palmitic acid has been researched along with Insulinoma in 22 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since improvement of β-cell viability is a promising anti-diabetic strategy, the protective effect of metformin, a known insulin sensitizer was studied in rat insulinoma cells." | 7.80 | Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. ( Csala, M; Kéri, G; Kokas, M; Mandl, J; Simon-Szabó, L, 2014) |
| " Since improvement of β-cell viability is a promising anti-diabetic strategy, the protective effect of metformin, a known insulin sensitizer was studied in rat insulinoma cells." | 3.80 | Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. ( Csala, M; Kéri, G; Kokas, M; Mandl, J; Simon-Szabó, L, 2014) |
| "Rat pancreatic islets or insulinoma cells (RIN) were co-cultivated with concanavalin A (ConA)-stimulated rat lymph node cells (LNC), or they were treated with cell-free supernatants (Sn) obtained from ConA-stimulated spleen cells or from activated CD3+ cells, in the absence or presence of palmitic acid (PA)." | 3.75 | T cells cooperate with palmitic acid in induction of beta cell apoptosis. ( Cvjetićanin, T; Miljković, D; Stojanović, I; Stosić-Grujicić, S; Timotijević, G, 2009) |
| " Palmitate is not toxic when administered at low glucose unless fatty acid β-oxidation is inhibited." | 1.39 | Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells. ( Affourtit, C; Barlow, J, 2013) |
| " Taken as whole, the toxic effect of the FA on insulin-producing RINm5F cells varied irrespective of the chain length and the degree of unsaturation." | 1.33 | Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. ( Azevedo-Martins, AK; Curi, R; Lenzen, S; Lima, CL; Monteiro, AP, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (68.18) | 29.6817 |
| 2010's | 5 (22.73) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Brun, T | 1 |
| Jiménez-Sánchez, C | 1 |
| Madsen, JGS | 1 |
| Hadadi, N | 1 |
| Duhamel, D | 1 |
| Bartley, C | 2 |
| Oberhauser, L | 1 |
| Trajkovski, M | 1 |
| Mandrup, S | 1 |
| Maechler, P | 1 |
| Ruan, JS | 1 |
| Lin, JK | 1 |
| Kuo, YY | 1 |
| Chen, YW | 1 |
| Chen, PC | 1 |
| Barlow, J | 1 |
| Affourtit, C | 1 |
| Simon-Szabó, L | 1 |
| Kokas, M | 1 |
| Mandl, J | 1 |
| Kéri, G | 1 |
| Csala, M | 1 |
| Gjoni, E | 1 |
| Brioschi, L | 1 |
| Cinque, A | 1 |
| Coant, N | 1 |
| Islam, MN | 1 |
| Ng, CK | 1 |
| Verderio, C | 1 |
| Magnan, C | 1 |
| Riboni, L | 1 |
| Viani, P | 1 |
| Le Stunff, H | 1 |
| Giussani, P | 1 |
| Janikiewicz, J | 1 |
| Hanzelka, K | 1 |
| Dziewulska, A | 1 |
| Kozinski, K | 1 |
| Dobrzyn, P | 1 |
| Bernas, T | 1 |
| Dobrzyn, A | 1 |
| Choi, SE | 2 |
| Lee, SM | 1 |
| Lee, YJ | 2 |
| Li, LJ | 1 |
| Lee, SJ | 1 |
| Lee, JH | 1 |
| Kim, Y | 1 |
| Jun, HS | 2 |
| Lee, KW | 2 |
| Kang, Y | 2 |
| Cvjetićanin, T | 1 |
| Stojanović, I | 1 |
| Timotijević, G | 1 |
| Stosić-Grujicić, S | 1 |
| Miljković, D | 1 |
| Preston, AM | 1 |
| Gurisik, E | 1 |
| Laybutt, DR | 1 |
| Biden, TJ | 1 |
| Liu, L | 1 |
| Wang, RP | 1 |
| Liu, XH | 1 |
| Wang, LX | 1 |
| Liu, XY | 1 |
| Chen, WJ | 1 |
| Liu, LB | 1 |
| Bollheimer, LC | 2 |
| Kemptner, DM | 1 |
| Kagerbauer, SM | 1 |
| Kestler, TM | 1 |
| Wrede, CE | 2 |
| Buettner, R | 2 |
| Eitel, K | 1 |
| Staiger, H | 1 |
| Rieger, J | 1 |
| Mischak, H | 1 |
| Brandhorst, H | 1 |
| Brendel, MD | 1 |
| Bretzel, RG | 1 |
| Häring, HU | 1 |
| Kellerer, M | 1 |
| Beeharry, N | 1 |
| Chambers, JA | 1 |
| Green, IC | 1 |
| Rockmann, F | 1 |
| Ottinger, I | 1 |
| Schölmerich, J | 1 |
| Moffitt, JH | 1 |
| Fielding, BA | 1 |
| Evershed, R | 1 |
| Berstan, R | 1 |
| Currie, JM | 1 |
| Clark, A | 1 |
| Higa, M | 1 |
| Shimabukuro, M | 1 |
| Shimajiri, Y | 1 |
| Takasu, N | 1 |
| Shinjyo, T | 1 |
| Inaba, T | 1 |
| Azevedo-Martins, AK | 1 |
| Monteiro, AP | 1 |
| Lima, CL | 1 |
| Lenzen, S | 1 |
| Curi, R | 1 |
| Grempler, R | 1 |
| Leicht, S | 1 |
| Kischel, I | 1 |
| Eickelmann, P | 1 |
| Redemann, N | 1 |
| Martinez, SC | 1 |
| Tanabe, K | 1 |
| Cras-Méneur, C | 1 |
| Abumrad, NA | 1 |
| Bernal-Mizrachi, E | 1 |
| Permutt, MA | 1 |
| Jang, HJ | 1 |
| Kim, YS | 1 |
| Kang, SS | 1 |
| Chun, J | 1 |
| Kawai, T | 1 |
| Hirose, H | 1 |
| Seto, Y | 1 |
| Fujita, H | 2 |
| Ukeda, K | 1 |
| Saruta, T | 1 |
| Giroix, MH | 1 |
| Blachier, F | 1 |
| Sener, A | 1 |
| Malaisse, WJ | 1 |
22 other studies available for palmitic acid and Insulinoma
| Article | Year |
|---|---|
AMPK Profiling in Rodent and Human Pancreatic Beta-Cells under Nutrient-Rich Metabolic Stress.
Topics: Adult; AMP-Activated Protein Kinases; Animals; Apoptosis; Blood Glucose; Female; Fructose; Gene Expr | 2020 |
Chronic palmitic acid-induced lipotoxicity correlates with defective trafficking of ATP sensitive potassium channels in pancreatic β cells.
Topics: Animals; Cell Line, Tumor; Diabetes Mellitus, Experimental; Glyburide; Insulin-Secreting Cells; Insu | 2018 |
Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells.
Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Enzyme Inhibitors; Glucose; Insulin; Insulin Secr | 2013 |
Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells.
Topics: Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Endoplasmic Reticulum Stress; Eukaryotic Initiation | 2014 |
Glucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in INS-1 β-cells.
Topics: Animals; Cell Line; Cell Survival; Ceramides; Diabetes Mellitus; Endoplasmic Reticulum; Endoplasmic | 2014 |
Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells.
Topics: Animals; Apoptosis; Autophagy; Cell Line, Tumor; Enzyme Inhibitors; Insulin; Insulin-Secreting Cells | 2015 |
Protective role of autophagy in palmitate-induced INS-1 beta-cell death.
Topics: Animals; Autophagy; Caspase 3; Cell Death; Cell Nucleus; Cell Survival; Glucose; Insulin-Secreting C | 2009 |
T cells cooperate with palmitic acid in induction of beta cell apoptosis.
Topics: Animals; Apoptosis; Caspase 3; Cell Communication; Cell Line, Tumor; Coculture Techniques; Cytokines | 2009 |
Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.
Topics: Animals; Cell Line, Tumor; Cycloheximide; Endoplasmic Reticulum; Genes, Reporter; Insulin-Secreting | 2009 |
[The chronic effect of palmitic acid on apoptosis of pancreatic islet beta-cells and the mechanism].
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cells, Cultured; Insulinoma; Islet | 2009 |
Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells.
Topics: Animals; Blotting, Northern; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; | 2003 |
Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells.
Topics: Animals; Apoptosis; Biological Transport; Caspase 3; Caspases; Cell Nucleus; Cells, Cultured; Enzyme | 2003 |
Fatty acid protection from palmitic acid-induced apoptosis is lost following PI3-kinase inhibition.
Topics: Androstadienes; Animals; Apoptosis; Cell Death; Cell Line, Tumor; Cell Survival; Chromones; Enzyme I | 2004 |
Glucagon production of the rat insulinoma cell line INS-1-A quantitative comparison with primary rat pancreatic islets.
Topics: Animals; Cell Line, Tumor; Glucagon; Insulinoma; Islets of Langerhans; Palmitic Acid; Radioimmunoass | 2005 |
Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; COS Cells; Fatty Acids, N | 2005 |
Protein kinase B/Akt signalling is required for palmitate-induced beta-cell lipotoxicity.
Topics: Animals; Cell Death; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, | 2006 |
Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells.
Topics: Animals; Arachidonic Acid; Cell Line, Tumor; Cell Membrane; Chromatography, High Pressure Liquid; DN | 2006 |
Inhibition of SH2-domain containing inositol phosphatase 2 (SHIP2) in insulin producing INS1E cells improves insulin signal transduction and induces proliferation.
Topics: Apoptosis; Cell Proliferation; Cyclin A; Extracellular Signal-Regulated MAP Kinases; Gene Expression | 2007 |
Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.
Topics: Animals; Apoptosis; Cell Death; Cell Line, Tumor; Endoplasmic Reticulum; Fatty Acids, Nonesterified; | 2008 |
A chemical chaperone 4-PBA ameliorates palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS).
Topics: Animals; Butylamines; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endoplasmic | 2008 |
Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma.
Topics: Animals; Base Sequence; Cell Division; Cell Survival; Chromans; DNA Primers; Fatty Acids, Nonesterif | 2002 |
Metabolic and secretory response of tumoral-insulin producing cells to D-fructose and D-galactose.
Topics: Adenine Nucleotides; Adenoma, Islet Cell; Animals; Energy Metabolism; Fructose; Galactose; Glutamine | 1987 |