palmitic acid and Diabetes Mellitus, Adult-Onset studies

Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.

Research Excerpts

Excerpt	Relevance	Reference
"Patients with type 2 diabetes respond differently to sitagliptin, an oral anti-hyperglycemic medication."	5.91	The impact of sitagliptin in palmitic acid-induced insulin resistance in human HepG2 cells through the suppressor of cytokine signaling 3/phosphoinositide 3-kinase/protein kinase B pathway. ( Aleteng, QQ; Jiang, S; Li, L; Ma, R; Quan, L; Zhu, J, 2023)
" However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits beneficial effects on insulin sensitivity, and the dietary palmitic acid:oleic acid ratio impacts diabetes risk in humans."	4.98	Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus. ( Barroso, E; Palomer, X; Pizarro-Delgado, J; Vázquez-Carrera, M, 2018)
"The study aims to investigate the effects of PZ-DHA on insulin resistance in the skeletal muscle and the related mechanisms; we used palmitic acid (PA)-treated C2C12 myotubes as an insulin resistance model."	4.12	Docosahexaenoic Acid Ester of Phloridzin Reduces Inflammation and Insulin Resistance ( Chen, J; Dong, Q; Qiu, Y; Si, X; Sun, T; Wang, J; Wu, W; Wu, Z; Zhang, R, 2022)
" To simulate a similar in-vivo condition, we persuaded insulin resistance in H9c2 cells by palmitic acid (PA) treatment."	4.12	Empagliflozin prohibits high-fructose diet-induced cardiac dysfunction in rats via attenuation of mitochondria-driven oxidative stress. ( Alam, MJ; Arava, S; Banerjee, SK; Bugga, P; Katare, P; Maulik, SK; Meghwani, H; Mohammed, SA, 2022)
" The iron chelator deferoxamine dramatically inhibited PA-induced insulin resistance, and iron donors impaired insulin sensitivity by activating JNK."	3.91	Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells. ( Choi, SE; Cui, R; Jeon, JY; Kang, Y; Kim, HJ; Kim, TH; Lee, HJ; Lee, KW; Lee, SJ, 2019)
" For primary skeletal muscle satellite cells, inhibition of differentiation was observed in palmitic acid-induced insulin resistance model."	3.91	Mitochondrial dysfunction and inhibition of myoblast differentiation in mice with high-fat-diet-induced pre-diabetes. ( Fan, S; Han, S; Hassan, HM; Jiang, Z; Sun, Z; Wang, L; Wang, T; Xu, D; Zhang, L; Zhao, G; Zhou, W, 2019)
"To investigate whether ezetimibe ameliorates hepatic steatosis and induces autophagy in a rat model of obesity and type 2 diabetes."	3.81	Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. ( Chang, E; Kim, L; Lee, WY; Oh, KW; Park, CY; Park, SE; Park, SW; Rhee, EJ, 2015)
" In addition, it was validated if IMTG palmitic acid is associated with insulin resistance as suggested earlier."	3.76	Desaturation of excess intramyocellular triacylglycerol in obesity: implications for glycemic control. ( Haugaard, SB; Madsbad, S; Mu, H; Vaag, A, 2010)
"Adipose tissue enriched with palmitic acid and depleted of essential PUFAs is associated with insulin resistance."	3.76	Adipose tissue fatty acids and insulin sensitivity in elderly men. ( Arnlöv, J; Cederholm, T; Iggman, D; Risérus, U; Sjögren, P; Vessby, B, 2010)
"We found strong positive relationships between adipose tissue TG content of the fatty acids myristic acid (14:0) and stearic acid (18:0) with insulin sensitivity (HOMA model) (p < 0."	3.75	Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans. ( Dennis, AL; Frayn, KN; Harnden, KE; Hodson, L; Humphreys, SM; Micklem, KJ; Neville, MJ; Roberts, R, 2009)
"A total of 15 NIDDM patients participated in a randomized crossover study with three 3-week diet interventions separated by 2-week washout periods."	2.68	Comparison of a carbohydrate-rich diet and diets rich in stearic or palmitic acid in NIDDM patients. Effects on lipids, glycemic control, and diurnal blood pressure. ( Christiansen, C; Hermansen, K; Pedersen, E; Rasmussen, O; Storm, H; Thomsen, C, 1997)
"Palmitic acid is a saturated fat found in foods that lead to obesity, cardiovascular disease, and Type II diabetes."	2.47	The twists and turns of sphingolipid pathway in glucose regulation. ( Deevska, GM; Nikolova-Karakashian, MN, 2011)
"Patients with type 2 diabetes respond differently to sitagliptin, an oral anti-hyperglycemic medication."	1.91	The impact of sitagliptin in palmitic acid-induced insulin resistance in human HepG2 cells through the suppressor of cytokine signaling 3/phosphoinositide 3-kinase/protein kinase B pathway. ( Aleteng, QQ; Jiang, S; Li, L; Ma, R; Quan, L; Zhu, J, 2023)
"Ultrasound was used to estimate NAFLD at admission."	1.72	Long-chain saturated fatty acids and its interaction with insulin resistance and the risk of nonalcoholic fatty liver disease in type 2 diabetes in Chinese. ( Jiang, LP; Sun, HZ, 2022)
"Non-alcoholic fatty liver disease (NAFLD), an emerging risk factor for diabetes, is now recognized as the most common liver disease worldwide."	1.62	Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1. ( Chen, L; Cui, C; Cui, Y; Guo, X; He, Q; Hu, H; Liang, K; Sha, S; Song, J; Sun, L; Wang, C; Wang, L; Yang, M; Zang, N, 2021)
"We recently published that type 2 diabetes promotes cell centrosome amplification via upregulation of Rho-associated protein kinase 1 (ROCK1) and 14-3-3 protein-σ (14-3-3σ)."	1.56	Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4. ( He, QJ; Lee, SC; Li, YF; Liu, QQ; Wang, J; Wang, P; Wu, QG, 2020)
"Furthermore, most people with type 2 diabetes are either obese or overweight, with the associated dyslipidaemia contributing to the development of insulin resistance and increased cardiovascular risk."	1.56	Identification of a subset of trace amine-associated receptors and ligands as potential modulators of insulin secretion. ( Bagnati, M; Berry, MD; Billacura, MP; Caton, PW; Cripps, MJ; Fair, K; Hanna, K; Hitman, GA; Jones, TA; Lowe, R; Nelson, C; Ogunkolade, BW; Sayers, SR; Turner, MD, 2020)
"During the onset of type 2 diabetes, excessive dietary intake of saturated NEFA and fructose lead to impaired insulin production and secretion by insulin-producing pancreatic beta cells."	1.56	Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity. ( Bellini, L; Campana, M; Cnop, M; Cosentino, C; Dairou, J; Fantuzzi, F; Göpel, SO; Le Stunff, H; Magnan, C; Marchetti, P; Oshima, M; Pechberty, S; Rouch, C; Scharfmann, R; Toivonen, S, 2020)
"Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factors that are characterized by insulin resistance in skeletal muscle, a prominent site of glucose disposal."	1.56	Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism. ( Astrup, A; Auwerx, J; Barrès, R; Bork-Jensen, J; Grarup, N; Hansen, AN; Hansen, T; Ingerslev, LR; Pedersen, O; Ribel-Madsen, R; Small, L; Williams, K; Wohlwend, M; Workman, CT, 2020)
"Human stem cell therapy for type 2 diabetes/obesity (T2D/O) complications is performedwith stem cell autografts, exposed to the noxious T2D/O milieu, often with suboptimal results."	1.56	Evaluation of the In Vitro Damage Caused by Lipid Factors on Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence. ( Cooper, C; DeCastro, WB; Gelfand, R; Gonzalez-Cadavid, NF; Kovanecz, I; Lin, G; Lue, T; Ohanian, A; Sharifzad, S, 2020)
"Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN)."	1.48	Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy. ( An, XR; Jin, SJ; Li, XX; Wei, W; Xu, M, 2018)
"Aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils in islets of Langerhans is associated with type 2 diabetes, and formation of toxic IAPP species is believed to contribute to the loss of insulin-producing beta cells."	1.48	BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells. ( Hermansson, E; Johansson, J; Oskarsson, ME; Presto, J; Wang, Y; Welsh, N; Westermark, GT, 2018)
"The incidence of type 2 diabetes, the most common cause of diabetic retinopathy (DR), is rapidly on the rise in developed countries due to overconsumption of calorie rich diets."	1.48	Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression. ( Dai, W; Dennis, MD; Dierschke, SK; Toro, AL, 2018)
"Serum samples from several cohorts with type 2 diabetes were analyzed for the presence of anti-LCSFA IgG, the cytokine IL-1β, and nonesterified fatty acids."	1.42	Identification of Anti-Long Chain Saturated Fatty Acid IgG Antibodies in Serum of Patients with Type 2 Diabetes. ( Beeson, WL; Boston, AM; Casiano, CA; Cordero-MacIntyre, Z; De Leon, M; Firek, AF; Kim, NS; Langridge, WH; Larios, M; Nicholas, DA; Salto, LM, 2015)
"A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin resistance--wherein insulin fails to suppress hepatic glucose production yet continues to stimulate lipogenesis, resulting in hyperglycemia, hyperlipidemia, and hepatic steatosis."	1.42	Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. ( Bears, M; Camporez, JP; Cline, GW; Gattu, AK; Jurczak, MJ; Kumashiro, N; Majumdar, SK; Petersen, MC; Rahimi, Y; Samuel, VT; Shulman, GI; Vatner, DF, 2015)
"Chronic inflammation is associated with insulin resistance, a characteristic of type 2 diabetes (T2D)."	1.42	Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes. ( Chen, J; He, C; Hu, X; Huang, Q; Wang, Y; Xu, Y; Xue, J; Zeng, Q; Zhang, W, 2015)
"Obvious obese feathers associated with type 2 diabetes were observed in HFD feeding mice, with decreased circulating irisin level and FNDC5/irisin secretion in adipose tissues."	1.42	Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice. ( Chen, X; Chen, Y; Yang, Z; Zhao, Q, 2015)
"SR-BI was higher in type 2 diabetes patients but not in those with hypercholesterolemia."	1.42	Hepatic scavenger receptor BI is associated with type 2 diabetes but unrelated to human and murine non-alcoholic fatty liver disease. ( Buechler, C; Eisinger, K; Krautbauer, S; Meier, EM; Pohl, R; Rein-Fischboeck, L; Weiss, TS, 2015)
"Type 2 diabetes is characterized by pancreatic beta-cell dysfunction and is associated with low-grade inflammation."	1.40	Deletion of apoptosis signal-regulating kinase 1 (ASK1) protects pancreatic beta-cells from stress-induced death but not from glucose homeostasis alterations under pro-inflammatory conditions. ( Alquier, T; Bernard, C; Chevet, E; Guardiola, B; Higa, A; Pepin, E; Schuster-Klein, C; Sulpice, T, 2014)
"Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome and type 2 diabetes."	1.38	Increased erythrocytes n-3 and n-6 polyunsaturated fatty acids is significantly associated with a lower prevalence of steatosis in patients with type 2 diabetes. ( Athias, A; Bouillet, B; Brindisi, MC; Cercueil, JP; Cottet, V; Duvillard, L; Gambert, P; Guiu, B; Habchi, M; Hillon, P; Jooste, V; Petit, JM; Verges, B, 2012)
"Overt type 2 diabetes is associated with diminished islet expression of SCD and Elovl6, and this can disrupt desaturation of saturated FAs to MUFAs, rendering β-cells more susceptible to saturated FA-induced ER stress and apoptosis."	1.37	Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6. ( Green, CD; Olson, LK, 2011)
"and results Left ventricular hypertrophy was induced surgically in Sprague-Dawley rats by inter-renal aortic constriction."	1.35	Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy. ( Akki, A; Seymour, AM, 2009)
"We conclude that subjects at risk for Type 2 diabetes have intrinsic differences in palmitate regulation of at least two enzymes (PP2A and glycogen synthase), contributing to abnormal insulin regulation of glucose metabolism."	1.35	Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes. ( Bogardus, C; Bunt, JC; Gessel, MC; Mott, DM; Stone, K, 2008)
"The present data indicate that type 2 diabetes is characterised by heterogeneity in the dysregulation of skeletal muscle fatty acid metabolism, with only the leg, but not the arm, showing an impairment of fatty acid kinetics at baseline and during a hyperinsulinaemic-euglycaemic clamp causing a physiological increase in insulin concentration."	1.33	Heterogeneity in limb fatty acid kinetics in type 2 diabetes. ( Olsen, DB; Sacchetti, M; Saltin, B; van Hall, G, 2005)
"The metabolic syndrome is accompanied by an elevated level of serum insulin, which is known to enhance the synthesis of saturated and monounsaturated fatty acids, such as 16:0 and 18:1, and to stimulate the activity delta-6 desaturase, decreasing the concentration of linoleic acid."	1.33	Serum fatty acids in postinfarction middle-aged men. ( Alho, H; Kunnas, T; Leskinen, MH; Nikkari, ST; Solakivi, T, 2005)
"Women with Type 2 diabetes appear to lose the protection against cardiovascular disease (CVD) afforded by oestrogens."	1.33	The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes. ( Burdge, GC; Masding, MG; Sandeman, DD; Stears, AJ; Wootton, SA, 2006)
"We hypothesised that in subjects with type 2 diabetes muscle malonyl-CoA (an inhibitor of fatty acid oxidation) would be elevated at baseline in comparison with control subjects and in particular during physiological hyperinsulinaemia with hyperglycaemia."	1.33	Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. ( Bell, JA; Cadenas, JG; Fujita, S; Rasmussen, BB; Volpi, E, 2006)
"In summary, type 2 diabetes impairs the ability of insulin to stimulate both MGU and SGU."	1.31	Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity. ( Basu, A; Basu, R; Jensen, MD; Johnson, CM; Nair, KS; Rizza, RA; Schwenk, WF; Shah, P; Vella, A, 2000)
"The onset of NIDDM in obese Zucker diabetic fatty (fa/fa) rats is preceded by a striking increase in the plasma levels of free fatty acids (FFAs) and by a sixfold rise in triglyceride content in the pancreatic islets."	1.30	Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM. ( Esser, V; Hirose, H; Lee, Y; McGarry, JD; Unger, RH; Zhou, YT, 1997)
"Although NIDDM was associated with greater (P < 0."	1.29	Assessment of insulin action in NIDDM in the presence of dynamic changes in insulin and glucose concentration. ( Caumo, A; Cobelli, C; Homan, M; Jensen, M; Katz, H; Rizza, R, 1994)
"In another group of patients with NIDDM, plasma FFA was markedly increased (plus approximately 1,500 mumol/l)."	1.28	Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources. ( Groop, L; Puhakainen, I; Saloranta, C; Taskinen, MR; Yki-Järvinen, H, 1991)

Research

Studies (155)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Baseline Glucose Disposal - a Measure of the Body's Ability to Process Sugars.

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (7.10)	18.2507
2000's	30 (19.35)	29.6817
2010's	74 (47.74)	24.3611
2020's	40 (25.81)	2.80

Authors	Studies
Lehmann, F	1
Haile, S	1
Axen, E	1
Medina, C	1
Uppenberg, J	1
Svensson, S	1
Lundbäck, T	1
Rondahl, L	1
Barf, T	1
Sæther, T	1
Paulsen, SM	1
Tungen, JE	1
Vik, A	1
Aursnes, M	1
Holen, T	1
Hansen, TV	1
Nebb, HI	1
Lee, J	2
Hong, SW	1
Kim, MJ	1
Moon, SJ	1
Kwon, H	1
Park, SE	2
Rhee, EJ	2
Lee, WY	2
Chen, Y	2
Li, X	1
Su, L	1
Hu, Q	1
Li, W	2
He, J	2
Zhao, L	2
Chen, J	4
Wu, Z	1
Wang, J	3
Si, X	1
Zhang, R	1
Sun, T	1
Dong, Q	1
Wu, W	2
Qiu, Y	1
Costabile, G	1
Della Pepa, G	1
Salamone, D	1
Luongo, D	1
Naviglio, D	1
Brancato, V	1
Cavaliere, C	1
Salvatore, M	1
Cipriano, P	1
Vitale, M	1
Corrado, A	1
Rivellese, AA	1
Annuzzi, G	1
Bozzetto, L	1
Tao, G	1
Zhang, G	1
Chen, W	2
Yang, C	1
Xue, Y	1
Song, G	1
Qin, S	1
Xue, WJ	2
He, CF	2
Zhou, RY	1
Xu, XD	2
Xiang, LX	1
Wang, JT	2
Wang, XR	1
Zhou, HG	2
Guo, JC	2
Ávalos, Y	1
Hernández-Cáceres, MP	1
Lagos, P	1
Pinto-Nuñez, D	1
Rivera, P	1
Burgos, P	1
Díaz-Castro, F	1
Joy-Immediato, M	1
Venegas-Zamora, L	1
Lopez-Gallardo, E	1
Kretschmar, C	1
Batista-Gonzalez, A	1
Cifuentes-Araneda, F	1
Toledo-Valenzuela, L	1
Rodriguez-Peña, M	1
Espinoza-Caicedo, J	1
Perez-Leighton, C	1
Bertocchi, C	1
Cerda, M	1
Troncoso, R	1
Parra, V	1
Budini, M	1
Burgos, PV	1
Criollo, A	1
Morselli, E	1
Bugga, P	1
Mohammed, SA	1
Alam, MJ	1
Katare, P	1
Meghwani, H	1
Maulik, SK	1
Arava, S	1
Banerjee, SK	1
Xie, S	1
Zhang, M	1
Shi, W	1
Xing, Y	1
Huang, Y	1
Fang, WX	1
Liu, SQ	1
Chen, MY	1
Zhang, T	1
Chen, S	2
Zeng, X	1
Wang, S	1
Deng, W	1
Tang, Q	1
Alka, K	1
Mohammad, G	1
Kowluru, RA	1
Zhu, P	2
Zhang, JJ	1
Cen, Y	1
Yang, Y	1
Wang, F	1
Gu, KP	1
Yang, HT	1
Wang, YZ	1
Zou, ZQ	1
Pan, X	4
Mizukami, H	3
Hara, Y	3
Yamada, T	3
Yamazaki, K	3
Kudoh, K	3
Takeuchi, Y	3
Sasaki, T	3
Kushibiki, H	3
Igawa, A	3
Hakamada, K	3
Jiang, LP	1
Sun, HZ	1
Su, Q	1
Huang, J	4
Chen, X	2
Wang, Y	4
Shao, M	1
Yan, H	1
Chen, C	2
Ren, H	1
Zhang, F	1
Ni, Y	2
Jose, PA	1
Zhong, J	1
Yang, J	1
Guo, F	1
Yao, L	1
Zhang, W	2
Chen, P	1
Hao, R	1
Huang, X	1
Jiang, J	1
Wu, S	1
Li, P	1
Dai, S	1
Gao, X	1
Zhu, Y	3
Li, J	3
Ba, T	1
Sun, Y	2
Chang, X	2
Du, Q	1
Wu, X	1
Ma, K	1
Liu, W	1
Liu, P	2
Hayashi, T	1
Mizuno, K	1
Hattori, S	1
Fujisaki, H	1
Ikejima, T	1
Ma, R	1
Quan, L	1
Aleteng, QQ	1
Li, L	2
Zhu, J	1
Jiang, S	1
Qi, J	1
Yan, X	1
Qiu, K	1
Huang, W	1
Zhou, Z	1
He, QJ	1
Wang, P	2
Liu, QQ	1
Wu, QG	1
Li, YF	2
Lee, SC	2
Marei, WFA	1
Van den Bosch, L	1
Pintelon, I	1
Mohey-Elsaeed, O	1
Bols, PEJ	1
Leroy, JLMR	1
Xie, T	1
So, WY	1
Li, XY	1
Leung, PS	1
Cripps, MJ	1
Bagnati, M	1
Jones, TA	1
Ogunkolade, BW	1
Sayers, SR	1
Caton, PW	1
Hanna, K	1
Billacura, MP	1
Fair, K	1
Nelson, C	1
Lowe, R	1
Hitman, GA	1
Berry, MD	1
Turner, MD	1
Oshima, M	1
Pechberty, S	1
Bellini, L	1
Göpel, SO	1
Campana, M	1
Rouch, C	1
Dairou, J	1
Cosentino, C	1
Fantuzzi, F	1
Toivonen, S	1
Marchetti, P	2
Magnan, C	1
Cnop, M	2
Le Stunff, H	1
Scharfmann, R	1
Huang, F	1
Lin, W	1
Al-Mrabeh, A	1
Zhyzhneuskaya, SV	1
Peters, C	1
Barnes, AC	1
Melhem, S	1
Jesuthasan, A	1
Aribisala, B	1
Hollingsworth, KG	1
Lietz, G	1
Mathers, JC	1
Sattar, N	1
Lean, MEJ	1
Taylor, R	1
Guo, R	2
Yu, Y	2
Zhang, Y	6
Li, Y	1
Chu, X	2
Lu, H	3
Sun, C	2
Williams, K	1
Ingerslev, LR	1
Bork-Jensen, J	1
Wohlwend, M	1
Hansen, AN	1
Small, L	1
Ribel-Madsen, R	1
Astrup, A	1
Pedersen, O	1
Auwerx, J	1
Workman, CT	1
Grarup, N	1
Hansen, T	1
Barrès, R	1
Kovanecz, I	1
Gelfand, R	1
Sharifzad, S	1
Ohanian, A	1
DeCastro, WB	1
Cooper, C	1
Lin, G	1
Lue, T	1
Gonzalez-Cadavid, NF	1
Huang, JS	1
Guo, BB	1
Wang, GH	1
Zeng, LM	1
Hu, YH	1
Wang, T	3
Wang, HY	1
Hu, HQ	1
Qiao, JT	1
Liu, FQ	1
Wang, JB	1
Sha, S	2
He, Q	2
Cui, C	2
Song, J	2
Zang, N	2
Wang, LS	1
Sun, Z	2
Chen, L	2
Hou, XG	1
Zhao, Y	1
Ma, S	1
Hu, X	2
Feng, M	1
Xiang, R	1
Li, M	1
Liu, C	2
Lu, T	1
Huang, A	1
Wu, M	1
Wang, X	2
Ding, Y	1
Wu, MX	1
Wang, SH	1
Xie, Y	1
Chen, ZT	1
Guo, Q	1
Yuan, WL	1
Guan, C	1
Xu, CZ	1
Huang, YN	1
Wang, JF	1
Zhang, HF	1
Chen, YX	1
Li, XD	1
He, SS	1
Wan, TT	1
Li, YB	1
van Dierendonck, XAMH	1
Sancerni, T	1
Alves-Guerra, MC	1
Stienstra, R	1
Yu, ZY	1
Tao, YH	1
Liu, YC	1
Wang, YM	1
Guo, QL	1
Xue, JZ	1
Wen, XH	1
Zhang, Q	3
Yang, M	1
Cui, Y	1
Wang, L	3
Liang, K	1
Wang, C	2
Hu, H	1
Guo, X	1
Sun, L	2
Zhang, N	1
Xu, D	2
Gui, L	1
Lu, Y	1
Shi, LJ	1
Wang, JW	1
Shi, GY	1
Ali, ES	1
Girard, D	1
Petrovsky, N	1
Su, S	1
Zhao, Q	2
Shi, H	1
Sun, H	1
Li, S	1
Shi, D	1
Purwana, I	1
Liu, JJ	1
Portha, B	1
Buteau, J	1
Palomer, X	1
Pizarro-Delgado, J	1
Barroso, E	1
Vázquez-Carrera, M	1
Wei, W	1
An, XR	1
Jin, SJ	1
Li, XX	1
Xu, M	2
Oskarsson, ME	1
Hermansson, E	1
Welsh, N	1
Presto, J	1
Johansson, J	1
Westermark, GT	1
Cha, SH	1
Hwang, Y	1
Kim, KN	1
Jun, HS	1
Lee, E	1
Lee, HS	1
Groebe, K	1
Cen, J	1
Schvartz, D	1
Sargsyan, E	2
Chowdhury, A	1
Roomp, K	1
Schneider, R	1
Alderborn, A	1
Sanchez, JC	1
Bergsten, P	2
Cui, R	1
Choi, SE	1
Kim, TH	2
Lee, HJ	1
Lee, SJ	1
Kang, Y	1
Jeon, JY	1
Kim, HJ	2
Lee, KW	1
Dai, W	1
Dierschke, SK	1
Toro, AL	1
Dennis, MD	1
Lin, JS	2
Dong, HL	1
Chen, GD	1
Chen, ZY	1
Dong, XW	1
Zheng, JS	1
Chen, YM	1
Jiang, Z	1
Zhao, G	1
Hassan, HM	1
Fan, S	1
Zhou, W	2
Han, S	1
Zhang, L	1
Tian, J	1
Tang, W	3
Zhang, C	1
Zhao, P	1
Cao, T	1
Shan, X	1
Lu, R	1
Guo, W	1
Wang, K	1
Liu, D	1
Xu, R	1
Pang, J	1
Li, K	1
Sun, P	2
Han, X	2
Ahmad, R	1
Akhter, N	1
Al-Roub, A	1
Kochumon, S	1
Wilson, A	1
Thomas, R	1
Ali, S	1
Tuomilehto, J	1
Sindhu, S	1
Huang, L	1
Aris, IM	1
Yang, G	1
Chen, WQ	1
Li, LJ	1
Guo, T	1
Liu, T	1
Liu, X	2
Xiong, R	1
Li, H	1
Li, Z	1
Zhang, Z	1
Tian, Z	1
Tian, Y	1
Zhou, T	1
Wang, G	1
Lyu, Y	1
Zuo, S	1
Zou, J	1
Zhao, W	1
Shu, C	1
Yang, YG	1
Hu, Z	1
Simon, MC	1
Bilan, S	1
Nowotny, B	1
Dickhaus, T	1
Burkart, V	1
Schloot, NC	1
Boslem, E	1
Weir, JM	1
MacIntosh, G	1
Sue, N	1
Cantley, J	1
Meikle, PJ	1
Biden, TJ	1
Sertoglu, E	1
Kurt, I	1
Tapan, S	1
Uyanik, M	1
Serdar, MA	1
Kayadibi, H	1
El-Fawaeir, S	1
Prause, M	1
Christensen, DP	1
Billestrup, N	1
Mandrup-Poulsen, T	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Medium-term Effects of a Portfolio Diet on Non-alcoholic Fatty Liver Disease in Type 2 Diabetic Patients[NCT03380416]		49 participants (Actual)	Interventional	2017-04-04	Completed
The Cardiovascular Health Study[NCT00005133]		5,888 participants (Actual)	Observational	1988-06-30	Active, not recruiting
"ACTIVValidation of a Paradigm for the Evaluation of Compounds That Activate Mitochondrial Biogenesis in Skeletal Muscle"[NCT00401791]		40 participants (Actual)	Interventional	2006-11-30	Completed
Fat Cell Size and Overfeeding and Etopic Study[NCT01672632]		40 participants (Actual)	Interventional	2008-05-31	Completed
Recombinant Human Leptin Therapy Effects on Insulin Action[NCT01207934]		18 participants (Actual)	Interventional	1998-08-31	Completed
Insulin and Sarcopenia in the Elderly[NCT00690534]	Phase 1	88 participants (Actual)	Interventional	2005-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

pre-treatment glucose disposal. In general, a high glucose disposal rate is a marker of healthy metabolic function. Glucose disposal is measured by tracking the amount of tagged glucose in the bloodstream over time. It is adjusted to subject body weight. (NCT01207934)
Timeframe: baseline

Baseline Plasma Leptin Concentrations

Intervention	mmol/kg body weight/minute (Mean)
Placebo	14.3
Low Dose Leptin	18.4
High Dose Leptin	16.7

Leptin is an endogenous hormone. Here we measure the pre-treatment concentration of naturally-occurring leptin in the blood. (NCT01207934)
Timeframe: baseline

Post-treatment Glucose Disposal. I.e. Glucose Disposal After Treatment With Leptin or Placebo.

Intervention	Micrograms/Liter (Mean)
Placebo	27
Low Dose Leptin	24
High Dose Leptin	35

This is a measure of the body's ability to metabolize sugar after treatment with either leptin or a placebo. We compare the effect of leptin therapy on insulin-mediated stimulation of glucose disposal with that of placebo. In general, a high glucose disposal rate is a marker of healthy metabolic function. Glucose disposal is measured by tracking the amount of tagged glucose in the bloodstream over time. It is adjusted to subject body weight. (NCT01207934)
Timeframe: fourteen days

Post-treatment Plasma Leptin Levels

Intervention	mmol/kg body weight/minute (Mean)
Placebo	17.5
Low Dose Leptin	20.7
High Dose Leptin	19.1

plasma leptin levels after fourteen days ingestion of either leptin or placebo. (NCT01207934)
Timeframe: fourteen days

Reviews

Trials

Other Studies

142 other studies available for palmitic acid and Diabetes Mellitus, Adult-Onset

Article	Year
Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus. Trends in endocrinology and metabolism: TEM, 2018, Volume: 29, Issue:3 Topics: Animals; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Insulin-Secreting Cells; Oleic Acid;	2018
Circulating Saturated Fatty Acids and Incident Type 2 Diabetes: A Systematic Review and Meta-Analysis. Nutrients, 2019, May-01, Volume: 11, Issue:5 Topics: Correlation of Data; Diabetes Mellitus, Type 2; Eicosanoic Acids; Fatty Acids; Humans; Incidence; My	2019
Biological and Nutritional Properties of Palm Oil and Palmitic Acid: Effects on Health. Molecules (Basel, Switzerland), 2015, Sep-18, Volume: 20, Issue:9 Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dietary Fats; Humans; Mice; Neoplasms;	2015
The twists and turns of sphingolipid pathway in glucose regulation. Biochimie, 2011, Volume: 93, Issue:1 Topics: Animals; Ceramides; Diabetes Mellitus, Type 2; Dietary Fats; Glucose; Humans; Hyperglycemia; Insulin	2011

Article	Year
Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial. Nutrients, 2022, May-23, Volume: 14, Issue:10 Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus, Type 2; Diet; Humans; Lipogenesis; Non-alcoholic Fatty Liv	2022
A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease. Journal of cellular and molecular medicine, 2022, Volume: 26, Issue:14 Topics: Animals; Anti-Inflammatory Agents; Diabetes Mellitus, Type 2; Humans; Hydrogen; Liver; Mice; Mice, I	2022
Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss. Cell metabolism, 2020, 02-04, Volume: 31, Issue:2 Topics: Diabetes Mellitus, Type 2; Female; Humans; Insulin-Secreting Cells; Lipid Metabolism; Lipoproteins,	2020
Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study. The American journal of clinical nutrition, 2015, Volume: 101, Issue:1 Topics: Aged; Biomarkers; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Follow	2015
Perilipin 3 Differentially Regulates Skeletal Muscle Lipid Oxidation in Active, Sedentary, and Type 2 Diabetic Males. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:10 Topics: Adult; Carrier Proteins; Colforsin; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Lipi	2015
Perilipin 3 Differentially Regulates Skeletal Muscle Lipid Oxidation in Active, Sedentary, and Type 2 Diabetic Males. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:10 Topics: Adult; Carrier Proteins; Colforsin; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Lipi	2015
Perilipin 3 Differentially Regulates Skeletal Muscle Lipid Oxidation in Active, Sedentary, and Type 2 Diabetic Males. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:10 Topics: Adult; Carrier Proteins; Colforsin; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Lipi	2015
Perilipin 3 Differentially Regulates Skeletal Muscle Lipid Oxidation in Active, Sedentary, and Type 2 Diabetic Males. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:10 Topics: Adult; Carrier Proteins; Colforsin; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Lipi	2015
Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes. Diabetes, 2011, Volume: 60, Issue:5 Topics: Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glycero	2011
Metabolic and dietary determinants of serum lipids in obese patients with recently diagnosed non-insulin-dependent diabetes. Annals of medicine, 1994, Volume: 26, Issue:2 Topics: Adult; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diet, Reducing; Female; Follow-Up	1994
Comparison of a carbohydrate-rich diet and diets rich in stearic or palmitic acid in NIDDM patients. Effects on lipids, glycemic control, and diurnal blood pressure. Diabetes care, 1997, Volume: 20, Issue:12 Topics: Adult; Blood Glucose; Blood Pressure; Circadian Rhythm; Cohort Studies; Cross-Over Studies; Diabetes	1997
Measurement of free fatty acid kinetics during non-equilibrium tracer conditions in man: implications for the estimation of the rate of appearance of free fatty acids. European journal of clinical investigation, 1998, Volume: 28, Issue:2 Topics: Adult; Aged; Carbon Radioisotopes; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Half-Life;	1998

Article	Year
Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorganic & medicinal chemistry letters, 2004, Sep-06, Volume: 14, Issue:17 Topics: Adipocytes; Amino Acid Sequence; Binding Sites; Carrier Proteins; Diabetes Mellitus, Type 2; Drug De	2004
Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects. European journal of medicinal chemistry, 2018, Jul-15, Volume: 155 Topics: Animals; Cells, Cultured; Chlorocebus aethiops; COS Cells; Diabetes Mellitus, Type 2; Dose-Response	2018
Dulaglutide Ameliorates Palmitic Acid-Induced Hepatic Steatosis by Activating FAM3A Signaling Pathway. Endocrinology and metabolism (Seoul, Korea), 2022, Volume: 37, Issue:1 Topics: Diabetes Mellitus, Type 2; Glucagon-Like Peptides; Humans; Immunoglobulin Fc Fragments; Non-alcoholi	2022
Cyanidin-3-O-Glucoside Ameliorates Palmitic-Acid-Induced Pancreatic Beta Cell Dysfunction by Modulating CHOP-Mediated Endoplasmic Reticulum Stress Pathways. Nutrients, 2022, Apr-28, Volume: 14, Issue:9 Topics: Animals; Anthocyanins; Apoptosis; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Stress; Glucoside	2022
Docosahexaenoic Acid Ester of Phloridzin Reduces Inflammation and Insulin Resistance Current pharmaceutical design, 2022, Volume: 28, Issue:22 Topics: AMP-Activated Protein Kinases; Cell Line; Diabetes Mellitus, Type 2; Docosahexaenoic Acids; Esters;	2022
High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression. Molecular brain, 2022, 07-18, Volume: 15, Issue:1 Topics: Animals; Autophagy; Diabetes Mellitus, Type 2; Glucose; Membrane Proteins; Mice; Neurons; Palmitic A	2022
Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism. Cell death & disease, 2022, 07-28, Volume: 13, Issue:7 Topics: Animals; Autophagy; Cilia; Diabetes Mellitus, Type 2; Humans; Hypothalamus; Insulin; Insulin Resista	2022
Empagliflozin prohibits high-fructose diet-induced cardiac dysfunction in rats via attenuation of mitochondria-driven oxidative stress. Life sciences, 2022, Oct-15, Volume: 307 Topics: Animals; Benzhydryl Compounds; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mel	2022
Long-Term Activation of Glucagon-like peptide-1 receptor by Dulaglutide Prevents Diabetic Heart Failure and Metabolic Remodeling in Type 2 Diabetes. Journal of the American Heart Association, 2022, 10-04, Volume: 11, Issue:19 Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2;	2022
Regulation of serine palmitoyl-transferase and Rac1-Nox2 signaling in diabetic retinopathy. Scientific reports, 2022, 10-06, Volume: 12, Issue:1 Topics: Animals; Ceramides; Cytosine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic R	2022
High Endogenously Synthesized N-3 Polyunsaturated Fatty Acids in Fat-1 Mice Attenuate High-Fat Diet-Induced Insulin Resistance by Inhibiting NLRP3 Inflammasome Activation via Akt/GSK-3β/TXNIP Pathway. Molecules (Basel, Switzerland), 2022, Sep-27, Volume: 27, Issue:19 Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antioxidants; Carrier Proteins; Di	2022
Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma. Journal of diabetes investigation, 2023, Volume: 14, Issue:1 Topics: Carcinoma, Pancreatic Ductal; Diabetes Mellitus, Type 2; DNA Mismatch Repair; Humans; Mismatch Repai	2023
Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma. Journal of diabetes investigation, 2023, Volume: 14, Issue:1 Topics: Carcinoma, Pancreatic Ductal; Diabetes Mellitus, Type 2; DNA Mismatch Repair; Humans; Mismatch Repai	2023
Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma. Journal of diabetes investigation, 2023, Volume: 14, Issue:1 Topics: Carcinoma, Pancreatic Ductal; Diabetes Mellitus, Type 2; DNA Mismatch Repair; Humans; Mismatch Repai	2023
Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma. Journal of diabetes investigation, 2023, Volume: 14, Issue:1 Topics: Carcinoma, Pancreatic Ductal; Diabetes Mellitus, Type 2; DNA Mismatch Repair; Humans; Mismatch Repai	2023
Long-chain saturated fatty acids and its interaction with insulin resistance and the risk of nonalcoholic fatty liver disease in type 2 diabetes in Chinese. Frontiers in endocrinology, 2022, Volume: 13 Topics: Diabetes Mellitus, Type 2; East Asian People; Fatty Acids; Humans; Insulin Resistance; Myristic Acid	2022
Long-Term High-Fat Diet Decreases Renal Insulin-Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway. Molecular nutrition & food research, 2023, Volume: 67, Issue:7 Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Insulin; Insulin Resistance; Insulysin; Kidney;	2023
The therapeutic mechanism of Yuye decoction on type 2 diabetes mellitus based on network pharmacology and experimental verification. Journal of ethnopharmacology, 2023, May-23, Volume: 308 Topics: Animals; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Glucose; Mice; Molecular Docking Simulati	2023
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery. Journal of physiology and biochemistry, 2023, Volume: 79, Issue:3 Topics: Animals; Chromatography, Liquid; Diabetes Mellitus, Type 2; Gastric Bypass; Insulin-Secreting Cells;	2023
RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway. Autoimmunity, 2023, Volume: 56, Issue:1 Topics: Apoptosis; Chemokines; Cytokines; Diabetes Mellitus, Type 2; Humans; Inflammation; Insulin-Secreting	2023
Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy. Archives of biochemistry and biophysics, 2023, 07-15, Volume: 743 Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ferroptosis; Glucose; Mitophagy	2023
The impact of sitagliptin in palmitic acid-induced insulin resistance in human HepG2 cells through the suppressor of cytokine signaling 3/phosphoinositide 3-kinase/protein kinase B pathway. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2023, Volume: 74, Issue:2 Topics: Cytokines; Diabetes Mellitus, Type 2; Glucose; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Humans	2023
CXCL5 promotes lipotoxicity of hepatocytes through upregulating NLRP3/Caspase-1/IL-1β signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in mice. International immunopharmacology, 2023, Volume: 123 Topics: Animals; Caspase 1; Diabetes Mellitus, Type 2; Hepatocytes; Inflammasomes; Interleukin-1beta; Kupffe	2023
Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4. American journal of physiology. Cell physiology, 2020, 01-01, Volume: 318, Issue:1 Topics: 14-3-3 Proteins; Animals; Biomarkers, Tumor; Blood Glucose; Centrosome; Diabetes Mellitus, Experimen	2020
Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: a bovine in vitro model. Human reproduction (Oxford, England), 2019, 10-02, Volume: 34, Issue:10 Topics: Animals; Antioxidants; Cattle; Culture Media; Diabetes Mellitus, Type 2; Disease Models, Animal; Emb	2019
Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism. Clinical science (London, England : 1979), 2019, 10-15, Volume: 133, Issue:19 Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Antibodies, Monoclonal, Humanized; A	2019
Identification of a subset of trace amine-associated receptors and ligands as potential modulators of insulin secretion. Biochemical pharmacology, 2020, Volume: 171 Topics: Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Gene Expression Profiling; Glucose; Humans; In	2020
Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity. Diabetologia, 2020, Volume: 63, Issue:2 Topics: Apoptosis; Cells, Cultured; Diabetes Mellitus, Type 2; Humans; Induced Pluripotent Stem Cells; Insul	2020
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway. BioMed research international, 2019, Volume: 2019 Topics: Diabetes Mellitus, Type 2; Fatty Acids; Gene Expression Regulation; Glucose; Glucose Transporter Typ	2019
Overexpression of miR-297b-5p protects against stearic acid-induced pancreatic β-cell apoptosis by targeting LATS2. American journal of physiology. Endocrinology and metabolism, 2020, 03-01, Volume: 318, Issue:3 Topics: Animals; Apoptosis; Cell Line; Cells, Cultured; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterifie	2020
Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism. Nature communications, 2020, 06-01, Volume: 11, Issue:1 Topics: Animals; Cell Line; Chromatin; Diabetes Mellitus, Type 2; Enhancer Elements, Genetic; Female; Gene E	2020
Evaluation of the In Vitro Damage Caused by Lipid Factors on Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence. International journal of molecular sciences, 2020, Jul-17, Volume: 21, Issue:14 Topics: Animals; Apoptosis; Cells, Cultured; Cholesterol; Diabetes Mellitus, Type 2; Disease Models, Animal;	2020
DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis. Acta pharmacologica Sinica, 2021, Volume: 42, Issue:2 Topics: Animals; Apoptosis; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty	2021
The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes. Molecular and cellular endocrinology, 2020, 12-01, Volume: 518 Topics: Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ins	2020
JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes. Journal of physiology and biochemistry, 2020, Volume: 76, Issue:4 Topics: Animals; COP9 Signalosome Complex; Diabetes Mellitus, Type 2; Hep G2 Cells; Humans; Inflammation; In	2020
Histone methyltransferases G9a mediated lipid-induced M1 macrophage polarization through negatively regulating CD36. Metabolism: clinical and experimental, 2021, Volume: 114 Topics: Animals; CD36 Antigens; Cell Polarity; Diabetes Mellitus, Type 2; Flow Cytometry; Histone Methyltran	2021
Interleukin-33 alleviates diabetic cardiomyopathy through regulation of endoplasmic reticulum stress and autophagy via insulin-like growth factor-binding protein 3. Journal of cellular physiology, 2021, Volume: 236, Issue:6 Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Proteins; Cells, Cultured; Diab	2021
Liraglutide protects palmitate-induced INS-1 cell injury by enhancing autophagy mediated via FoxO1. Molecular medicine reports, 2021, Volume: 23, Issue:2 Topics: Animals; Autophagy; Cell Line, Tumor; Diabetes Mellitus, Type 2; Insulin-Secreting Cells; Liraglutid	2021
The role of uncoupling protein 2 in macrophages and its impact on obesity-induced adipose tissue inflammation and insulin resistance. The Journal of biological chemistry, 2020, 12-18, Volume: 295, Issue:51 Topics: Adipose Tissue; Animals; Carnitine O-Palmitoyltransferase; Diabetes Mellitus, Type 2; Diet, High-Fat	2020
A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy. CNS neuroscience & therapeutics, 2021, Volume: 27, Issue:4 Topics: Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Diabetes Mellitus, Type 2; Male; Mice; Mice	2021
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1. Biochemical and biophysical research communications, 2021, 03-26, Volume: 546 Topics: Animals; Apoptosis; Cell Line; Cells, Cultured; Culture Media, Conditioned; Diabetes Mellitus, Type	2021
Liraglutide regulates lipid metabolism via FGF21- LKB1- AMPK- ACC1 pathway in white adipose tissues and macrophage of type 2 diabetic mice. Biochemical and biophysical research communications, 2021, 04-09, Volume: 548 Topics: Acetyl-CoA Carboxylase; Adipocytes; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; B	2021
Binding between ROCK1 and DCTN2 triggers diabetes‑associated centrosome amplification in colon cancer cells. Oncology reports, 2021, Volume: 46, Issue:1 Topics: Cell Line, Tumor; Centrosome; Colonic Neoplasms; Diabetes Mellitus, Type 2; Dynactin Complex; Glucos	2021
Impaired Ca American journal of physiology. Cell physiology, 2021, 07-01, Volume: 321, Issue:1 Topics: Alstrom Syndrome; Animals; Blood Glucose; Calcium; Calcium Signaling; Diabetes Mellitus, Type 2; Dis	2021
Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression. Diabetes, 2021, Volume: 70, Issue:10 Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Diet, High-Fat; Down-Regulation; Gene Expressio	2021
HSF1 acetylation decreases its transcriptional activity and enhances glucolipotoxicity-induced apoptosis in rat and human beta cells. Diabetologia, 2017, Volume: 60, Issue:8 Topics: Acetylation; Animals; Apoptosis; Chromatin Immunoprecipitation; Diabetes Mellitus, Type 2; DNA-Bindi	2017
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy. Scientific reports, 2018, 01-08, Volume: 8, Issue:1 Topics: Alprostadil; Animals; Autophagy; Cell Survival; Diabetes Mellitus, Type 2; Diabetic Nephropathies; D	2018
BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells. Proceedings of the National Academy of Sciences of the United States of America, 2018, 03-20, Volume: 115, Issue:12 Topics: Adaptor Proteins, Signal Transducing; Amyloid; Animals; Animals, Genetically Modified; Apoptosis; Br	2018
Palmitate induces nitric oxide production and inflammatory cytokine expression in zebrafish. Fish & shellfish immunology, 2018, Volume: 79 Topics: Animals; Biomarkers; Cytokines; Diabetes Mellitus, Type 2; Disease Models, Animal; Embryo, Nonmammal	2018
Peroxidase expression is decreased by palmitate in cultured podocytes but increased in podocytes of advanced diabetic nephropathy. Journal of cellular physiology, 2018, Volume: 233, Issue:12 Topics: Antioxidants; Apoptosis; Catalase; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Nephropathie	2018
Palmitate-Induced Insulin Hypersecretion and Later Secretory Decline Associated with Changes in Protein Expression Patterns in Human Pancreatic Islets. Journal of proteome research, 2018, 11-02, Volume: 17, Issue:11 Topics: Adolescent; Autophagy; Calcium-Binding Proteins; Child; Chromatography, Liquid; Computational Biolog	2018
Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:2 Topics: Adult; Animals; Antigens, CD; Case-Control Studies; Cells, Cultured; Deferoxamine; Diabetes Mellitus	2019
Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression. Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:12 Topics: Acetylglucosamine; Acylation; Animals; Cell Line; Ceramides; Diabetes Mellitus, Type 2; Diabetic Ret	2018
Erythrocyte Saturated Fatty Acids and Incident Type 2 Diabetes in Chinese Men and Women: A Prospective Cohort Study. Nutrients, 2018, Oct-01, Volume: 10, Issue:10 Topics: Adult; Aged; China; Diabetes Mellitus, Type 2; Eicosanoic Acids; Erythrocytes; Fatty Acids; Female;	2018
Mitochondrial dysfunction and inhibition of myoblast differentiation in mice with high-fat-diet-induced pre-diabetes. Journal of cellular physiology, 2019, Volume: 234, Issue:5 Topics: Adenosine Triphosphate; Animals; Blood Glucose; Cell Differentiation; Diabetes Mellitus, Type 2; Die	2019
Shengmai San Alleviates Diabetic Cardiomyopathy Through Improvement of Mitochondrial Lipid Metabolic Disorder. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 50, Issue:5 Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Drug C	2018
SAD-A, a downstream mediator of GLP-1 signaling, promotes the phosphorylation of Bad S155 to regulate in vitro β-cell functions. Biochemical and biophysical research communications, 2019, 01-29, Volume: 509, Issue:1 Topics: Animals; Apoptosis; bcl-Associated Death Protein; Cell Line; Cells, Cultured; Diabetes Mellitus, Typ	2019
MIP-1α Induction by Palmitate in the Human Monocytic Cells Implicates TLR4 Signaling Mechanism. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2019, Volume: 52, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Diabetes Mellitus, Type 2; Humans; Macrophages; MAP Kinase Sig	2019
Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1/Parkin-dependent mitophagy. Cell death & disease, 2019, 06-11, Volume: 10, Issue:6 Topics: Animals; Carrier Proteins; Cell Line; Cell Survival; Diabetes Mellitus, Type 2; Inflammation; Insuli	2019
Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes. Cell death & disease, 2019, 07-22, Volume: 10, Issue:8 Topics: Adult; CD4-Positive T-Lymphocytes; Cytokines; Diabetes Mellitus, Type 2; Female; Humans; Inflammatio	2019
Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes. Clinical and experimental immunology, 2013, Volume: 172, Issue:3 Topics: Adult; alpha-Linolenic Acid; Case-Control Studies; Chemokines; Cytokines; Diabetes Mellitus, Type 1;	2013
Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells. The Journal of biological chemistry, 2013, Sep-13, Volume: 288, Issue:37 Topics: Animals; Apoptosis; Cell Line; Ceramides; Cholesterol; Diabetes Mellitus, Type 2; Endoplasmic Reticu	2013
Comparison of plasma and erythrocyte membrane fatty acid compositions in patients with end-stage renal disease and type 2 diabetes mellitus. Chemistry and physics of lipids, 2014, Volume: 178 Topics: Adult; Cell Membrane; Diabetes Mellitus, Type 2; Docosahexaenoic Acids; Erythrocyte Membrane; Fatty	2014
JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. PloS one, 2014, Volume: 9, Issue:1 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Caspase 9; Cell Line; Diabetes Mellitu	2014
Protection of palmitic acid-mediated lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12. Journal of biomedical science, 2014, Feb-12, Volume: 21 Topics: Animals; Apoptosis; Arachidonic Acid; Diabetes Mellitus, Type 2; Glucose; Humans; Insulin; Insulin-S	2014
Clustering effects on postprandial insulin secretion and sensitivity in response to meals with different fatty acid compositions. Food & function, 2014, Jul-25, Volume: 5, Issue:7 Topics: Adult; Blood Glucose; Body Mass Index; Cluster Analysis; Diabetes Mellitus, Type 2; Diet; Dietary Fa	2014
Increased pyruvate dehydrogenase kinase expression in cultured myotubes from obese and diabetic individuals. European journal of nutrition, 2015, Volume: 54, Issue:7 Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; Cells, Cultured; Cholesterol; Diabetes Mellitus,	2015
Deletion of apoptosis signal-regulating kinase 1 (ASK1) protects pancreatic beta-cells from stress-induced death but not from glucose homeostasis alterations under pro-inflammatory conditions. PloS one, 2014, Volume: 9, Issue:11 Topics: Animals; Cells, Cultured; Cytokines; Diabetes Mellitus, Type 2; Glucose; Humans; Inflammation; Insul	2014
Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. Proceedings of the National Academy of Sciences of the United States of America, 2015, Jan-27, Volume: 112, Issue:4 Topics: Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Insulin; Insulin Resistance; Liver; Palmitic	2015
Association of low GLP-1 with oxidative stress is related to cardiac disease and outcome in patients with type 2 diabetes mellitus: a pilot study. Free radical biology & medicine, 2015, Volume: 81 Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Animals; Antioxidants; Atrial Remodeling; Cardiomegaly; Cardiovas	2015
Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS. Journal of lipid research, 2015, Volume: 56, Issue:3 Topics: Animals; Biological Assay; Cell Line; Diabetes Mellitus, Type 2; Diglycerides; Drug Evaluation, Prec	2015
Possible Involvement of Palmitate in Pathogenesis of Periodontitis. Journal of cellular physiology, 2015, Volume: 230, Issue:12 Topics: Animals; CD36 Antigens; Cell Line, Tumor; Cytokines; Diabetes Mellitus, Type 2; Disease Models, Anim	2015
Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes. EBioMedicine, 2015, Volume: 2, Issue:5 Topics: Animals; Apoptosis; bcl-X Protein; Biomarkers; Cell Survival; Diabetes Mellitus, Type 2; Endoplasmic	2015
Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic β-Cells via Regulation of Endoplasmic Reticulum Stress. PloS one, 2015, Volume: 10, Issue:7 Topics: Animals; Apoptosis; Calcium Signaling; Cell Line, Tumor; Diabetes Mellitus, Type 2; Diazoxide; Endop	2015
Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World journal of gastroenterology, 2015, Jul-07, Volume: 21, Issue:25 Topics: Animals; Anticholesteremic Agents; Autophagy; Biomarkers; Blood Glucose; Cells, Cultured; Diabetes M	2015
Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes. Molecular medicine reports, 2015, Volume: 12, Issue:4 Topics: Adult; Biomarkers; Blood Glucose; Case-Control Studies; Chronic Disease; Cytokines; Diabetes Mellitu	2015
Palmitic acid increases pro-oxidant adaptor protein p66Shc expression and affects vascularization factors in angiogenic mononuclear cells: Action of resveratrol. Vascular pharmacology, 2015, Volume: 75 Topics: Antioxidants; Case-Control Studies; Cell Movement; Cells, Cultured; Diabetes Mellitus, Type 2; Gene	2015
Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:6 Topics: Adipose Tissue; Animals; Biomarkers; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Diet, High	2015
Hepatic scavenger receptor BI is associated with type 2 diabetes but unrelated to human and murine non-alcoholic fatty liver disease. Biochemical and biophysical research communications, 2015, Nov-13, Volume: 467, Issue:2 Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Animals; Chemokines; Cytokines; Diabetes Mellitus, Type	2015
Identification of Anti-Long Chain Saturated Fatty Acid IgG Antibodies in Serum of Patients with Type 2 Diabetes. Mediators of inflammation, 2015, Volume: 2015 Topics: Adult; Aged; Antibody Specificity; Dendritic Cells; Diabetes Mellitus, Type 2; Enzyme-Linked Immunos	2015
Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9). Cardiovascular diabetology, 2016, Feb-01, Volume: 15 Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Down-Regulati	2016
Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504. Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:5 Topics: Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Cell Movement; Cell Proliferation; Cells	2016
Trans-11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro. Molecular nutrition & food research, 2016, Volume: 60, Issue:4 Topics: Aged; Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet,	2016
A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals. Scientific reports, 2016, 06-27, Volume: 6 Topics: 8,11,14-Eicosatrienoic Acid; Adult; Arachidonic Acid; Area Under Curve; Body Mass Index; Cardiovascu	2016
SIRT6 protects against palmitate-induced pancreatic β-cell dysfunction and apoptosis. The Journal of endocrinology, 2016, Volume: 231, Issue:2 Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cellular Senescence; Diabetes Mellitus, Type 2; Fatty	2016
Thioredoxin interacting protein mediates lipid-induced impairment of glucose uptake in skeletal muscle. Biochemical and biophysical research communications, 2016, Oct-28, Volume: 479, Issue:4 Topics: AMP-Activated Protein Kinases; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors;	2016
Fatty acid synthesis configures the plasma membrane for inflammation in diabetes. Nature, 2016, 11-10, Volume: 539, Issue:7628 Topics: Adipose Tissue; Animals; Cell Adhesion; Cell Membrane; Cell Movement; Cholesterol; Diabetes Mellitus	2016
Suppression of Rho-kinase 1 is responsible for insulin regulation of the AMPK/SREBP-1c pathway in skeletal muscle cells exposed to palmitate. Acta diabetologica, 2017, Volume: 54, Issue:7 Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Insulin; Male; M	2017
Reduced tricarboxylic acid cycle flux in type 2 diabetes mellitus? Diabetologia, 2008, Volume: 51, Issue:9 Topics: Adult; Citric Acid Cycle; Diabetes Mellitus, Type 2; Humans; Kinetics; Middle Aged; Palmitic Acid; P	2008
Fatty acid metabolism in patients with PPARgamma mutations. The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:11 Topics: Adipose Tissue; Adult; Amino Acid Substitution; Diabetes Mellitus, Type 2; Fatty Acids; Fatty Acids,	2008
Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy. Cardiovascular research, 2009, Feb-15, Volume: 81, Issue:3 Topics: Acyl-CoA Dehydrogenase; Animals; CD36 Antigens; Diabetes Mellitus, Type 2; Dietary Fats; Disease Mod	2009
Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization. The Biochemical journal, 2009, Mar-01, Volume: 418, Issue:2 Topics: Cells, Cultured; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Gene Knockdown Techniques;	2009
Fatty acid incubation of myotubes from humans with type 2 diabetes leads to enhanced release of beta-oxidation products because of impaired fatty acid oxidation: effects of tetradecylthioacetic acid and eicosapentaenoic acid. Diabetes, 2009, Volume: 58, Issue:3 Topics: Carbon Dioxide; Carbon Radioisotopes; Carnitine O-Palmitoyltransferase; Diabetes Mellitus, Type 2; E	2009
Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells. American journal of physiology. Endocrinology and metabolism, 2009, Volume: 296, Issue:4 Topics: Animals; Calcium; Calcium Signaling; Cell Death; Cells, Cultured; Cytosol; Diabetes Mellitus, Type 2	2009
Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans. Diabetologia, 2009, Volume: 52, Issue:5 Topics: Adipocytes; Adipose Tissue; Biopsy; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Angiopathies;	2009
Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes. Diabetologia, 2009, Volume: 52, Issue:10 Topics: Cells, Cultured; Diabetes Mellitus, Type 2; Female; Gene Expression; Glucose; Humans; Interleukin-6;	2009
Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes. FEBS letters, 2009, Nov-19, Volume: 583, Issue:22 Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Aminoimidazole Carboxamide; Body Mass Index; Cells, Cul	2009
Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice. The Journal of endocrinology, 2010, Volume: 204, Issue:2 Topics: Aging; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Fatty Acids; Glucose Tolerance Test; Hyper	2010
Desaturation of excess intramyocellular triacylglycerol in obesity: implications for glycemic control. International journal of obesity (2005), 2010, Volume: 34, Issue:3 Topics: Analysis of Variance; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Diabetes Mellitus, Ty	2010
The fatty acid conjugated exendin-4 analogs for type 2 antidiabetic therapeutics. Journal of controlled release : official journal of the Controlled Release Society, 2010, May-21, Volume: 144, Issue:1 Topics: Animals; Antigens; Diabetes Mellitus; Diabetes Mellitus, Type 2; Exenatide; Fatty Acids; Glucagon-Li	2010
Palmitate-induced changes in protein expression of insulin secreting INS-1E cells. Journal of proteomics, 2010, Apr-18, Volume: 73, Issue:6 Topics: Diabetes Mellitus, Type 2; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Glycol	2010
Adipose tissue fatty acids and insulin sensitivity in elderly men. Diabetologia, 2010, Volume: 53, Issue:5 Topics: Adipose Tissue; Aged; Chromatography, Gas; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dieta	2010
A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell metabolism, 2010, Nov-03, Volume: 12, Issue:5 Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Diabetes Mellitus, Type 2; Female; Gene Deletion;	2010
Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6. American journal of physiology. Endocrinology and metabolism, 2011, Volume: 300, Issue:4 Topics: Acetyltransferases; Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes M	2011
Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance. Journal of lipid research, 2011, Volume: 52, Issue:6 Topics: Animals; Blood Proteins; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Si	2011
Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. Nature medicine, 2011, Aug-14, Volume: 17, Issue:9 Topics: Analysis of Variance; Animals; Blood Chemical Analysis; Blood Glucose; Cloning, Molecular; Diabetes	2011
Suppression of FoxO1/cell death-inducing DNA fragmentation factor α-like effector A (Cidea) axis protects mouse β-cells against palmitic acid-induced apoptosis. Molecular and cellular endocrinology, 2012, Jan-02, Volume: 348, Issue:1 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Diabetes Mellitus, Type 2; DNA Fragmen	2012
Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis. Immunology and cell biology, 2012, Volume: 90, Issue:7 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blood Glucose; Caspase 9; Cell Line, Tumor; Diabetes	2012
Protective effects of arachidonic acid against palmitic acid-mediated lipotoxicity in HIT-T15 cells. Molecular and cellular biochemistry, 2012, Volume: 364, Issue:1-2 Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Cell Survival; Cricetinae; Diabetes Mell	2012
Increased erythrocytes n-3 and n-6 polyunsaturated fatty acids is significantly associated with a lower prevalence of steatosis in patients with type 2 diabetes. Clinical nutrition (Edinburgh, Scotland), 2012, Volume: 31, Issue:4 Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dietary Fats; Dietary Supplements; Erythro	2012
Optimal elevation of β-cell 11β-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high-fat diet-induced β-cell failure. Diabetes, 2012, Volume: 61, Issue:3 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Cyclic AMP-Dependent Protein Kinases; Cyclin-D	2012
Pulmonary administered palmitic-acid modified exendin-4 peptide prolongs hypoglycemia in type 2 diabetic db/db mice. Regulatory peptides, 2012, Aug-20, Volume: 177, Issue:1-3 Topics: Administration, Inhalation; Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus,	2012
Distribution of fatty acids in adipose tissue of patients with type 2 diabetes. Clinical laboratory, 2012, Volume: 58, Issue:5-6 Topics: Blood Glucose; Case-Control Studies; Cholesterol; Cholesterol, HDL; Chromatography, Gas; Diabetes Me	2012
Macrophage migration inhibitory factor (MIF) enhances palmitic acid- and glucose-induced murine beta cell dysfunction and destruction in vitro. Growth factors (Chur, Switzerland), 2012, Volume: 30, Issue:6 Topics: Animals; Apoptosis; Caspase 3; Cell Line; Cytokines; Diabetes Mellitus, Type 2; DNA Fragmentation; G	2012
Increase of palmitic acid concentration impairs endothelial progenitor cell and bone marrow-derived progenitor cell bioavailability: role of the STAT5/PPARγ transcriptional complex. Diabetes, 2013, Volume: 62, Issue:4 Topics: Animals; Bone Marrow Cells; Cell Movement; Cell Proliferation; Cells, Cultured; Diabetes Mellitus, T	2013
Serotonin receptor 2C and insulin secretion. PloS one, 2013, Volume: 8, Issue:1 Topics: Aminopyridines; Animals; Blotting, Western; Cell Line, Tumor; Diabetes Mellitus, Type 2; Dose-Respon	2013
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu Circulation. Cardiovascular genetics, 2013, Volume: 6, Issue:2 Topics: Adult; Aged; Chromosomes, Human, Pair 2; Cohort Studies; Coronary Disease; Delta-5 Fatty Acid Desatu	2013
Thiazolidinediones upregulate impaired fatty acid uptake in skeletal muscle of type 2 diabetic subjects. American journal of physiology. Endocrinology and metabolism, 2003, Volume: 285, Issue:2 Topics: Adult; CD36 Antigens; Cells, Cultured; Chromans; Diabetes Mellitus, Type 2; Fatty Acids; Fatty Acids	2003
[Apoptosis-inducing effect of palmitic acids on rat pancreatic islet cells in primary culture: a preliminary study]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 2003, Volume: 23, Issue:5 Topics: Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; In	2003
Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:10 Topics: Aged; Biological Transport; Body Mass Index; Carrier Proteins; CD36 Antigens; Diabetes Mellitus, Typ	2004
The reduced insulin-mediated glucose oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin--evidence from cultured myotubes. Biochimica et biophysica acta, 2004, Sep-06, Volume: 1690, Issue:1 Topics: Cells, Cultured; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Glucose; Glycogen; Humans; I	2004
Differential utilization of saturated palmitate and unsaturated oleate: evidence from cultured myotubes. Diabetes, 2005, Volume: 54, Issue:3 Topics: Diabetes Mellitus, Type 2; Glucose; Humans; In Vitro Techniques; Insulin; Lipid Metabolism; Male; Mi	2005
Heterogeneity in limb fatty acid kinetics in type 2 diabetes. Diabetologia, 2005, Volume: 48, Issue:5 Topics: Arm; Biological Transport; Blood Flow Velocity; Body Composition; Body Mass Index; Diabetes Mellitus	2005
Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect. Biochimica et biophysica acta, 2005, Jun-30, Volume: 1741, Issue:1-2 Topics: 3-Hydroxyacyl CoA Dehydrogenases; Cells, Cultured; Citrate (si)-Synthase; Diabetes Mellitus, Type 2;	2005
Serum fatty acids in postinfarction middle-aged men. Scandinavian journal of clinical and laboratory investigation, 2005, Volume: 65, Issue:6 Topics: Aged; Body Mass Index; Cholesterol, HDL; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dietary	2005
Perfused hearts from Type 2 diabetic (db/db) mice show metabolic responsiveness to insulin. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:5 Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Glucos	2006
Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2006, Volume: 47, Issue:4 Topics: Acetic Acid; Animals; Blood Glucose; Carbon Radioisotopes; Coronary Circulation; Diabetes Mellitus,	2006
The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes. Diabetic medicine : a journal of the British Diabetic Association, 2006, Volume: 23, Issue:7 Topics: Blood Glucose; Cholesterol; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Estrogen Replacement	2006
Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. Diabetologia, 2006, Volume: 49, Issue:9 Topics: Adult; Blood Glucose; Carbon Isotopes; Case-Control Studies; Diabetes Mellitus, Type 2; Fatty Acids;	2006
Short-term activation of peroxysome proliferator-activated receptor beta/delta increases fatty acid oxidation but does not restore insulin action in muscle cells from type 2 diabetic patients. Journal of molecular medicine (Berlin, Germany), 2006, Volume: 84, Issue:9 Topics: Cells, Cultured; Diabetes Mellitus, Type 2; Female; Glycogen; Humans; Insulin; Male; Middle Aged; Mu	2006
Sustained endogenous glucose production, diminished lipolysis and non-esterified fatty acid appearance and oxidation in non-obese women at high risk of type 2 diabetes. European journal of endocrinology, 2006, Volume: 155, Issue:3 Topics: Adiposity; Adult; Body Weight; Catecholamines; Diabetes Mellitus, Type 2; Epinephrine; Fatty Acids,	2006
Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes. Biological chemistry, 2007, Volume: 388, Issue:2 Topics: Acylation; Animals; Binding Sites; Cyclic AMP; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypep	2007
Obesity increases free thyroxine proportionally to nonesterified fatty acid concentrations in adult neutered female cats. The Journal of endocrinology, 2007, Volume: 194, Issue:2 Topics: Animals; Cats; Diabetes Mellitus, Type 2; Disease Progression; Fatty Acids, Nonesterified; Female; I	2007
Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes. American journal of physiology. Endocrinology and metabolism, 2008, Volume: 294, Issue:2 Topics: Adolescent; Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fem	2008
Effects of ethanol on pancreatic beta-cell death: interaction with glucose and fatty acids. Cell biology and toxicology, 2009, Volume: 25, Issue:2 Topics: Animals; Apoptosis; Cell Line; Central Nervous System Depressants; Diabetes Mellitus, Type 2; Drug I	2009
Metabolism of endogenous nutrients in islets of Goto-Kakizaki (GK) rats. The Biochemical journal, 1993, Dec-01, Volume: 296 ( Pt 2) Topics: Ammonia; Animals; Blood Glucose; Carbon Dioxide; Carbon Radioisotopes; Diabetes Mellitus, Type 2; Gl	1993
Assessment of insulin action in NIDDM in the presence of dynamic changes in insulin and glucose concentration. Diabetes, 1994, Volume: 43, Issue:2 Topics: Blood Glucose; C-Peptide; Carbon Radioisotopes; Diabetes Mellitus, Type 2; Eating; Female; Forearm;	1994
Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM. Diabetes, 1997, Volume: 46, Issue:3 Topics: Acyl-CoA Oxidase; Animals; Brain; Cells, Cultured; Coenzyme A Ligases; Diabetes Mellitus; Diabetes M	1997
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proceedings of the National Academy of Sciences of the United States of America, 1998, Mar-03, Volume: 95, Issue:5 Topics: Animals; Apoptosis; Cells, Cultured; Ceramides; Chromans; Coenzyme A Ligases; Diabetes Mellitus; Dia	1998
Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake. European journal of biochemistry, 1999, Volume: 266, Issue:1 Topics: Animals; Biological Transport, Active; Cells, Cultured; Deoxyglucose; Diabetes Mellitus, Type 2; Dow	1999
Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity. Diabetes, 2000, Volume: 49, Issue:2 Topics: Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucokinase; Glucose; Human Growth Hormone; Huma	2000
The fate of [U-(13)C]palmitate extracted by skeletal muscle in subjects with type 2 diabetes and control subjects. Diabetes, 2002, Volume: 51, Issue:3 Topics: Adrenergic beta-Agonists; Arteries; Blood Flow Velocity; Carbon Dioxide; Carbon Isotopes; Diabetes M	2002
Increased ketogenesis related to insulin deficiency in isolated hepatocytes from NIDDM model rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1992, Volume: 24, Issue:6 Topics: Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; In Vitro Techniques; Insulin; Ketone	1992
Myocardial 11C-palmitate kinetics in patients with coronary heart disease. Effect of non-insulin dependent diabetes mellitus. Acta radiologica. Supplementum, 1991, Volume: 376 Topics: Carbon Radioisotopes; Coronary Disease; Diabetes Mellitus, Type 2; Humans; Myocardium; Palmitic Acid	1991
Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources. The American journal of physiology, 1991, Volume: 260, Issue:5 Pt 1 Topics: Blood Glucose; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Energy Metabolism; Fasting; Fa	1991