palmitic acid has been researched along with Diabetic Glomerulosclerosis in 13 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we report that KIM-1 mediates PT uptake of palmitic acid (PA)-bound albumin, leading to enhanced tubule injury with DNA damage, PT cell-cycle arrest, interstitial inflammation and fibrosis, and secondary glomerulosclerosis." | 4.02 | KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. ( Ajay, AK; Bonventre, JV; Brooks, CR; Chang, JH; Galichon, P; Hawkins, J; Henderson, JM; Ichimura, T; Kishi, S; Kuchroo, VK; Li, J; Li, L; Mori, Y; Mou, S; Palmer, SC; Sabbisetti, VS; Woo, HM; Xiao, S; Zhao, H, 2021) |
| "Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN)." | 1.48 | Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy. ( An, XR; Jin, SJ; Li, XX; Wei, W; Xu, M, 2018) |
| "Loss of podocytes is a hallmark of diabetic nephropathy, and podocytes are highly susceptible to saturated FFAs but not to protective, monounsaturated FFAs." | 1.39 | Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2. ( Cohen, CD; Gruber, S; Jehle, AW; Kampe, K; Lindenmeyer, MT; Mundel, P; Orellana, JM; Sieber, J; Weins, A, 2013) |
| "Cellular insulin resistance is the hallmark of type 2 diabetes and predominantly affects adipose and muscle cells." | 1.35 | Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy. ( Coward, RJ; Lennon, R; Mathieson, PW; Pons, D; Sabin, MA; Saleem, MA; Shield, JP; Tavaré, JM; Wei, C; Welsh, GI, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 5 (38.46) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, S | 1 |
| Da, J | 1 |
| Yu, J | 1 |
| Dong, R | 1 |
| Yuan, J | 1 |
| Yu, F | 1 |
| Zha, Y | 1 |
| Kaewin, S | 1 |
| Changsorn, K | 1 |
| Sungkaworn, T | 1 |
| Hiranmartsuwan, P | 1 |
| Yaosanit, W | 1 |
| Rukachaisirikul, V | 1 |
| Muanprasat, C | 1 |
| Zhao, C | 1 |
| Li, L | 2 |
| Li, C | 1 |
| Tang, C | 1 |
| Cai, J | 1 |
| Liu, Y | 2 |
| Yang, J | 1 |
| Xi, Y | 1 |
| Yang, M | 1 |
| Jiang, N | 1 |
| Han, Y | 1 |
| Luo, S | 1 |
| Xiao, L | 1 |
| Sun, L | 1 |
| Wang, X | 2 |
| Liu, Q | 1 |
| Kong, D | 1 |
| Long, Z | 1 |
| Guo, Y | 1 |
| Wang, S | 1 |
| Liu, R | 1 |
| Hai, C | 1 |
| Mori, Y | 1 |
| Ajay, AK | 1 |
| Chang, JH | 1 |
| Mou, S | 1 |
| Zhao, H | 1 |
| Kishi, S | 1 |
| Li, J | 1 |
| Brooks, CR | 1 |
| Xiao, S | 1 |
| Woo, HM | 1 |
| Sabbisetti, VS | 1 |
| Palmer, SC | 1 |
| Galichon, P | 1 |
| Henderson, JM | 1 |
| Kuchroo, VK | 1 |
| Hawkins, J | 1 |
| Ichimura, T | 1 |
| Bonventre, JV | 1 |
| Huang, Y | 1 |
| Sun, Y | 1 |
| Cao, Y | 1 |
| Sun, H | 1 |
| Li, M | 1 |
| You, H | 1 |
| Su, D | 1 |
| Li, Y | 1 |
| Liang, X | 1 |
| Wei, W | 1 |
| An, XR | 1 |
| Jin, SJ | 1 |
| Li, XX | 1 |
| Xu, M | 1 |
| Lee, E | 1 |
| Lee, HS | 1 |
| Sieber, J | 1 |
| Weins, A | 1 |
| Kampe, K | 1 |
| Gruber, S | 1 |
| Lindenmeyer, MT | 1 |
| Cohen, CD | 1 |
| Orellana, JM | 1 |
| Mundel, P | 1 |
| Jehle, AW | 1 |
| Kumar, S | 1 |
| Tikoo, K | 1 |
| Xin, W | 1 |
| Zhao, X | 1 |
| Liu, L | 1 |
| Xu, Y | 1 |
| Li, Z | 1 |
| Chen, L | 1 |
| Yi, F | 1 |
| Wan, Q | 1 |
| Lennon, R | 1 |
| Pons, D | 1 |
| Sabin, MA | 1 |
| Wei, C | 1 |
| Shield, JP | 1 |
| Coward, RJ | 1 |
| Tavaré, JM | 1 |
| Mathieson, PW | 1 |
| Saleem, MA | 1 |
| Welsh, GI | 1 |
| Lim, JC | 1 |
| Lim, SK | 1 |
| Han, HJ | 1 |
| Park, SH | 1 |
13 other studies available for palmitic acid and Diabetic Glomerulosclerosis
| Article | Year |
|---|---|
Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus; Diabetic Nephropathies; Leptin; Lipid Met | 2022 |
Fungus-Derived 3-Hydroxyterphenyllin and Candidusin A Ameliorate Palmitic Acid-Induced Human Podocyte Injury via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Topics: Apoptosis; Diabetic Nephropathies; Fungi; Humans; Palmitic Acid; Podocytes; Proto-Oncogene Proteins | 2022 |
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease.
Topics: Animals; Cholesterol; Diabetes Mellitus; Diabetic Nephropathies; Glucose; Hypercholesterolemia; Kidn | 2022 |
Down-regulation of SETD6 protects podocyte against high glucose and palmitic acid-induced apoptosis, and mitochondrial dysfunction via activating Nrf2-Keap1 signaling pathway in diabetic nephropathy.
Topics: Animals; Apoptosis; Biomarkers; Blood Glucose; Diabetic Nephropathies; Gene Expression Regulation; K | 2020 |
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease.
Topics: Animals; Benzamides; Cell Cycle Checkpoints; Diabetes Mellitus, Experimental; Diabetic Nephropathies | 2021 |
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2α ubiquitylation and degradation.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line; Diabetic Nephropathies; Diseas | 2017 |
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy.
Topics: Alprostadil; Animals; Autophagy; Cell Survival; Diabetes Mellitus, Type 2; Diabetic Nephropathies; D | 2018 |
Peroxidase expression is decreased by palmitate in cultured podocytes but increased in podocytes of advanced diabetic nephropathy.
Topics: Antioxidants; Apoptosis; Catalase; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Nephropathie | 2018 |
Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.
Topics: Benzoates; Benzylamines; Carnitine O-Palmitoyltransferase; Cell Death; Cells, Cultured; Diabetic Nep | 2013 |
Independent role of PP2A and mTORc1 in palmitate induced podocyte death.
Topics: Cell Death; Diabetic Nephropathies; Enzyme Inhibitors; Humans; MAP Kinase Signaling System; Mechanis | 2015 |
Acetyl-CoA carboxylase 2 suppression rescues human proximal tubular cells from palmitic acid induced lipotoxicity via autophagy.
Topics: Acetyl-CoA Carboxylase; Autophagy; Cell Line; Cell Survival; Diabetic Nephropathies; Gene Silencing; | 2015 |
Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy.
Topics: Adenosine Triphosphate; Cell Line; Cell Survival; Ceramides; Diabetic Nephropathies; Fatty Acids; Ge | 2009 |
Cannabinoid receptor 1 mediates palmitic acid-induced apoptosis via endoplasmic reticulum stress in human renal proximal tubular cells.
Topics: Activating Transcription Factor 4; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferat | 2010 |