palmitic acid has been researched along with Inflammation in 188 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to determine the relative comparability of diets enriched in palmitic acid, stearic acid, and oleic acid on inflammation and coagulation markers, T lymphocyte proliferation/ex-vivo cytokine secretion, plasma cardiometabolic risk factors, and fecal bile acid concentrations." | 9.30 | Comparison of diets enriched in stearic, oleic, and palmitic acids on inflammation, immune response, cardiometabolic risk factors, and fecal bile acid concentrations in mildly hypercholesterolemic postmenopausal women-randomized crossover trial. ( Cohen, R; Dolnikowski, GG; Galluccio, JM; Li, L; Lichtenstein, AH; Matthan, NR; Meng, H; Rodríguez-Morató, J; Wu, D, 2019) |
| "To evaluate the potential of GB as a material for the mitigation of NAFLD, we investigated the effects of GB hydrolysates on the hepatic lipid accumulation, inflammation, and endoplasmic reticulum (ER) stress in human hepatoma G2 (Hep G2) cells treated with palmitic acid (PA)." | 8.12 | Gryllus bimaculatus De Geer hydrolysates alleviate lipid accumulation, inflammation, and endoplasmic reticulum stress in palmitic acid-treated human hepatoma G2 cells. ( Jeong, Y; Jo, EB; Jung, S; Kim, N; Lee, E; Yoon, S, 2022) |
| "This study aimed to develop a model of dysregulated lipid metabolism and inflammation by treating 3T3-L1 adipocytes with tumor necrosis factor alpha (TNFα), lipopolysaccharide (LPS), and palmitic acid (PA) individually or in combination to assess their effects and mechanism of action." | 8.12 | Comparing the effects of tumor necrosis factor alpha, lipopolysaccharide and palmitic acid on lipid metabolism and inflammation in murine 3T3-L1 adipocytes. ( Dias, S; Jack, BU; Mamushi, M; Pheiffer, C; Viraragavan, A, 2022) |
| "Our previous results have shown that obesity-induced excessive palmitic acid (PA) can promote the expression of KLF7, which plays a vital role in regulation of inflammation, glucose metabolism." | 8.12 | Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway. ( Chang, Y; Chu, X; Pan, C; Qiu, T; Wang, C; Wang, J; Xie, J; Xiong, J; Yang, X; Zhang, J, 2022) |
| "Objective To investigate the molecular mechanism of palmitic acid (PA) inducing inflammation and epithelial to mesenchymal transdifferentiation (EMT) in human renal tubular epithelial cells (RTECs)." | 8.12 | [Palmitic acid induces inflammation and transdifferentiation by activating cGAS/STING pathway in human renal tubular epithelial cells]. ( Cen, M; He, G; Jing, G; Tang, X; Wang, L; Zhao, N, 2022) |
| " Our experiments in 3T3-L1 adipocytes show that inhibition of Lpcat3 does not change triglyceride accumulation but increases palmitic acid-induced inflammation and lipolysis." | 8.12 | Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation. ( Deng, Y; Ding, T; Dong, J; Hu, J; Liang, Y; Lou, B, 2022) |
| " The aim of the present study was to investigate whether CCN1 could regulate the inflammation and apoptosis of endothelial cells induced by palmitic acid (PA)." | 8.02 | Dickkopf‑1/cysteine‑rich angiogenic inducer 61 axis mediates palmitic acid‑induced inflammation and apoptosis of vascular endothelial cells. ( Ding, GW; Ding, YH; Gan, YR; Kou, ZK; Liang, TX; Wang, YZ; Wei, L; Xie, DX, 2021) |
| "Saturated fatty acids such as palmitic acid promote inflammation and insulin resistance in peripheral tissues, contrasting with the protective action of polyunsaturated fatty acids such docosahexaenoic acid." | 8.02 | Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma. ( Amine, H; Benomar, Y; Taouis, M, 2021) |
| " However, in VAT, GCs induce DNL, higher palmitic acid (PA), macrophage infiltration, and proinflammatory cytokine levels, accompanied by systemic nonesterified fatty acid (NEFA) elevation, hyperinsulinemia, and higher homeostatic model assessment for insulin resistance (HOMA-IR) levels compared with diet-induced obesity." | 7.96 | Long-term hypercortisolism induces lipogenesis promoting palmitic acid accumulation and inflammation in visceral adipose tissue compared with HFD-induced obesity. ( García-Eguren, G; Giró, O; Hanzu, FA; Sala-Vila, A; Vega-Beyhart, A, 2020) |
| " However, the function and mechanism of TSG in palmitic acid (PA)-induced inflammation and apoptosis in cardiomyocytes are still unknown." | 7.91 | Tetrahydroxy stilbene glucoside alleviates palmitic acid-induced inflammation and apoptosis in cardiomyocytes by regulating miR-129-3p/Smad3 signaling. ( Kong, M; Zou, Y, 2019) |
| "High concentrations of palmitic acid in plasma increase both the inflammation associated with obesity and the susceptibility to develop a neurodegenerative event." | 7.88 | Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta. ( Ávila-Rodriguez, M; Baez-Jurado, E; Barreto, GE; Echeverria, V; Garcia-Segura, LM; Hidalgo-Lanussa, O; Zamudio, J, 2018) |
| "Fenofibrate (FF) is commonly used clinically as a lipid-lowering drug, but whether it participates in endoplasmic reticulum (ER) stress and decreases inflammation in skeletal muscle is still unknown." | 7.83 | Fenofibrate improves high-fat diet-induced and palmitate-induced endoplasmic reticulum stress and inflammation in skeletal muscle. ( Bao, YY; Chen, GJ; Chen, L; Dai, F; Jiang, T; Lu, YX; Zhang, Q, 2016) |
| "Palmitic acid (PA)-induced vascular endothelial inflammation plays a pivotal role in the occurrence and development of vascular diseases." | 7.83 | Homoplantaginin Inhibits Palmitic Acid-induced Endothelial Cells Inflammation by Suppressing TLR4 and NLRP3 Inflammasome. ( He, B; Liang, J; Lin, Y; Ma, S; Qin, W; Shi, X; Wang, L; Wu, F; Zhang, B, 2016) |
| " Palmitic acid (PA) has been shown to decrease eNOS activity and induce inflammation, both are the causes of endothelial dysfunction, in an endothelial cell culture model." | 7.78 | Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability. ( Li, X; Ning, Y; Qiu, Y; Tian, D; Wang, X; Yin, L; Zhan, Y; Zhi, X, 2012) |
| "Non-alcoholic fatty liver disease (NAFLD) is a clinical pathological syndrome of hepatic parenchymal cell steatosis caused by excessive lipid deposition, which is the chronic liver disease with the highest incidence in China." | 5.91 | Asperuloside alleviates lipid accumulation and inflammation in HFD-induced NAFLD via AMPK signaling pathway and NLRP3 inflammasome. ( Chen, S; Chen, Y; Hou, S; Huang, S; Li, W; Liang, J; Pei, C; Shen, Q; Shi, J; Shi, X, 2023) |
| "Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases worldwide." | 5.72 | PREX1 depletion ameliorates high-fat diet-induced non-alcoholic fatty liver disease in mice and mitigates palmitic acid-induced hepatocellular injury via suppressing the NF-κB signaling pathway. ( Gong, W; Li, Z; Wang, H; Wang, P; Wu, K; Zou, Y, 2022) |
| "Maternal obesity is a risk factor for placental dysfunction, suggesting that factors within an obese environment may impair early placental development." | 5.56 | Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1. ( Dunk, CE; Lye, SJ; Rampersaud, AM; Renaud, SJ, 2020) |
| "Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease, sometimes ranges from simple steatosis to nonalcoholic steatohepatitis (NASH)." | 5.56 | Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes. ( Iida, K; Kishimoto, Y; Kondo, K; Mabashi-Asazuma, H; Sato, A; Tanaka, M, 2020) |
| "Obesity is closely associated with neuroinflammation in the hypothalamus, which is characterized by over-activated microglia and excessive production of pro-inflammatory cytokines." | 5.51 | Green Tea Polyphenol (-)-Epigallocatechin Gallate (EGCG) Attenuates Neuroinflammation in Palmitic Acid-Stimulated BV-2 Microglia and High-Fat Diet-Induced Obese Mice. ( Hochstetter, D; Mao, L; Wang, Y; Xu, P; Yao, L; Zhao, Y; Zhou, J, 2019) |
| "The eruptive xanthomata are formed in vivo under realization of biological function of endoecology." | 5.46 | [The disturbance of unification of coupled biochemical reactions in synthesis of endogenous ω-9 oleic acid. The resistance to insulin, stearic triglycerides and pathogenesis of eruptive xanthomata]. ( Rozhkova, TA; Samokhodskaya, LM; Titov, VN, 2017) |
| "Hypertriglyceridemia is an independent risk factor for acute pancreatitis, in which the pathological mechanisms are not fully illustrated." | 5.43 | Palmitic acid aggravates inflammation of pancreatic acinar cells by enhancing unfolded protein response induced CCAAT-enhancer-binding protein β-CCAAT-enhancer-binding protein α activation. ( Chen, J; Hu, G; Lu, Y; Wang, X; Wu, J; Zeng, Y; Zheng, J, 2016) |
| "Bortezomib is an anti-cancer agent that induces ER stress by inhibiting proteasomal degradation." | 5.43 | Bortezomib attenuates palmitic acid-induced ER stress, inflammation and insulin resistance in myotubes via AMPK dependent mechanism. ( Bae, YA; Cheon, HG; Choi, HE; Jang, J; Kwak, HJ; Park, SK, 2016) |
| "Insulin resistance is associated with severe alterations in adipokines characterized by release of increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines from adipose tissue." | 5.42 | Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance. ( James, J; Roy, D; Shihabudeen, MS; Thirumurugan, K, 2015) |
| "Tectorigenin also can inhibit inflammation-stimulated IRS-1 serine phosphorylation and restore the impaired insulin PI3K signaling, leading to a decreased NO production." | 5.39 | Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway. ( Cheng, XL; Gao, XJ; Liu, BL; Liu, K; Qin, MJ; Qin, XY; Qin, Y; Wang, Q; Xie, GY; Zhang, DY; Zhou, L, 2013) |
| "Increased inflammation was associated with impaired glucose tolerance and hyperinsulinemia as a result of reduced hepatic but not skeletal muscle insulin sensitivity." | 5.37 | Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance. ( Fynch, SL; Galic, S; Graham, KL; Hewitt, KA; Honeyman, JE; Kay, TW; Sachithanandan, N; Steinberg, GR, 2011) |
| "The aim of this study was to determine the relative comparability of diets enriched in palmitic acid, stearic acid, and oleic acid on inflammation and coagulation markers, T lymphocyte proliferation/ex-vivo cytokine secretion, plasma cardiometabolic risk factors, and fecal bile acid concentrations." | 5.30 | Comparison of diets enriched in stearic, oleic, and palmitic acids on inflammation, immune response, cardiometabolic risk factors, and fecal bile acid concentrations in mildly hypercholesterolemic postmenopausal women-randomized crossover trial. ( Cohen, R; Dolnikowski, GG; Galluccio, JM; Li, L; Lichtenstein, AH; Matthan, NR; Meng, H; Rodríguez-Morató, J; Wu, D, 2019) |
| "We recently reported that lowering the high, habitual palmitic acid (PA) intake in ovulating women improved insulin sensitivity and both inflammatory and oxidative stress." | 5.20 | Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes. ( Anathy, V; Bunn, JY; Crain, KI; Ebenstein, DB; Fukagawa, NK; Kien, CL; Matthews, DE; Poynter, ME; Pratley, RE; Tarleton, EK, 2015) |
| "Caco-2 exposed to palmitic acid (PA) in the serosal (basolateral) side showed a combined state of epithelial inflammation, inducing NF-κB pathway and downstream cytokines, that was reverted by C3G apical pre-treatment." | 4.31 | Cyanidin-3-O-glucoside protects intestinal epithelial cells from palmitate-induced lipotoxicity. ( Bashllari, R; Cimino, F; Molonia, MS; Muscarà, C; Saija, A; Speciale, A; Wilde, PJ, 2023) |
| "In primary hepatocytes and AML-12 cells, JM-2 treatment significantly suppressed palmitic acid (PA)-induced JNK activation and PA-induced inflammation and cell apoptosis." | 4.31 | A small-molecule JNK inhibitor JM-2 attenuates high-fat diet-induced non-alcoholic fatty liver disease in mice. ( Jin, L; Liang, G; Lou, S; Luo, W; Wang, M; Yang, B; Ye, L; Zhang, Q; Zhang, Y; Zhu, W, 2023) |
| "Palmitic acid (PA) is considered a major contributor to the inflammation in many metabolic diseases; however, this role has been questioned recently for the complicated procedures in preparing PA-bovine serum albumin (BSA) complex." | 4.31 | Palmitate lipotoxicity is closely associated with the fatty acid-albumin complexes in BV-2 microglia. ( Li, B; Yang, Y; Yang, Z; Yu, Q; Yuan, F; Zhang, S, 2023) |
| "C2C12 myotubes were challenged by palmitic acid (PA) to mimic the obese microenvironment and inflammation, cell vitality, and glucose utilization were determined." | 4.31 | Lunasin ameliorates glucose utilization in C2C12 myotubes and metabolites profile in diet-induced obese mice benefiting metabolic disorders. ( Chiang, CC; Hsieh, CC; Huang, CY; Huang, PY; Kuo, CH; Kuo, HC; Lin, PY, 2023) |
| "The study aims to investigate the effects of PZ-DHA on insulin resistance in the skeletal muscle and the related mechanisms; we used palmitic acid (PA)-treated C2C12 myotubes as an insulin resistance model." | 4.12 | Docosahexaenoic Acid Ester of Phloridzin Reduces Inflammation and Insulin Resistance ( Chen, J; Dong, Q; Qiu, Y; Si, X; Sun, T; Wang, J; Wu, W; Wu, Z; Zhang, R, 2022) |
| "To evaluate the potential of GB as a material for the mitigation of NAFLD, we investigated the effects of GB hydrolysates on the hepatic lipid accumulation, inflammation, and endoplasmic reticulum (ER) stress in human hepatoma G2 (Hep G2) cells treated with palmitic acid (PA)." | 4.12 | Gryllus bimaculatus De Geer hydrolysates alleviate lipid accumulation, inflammation, and endoplasmic reticulum stress in palmitic acid-treated human hepatoma G2 cells. ( Jeong, Y; Jo, EB; Jung, S; Kim, N; Lee, E; Yoon, S, 2022) |
| "This study aimed to develop a model of dysregulated lipid metabolism and inflammation by treating 3T3-L1 adipocytes with tumor necrosis factor alpha (TNFα), lipopolysaccharide (LPS), and palmitic acid (PA) individually or in combination to assess their effects and mechanism of action." | 4.12 | Comparing the effects of tumor necrosis factor alpha, lipopolysaccharide and palmitic acid on lipid metabolism and inflammation in murine 3T3-L1 adipocytes. ( Dias, S; Jack, BU; Mamushi, M; Pheiffer, C; Viraragavan, A, 2022) |
| "Chronic low-grade systemic inflammation (SI), including activation of the NLRP3 inflammasome, is a feature of obesity, associated with increased circulating saturated fatty acids, such as palmitic acid (PA), and bacterial endotoxin lipopolysaccharide (LPS)." | 4.12 | Sulforaphane reduces pro-inflammatory response to palmitic acid in monocytes and adipose tissue macrophages. ( Baines, KJ; Berthon, BS; Eslick, S; Gately, M; Guilleminault, L; Karihaloo, C; Williams, EJ; Wood, LG; Wright, T, 2022) |
| "Our previous results have shown that obesity-induced excessive palmitic acid (PA) can promote the expression of KLF7, which plays a vital role in regulation of inflammation, glucose metabolism." | 4.12 | Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway. ( Chang, Y; Chu, X; Pan, C; Qiu, T; Wang, C; Wang, J; Xie, J; Xiong, J; Yang, X; Zhang, J, 2022) |
| "Objective To investigate the molecular mechanism of palmitic acid (PA) inducing inflammation and epithelial to mesenchymal transdifferentiation (EMT) in human renal tubular epithelial cells (RTECs)." | 4.12 | [Palmitic acid induces inflammation and transdifferentiation by activating cGAS/STING pathway in human renal tubular epithelial cells]. ( Cen, M; He, G; Jing, G; Tang, X; Wang, L; Zhao, N, 2022) |
| " Our experiments in 3T3-L1 adipocytes show that inhibition of Lpcat3 does not change triglyceride accumulation but increases palmitic acid-induced inflammation and lipolysis." | 4.12 | Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation. ( Deng, Y; Ding, T; Dong, J; Hu, J; Liang, Y; Lou, B, 2022) |
| "In this article, we investigated the in vitro potential beneficial effects of the anthocyanin cyanidin-3-O-glucoside (C3G) on inflammation and insulin resistance markers induced by palmitic acid (PA) in human SGBS adipocytes." | 4.02 | In Vitro Effects of Cyanidin-3-O-Glucoside on Inflammatory and Insulin-Sensitizing Genes in Human Adipocytes Exposed to Palmitic Acid. ( Cimino, F; Molonia, MS; Muscarà, C; Quesada-Lopez, T; Saija, A; Speciale, A; Villarroya, F, 2021) |
| " The aim of the present study was to investigate whether CCN1 could regulate the inflammation and apoptosis of endothelial cells induced by palmitic acid (PA)." | 4.02 | Dickkopf‑1/cysteine‑rich angiogenic inducer 61 axis mediates palmitic acid‑induced inflammation and apoptosis of vascular endothelial cells. ( Ding, GW; Ding, YH; Gan, YR; Kou, ZK; Liang, TX; Wang, YZ; Wei, L; Xie, DX, 2021) |
| "Saturated fatty acids such as palmitic acid promote inflammation and insulin resistance in peripheral tissues, contrasting with the protective action of polyunsaturated fatty acids such docosahexaenoic acid." | 4.02 | Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma. ( Amine, H; Benomar, Y; Taouis, M, 2021) |
| " However, in VAT, GCs induce DNL, higher palmitic acid (PA), macrophage infiltration, and proinflammatory cytokine levels, accompanied by systemic nonesterified fatty acid (NEFA) elevation, hyperinsulinemia, and higher homeostatic model assessment for insulin resistance (HOMA-IR) levels compared with diet-induced obesity." | 3.96 | Long-term hypercortisolism induces lipogenesis promoting palmitic acid accumulation and inflammation in visceral adipose tissue compared with HFD-induced obesity. ( García-Eguren, G; Giró, O; Hanzu, FA; Sala-Vila, A; Vega-Beyhart, A, 2020) |
| " However, the function and mechanism of TSG in palmitic acid (PA)-induced inflammation and apoptosis in cardiomyocytes are still unknown." | 3.91 | Tetrahydroxy stilbene glucoside alleviates palmitic acid-induced inflammation and apoptosis in cardiomyocytes by regulating miR-129-3p/Smad3 signaling. ( Kong, M; Zou, Y, 2019) |
| " The current study investigated the effect of exosomes derived from mangiferin‑stimulated PVAT on endothelial function, including regeneration, migration, apoptosis and inflammation." | 3.91 | Exosomes derived from mangiferin‑stimulated perivascular adipose tissue ameliorate endothelial dysfunction. ( Huang, F; Li, Y; Liu, B; Yang, J; Zhao, Q, 2019) |
| " The effects of vitamin D, alone or in combination with niacin, on endothelial cell (EC) angiogenic function and on revascularization in obese animals with peripheral ischemia are unknown." | 3.91 | Vitamin D intervention does not improve vascular regeneration in diet-induced obese male mice with peripheral ischemia. ( Borradaile, NM; Nong, Z; Park, C; Peters, KM; Pickering, JG; Sawyez, CG; Sutherland, BG; Wilson, RB; Yin, H; Zhang, R, 2019) |
| "High concentrations of palmitic acid in plasma increase both the inflammation associated with obesity and the susceptibility to develop a neurodegenerative event." | 3.88 | Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta. ( Ávila-Rodriguez, M; Baez-Jurado, E; Barreto, GE; Echeverria, V; Garcia-Segura, LM; Hidalgo-Lanussa, O; Zamudio, J, 2018) |
| "The accumulation of palmitic acid (PA), implicated in obesity, can induce apoptotic cell death and inflammation of astrocytes." | 3.88 | The autophagic degradation of Cav-1 contributes to PA-induced apoptosis and inflammation of astrocytes. ( Chen, Z; Li, X; Ma, LR; Nie, SD; Qu, ML; Shi, XJ; Wang, S; Wu, J; Wu, LY; Zhou, D; Zhou, SL, 2018) |
| "The level of saturated fatty acids, such as palmitic acid (PA), correlates with chronic inflammation in obese and metabolic syndrome patients." | 3.85 | Effects of 1α,25 Dihydroxyvitamin D ( d'Arqom, A; Luangwedchakarn, V; Tantibhedyangkul, W; Umrod, P; Wongprompitak, P, 2017) |
| "In the present experiment, we used HepG2 cells, a human hepatoma cell line, and a MSC-HepG2 transwell culturing system to investigate the anti-inflammatory mechanism of human umbilical cord-derived MSCs (UC-MSCs) under palmitic acid (PA) and lipopolysaccharide (LPS)-induced insulin resistance in vitro." | 3.85 | Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats. ( Dong, L; Han, Q; Han, W; Hao, H; Liu, J; Mu, Y; Song, X; Sun, X, 2017) |
| "Palmitic acid (PA)-induced vascular endothelial inflammation plays a pivotal role in the occurrence and development of vascular diseases." | 3.83 | Homoplantaginin Inhibits Palmitic Acid-induced Endothelial Cells Inflammation by Suppressing TLR4 and NLRP3 Inflammasome. ( He, B; Liang, J; Lin, Y; Ma, S; Qin, W; Shi, X; Wang, L; Wu, F; Zhang, B, 2016) |
| "Fenofibrate (FF) is commonly used clinically as a lipid-lowering drug, but whether it participates in endoplasmic reticulum (ER) stress and decreases inflammation in skeletal muscle is still unknown." | 3.83 | Fenofibrate improves high-fat diet-induced and palmitate-induced endoplasmic reticulum stress and inflammation in skeletal muscle. ( Bao, YY; Chen, GJ; Chen, L; Dai, F; Jiang, T; Lu, YX; Zhang, Q, 2016) |
| " We observed that palmitic acid treatment in cardiac-derived H9c2 cells induced a significant increase in reactive oxygen species, inflammation, apoptosis, fibrosis and hypertrophy." | 3.83 | Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity. ( Chen, G; Chen, X; Li, X; Liang, G; Lu, K; Peng, K; Qian, Y; Xu, Z; Zhang, Y; Zhong, P, 2016) |
| " In this study, we explored the effects of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), arachidonic acid (AA), and long-chain polyunsaturated fatty acids (PUFAs) on palmitic acid (PA)-induced inflammatory responses and insulin resistance in C2C12 myotubes." | 3.83 | Long-chain polyunsaturated fatty acids amend palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes. ( Chen, CW; Chen, HW; Chen, PY; Chen, SC; Lii, CK; Liu, KL; Sun, HL; Wu, YL, 2016) |
| " Utilising the 1961-2009 annual food supply data from the UN FAO, the present study investigated changes in the intake of macronutrient and specific fatty acid in the Australian population, including that of the PUFA linoleic acid (LA), due to its hypothesised role in inflammation and risk for obesity." | 3.81 | Australia's nutrition transition 1961-2009: a focus on fats. ( Hryciw, DH; Mathai, ML; McAinch, AJ; Naughton, SS, 2015) |
| " A diet high in saturated fats can induce inflammation and impair leptin signaling in the hypothalamus." | 3.81 | Palmitic acid induces central leptin resistance and impairs hepatic glucose and lipid metabolism in male mice. ( Camer, D; Cheng, L; Huang, XF; Szabo, A; Wang, H; Wu, Y; Yu, Y, 2015) |
| " Since plasma free fatty acids (FAs) are elevated in obese patients and saturated FAs such as palmitic acid (PA) have been shown to increase host inflammatory response, we sought to find out how PA interacts with lipopolysaccharide (LPS), an important pathological factor involved in periodontal disease, to enhance inflammation." | 3.79 | Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. ( Cowart, LA; Hannun, YA; Huang, Y; Jin, J; Li, Y; Lu, Z; Perry, DM; Russo, SB; Zhang, X, 2013) |
| " Palmitic acid (PA) has been shown to decrease eNOS activity and induce inflammation, both are the causes of endothelial dysfunction, in an endothelial cell culture model." | 3.78 | Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability. ( Li, X; Ning, Y; Qiu, Y; Tian, D; Wang, X; Yin, L; Zhan, Y; Zhi, X, 2012) |
| " The aim of the present study was to determine the mechanisms by which n-3 PUFA (EPA, DHA) and n-6 PUFA (linoleic acid (LA), arachidonic acid (AA)) relative to SFA (myristic acid (MA), palmitic acid (PA)) alter markers of inflammation and cholesterol accumulation in macrophages (MPhi)." | 3.75 | In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation. ( Honda, KL; Lamon-Fava, S; Lichtenstein, AH; Matthan, NR; Wang, S; Wu, D, 2009) |
| "Non-alcoholic fatty liver disease (NAFLD) is a clinical pathological syndrome of hepatic parenchymal cell steatosis caused by excessive lipid deposition, which is the chronic liver disease with the highest incidence in China." | 1.91 | Asperuloside alleviates lipid accumulation and inflammation in HFD-induced NAFLD via AMPK signaling pathway and NLRP3 inflammasome. ( Chen, S; Chen, Y; Hou, S; Huang, S; Li, W; Liang, J; Pei, C; Shen, Q; Shi, J; Shi, X, 2023) |
| "Patients with psoriasis are frequently complicated with metabolic syndrome; however, it is not fully understood how obesity and dyslipidemia contribute to the pathogenesis of psoriasis." | 1.72 | Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation. ( Akagi, T; Hiramatsu-Asano, S; Ikeda, K; Iseki, M; Ishihara, K; Kaneto, H; Morita, Y; Morizane, S; Mukai, T; Tachibana, K; Wada, J; Yahagi, A, 2022) |
| "Systemic inflammation is associated with an increased risk of non-communicable diseases, such as cardiovascular diseases and diabetes." | 1.72 | Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year. ( Arancibia-Riveros, C; Casas, R; Domínguez-López, I; Estruch, R; Fitó, M; Hu, FB; Lamuela-Raventós, RM; López-Sabater, MC; Martínez-González, MÁ; Razquin, C; Ros, E; Tresserra-Rimbau, A, 2022) |
| "Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases worldwide." | 1.72 | PREX1 depletion ameliorates high-fat diet-induced non-alcoholic fatty liver disease in mice and mitigates palmitic acid-induced hepatocellular injury via suppressing the NF-κB signaling pathway. ( Gong, W; Li, Z; Wang, H; Wang, P; Wu, K; Zou, Y, 2022) |
| "Gambogic acid has been reported to have anti-inflammatory effect." | 1.62 | Gambogic acid ameliorates high glucose- and palmitic acid-induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo. ( Chen, J; Chen, L; Li, L; Zhang, J; Zhou, Y, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD) is a global clinical problem." | 1.62 | Exercise-Induced Irisin Decreases Inflammation and Improves NAFLD by Competitive Binding with MD2. ( Ha, H; Huh, JY; Javaid, HMA; Liang, G; Pak, ES; Sahar, NE; Wang, Y; Zhu, W, 2021) |
| "Neuroinflammation has been implicated in the pathogenesis of neurodegeneration and is now accepted as a common molecular feature underpinning neuronal damage and death." | 1.62 | The Neuroinflammatory and Neurotoxic Potential of Palmitic Acid Is Mitigated by Oleic Acid in Microglial Cells and Microglial-Neuronal Co-cultures. ( Beaulieu, J; Costa, G; Glémet, H; Martinoli, MG; Moitié, A; Renaud, J; Sergi, D, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD), an emerging risk factor for diabetes, is now recognized as the most common liver disease worldwide." | 1.62 | Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1. ( Chen, L; Cui, C; Cui, Y; Guo, X; He, Q; Hu, H; Liang, K; Sha, S; Song, J; Sun, L; Wang, C; Wang, L; Yang, M; Zang, N, 2021) |
| "Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease, sometimes ranges from simple steatosis to nonalcoholic steatohepatitis (NASH)." | 1.56 | Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes. ( Iida, K; Kishimoto, Y; Kondo, K; Mabashi-Asazuma, H; Sato, A; Tanaka, M, 2020) |
| " Glycycoumarin (GCM) is a major coumarin compound isolated from licorice with favorable bioavailability property." | 1.56 | Involvement of activation of PLIN5-Sirt1 axis in protective effect of glycycoumarin on hepatic lipotoxicity. ( Fan, L; Hu, H; Yin, S; Zhang, E; Zhao, C, 2020) |
| "Maternal obesity is a risk factor for placental dysfunction, suggesting that factors within an obese environment may impair early placental development." | 1.56 | Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1. ( Dunk, CE; Lye, SJ; Rampersaud, AM; Renaud, SJ, 2020) |
| "In the mouse model of NAFLD induced by a high-fat diet, we observed that LRRK2 was decreased in livers." | 1.56 | LRRK2 Regulates CPT1A to Promote β-Oxidation in HepG2 Cells. ( Ding, ST; Lin, CW; Lin, YY; Mersmann, HJ; Peng, YJ, 2020) |
| "Obesity is closely associated with neuroinflammation in the hypothalamus, which is characterized by over-activated microglia and excessive production of pro-inflammatory cytokines." | 1.51 | Green Tea Polyphenol (-)-Epigallocatechin Gallate (EGCG) Attenuates Neuroinflammation in Palmitic Acid-Stimulated BV-2 Microglia and High-Fat Diet-Induced Obese Mice. ( Hochstetter, D; Mao, L; Wang, Y; Xu, P; Yao, L; Zhao, Y; Zhou, J, 2019) |
| "These results provide a new potential treatment for obesity in the future." | 1.51 | Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice. ( Chen, CC; Lee, TY; Leu, YL; Wang, SH, 2019) |
| "Palmitic acid (PA) is a main component of saturated fatty acids composing NEFA." | 1.51 | Palmitic Acid and β-Hydroxybutyrate Induce Inflammatory Responses in Bovine Endometrial Cells by Activating Oxidative Stress-Mediated NF-κB Signaling. ( Cheng, X; Guo, Y; He, J; Li, L; Li, P; Long, M; Yang, S; Zhang, C; Zhang, Y, 2019) |
| "Obesity is a risk factor for infertility, but mechanisms underlying this risk are unclear." | 1.48 | Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1. ( Bertsch, AD; Dao, N; Gray, NW; Grzybowski, CW; Lenkey, JA; Levi, NJ; Moseman, AW; Redweik, GAJ; Walsh, HE; Wilson, CW, 2018) |
| "The effect of hyperlipidemia on hepatic HPS expression was evaluated in primary hepatocytes and liver of mice." | 1.48 | Hyperlipidemia-induced hepassocin in the liver contributes to insulin resistance in skeletal muscle. ( Abd El-Aty, AM; Chung, YH; Jeong, JH; Jung, TW; Kim, HC, 2018) |
| "Insulin sensitivity was scored by Akt phosphorylation and glucose transporter 4 (GLUT4) translocation, while pro-inflammatory indices were estimated by IκBα degradation and cytokine expression." | 1.48 | Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells. ( Bilan, PJ; Brozinick, JT; Frendo-Cumbo, S; Hoang Bui, H; Jacobson, MR; Klip, A; Liu, Z; Milligan, PL; Pillon, NJ; Zierath, JR, 2018) |
| " Although it is known that SFA or LPS promote hepatic inflammation, a hallmark of NAFLD, it remains unclear how SFA in combination with LPS stimulates host inflammatory response in hepatocytes." | 1.48 | Saturated fatty acid combined with lipopolysaccharide stimulates a strong inflammatory response in hepatocytes in vivo and in vitro. ( Huang, Y; Li, Y; Lopes-Virella, MF; Lu, Z; Lyons, TJ; Ru, JH, 2018) |
| "Treatment with Senicapoc decreased palmitic acid-driven HepG2 cell death." | 1.46 | Anti-steatotic and anti-fibrotic effects of the KCa3.1 channel inhibitor, Senicapoc, in non-alcoholic liver disease. ( Duan, B; Goldberg, ID; Hao, YJ; Jiang, K; Jung, D; Li, JS; McCormack, S; Narayan, P; Paka, L; Shi, J; Smith, DE; Yamin, M; Zhou, P, 2017) |
| "Palmitic acid treatment caused mitochondrial damage and leakage of mitochondrial DNA into the cytosol." | 1.46 | STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity. ( Abe, JI; Fujiwara, K; LeMaire, SA; Luo, W; Mao, Y; Shen, YH; Song, J; Wang, XL; Wu, W; Xu, H; Yuan, L; Zhang, L, 2017) |
| "The eruptive xanthomata are formed in vivo under realization of biological function of endoecology." | 1.46 | [The disturbance of unification of coupled biochemical reactions in synthesis of endogenous ω-9 oleic acid. The resistance to insulin, stearic triglycerides and pathogenesis of eruptive xanthomata]. ( Rozhkova, TA; Samokhodskaya, LM; Titov, VN, 2017) |
| "Hypertriglyceridemia is an independent risk factor for acute pancreatitis, in which the pathological mechanisms are not fully illustrated." | 1.43 | Palmitic acid aggravates inflammation of pancreatic acinar cells by enhancing unfolded protein response induced CCAAT-enhancer-binding protein β-CCAAT-enhancer-binding protein α activation. ( Chen, J; Hu, G; Lu, Y; Wang, X; Wu, J; Zeng, Y; Zheng, J, 2016) |
| "Bortezomib is an anti-cancer agent that induces ER stress by inhibiting proteasomal degradation." | 1.43 | Bortezomib attenuates palmitic acid-induced ER stress, inflammation and insulin resistance in myotubes via AMPK dependent mechanism. ( Bae, YA; Cheon, HG; Choi, HE; Jang, J; Kwak, HJ; Park, SK, 2016) |
| "LBP KD of 3T3-L1 cells led to a potentiated adipocyte differentiation with a dose-response relationship; genes involved in mitochondrial biogenesis, fatty acid metabolism and peroxisome proliferator-activated receptor γ (PPAR-γ) action were dramatically upregulated in parallel to increased insulin signalling." | 1.42 | Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation. ( Camps, M; Escoté, X; Fernández-Real, JM; Moreno-Navarrete, JM; Ortega, F; Ricart, W; Vendrell, J; Vidal-Puig, A; Zorzano, A, 2015) |
| "Chronic inflammation is associated with insulin resistance, a characteristic of type 2 diabetes (T2D)." | 1.42 | Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes. ( Chen, J; He, C; Hu, X; Huang, Q; Wang, Y; Xu, Y; Xue, J; Zeng, Q; Zhang, W, 2015) |
| "Obesity is a state of chronic, low-grade inflammation, and increased inflammation in the adipose and kidney tissues has been shown to promote the progression of renal damage in obesity." | 1.42 | Inhibition of mitogen-activated protein kinases/nuclear factor κB-dependent inflammation by a novel chalcone protects the kidney from high fat diet-induced injuries in mice. ( Deng, L; Fang, Q; Liang, G; Pan, Y; Tong, C; Wang, J; Wang, L; Weng, Q; Yin, H; Zhang, Y, 2015) |
| " The excess calories are stored as triglycerides in adipose tissue, but also may accumulate ectopically in other organs, including the kidney, which contributes to the damage through a toxic process named lipotoxicity." | 1.42 | Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes. ( Chen, S; Izquierdo-Lahuerta, A; Martínez-García, C; Medina-Gomez, G; Velasco, I; Vivas, Y; Yeo, TK, 2015) |
| "Insulin resistance is associated with severe alterations in adipokines characterized by release of increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines from adipose tissue." | 1.42 | Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance. ( James, J; Roy, D; Shihabudeen, MS; Thirumurugan, K, 2015) |
| "Type 2 diabetes is characterized by pancreatic beta-cell dysfunction and is associated with low-grade inflammation." | 1.40 | Deletion of apoptosis signal-regulating kinase 1 (ASK1) protects pancreatic beta-cells from stress-induced death but not from glucose homeostasis alterations under pro-inflammatory conditions. ( Alquier, T; Bernard, C; Chevet, E; Guardiola, B; Higa, A; Pepin, E; Schuster-Klein, C; Sulpice, T, 2014) |
| " The vesicles were characterized for physicochemical properties, ex vivo permeation using human skin and pharmacokinetic parameters and anti-inflammatory activity in rats." | 1.40 | Ceramide-2 nanovesicles for effective transdermal delivery: development, characterization and pharmacokinetic evaluation. ( Bhandari, A; Gaur, PK; Kumar, Y; Mishra, S; Purohit, S, 2014) |
| "Tectorigenin also can inhibit inflammation-stimulated IRS-1 serine phosphorylation and restore the impaired insulin PI3K signaling, leading to a decreased NO production." | 1.39 | Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway. ( Cheng, XL; Gao, XJ; Liu, BL; Liu, K; Qin, MJ; Qin, XY; Qin, Y; Wang, Q; Xie, GY; Zhang, DY; Zhou, L, 2013) |
| "Palmitic acid was administered in amounts able to elicit significant hyperproliferation and can be attenuated by IL-6 blockage." | 1.39 | Palmitic acid induces production of proinflammatory cytokines interleukin-6, interleukin-1β, and tumor necrosis factor-α via a NF-κB-dependent mechanism in HaCaT keratinocytes. ( Luo, D; Permatasari, F; Wu, D; Xu, Y; Yin, ZQ; Zhang, JA; Zhang, Q; Zhou, BR, 2013) |
| "Chronic low-grade inflammation is a key contributor to high-fat diet (HFD)-related diseases, such as type 2 diabetes, non-alcoholic steatohepatitis, and atherosclerosis." | 1.39 | Saturated fatty acid palmitate induces extracellular release of histone H3: a possible mechanistic basis for high-fat diet-induced inflammation and thrombosis. ( Hashiguchi, T; Ito, T; Kawahara, K; Maruyama, I; Shrestha, B; Shrestha, C; Yamakuchi, M, 2013) |
| "Increased inflammation was associated with impaired glucose tolerance and hyperinsulinemia as a result of reduced hepatic but not skeletal muscle insulin sensitivity." | 1.37 | Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance. ( Fynch, SL; Galic, S; Graham, KL; Hewitt, KA; Honeyman, JE; Kay, TW; Sachithanandan, N; Steinberg, GR, 2011) |
| "Depression is characterized by IgM-related autoimmune responses directed against a) neoepitopes that are normally not detected by the immune system but that due to damage by O&NS have become immunogenic; and b) anchorage epitopes, i." | 1.37 | IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: new pathways that underpin the inflammatory and neuroprogressive pathophysiology. ( Geffard, M; Kubera, M; Leunis, JC; Maes, M; Mihaylova, I, 2011) |
| "Palmitate-induced inflammation is involved in the development of insulin resistance in skeletal muscle cells." | 1.36 | Cyclooxygenase 2 inhibition exacerbates palmitate-induced inflammation and insulin resistance in skeletal muscle cells. ( Blanco-Vaca, F; Coll, T; Escolà-Gil, JC; Laguna, JC; Palomer, X; Sánchez, RM; Vázquez-Carrera, M, 2010) |
| "Lipid-induced insulin resistance is associated with inflammatory state in epidemiological studies." | 1.36 | Overactivation of NF-κB impairs insulin sensitivity and mediates palmitate-induced insulin resistance in C2C12 skeletal muscle cells. ( Ding, H; Guo, Y; Li, D; Wu, W; Zhang, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.53) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (3.72) | 29.6817 |
| 2010's | 116 (61.70) | 24.3611 |
| 2020's | 64 (34.04) | 2.80 |
| Authors | Studies |
|---|---|
| Ku, CW | 1 |
| Ho, TJ | 1 |
| Huang, CY | 2 |
| Chu, PM | 1 |
| Ou, HC | 1 |
| Hsieh, PL | 1 |
| Molonia, MS | 4 |
| Quesada-Lopez, T | 1 |
| Speciale, A | 4 |
| Muscarà, C | 4 |
| Saija, A | 4 |
| Villarroya, F | 2 |
| Cimino, F | 4 |
| Occhiuto, C | 2 |
| Ruberto, G | 1 |
| Siracusa, L | 1 |
| Cristani, M | 2 |
| Cai, JL | 1 |
| Li, XP | 1 |
| Zhu, YL | 1 |
| Yi, GQ | 1 |
| Wang, W | 1 |
| Chen, XY | 1 |
| Deng, GM | 1 |
| Yang, L | 2 |
| Cai, HZ | 1 |
| Tong, QZ | 1 |
| Zhou, L | 2 |
| Tian, M | 1 |
| Xia, XH | 1 |
| Liu, PA | 1 |
| Zhu, W | 2 |
| Sahar, NE | 1 |
| Javaid, HMA | 1 |
| Pak, ES | 1 |
| Liang, G | 6 |
| Wang, Y | 8 |
| Ha, H | 1 |
| Huh, JY | 1 |
| Dai, HB | 1 |
| Wang, HY | 1 |
| Wang, FZ | 1 |
| Qian, P | 1 |
| Gao, Q | 1 |
| Zhou, H | 2 |
| Zhou, YB | 1 |
| Howe, AM | 1 |
| Burke, S | 1 |
| O'Reilly, ME | 1 |
| McGillicuddy, FC | 1 |
| Costello, DA | 1 |
| Kim, N | 1 |
| Jung, S | 1 |
| Lee, E | 1 |
| Jo, EB | 1 |
| Yoon, S | 1 |
| Jeong, Y | 1 |
| Jack, BU | 1 |
| Mamushi, M | 1 |
| Viraragavan, A | 1 |
| Dias, S | 1 |
| Pheiffer, C | 1 |
| Lin, K | 1 |
| Yang, N | 1 |
| Luo, W | 3 |
| Qian, JF | 1 |
| Zhu, WW | 1 |
| Ye, SJ | 1 |
| Yuan, CX | 1 |
| Xu, DY | 1 |
| Huang, WJ | 1 |
| Shan, PR | 1 |
| Williams, EJ | 1 |
| Guilleminault, L | 1 |
| Berthon, BS | 1 |
| Eslick, S | 1 |
| Wright, T | 1 |
| Karihaloo, C | 1 |
| Gately, M | 1 |
| Baines, KJ | 1 |
| Wood, LG | 1 |
| Shi, P | 1 |
| Liao, K | 1 |
| Xu, J | 2 |
| Xu, S | 1 |
| Yan, X | 1 |
| Qiu, T | 1 |
| Yang, X | 1 |
| Wang, J | 4 |
| Pan, C | 1 |
| Chu, X | 2 |
| Xiong, J | 1 |
| Xie, J | 1 |
| Chang, Y | 1 |
| Wang, C | 3 |
| Zhang, J | 3 |
| Ikeda, K | 1 |
| Morizane, S | 1 |
| Akagi, T | 1 |
| Hiramatsu-Asano, S | 1 |
| Tachibana, K | 1 |
| Yahagi, A | 1 |
| Iseki, M | 1 |
| Kaneto, H | 1 |
| Wada, J | 1 |
| Ishihara, K | 1 |
| Morita, Y | 1 |
| Mukai, T | 1 |
| Domínguez-López, I | 1 |
| Arancibia-Riveros, C | 1 |
| Casas, R | 1 |
| Tresserra-Rimbau, A | 1 |
| Razquin, C | 1 |
| Martínez-González, MÁ | 1 |
| Hu, FB | 1 |
| Ros, E | 1 |
| Fitó, M | 1 |
| Estruch, R | 1 |
| López-Sabater, MC | 1 |
| Lamuela-Raventós, RM | 1 |
| Chen, J | 6 |
| Wu, Z | 1 |
| Si, X | 1 |
| Zhang, R | 3 |
| Sun, T | 1 |
| Dong, Q | 1 |
| Wu, W | 3 |
| Qiu, Y | 2 |
| He, G | 1 |
| Wang, L | 7 |
| Jing, G | 1 |
| Cen, M | 1 |
| Zhao, N | 1 |
| Tang, X | 1 |
| Li, Z | 4 |
| Wu, K | 1 |
| Zou, Y | 2 |
| Gong, W | 1 |
| Wang, P | 1 |
| Wang, H | 3 |
| Fang, W | 1 |
| Liu, Y | 5 |
| Chen, Q | 1 |
| Xu, D | 1 |
| Liu, Q | 3 |
| Cao, X | 1 |
| Hao, T | 1 |
| Zhang, L | 2 |
| Mai, K | 2 |
| Ai, Q | 2 |
| Seufert, AL | 1 |
| Hickman, JW | 1 |
| Traxler, SK | 1 |
| Peterson, RM | 1 |
| Waugh, TA | 1 |
| Lashley, SJ | 1 |
| Shulzhenko, N | 1 |
| Napier, RJ | 1 |
| Napier, BA | 1 |
| Hu, J | 1 |
| Deng, Y | 1 |
| Ding, T | 1 |
| Dong, J | 1 |
| Liang, Y | 1 |
| Lou, B | 1 |
| Jin, L | 1 |
| Wang, M | 1 |
| Yang, B | 1 |
| Ye, L | 1 |
| Zhang, Q | 3 |
| Lou, S | 1 |
| Zhang, Y | 9 |
| Wu, S | 1 |
| Zhu, J | 1 |
| Wu, G | 1 |
| Hu, Z | 2 |
| Ying, P | 1 |
| Bao, Z | 1 |
| Ding, Z | 1 |
| Tan, X | 1 |
| Golfetto Miskiewicz, IC | 1 |
| Cho, HC | 1 |
| Lee, JI | 1 |
| Lee, J | 2 |
| Lee, Y | 1 |
| Lee, YK | 1 |
| Choi, SH | 1 |
| Shen, Q | 1 |
| Chen, Y | 4 |
| Shi, J | 2 |
| Pei, C | 1 |
| Chen, S | 2 |
| Huang, S | 2 |
| Li, W | 2 |
| Shi, X | 2 |
| Liang, J | 2 |
| Hou, S | 1 |
| Zhou, Q | 1 |
| Lu, Z | 7 |
| Wang, B | 1 |
| Li, L | 4 |
| You, M | 1 |
| Cao, T | 1 |
| Zhao, Y | 3 |
| Li, Q | 1 |
| Mou, A | 1 |
| Shu, W | 1 |
| He, H | 1 |
| Zhao, Z | 1 |
| Liu, D | 1 |
| Zhu, Z | 1 |
| Gao, P | 1 |
| Yan, Z | 1 |
| Sun, J | 1 |
| Zhu, Y | 1 |
| Li, J | 8 |
| Ba, T | 1 |
| Sun, Y | 2 |
| Chang, X | 1 |
| Yang, Y | 1 |
| Yu, Q | 1 |
| Li, B | 2 |
| Yang, Z | 1 |
| Zhang, S | 4 |
| Yuan, F | 1 |
| Li, Y | 8 |
| Chowdhury, N | 1 |
| Yu, H | 2 |
| Syn, WK | 1 |
| Lopes-Virella, M | 1 |
| Yilmaz, Ö | 1 |
| Huang, Y | 7 |
| Wang, G | 2 |
| Bojmar, L | 1 |
| Chen, H | 2 |
| Tobias, GC | 1 |
| Hu, M | 2 |
| Homan, EA | 1 |
| Lucotti, S | 1 |
| Zhao, F | 1 |
| Posada, V | 1 |
| Oxley, PR | 1 |
| Cioffi, M | 1 |
| Kim, HS | 1 |
| Lauritzen, P | 1 |
| Boudreau, N | 1 |
| Shi, Z | 1 |
| Burd, CE | 1 |
| Zippin, JH | 1 |
| Lo, JC | 1 |
| Pitt, GS | 1 |
| Hernandez, J | 1 |
| Zambirinis, CP | 1 |
| Hollingsworth, MA | 1 |
| Grandgenett, PM | 1 |
| Jain, M | 1 |
| Batra, SK | 1 |
| DiMaio, DJ | 1 |
| Grem, JL | 1 |
| Klute, KA | 1 |
| Trippett, TM | 1 |
| Egeblad, M | 1 |
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| Bromberg, J | 1 |
| Kelsen, D | 1 |
| Rajasekhar, VK | 1 |
| Healey, JH | 1 |
| Matei, IR | 1 |
| Jarnagin, WR | 1 |
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| Lyden, D | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Dietary Fatty Acids on Cardiovascular Disease Risk Indicators and Inflammation.[NCT02145936] | 20 participants (Anticipated) | Interventional | 2013-01-31 | Completed | |||
| Full-fat Yogurt and Glucose Tolerance[NCT03577119] | 13 participants (Actual) | Interventional | 2018-06-01 | Completed | |||
| Palmitate Metabolism and Insulin Resistance[NCT01612234] | 70 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| Calorie Restriction and Metabolic Health[NCT01538836] | 75 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Effect of Oral Supplementation With One Form of L-arginine on Vascular Endothelial Function in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02354794] | 36 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| Characterization of the Metabolic Fate of an Oral L-arginine Form in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02352740] | 32 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for palmitic acid and Inflammation
| Article | Year |
|---|---|
Protein cysteine palmitoylation in immunity and inflammation.
Topics: Animals; Cysteine; Cytokines; Humans; Inflammation; Palmitic Acid; Signal Transduction | 2021 |
Palmitic acid is an intracellular signaling molecule involved in disease development.
Topics: Animals; Autophagy; Cardiovascular Diseases; Humans; Inflammation; Metabolic Syndrome; Neoplasms; Ne | 2019 |
A sexually dimorphic hypothalamic response to chronic high-fat diet consumption.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Estrogen Receptor alpha; Female; Hypothalamus; Infl | 2016 |
[Prevention of atherosclerosis. Excess of palmitic acid in food--a cause of hypercholesterolemia, inflammatory syndrome, insulin resistance in myocytes, and apoptosis].
Topics: Apoptosis; Atherosclerosis; Dietary Fats; Humans; Hypercholesterolemia; Inflammation; Insulin Resist | 2011 |
3 trials available for palmitic acid and Inflammation
181 other studies available for palmitic acid and Inflammation
| Article | Year |
|---|---|
Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway.
Topics: Apoptosis; Cell Line; Cordyceps; Deoxyadenosines; Endothelial Cells; Humans; Inflammation; Molecular | 2021 |
In Vitro Effects of Cyanidin-3-O-Glucoside on Inflammatory and Insulin-Sensitizing Genes in Human Adipocytes Exposed to Palmitic Acid.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anthocyanins; Cytokines; Dose-Response Relationship, Drug; Humans | 2021 |
Effects of a pinitol-rich
Topics: Adipocytes; Animals; Glycyrrhiza; Humans; Hypertrophy; Inflammation; Inositol; Insulin; Insulin Resi | 2022 |
Topics: Animals; Base Sequence; Cell Line; Cell Survival; Gene Expression Regulation; Glucose; Inflammation; | 2021 |
Exercise-Induced Irisin Decreases Inflammation and Improves NAFLD by Competitive Binding with MD2.
Topics: Animals; Binding, Competitive; Blood Circulation; Diet, High-Fat; Fibronectins; Hepatocytes; Inflamm | 2021 |
Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes.
Topics: Adipocytes; Adrenomedullin; Animals; Inflammation; Insulin; Insulin Resistance; Obesity; Palmitic Ac | 2022 |
Palmitic Acid and Oleic Acid Differently Modulate TLR2-Mediated Inflammatory Responses in Microglia and Macrophages.
Topics: Cytokines; Dietary Fats; Fatty Acids; Fatty Acids, Monounsaturated; Humans; Inflammation; Macrophage | 2022 |
Gryllus bimaculatus De Geer hydrolysates alleviate lipid accumulation, inflammation, and endoplasmic reticulum stress in palmitic acid-treated human hepatoma G2 cells.
Topics: Carcinoma, Hepatocellular; Endoplasmic Reticulum Stress; Hep G2 Cells; Hepatocytes; Humans; Inflamma | 2022 |
Comparing the effects of tumor necrosis factor alpha, lipopolysaccharide and palmitic acid on lipid metabolism and inflammation in murine 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Inflammation; Lipid Metabolism; Lipopolysaccharides; Mice; Palmit | 2022 |
Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling.
Topics: Animals; Benzhydryl Compounds; Cardiomyopathies; Glucosides; Inflammation; Mice; Mice, Inbred C57BL; | 2022 |
Sulforaphane reduces pro-inflammatory response to palmitic acid in monocytes and adipose tissue macrophages.
Topics: Adipose Tissue; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Isothiocyanates; Lipopolysac | 2022 |
Eicosapentaenoic acid mitigates palmitic acid-induced heat shock response, inflammation and repair processes in fish intestine.
Topics: Animals; Collagen Type I; Cyclooxygenase 2; Dinoprostone; Docosahexaenoic Acids; Eicosapentaenoic Ac | 2022 |
Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway.
Topics: Animals; Glucose; Glucose Metabolism Disorders; Inflammation; Kruppel-Like Transcription Factors; Mi | 2022 |
Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation.
Topics: Animals; Dermatitis; Dyslipidemias; Humans; Inflammation; Interleukin-17; Keratinocytes; Leptin; Mic | 2022 |
Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year.
Topics: Biomarkers; Fatty Acids; Humans; Inflammation; Interleukin-6; Longitudinal Studies; Palmitic Acid | 2022 |
Docosahexaenoic Acid Ester of Phloridzin Reduces Inflammation and Insulin Resistance
Topics: AMP-Activated Protein Kinases; Cell Line; Diabetes Mellitus, Type 2; Docosahexaenoic Acids; Esters; | 2022 |
[Palmitic acid induces inflammation and transdifferentiation by activating cGAS/STING pathway in human renal tubular epithelial cells].
Topics: Cell Transdifferentiation; Collagen Type I; Epithelial Cells; Humans; Inflammation; Interleukin-6; I | 2022 |
PREX1 depletion ameliorates high-fat diet-induced non-alcoholic fatty liver disease in mice and mitigates palmitic acid-induced hepatocellular injury via suppressing the NF-κB signaling pathway.
Topics: Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Guanine Nucleotide Exchange Factors; Inflammatio | 2022 |
Palmitic acid induces intestinal lipid metabolism disorder, endoplasmic reticulum stress and inflammation by affecting phosphatidylethanolamine content in large yellow croaker
Topics: Animals; Diet; Endoplasmic Reticulum Stress; Fatty Acids; Humans; Inflammation; Intestines; Lipid Me | 2022 |
Enriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection.
Topics: Animals; Ceramides; Diet; Endotoxemia; Fatty Acids; Immunity, Innate; Inflammation; Lipopolysacchari | 2022 |
Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; 3T3-L1 Cells; Adipocytes; Animals; Inflammation; Mamm | 2022 |
A small-molecule JNK inhibitor JM-2 attenuates high-fat diet-induced non-alcoholic fatty liver disease in mice.
Topics: Animals; Diet, High-Fat; Fibrosis; Hepatocytes; Inflammation; Liver; Mice; Mice, Inbred C57BL; Non-a | 2023 |
6-Gingerol Alleviates Ferroptosis and Inflammation of Diabetic Cardiomyopathy via the Nrf2/HO-1 Pathway.
Topics: Animals; Diabetes Mellitus; Diabetic Cardiomyopathies; Glucose; Inflammation; Mice; NF-E2-Related Fa | 2022 |
Effect of atorvastatin on lipoxygenase pathway-related gene expression in an in vitro model of lipid accumulation in hepatocytes.
Topics: Atorvastatin; Gene Expression; Hepatocytes; Humans; Inflammation; Lipoxygenase; Lipoxygenases; Palmi | 2023 |
Asperuloside alleviates lipid accumulation and inflammation in HFD-induced NAFLD via AMPK signaling pathway and NLRP3 inflammasome.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Inflammasomes; Inflammation; Lipid Metabolis | 2023 |
Mitochondrial dysfunction caused by SIRT3 inhibition drives proinflammatory macrophage polarization in obesity.
Topics: Animals; Body Weight; Diet, High-Fat; Inflammation; Insulin Resistance; Macrophages; Mice; Mice, Inb | 2023 |
Effects of GRP78 on Endoplasmic Reticulum Stress and Inflammatory Response in Macrophages of Large Yellow Croaker (
Topics: Animals; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Inflammation; Macrophage | 2023 |
RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway.
Topics: Apoptosis; Chemokines; Cytokines; Diabetes Mellitus, Type 2; Humans; Inflammation; Insulin-Secreting | 2023 |
Palmitate lipotoxicity is closely associated with the fatty acid-albumin complexes in BV-2 microglia.
Topics: 2-Propanol; Fatty Acids; Humans; Inflammation; Lipopolysaccharides; Microglia; Palmitates; Palmitic | 2023 |
The Presence of Periodontitis Exacerbates Non-Alcoholic Fatty Liver Disease via Sphingolipid Metabolism-Associated Insulin Resistance and Hepatic Inflammation in Mice with Metabolic Syndrome.
Topics: Animals; Ceramides; Diet, High-Fat; Imipramine; Inflammation; Insulin Resistance; Lipopolysaccharide | 2023 |
Tumour extracellular vesicles and particles induce liver metabolic dysfunction.
Topics: Animals; Cytochrome P-450 Enzyme System; Extracellular Vesicles; Fatty Acids; Fatty Liver; Humans; I | 2023 |
Palmitic Acid Modulates Microglial Cell Response to Metabolic Endotoxemia in an In Vitro Study.
Topics: Endotoxemia; Humans; Inflammation; Lipopolysaccharides; Microglia; Palmitic Acid | 2023 |
Lunasin ameliorates glucose utilization in C2C12 myotubes and metabolites profile in diet-induced obese mice benefiting metabolic disorders.
Topics: Animals; Diet; Glucose; Glucose Intolerance; Inflammation; Insulin Resistance; Metabolic Diseases; M | 2023 |
Nuciferine Protects against Obesity-Induced Nephrotoxicity through Its Hypolipidemic, Anti-Inflammatory, and Antioxidant Effects.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antioxidants; Diet, High-Fat; Infl | 2023 |
Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Diet, High-Fat; Disease Models, Animal; Down-Regu | 2019 |
Berberine (BBR) Attenuated Palmitic Acid (PA)-Induced Lipotoxicity in Human HK-2 Cells by Promoting Peroxisome Proliferator-Activated Receptor α (PPAR-α).
Topics: Apoptosis; Berberine; Cell Line; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; | 2019 |
Green Tea Polyphenol (-)-Epigallocatechin Gallate (EGCG) Attenuates Neuroinflammation in Palmitic Acid-Stimulated BV-2 Microglia and High-Fat Diet-Induced Obese Mice.
Topics: Animals; Anti-Obesity Agents; Catechin; Cell Line; Diet, High-Fat; Disease Models, Animal; Hypothala | 2019 |
Exogenous Hydrogen Sulfide Alleviates-Induced Intracellular Inflammation in HepG2 Cells.
Topics: Cytokines; Hep G2 Cells; Hepatocytes; Humans; Hydrogen Sulfide; Inflammasomes; Inflammation; NLR Fam | 2020 |
PNPLA3 I148M mediates the regulatory effect of NF-kB on inflammation in PA-treated HepG2 cells.
Topics: Base Sequence; Binding Sites; Endoplasmic Reticulum Stress; Endoribonucleases; Gene Expression Regul | 2020 |
Targeting DUSP16/TAK1 signaling alleviates hepatic dyslipidemia and inflammation in high fat diet (HFD)-challenged mice through suppressing JNK MAPK.
Topics: Animals; Cell Line; Diet, High-Fat; Dual-Specificity Phosphatases; Dyslipidemias; Feeding Behavior; | 2020 |
Mitigation of Glucolipotoxicity-Induced Apoptosis, Mitochondrial Dysfunction, and Metabolic Stress by
Topics: Acetylcysteine; Animals; Apoptosis; Autophagy; Cell Line; DNA Damage; DNA Fragmentation; Fatty Acids | 2020 |
Palmitic acid activates NLRP3 inflammasome and induces placental inflammation during pregnancy in mice.
Topics: Animals; Female; Inflammasomes; Inflammation; Interleukin-1beta; Mice; NLR Family, Pyrin Domain-Cont | 2020 |
Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways.
Topics: AMP-Activated Protein Kinases; Animals; Gene Expression Regulation; Hep G2 Cells; Humans; Inflammati | 2020 |
Long-term hypercortisolism induces lipogenesis promoting palmitic acid accumulation and inflammation in visceral adipose tissue compared with HFD-induced obesity.
Topics: Animals; Corticosterone; Cushing Syndrome; Cytokines; Diet, High-Fat; Fatty Acids; Fatty Acids, None | 2020 |
Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes.
Topics: Animals; Berberine; Cytokines; Endoplasmic Reticulum Stress; Hepatocytes; Inflammation; Lipopolysacc | 2020 |
Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Caspase 3; Caspase 7; Gallic Acid; Gene Expressio | 2020 |
Involvement of activation of PLIN5-Sirt1 axis in protective effect of glycycoumarin on hepatic lipotoxicity.
Topics: Animals; Cell Line; Coumarins; Endoplasmic Reticulum Stress; Hepatocytes; Inflammation; Liver; Male; | 2020 |
Cyanidin-3-O-glucoside restores insulin signaling and reduces inflammation in hypertrophic adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adiponectin; Animals; Anthocyanins; Fatty Acid-Binding Prote | 2020 |
Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1.
Topics: Adult; Cell Movement; Cells, Cultured; Decidua; Female; HEK293 Cells; Humans; Inflammation; Inflamma | 2020 |
LRRK2 Regulates CPT1A to Promote β-Oxidation in HepG2 Cells.
Topics: Animals; Carnitine O-Palmitoyltransferase; Cell Nucleus; Cytokines; Diet, High-Fat; Hep G2 Cells; Hu | 2020 |
Long-chain acyl-CoA synthetase-1 mediates the palmitic acid-induced inflammatory response in human aortic endothelial cells.
Topics: Aorta; Coenzyme A Ligases; E-Selectin; Endothelial Cells; Endothelium, Vascular; Humans; Inflammatio | 2020 |
Cyanidin-3-O-glucoside protects intestinal epithelial cells from palmitate-induced lipotoxicity.
Topics: Anthocyanins; Caco-2 Cells; Epithelial Cells; Glucosides; Humans; Inflammation; NF-E2-Related Factor | 2023 |
JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes.
Topics: Animals; COP9 Signalosome Complex; Diabetes Mellitus, Type 2; Hep G2 Cells; Humans; Inflammation; In | 2020 |
[An abnormal palmitoylation arising from a mutation of CDC42 results in a severe autoinflammatory syndrome].
Topics: Amino Acid Substitution; Arginine; Autoimmune Diseases; cdc42 GTP-Binding Protein; Cysteine; Humans; | 2020 |
Gambogic acid ameliorates high glucose- and palmitic acid-induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo.
Topics: Cell Line; Diabetic Retinopathy; Humans; Inflammation; NF-E2-Related Factor 2; Palmitic Acid; Xantho | 2021 |
Dickkopf‑1/cysteine‑rich angiogenic inducer 61 axis mediates palmitic acid‑induced inflammation and apoptosis of vascular endothelial cells.
Topics: Apoptosis; Cysteine-Rich Protein 61; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; I | 2021 |
The Inhibition of Metabolic Inflammation by EPA Is Associated with Enhanced Mitochondrial Fusion and Insulin Signaling in Human Primary Myotubes.
Topics: Cells, Cultured; Eicosapentaenoic Acid; Glucose; Humans; Inflammation; Insulin; Insulin Resistance; | 2021 |
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Topics: Animals; Apoptosis; Cell Line; Cells, Cultured; Culture Media, Conditioned; Diabetes Mellitus, Type | 2021 |
The Neuroinflammatory and Neurotoxic Potential of Palmitic Acid Is Mitigated by Oleic Acid in Microglial Cells and Microglial-Neuronal Co-cultures.
Topics: Animals; Cell Death; Cell Line; Cell Survival; Coculture Techniques; Inflammation; Interleukin-6; Li | 2021 |
Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma.
Topics: Cell Line, Tumor; Humans; Inflammation; Insulin Resistance; Neoplasm Proteins; Neuroblastoma; Palmit | 2021 |
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.
Topics: Animals; Autophagy; Cell Death; Inflammation; Mice; Non-alcoholic Fatty Liver Disease; Palmitic Acid | 2022 |
Epidermal Growth Factor Modulates Palmitic Acid-Induced Inflammatory and Lipid Signaling Pathways in SZ95 Sebocytes.
Topics: Cell Line; Epidermal Growth Factor; Epithelial Cells; Humans; Inflammation; Interleukin-6; Palmitic | 2021 |
Anti-Inflammatory Effect of Auranofin on Palmitic Acid and LPS-Induced Inflammatory Response by Modulating TLR4 and NOX4-Mediated NF-κB Signaling Pathway in RAW264.7 Macrophages.
Topics: Animals; Auranofin; Gene Expression Regulation; Humans; Inflammation; Lipopolysaccharides; Macrophag | 2021 |
Transcriptional Profiles Reveal Deregulation of Lipid Metabolism and Inflammatory Pathways in Neurons Exposed to Palmitic Acid.
Topics: Animals; Hippocampus; Inflammation; Lipid Metabolism; Neurons; Palmitic Acid; Rats; Rats, Wistar; Si | 2021 |
Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Diet, High-Fat; Down-Regulation; Gene Expressio | 2021 |
Activation of κ-opioid receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Cas | 2021 |
Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue.
Topics: Adult; Arachidonic Acids; Chemokine CCL20; Docosahexaenoic Acids; Fatty Acids; Female; Humans; Infla | 2017 |
Anti-steatotic and anti-fibrotic effects of the KCa3.1 channel inhibitor, Senicapoc, in non-alcoholic liver disease.
Topics: Acetamides; Animals; Apoptosis; Biomarkers, Tumor; Diet, High-Fat; Fibrosis; Gene Expression Regulat | 2017 |
NLRP3 Deletion Inhibits the Non-alcoholic Steatohepatitis Development and Inflammation in Kupffer Cells Induced by Palmitic Acid.
Topics: Animals; Inflammation; Interleukin-18; Interleukin-1beta; Kupffer Cells; Liver; Mice; NLR Family, Py | 2017 |
TRIF-dependent Toll-like receptor signaling suppresses
Topics: Adaptor Proteins, Vesicular Transport; Animals; Diet, High-Fat; Fatty Liver; HEK293 Cells; Hepatocyt | 2017 |
Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta.
Topics: Animals; Antioxidants; Cell Line; Cell Nucleus; Cell Shape; Cell Survival; DNA Fragmentation; Estrog | 2018 |
Inhibition of MD2-dependent inflammation attenuates the progression of non-alcoholic fatty liver disease.
Topics: Animals; Chalcones; Diet, High-Fat; Disease Progression; Gene Expression Regulation; Hep G2 Cells; H | 2018 |
Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats.
Topics: Animals; Caspase 3; Coculture Techniques; Diabetes Mellitus, Experimental; Female; Fetal Blood; Gene | 2017 |
Hyperlipidemia-induced hepassocin in the liver contributes to insulin resistance in skeletal muscle.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Endoplasmic Reticulum Stress; Enzyme Activation; ErbB | 2018 |
Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid.
Topics: Animals; Cell Movement; Cells, Cultured; Female; Inflammation; Interferon-gamma; Male; Microglia; Pa | 2018 |
Effects of 1α,25 Dihydroxyvitamin D
Topics: Calcitriol; Cytokines; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Male; Monocytes; Palm | 2017 |
Macrophages with a deletion of the
Topics: Animals; Cell Polarity; Gene Deletion; Glucose; Glutamine; Inflammation; Macrophages; Mice; Palmitic | 2018 |
Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.
Topics: Adiposity; Animals; Eating; Glucose; HEK293 Cells; Homeostasis; Humans; Inflammation; Insulin Resist | 2018 |
An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation.
Topics: Acyl Coenzyme A; Animals; Cholesterol; Fatty Acid Synthase, Type I; Inflammation; Macrophage Activat | 2018 |
Docosahexaenoic acid antagonizes the boosting effect of palmitic acid on LPS inflammatory signaling by inhibiting gene transcription and ceramide synthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Ceramides; Docosahexaenoic Acids; Enzym | 2018 |
The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling.
Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Line; Cells, Cultu | 2018 |
Frontline Science: Specialized proresolving lipid mediators inhibit the priming and activation of the macrophage NLRP3 inflammasome.
Topics: Adenosine Triphosphate; Animals; Bone Marrow Cells; Caspase 1; Caspase Inhibitors; Docosahexaenoic A | 2019 |
Palmitic Acid Induces Müller Cell Inflammation that is Potentiated by Co-treatment with Glucose.
Topics: Diabetic Retinopathy; Drug Interactions; Ependymoglial Cells; Gene Expression Regulation; Glucose; H | 2018 |
Celastrol reverses palmitic acid (PA)-caused TLR4-MD2 activation-dependent insulin resistance via disrupting MD2-related cellular binding to PA.
Topics: Animals; Diet, High-Fat; Gene Expression Regulation; Humans; Inflammation; Insulin Resistance; Mice, | 2018 |
Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK.
Topics: 3T3-L1 Cells; Adenylate Kinase; Adipocytes; Aminoimidazole Carboxamide; Animals; Chemokine CCL2; Inf | 2018 |
Acetyl-CoA from inflammation-induced fatty acids oxidation promotes hepatic malate-aspartate shuttle activity and glycolysis.
Topics: Acetyl Coenzyme A; Acetylation; Animals; Aspartate Aminotransferase, Mitochondrial; Aspartic Acid; C | 2018 |
Palmitate induces nitric oxide production and inflammatory cytokine expression in zebrafish.
Topics: Animals; Biomarkers; Cytokines; Diabetes Mellitus, Type 2; Disease Models, Animal; Embryo, Nonmammal | 2018 |
Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells.
Topics: Animals; Fatty Acids; Glucose Transporter Type 4; Inflammation; Insulin Resistance; Muscle Fibers, S | 2018 |
Saturated fatty acid combined with lipopolysaccharide stimulates a strong inflammatory response in hepatocytes in vivo and in vitro.
Topics: Animals; Diet, High-Fat; Fatty Acids; Hepatocytes; Inflammation; Interleukin-6; Lipopolysaccharides; | 2018 |
The autophagic degradation of Cav-1 contributes to PA-induced apoptosis and inflammation of astrocytes.
Topics: Animals; Apoptosis; Astrocytes; Autophagy; Blotting, Western; Caveolin 1; Cells, Cultured; Fluoresce | 2018 |
Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1.
Topics: Animals; Cell Line; Endoplasmic Reticulum Stress; Gene Expression Regulation; Gonadotropin-Releasing | 2018 |
METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice.
Topics: AMP-Activated Protein Kinases; Animals; Cell Differentiation; Cell Line; Diet, High-Fat; Endoplasmic | 2018 |
Protective effects of Danzhi jiangtang capsule on vascular endothelial damages induced by high-fat diet and palmitic acid.
Topics: Administration, Oral; Animals; Antioxidants; Aorta, Thoracic; Apoptosis; Diet, High-Fat; Dose-Respon | 2018 |
Inhibition of protein kinase R protects against palmitic acid-induced inflammation, oxidative stress, and apoptosis through the JNK/NF-kB/NLRP3 pathway in cultured H9C2 cardiomyocytes.
Topics: Animals; Cell Line; eIF-2 Kinase; Inflammation; MAP Kinase Kinase 4; Myocytes, Cardiac; NF-kappa B; | 2019 |
9-PAHSA promotes browning of white fat via activating G-protein-coupled receptor 120 and inhibiting lipopolysaccharide / NF-kappa B pathway.
Topics: 3T3-L1 Cells; Adipocytes, White; Adipose Tissue, White; Animals; Cell Line; Fatty Acids, Omega-3; In | 2018 |
Palmitate Induces an Anti-Inflammatory Response in Immortalized Microglial BV-2 and IMG Cell Lines that Decreases TNFα Levels in mHypoE-46 Hypothalamic Neurons in Co-Culture.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cells, Cultured; Coculture Techniques; Hypothalamus; I | 2018 |
Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway.
Topics: Alkaloids; Animals; Apoptosis; Body Weight; Calcium; Cytosol; Diet, High-Fat; Endoplasmic Reticulum | 2018 |
Enhancement of lipid content and inflammatory cytokine secretion in SZ95 sebocytes by palmitic acid suggests a potential link between free fatty acids and acne aggravation.
Topics: Acne Vulgaris; Cell Line; Cytokines; Down-Regulation; Fatty Acids, Nonesterified; Humans; Inflammati | 2019 |
[The disturbance of unification of coupled biochemical reactions in synthesis of endogenous ω-9 oleic acid. The resistance to insulin, stearic triglycerides and pathogenesis of eruptive xanthomata].
Topics: Apolipoproteins E; Apoptosis; Biological Transport; Cholesterol; Glucose; Hepatocytes; Humans; Infla | 2017 |
The effect of enterolactone on liver lipid precursors of inflammation.
Topics: 4-Butyrolactone; Eicosanoids; Fatty Acids; Fatty Acids, Nonesterified; Fatty Acids, Omega-3; Fatty A | 2019 |
Tetrahydroxy stilbene glucoside alleviates palmitic acid-induced inflammation and apoptosis in cardiomyocytes by regulating miR-129-3p/Smad3 signaling.
Topics: Animals; Apoptosis; Cell Line; Glucosides; Inflammation; MicroRNAs; Myocytes, Cardiac; Palmitic Acid | 2019 |
Tibolone attenuates inflammatory response by palmitic acid and preserves mitochondrial membrane potential in astrocytic cells through estrogen receptor beta.
Topics: Astrocytes; Cell Line; Epigenesis, Genetic; Estradiol; Estrogen Receptor alpha; Estrogen Receptor be | 2019 |
Exosomes derived from mangiferin‑stimulated perivascular adipose tissue ameliorate endothelial dysfunction.
Topics: Adipose Tissue; Animals; Endothelial Cells; Endothelium, Vascular; Exosomes; Inflammation; Male; NF- | 2019 |
Oleic acid ameliorates palmitic acid-induced ER stress and inflammation markers in naive and cerulein-treated exocrine pancreas cells.
Topics: Acinar Cells; Animals; Cell Line; Cells, Cultured; Ceruletide; Dietary Fats; Endoplasmic Reticulum S | 2019 |
Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Cell Proliferation; Clone Cells; Di | 2019 |
Vitamin D intervention does not improve vascular regeneration in diet-induced obese male mice with peripheral ischemia.
Topics: Animals; Cell Movement; Cell Proliferation; Diet; Endothelial Cells; Gene Expression Profiling; Hind | 2019 |
Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1/Parkin-dependent mitophagy.
Topics: Animals; Carrier Proteins; Cell Line; Cell Survival; Diabetes Mellitus, Type 2; Inflammation; Insuli | 2019 |
Palmitic Acid and β-Hydroxybutyrate Induce Inflammatory Responses in Bovine Endometrial Cells by Activating Oxidative Stress-Mediated NF-κB Signaling.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cell Line; Endometrium; Female; Inflammation; NF-kappa B; Ox | 2019 |
High molecular weight adiponectin reduces glucolipotoxicity-induced inflammation and improves lipid metabolism and insulin sensitivity via APPL1-AMPK-GLUT4 regulation in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; Adiponectin; AMP-Activated Protein K | 2019 |
Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes.
Topics: Adult; CD4-Positive T-Lymphocytes; Cytokines; Diabetes Mellitus, Type 2; Female; Humans; Inflammatio | 2019 |
Eicosapentaenoic acid suppresses palmitate-induced cytokine production by modulating long-chain acyl-CoA synthetase 1 expression in human THP-1 macrophages.
Topics: Cell Line; Coenzyme A Ligases; Cytokines; Eicosapentaenoic Acid; Gene Expression Regulation, Enzymol | 2013 |
Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Biphenyl Compounds; Cell Line; Cell Nucleus; | 2013 |
AICAR inhibits PPARγ during monocyte differentiation to attenuate inflammatory responses to atherogenic lipids.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Anti-Inflammatory Agents; Atherosclerosis | 2013 |
Ceramide-2 nanovesicles for effective transdermal delivery: development, characterization and pharmacokinetic evaluation.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceramides; Chemistry, P | 2014 |
Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes.
Topics: Adipocytes; Animals; Cell Differentiation; Chemokine CCL2; Enzyme-Linked Immunosorbent Assay; Gene E | 2013 |
Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production.
Topics: Animals; Apoptosis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Fatty Acids; Humans | 2013 |
Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway.
Topics: Animals; Disease Models, Animal; Endothelium, Vascular; Gene Expression Regulation; Human Umbilical | 2013 |
Saturated fatty acid palmitate induces extracellular release of histone H3: a possible mechanistic basis for high-fat diet-induced inflammation and thrombosis.
Topics: Adipose Tissue; Animals; Cell Adhesion; Cell Line; Cell Survival; Coagulants; Diet, High-Fat; Gene E | 2013 |
Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages.
Topics: Animals; Cell Line; Inflammation; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Lipopoly | 2013 |
Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids.
Topics: Carrier Proteins; Caspase 1; Cell Line; Crystallography, X-Ray; Dietary Fats; Dimerization; Docosahe | 2013 |
Palmitic acid induces production of proinflammatory cytokines interleukin-6, interleukin-1β, and tumor necrosis factor-α via a NF-κB-dependent mechanism in HaCaT keratinocytes.
Topics: Cell Line; Cell Nucleus; Cell Proliferation; Cytoplasm; Enzyme-Linked Immunosorbent Assay; Gene Expr | 2013 |
Accumulation of lipids and oxidatively damaged DNA in hepatocytes exposed to particles.
Topics: Animals; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Fatty Acid Synthase, Type I; Fatty Liver; | 2014 |
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
Topics: Adipocytes; Animals; Eye Proteins; Gene Expression Regulation; Glucose Tolerance Test; Hepatocytes; | 2014 |
Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate.
Topics: Adipocytes, Brown; Animals; Cells, Cultured; Cytokines; Growth Differentiation Factor 5; Inflammatio | 2014 |
Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα.
Topics: Animals; Astrocytes; Cell Line; Diet, High-Fat; Estrogen Receptor alpha; Female; Hypothalamus; Infla | 2014 |
Deletion of apoptosis signal-regulating kinase 1 (ASK1) protects pancreatic beta-cells from stress-induced death but not from glucose homeostasis alterations under pro-inflammatory conditions.
Topics: Animals; Cells, Cultured; Cytokines; Diabetes Mellitus, Type 2; Glucose; Humans; Inflammation; Insul | 2014 |
Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells.
Topics: AMP-Activated Protein Kinases; Apoptosis; Carrier Proteins; Catechin; Cell Line; Endoplasmic Reticul | 2014 |
Metabolic syndrome exacerbates inflammation and bone loss in periodontitis.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Chemokine CCL2; Cytokines; Diet, | 2015 |
Elucidation of in-vitro anti-inflammatory bioactive compounds isolated from Jatropha curcas L. plant root.
Topics: Animals; Anti-Inflammatory Agents; Inflammation; Jatropha; Macrophages; Mice; Molybdenum; Palmitic A | 2015 |
18-carbon polyunsaturated fatty acids ameliorate palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes.
Topics: Animals; Cell Line; Fatty Acids, Unsaturated; Inflammation; Inflammation Mediators; Insulin Resistan | 2015 |
Palmitic acid induces central leptin resistance and impairs hepatic glucose and lipid metabolism in male mice.
Topics: Animals; Glucose; Hypothalamus; Inflammation; Leptin; Lipid Metabolism; Liver; Male; Mice; Mice, Inb | 2015 |
GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Hydrolysis; Inflammati | 2015 |
Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis.
Topics: Adipose Tissue; Cell Adhesion; Cells, Cultured; Endothelial Cells; Human Umbilical Vein Endothelial | 2015 |
Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process.
Topics: Angiotensin II; Animals; Apoptosis; Atherosclerosis; Blotting, Western; Cell Line; Cell Proliferatio | 2015 |
Australia's nutrition transition 1961-2009: a focus on fats.
Topics: Arachidonic Acid; Australia; Biological Availability; Culture; Diet; Diet, Western; Dietary Carbohyd | 2015 |
Bee's honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin-interacting protein-NLRP3 inflammasome pathway.
Topics: Animals; Carrier Proteins; Cell Cycle Proteins; Cell Line; Diet, High-Fat; Down-Regulation; Female; | 2016 |
Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance.
Topics: 3T3-L1 Cells; Adipokines; Adipose Tissue; Animals; Chenodeoxycholic Acid; Gene Expression Regulation | 2015 |
Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation.
Topics: 3T3-L1 Cells; Acute-Phase Proteins; Adipocytes; Adipogenesis; Animals; Carrier Proteins; Gene Expres | 2015 |
Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes.
Topics: Adult; Biomarkers; Blood Glucose; Case-Control Studies; Chronic Disease; Cytokines; Diabetes Mellitu | 2015 |
Fatty acids from fat cell lipolysis do not activate an inflammatory response but are stored as triacylglycerols in adipose tissue macrophages.
Topics: Adipocytes; Adipose Tissue; Adrenergic beta-3 Receptor Agonists; Animals; Cell Line; Dioxoles; Fatty | 2015 |
Inhibition of mitogen-activated protein kinases/nuclear factor κB-dependent inflammation by a novel chalcone protects the kidney from high fat diet-induced injuries in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chalcones; Cytokines; Diet, High- | 2015 |
Homoplantaginin Inhibits Palmitic Acid-induced Endothelial Cells Inflammation by Suppressing TLR4 and NLRP3 Inflammasome.
Topics: Carrier Proteins; Drugs, Chinese Herbal; Flavonoids; Glucosides; Human Umbilical Vein Endothelial Ce | 2016 |
Long-chain polyunsaturated fatty acids amend palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes.
Topics: Animals; Cell Line; Cell Survival; Cytokines; Extracellular Signal-Regulated MAP Kinases; Fatty Acid | 2016 |
Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes.
Topics: Actin Cytoskeleton; Animals; Apoptosis; Cell Line; Cytochalasin D; Endoplasmic Reticulum Stress; Inf | 2015 |
PGC-1β suppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation.
Topics: Adaptor Proteins, Signal Transducing; Adipose Tissue; Animals; Chemokine CCL2; Gene Expression Regul | 2016 |
Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity.
Topics: Animals; Apoptosis; Blood Glucose; Cardiomegaly; Cell Line; Diet, High-Fat; Fibrosis; Heart Injuries | 2016 |
Bortezomib attenuates palmitic acid-induced ER stress, inflammation and insulin resistance in myotubes via AMPK dependent mechanism.
Topics: AMP-Activated Protein Kinases; Animals; Bortezomib; Cell Line; Cytoprotection; Endoplasmic Reticulum | 2016 |
Fenofibrate improves high-fat diet-induced and palmitate-induced endoplasmic reticulum stress and inflammation in skeletal muscle.
Topics: Animals; Body Weight; Cell Line; Diet, High-Fat; Endoplasmic Reticulum Stress; Female; Fenofibrate; | 2016 |
Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells.
Topics: Caspase 1; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; Female; Humans; Inf | 2016 |
Pentraxin 3 is an anti-inflammatory protein associated with lipid-induced interleukin 10 in vitro.
Topics: Adult; Atherosclerosis; C-Reactive Protein; Cells, Cultured; Cytokines; Humans; Inflammation; Interl | 2016 |
Palmitic acid aggravates inflammation of pancreatic acinar cells by enhancing unfolded protein response induced CCAAT-enhancer-binding protein β-CCAAT-enhancer-binding protein α activation.
Topics: Acinar Cells; Animals; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; En | 2016 |
Adiponectin protects palmitic acid induced endothelial inflammation and insulin resistance via regulating ROS/IKKβ pathways.
Topics: Adiponectin; Cytokines; Human Umbilical Vein Endothelial Cells; Humans; I-kappa B Kinase; Inflammati | 2016 |
Protective Effect of 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione, Isolated from Averrhoa Carambola L., Against Palmitic Acid-Induced Inflammation and Apoptosis in Min6 Cells by Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Averrhoa; bcl-2-Associated X Protein; C | 2016 |
Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Apoptosis; Cell Survival; Ceramides; Endopla | 2016 |
Fatty acid synthesis configures the plasma membrane for inflammation in diabetes.
Topics: Adipose Tissue; Animals; Cell Adhesion; Cell Membrane; Cell Movement; Cholesterol; Diabetes Mellitus | 2016 |
Resveratrol Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Attenuating Oxidative Stress and JNK/NF-κB Pathway in a SIRT1-Independent Mechanism.
Topics: Animals; Cell Line; Inflammation; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Muscle Fib | 2017 |
STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity.
Topics: Active Transport, Cell Nucleus; Adipose Tissue; Animals; Cell Line, Tumor; Coculture Techniques; Die | 2017 |
Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo.
Topics: Body Composition; Cell Survival; Endoplasmic Reticulum; Fatty Acids, Nonesterified; Gene Expression | 2009 |
12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Arachido | 2009 |
In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation.
Topics: Analysis of Variance; Arachidonic Acid; Cell Line; Chemokine CCL2; Cholesterol; Docosahexaenoic Acid | 2009 |
Cyclooxygenase 2 inhibition exacerbates palmitate-induced inflammation and insulin resistance in skeletal muscle cells.
Topics: Animals; Cell Differentiation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; DNA Primers; Drug Syne | 2010 |
Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Cyc | 2010 |
Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Cyc | 2010 |
Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Cyc | 2010 |
Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Cyc | 2010 |
Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic β-cell dysfunction.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cells, Cultured; Cytokines; Hydrogen Peroxide; Inflammat | 2010 |
Overactivation of NF-κB impairs insulin sensitivity and mediates palmitate-induced insulin resistance in C2C12 skeletal muscle cells.
Topics: Animals; Cell Line; Deoxyglucose; Gene Expression Regulation; Gene Silencing; Glucose Transporter Ty | 2010 |
Inflammatory response of human coronary artery endothelial cells to saturated long-chain fatty acids.
Topics: CCAAT-Enhancer-Binding Protein-beta; Cells, Cultured; Chemokine CCL20; Chemokines, CXC; Coronary Ves | 2011 |
Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans.
Topics: 3T3-L1 Cells; Adipose Tissue; Analysis of Variance; Animals; Blotting, Western; Cells, Cultured; Hum | 2011 |
Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Fatty Acids; Humans; Inflammation; Inflamma | 2011 |
Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance.
Topics: Animals; Inflammation; Insulin; Insulin Resistance; Lipopolysaccharides; Liver; Macrophages; Male; M | 2011 |
Involvement of visfatin in palmitate-induced upregulation of inflammatory cytokines in hepatocytes.
Topics: Adenoviridae Infections; Animals; Blood Glucose; Cholesterol; Cytokines; Enzyme-Linked Immunosorbent | 2011 |
IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: new pathways that underpin the inflammatory and neuroprogressive pathophysiology.
Topics: Acetylcholine; Adult; Aged; Antibody Formation; Autoimmunity; Case-Control Studies; Cysteine; Depres | 2011 |
Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease.
Topics: Animals; Cell Death; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Diet; Endoplasmic Ret | 2011 |
Enzymatic activity and genetic variation in SCD1 modulate the relationship between fatty acids and inflammation.
Topics: Adult; C-Reactive Protein; Fatty Acids; Fatty Acids, Monounsaturated; Female; Genetic Variation; Gen | 2012 |
The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.
Topics: Adipocytes; Adipose Tissue; Animals; Antigens, CD; Antigens, Surface; Coculture Techniques; Dietary | 2012 |
Effect of endoplasmic reticulum stress on inflammation and adiponectin regulation in human adipocytes.
Topics: Adipocytes; Adiponectin; Body Mass Index; Cell Line; Endoplasmic Reticulum; Endoplasmic Reticulum Ch | 2012 |
TNF-related apoptosis-inducing ligand significantly attenuates metabolic abnormalities in high-fat-fed mice reducing adiposity and systemic inflammation.
Topics: Adiposity; Animals; Apoptosis; Calorimetry; Cytokines; Dietary Fats; Energy Intake; Glucose Toleranc | 2012 |
Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability.
Topics: Animals; Anti-Inflammatory Agents; Aorta, Thoracic; Biological Availability; Blotting, Western; Cell | 2012 |
Radioprotection by N-palmitoylated nonapeptide of human interleukin-1beta.
Topics: Adjuvants, Immunologic; Animals; Blood Platelets; Cytokines; Dose-Response Relationship, Radiation; | 2005 |
Thiazolidinediones enhance skeletal muscle triacylglycerol synthesis while protecting against fatty acid-induced inflammation and insulin resistance.
Topics: Animals; Dietary Fats; Fatty Acids; Glucose; Hindlimb; Inflammation; Insulin; Insulin Resistance; Li | 2007 |
Palmitate and oleate have distinct effects on the inflammatory phenotype of human endothelial cells.
Topics: Acyl Coenzyme A; Adenosine Diphosphate; Adenosine Triphosphate; Caspase 3; Cell Line; Cell Prolifera | 2007 |
Innate immune pathway links obesity to insulin resistance.
Topics: Animals; Aorta; Dietary Fats; Disease Models, Animal; Humans; Immunity, Innate; Inflammation; Insuli | 2007 |
Cytoplasmic lipid bodies of human neutrophilic leukocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Autoradiography; Cytoplasm; Esterification; Humans; Inflammatio | 1989 |