics: Alanine Transaminase; Animal Feed; Animals; Cell Death; Cell Survival; Endoplasmic Reticulum; Enzyme | 2010 |
Cellular glutathione in fatty liver in vitro models.
Topics: Dose-Response Relationship, Drug; Fatty Liver; Female; Glutathione; Hep G2 Cells; Hepatocytes; Human | 2011 |
Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes.
Topics: alpha-Linolenic Acid; Animals; Apoptosis; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinic | 2011 |
Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes.
Topics: Adenoviridae; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Die | 2011 |
Death receptor 5 signaling promotes hepatocyte lipoapoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 8; Cell Line, Tumor; Enzyme Inhibitors; Fatt | 2011 |
Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease.
Topics: Animals; Cell Death; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Diet; Endoplasmic Ret | 2011 |
Increased expression of zinc finger protein 267 in non-alcoholic fatty liver disease.
Topics: Cells, Cultured; Fatty Liver; Hepatocytes; Humans; Lipid Metabolism; Liver; Non-alcoholic Fatty Live | 2011 |
Increased erythrocytes n-3 and n-6 polyunsaturated fatty acids is significantly associated with a lower prevalence of steatosis in patients with type 2 diabetes.
Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dietary Fats; Dietary Supplements; Erythro | 2012 |
Liver Patt1 deficiency protects male mice from age-associated but not high-fat diet-induced hepatic steatosis.
Topics: Acetyltransferases; Animals; Body Weight; Cells, Cultured; Cholesterol; Diet, High-Fat; Eating; Fatt | 2012 |
Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway.
Topics: Activating Transcription Factor 4; Apoptosis; Cell Survival; eIF-2 Kinase; Endoplasmic Reticulum Str | 2012 |
Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice.
Topics: AMP-Activated Protein Kinases; Animals; Body Weight; Cell Line, Tumor; Cytokines; Diet, High-Fat; Ex | 2012 |
Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytokines; Dose-Response Relationship, Drug; | 2012 |
The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.
Topics: Adipocytes; Adipose Tissue; Animals; Antigens, CD; Antigens, Surface; Coculture Techniques; Dietary | 2012 |
Endoplasmic reticulum stress induces the expression of fetuin-A to develop insulin resistance.
Topics: Aged; alpha-2-HS-Glycoprotein; Animals; Biomarkers; Diabetes Mellitus; Endoplasmic Reticulum; Fatty | 2012 |
Elovl6 promotes nonalcoholic steatohepatitis.
Topics: Acetyltransferases; Analysis of Variance; Animals; Blood Glucose; Carrier Proteins; Cholesterol; Die | 2012 |
Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice.
Topics: Animals; Caspase 1; Fatty Liver; Hepatic Stellate Cells; Inflammasomes; Interleukin-1alpha; Interleu | 2013 |
Hepatic mitochondrial dysfunction induced by fatty acids and ethanol.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Cell Line, Tumor; Cell Survival; Energy Metabolism | 2012 |
Inhibition of uncoupling protein 2 with genipin exacerbates palmitate-induced hepatic steatosis.
Topics: CD36 Antigens; Fatty Liver; Hep G2 Cells; Humans; Ion Channels; Iridoids; Lipid Metabolism; Mitochon | 2012 |
[The unity of pathogenesis of insulin resistance syndrome and non-alcoholic fatty disease of liver. The metabolic disorder of fatty acids and triglycerides].
Topics: Animals; Apoptosis; Fatty Liver; Hepatocytes; Insulin Resistance; Lipid Metabolism; Liver; Non-alcoh | 2012 |
Propranolol decreases splanchnic triacylglycerol storage in burn patients receiving a high-carbohydrate diet.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Burns; Child; Child, Preschool; Dietary Carbohydrate | 2002 |
The incorporation of labeled palmitic acid into the phospholipids of normal and fatty livers.
Topics: Fatty Liver; Liver; Palmitic Acid; Phosphatidylethanolamines; Phospholipids | 1963 |
EFFECT OF ETHANOL OF THE SYNTHESIS OF LIVER TRIGLYCERIDES AND PHOSPHOLIPIDS FROM CIRCULATING PALMITIC ACID-1-C14.
Topics: Carbon Isotopes; Ethanol; Fatty Liver; Glycerides; Lipid Metabolism; Lipids; Liver; Palmitic Acid; P | 1963 |
UTILIZATION OF FATTY ACIDS BY RAT LIVER SLICES AS A FUNCTION OF MEDIUM CONCENTRATION.
Topics: Carbon Isotopes; Fatty Acids; Fatty Liver; Glycerides; Lipid Metabolism; Liver; Palmitic Acid; Phosp | 1964 |
LIVER LIPID ACCUMULATION IN ISOLEUCINE-DEFICIENT RATS.
Topics: Acetates; Blood Chemical Analysis; Carbon Isotopes; Cholesterol; Electrophoresis; Fatty Acids; Fatty | 1964 |
STUDIES ON FATTY LIVER INDUCTION BY 4-AMINOPYRAZOLOPYRIMIDINE.
Topics: Acetates; Antimetabolites; Carbon Isotopes; Cholesterol; Fatty Acids; Fatty Liver; Glycerides; Glyci | 1963 |
EFFECTS OF PALMITIC, OLEIC, AND LINOLEIC ACIDS ON HEPATIC AND VASCULAR LIPID DEPOSITS.
Topics: Cholesterol; Chromatography; Cocos; Cottonseed Oil; Dietary Fats; Fatty Acids; Fatty Liver; Glycerid | 1963 |
FATTY ACID COMPOSITION OF PORTAL FATTY LIVER IN LYSINE- AND THREONINE-DEFICIENT RATS.
Topics: Dietary Fats; Fatty Acids; Fatty Acids, Essential; Fatty Liver; Linoleic Acid; Lipids; Lysine; Metab | 1964 |
ALTERATIONS IN HEPATIC LIPID BIOSYNTHETIC PATHWAYS AFTER ETHANOL, ETHIONINE AND CARBON TETRACHLORIDE.
Topics: Biosynthetic Pathways; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Ethanol; Ethionine; Fat | 1963 |
STUDIES ON THE PATHOGENESIS OF THE ETHANOL-INDUCED FATTY LIVER. II. EFFECT OF ETHANOL ON PALMITATE-1-C-14 METABOLISM BY THE ISOLATED PERFUSED RAT LIVER.
Topics: Cholesterol; Ethanol; Fatty Acids; Fatty Liver; Glycerides; Lipid Metabolism; Liver; Palmitates; Pal | 1964 |
FATTY ACID SYNTHESIS DURING FAT-FREE REFEEDING OF STARVED RATS.
Topics: Acetates; Carbon Isotopes; Fatty Acids; Fatty Liver; Glucosephosphate Dehydrogenase; Glycerides; Lig | 1965 |
HEPATIC LIPID METABOLISM IN THE CORTISONE-TREATED RAT.
Topics: Adipose Tissue; Cortisone; Fatty Acids; Fatty Liver; Glycerides; Lipid Metabolism; Lipids; Liver; Pa | 1965 |
LIVER LIPIDS IN A CASE OF HYPERVITAMINOSIS A.
Topics: Chemical and Drug Induced Liver Injury; Cholesterol; Chromatography; Fatty Acids; Fatty Acids, Essen | 1965 |
FATTY ACID COMPOSITION OF RAT LIVER LIPIDS DURING CHOLINE DEFICIENCY.
Topics: Choline; Choline Deficiency; Dietary Fats; Dietary Proteins; Fatty Acids; Fatty Acids, Essential; Fa | 1965 |
PLASMA FREE FATTY ACID TURNOVER IN CARBON TETRACHLORIDE-TREATED RATS.
Topics: Blood Volume; Body Weight; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug I | 1965 |
Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease.
Topics: Adult; Carbon Isotopes; Cholesterol; Fatty Acids, Nonesterified; Fatty Liver; Female; Glucagon; Huma | 2003 |
A human hepatocellular in vitro model to investigate steatosis.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, D | 2007 |
Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Ceramide | 2007 |
Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes.
Topics: Cell Line, Tumor; Chemokines, CXC; Cytokines; Fatty Liver; Hepatocytes; Humans; Interleukin-8; Lipid | 2007 |
Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes.
Topics: Apoptosis; Cell Line; Cell Line, Tumor; Cytochromes c; Enzyme Inhibitors; Fatty Liver; Hepatocytes; | 2008 |
Inhibitory effect of D-galactosamine administration on fatty acid oxidation in rat hepatocytes.
Topics: Animals; Fatty Acids; Fatty Acids, Nonesterified; Fatty Liver; Galactosamine; In Vitro Techniques; L | 1982 |
Tetracycline-induced steatosis in primary canine hepatocyte cultures.
Topics: Animals; Anti-Bacterial Agents; Azo Compounds; Carbon Radioisotopes; Cells, Cultured; Coloring Agent | 1997 |
The fatty liver dystrophy mutant mouse: microvesicular steatosis associated with altered expression levels of peroxisome proliferator-regulated proteins.
Topics: Animals; Animals, Newborn; Autonomic Nervous System Diseases; Cells, Cultured; Fatty Liver; Genotype | 1998 |
Hepatic fatty acid composition in periparturient dairy cows with fatty liver induced by intake of a high energy diet in the dry period.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Energy Intake; Fatty Acids; Fatty Acids, No | 1999 |
Interrelation of fatty acid composition in adipose tissue, serum, and liver of dairy cows during the development of fatty liver postpartum.
Topics: Adipose Tissue; Animals; Cattle; Cattle Diseases; Diet; Energy Intake; Fatty Acids; Fatty Acids, Non | 2000 |