palmitic acid has been researched along with Diabetes Mellitus, Type 1 in 20 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment of nonobese diabetic (NOD) mice, a model of type 1 autoimmune diabetes (T1D), with palmitic acid hydroxy stearic acids (PAHSAs), a novel class of endogenous lipids with antidiabetic and antiinflammatory effects, delays the onset and reduces the incidence of T1D from 82% with vehicle treatment to 35% with PAHSAs." | 4.12 | PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53. ( Aguayo-Mazzucato, C; Bonner-Weir, S; Garcia-Martin, R; Kahn, BB; Lee, J; Rubin de Celis, MF; Syed, I, 2022) |
| " For kinetic parameters, such as area under the curve, clearance, elimination constant, time for maximum response, absorption rate and elimination rate, the values for palmitic acid in the diabetic and control series also did not differ significantly." | 2.41 | Kinetics of palmitic acid transport in insulin-dependent diabetic pregnancies: in vitro study. ( al-Rayyes, S; al-Yatama, M; Devarajan, L; Makhseed, M; Nandakumaran, M; Sugathan, T, 2000) |
| "To examine whether hyperglycemia is an independent regulator of adipose tissue lipolysis, we measured palmitate flux ([3H]palmitate) on two occasions in eight volunteers with insulin-dependent diabetes." | 1.29 | Lack of effect of hyperglycemia on lipolysis in humans. ( Cersosimo, E; Coppack, S; Jensen, M, 1993) |
| "Seven nondiabetic and seven IDDM subjects were studied with the pancreatic clamp technique to control plasma insulin, growth hormone, and glucagon concentrations at the desired levels." | 1.28 | Insulin regulation of lipolysis in nondiabetic and IDDM subjects. ( Caruso, M; Heiling, V; Jensen, MD; Miles, JM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rubin de Celis, MF | 2 |
| Garcia-Martin, R | 1 |
| Syed, I | 2 |
| Lee, J | 1 |
| Aguayo-Mazzucato, C | 1 |
| Bonner-Weir, S | 1 |
| Kahn, BB | 2 |
| Hamad, ARA | 1 |
| Sadasivam, M | 1 |
| Rabb, H | 1 |
| Mohan, JF | 1 |
| Moraes-Vieira, PM | 1 |
| Vijayakumar, A | 1 |
| Nelson, AT | 1 |
| Siegel, D | 1 |
| Saghatelian, A | 1 |
| Mathis, D | 1 |
| Simon, MC | 1 |
| Bilan, S | 1 |
| Nowotny, B | 1 |
| Dickhaus, T | 1 |
| Burkart, V | 1 |
| Schloot, NC | 1 |
| Niinistö, S | 1 |
| Takkinen, HM | 1 |
| Uusitalo, L | 1 |
| Rautanen, J | 1 |
| Nevalainen, J | 1 |
| Kenward, MG | 1 |
| Lumia, M | 1 |
| Simell, O | 1 |
| Veijola, R | 1 |
| Ilonen, J | 1 |
| Knip, M | 1 |
| Virtanen, SM | 1 |
| Wang, S | 1 |
| Crandell, JL | 1 |
| Couch, SC | 1 |
| King, IB | 1 |
| Lawrence, JM | 1 |
| Dabelea, D | 1 |
| Lamichhane, AP | 1 |
| Kim, G | 1 |
| Bell, RA | 1 |
| Zhu, S | 1 |
| Mayer-Davis, EJ | 1 |
| Broderick, TL | 1 |
| Hutchison, AK | 1 |
| Moller, N | 1 |
| Jensen, MD | 5 |
| Rizza, RA | 1 |
| Andrews, JC | 1 |
| Nair, KS | 1 |
| Cersosimo, E | 1 |
| Coppack, S | 1 |
| Jensen, M | 1 |
| Zhou, YT | 1 |
| Shimabukuro, M | 1 |
| Koyama, K | 1 |
| Lee, Y | 1 |
| Wang, MY | 1 |
| Trieu, F | 1 |
| Newgard, CB | 1 |
| Unger, RH | 1 |
| Divertie, GD | 2 |
| Cryer, PE | 1 |
| Miles, JM | 4 |
| Brod, SA | 1 |
| Malone, M | 1 |
| Darcan, S | 1 |
| Papolla, M | 1 |
| Nelson, L | 1 |
| Nandakumaran, M | 1 |
| Makhseed, M | 1 |
| al-Rayyes, S | 1 |
| al-Yatama, M | 1 |
| Devarajan, L | 1 |
| Sugathan, T | 1 |
| Avogaro, A | 1 |
| Valerio, A | 1 |
| Gnudi, L | 1 |
| Maran, A | 1 |
| Miola, M | 1 |
| Duner, E | 1 |
| Marescotti, C | 1 |
| Iori, E | 1 |
| Tiengo, A | 1 |
| Nosadini, R | 1 |
| Aoki, T | 1 |
| Hidaka, H | 1 |
| Kosugi, K | 1 |
| Kojima, H | 1 |
| Nakajima, Y | 1 |
| Nakamura, T | 1 |
| Harano, Y | 1 |
| Shigeta, Y | 1 |
| Caruso, M | 2 |
| Heiling, VJ | 1 |
| Brodersen, R | 1 |
| Andersen, S | 1 |
| Vorum, H | 1 |
| Nielsen, SU | 1 |
| Pedersen, AO | 1 |
| Heiling, V | 1 |
| Taylor, AJ | 1 |
| Jennings, PE | 1 |
| Barnett, AH | 1 |
| Pandov, HI | 1 |
| Lawson, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Ingested Interferon-Alpha: Prolongation or Permanence of the Honeymoon Phase in Newly Diagnosed Diabetes Mellitus"[NCT00024518] | Phase 2 | 57 participants (Actual) | Interventional | 2001-09-30 | Completed | ||
| Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (T1D)--Insulin Clamp Ancillary Study for Assessment of Insulin Resistance[NCT02045290] | Phase 3 | 37 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for palmitic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Kinetics of palmitic acid transport in insulin-dependent diabetic pregnancies: in vitro study.
Topics: Biological Transport; Diabetes Mellitus, Type 1; Female; Humans; In Vitro Techniques; Male; Palmitic | 2000 |
19 other studies available for palmitic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53.
Topics: Animals; Cellular Senescence; Diabetes Mellitus, Type 1; Humans; Insulin-Secreting Cells; Mice; Mice | 2022 |
Hybrid lipids, peptides, and lymphocytes: new era in type 1 diabetes research.
Topics: Animals; Cell Survival; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Esters; Hydroxy | 2019 |
PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.
Topics: Adult; Aged; Animals; Cell Survival; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Est | 2019 |
Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes.
Topics: Adult; alpha-Linolenic Acid; Case-Control Studies; Chemokines; Cytokines; Diabetes Mellitus, Type 1; | 2013 |
Maternal dietary fatty acid intake during pregnancy and the risk of preclinical and clinical type 1 diabetes in the offspring.
Topics: Animals; Autoantibodies; Cheese; Cohort Studies; Diabetes Mellitus, Type 1; Diet, Fat-Restricted; Di | 2014 |
Plasma nutrient biomarkers are associated with waist-to-height ratio in youth with type 1 diabetes.
Topics: Adolescent; Biomarkers; Body Height; Body Mass Index; Body Weight; Child; Child, Preschool; Cross-Se | 2015 |
Cardiac dysfunction in the euglycemic diabetic-prone BB Wor rat.
Topics: Animals; Aorta; Blood Pressure; Buffers; Cardiac Output; Cardiomyopathies; Diabetes Mellitus, Type 1 | 2004 |
Renal amino acid, fat and glucose metabolism in type 1 diabetic and non-diabetic humans: effects of acute insulin withdrawal.
Topics: Amino Acids; Blood Flow Velocity; Diabetes Mellitus, Type 1; Glucose; Humans; Hypoglycemic Agents; I | 2006 |
Lack of effect of hyperglycemia on lipolysis in humans.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Female; Glucagon; Glucose Clamp Techniqu | 1993 |
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation.
Topics: Adipocytes; Animals; Cells, Cultured; Diabetes Mellitus, Type 1; DNA Primers; Enzyme Induction; Epid | 1997 |
Lipolytic responsiveness to epinephrine in nondiabetic and diabetic humans.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Peptide; Carbon Radioisotopes; Diabetes Mellitus, Typ | 1997 |
Ingested interferon alpha suppresses type I diabetes in non-obese diabetic mice.
Topics: Adoptive Transfer; Animals; Concanavalin A; Diabetes Mellitus, Type 1; Female; Interferon-alpha; Int | 1998 |
The effects of different plasma insulin concentrations on lipolytic and ketogenic responses to epinephrine in normal and type 1 (insulin-dependent) diabetic humans.
Topics: Acetoacetates; Adult; Blood Glucose; Blood Pressure; C-Peptide; Diabetes Mellitus, Type 1; Epinephri | 1992 |
Increased ketogenesis related to insulin deficiency in isolated hepatocytes from NIDDM model rats.
Topics: Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; In Vitro Techniques; Insulin; Ketone | 1992 |
Lack of effect of hyperglycemia on lipolysis in humans.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Female; Gluc | 1990 |
Effects of glucagon on free fatty acid metabolism in humans.
Topics: Adipose Tissue; Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterifi | 1991 |
Multiple fatty acid binding to albumin in human blood plasma.
Topics: Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Humans; Kinetics; Linoleic Acid; Linoleic Aci | 1990 |
Insulin regulation of lipolysis in nondiabetic and IDDM subjects.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Female; Gluc | 1989 |
An alternative explanation for the changes in erythrocyte fatty acids observed in diabetes mellitus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Arachidonic Acids; Blood Glucose; Chro | 1987 |