palmitic acid has been researched along with Chemical and Drug Induced Liver Injury in 12 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of amlexanox (50 μM) showed significantly reduced phosphorylation of TBK1 and IKKε and hepatotoxicity as confirmed by decreased levels of lactate dehydrogenase released from hepatocytes." | 1.56 | Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro. ( Kim, B; Kim, JW; Lim, CW; Qi, J; Zhou, Z, 2020) |
| " In wild type and CHOP(-/-) mice treated with EtOH and high fat diet (HFD), EtOH worsened the HFD-induced liver injury and dyslipidemia, while CHOP knockout blocked toxic effects of EtOH and PA." | 1.42 | Ethanol promotes saturated fatty acid-induced hepatoxicity through endoplasmic reticulum (ER) stress response. ( Cao, W; Lu, J; Ma, YX; Wang, CF; Wang, XN; Wu, XD; Yi, HW, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, Z | 2 |
| Qi, J | 1 |
| Lim, CW | 1 |
| Kim, JW | 1 |
| Kim, B | 1 |
| Walker, RE | 1 |
| Savinova, OV | 1 |
| Pedersen, TL | 1 |
| Newman, JW | 1 |
| Shearer, GC | 1 |
| Ding, Q | 1 |
| Zhang, Z | 1 |
| Ran, C | 1 |
| He, S | 1 |
| Yang, Y | 1 |
| Du, Z | 1 |
| Zhang, J | 2 |
| Park, KH | 1 |
| Ye, ZW | 1 |
| Kim, SH | 1 |
| Yi, HW | 1 |
| Ma, YX | 1 |
| Wang, XN | 1 |
| Wang, CF | 1 |
| Lu, J | 1 |
| Cao, W | 1 |
| Wu, XD | 1 |
| Mao, Y | 1 |
| Wang, J | 1 |
| Yu, F | 1 |
| Li, Z | 1 |
| Li, H | 1 |
| Guo, C | 1 |
| Fan, X | 1 |
| Gentile, CL | 1 |
| Nivala, AM | 1 |
| Gonzales, JC | 1 |
| Pfaffenbach, KT | 1 |
| Wang, D | 1 |
| Wei, Y | 1 |
| Jiang, H | 1 |
| Orlicky, DJ | 1 |
| Petersen, DR | 1 |
| Pagliassotti, MJ | 1 |
| Maclean, KN | 1 |
| Krause, RF | 1 |
| SCHOTZ, MC | 1 |
| BAKER, N | 1 |
| CHAVEZ, MN | 1 |
| Chanda, S | 2 |
| Mehendale, M | 1 |
| Mehendale, HM | 1 |
| Le Dinh, T | 1 |
| Freneaux, E | 1 |
| Labbe, G | 1 |
| Letteron, P | 1 |
| Degott, C | 1 |
| Geneve, J | 1 |
| Berson, A | 1 |
| Larrey, D | 1 |
| Pessayre, D | 1 |
12 other studies available for palmitic acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro.
Topics: Aminopyridines; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cocultu | 2020 |
Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low-density lipoproteins in isolated perfused rat livers.
Topics: Adamantane; Animals; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Epoxide Hydrolases; | 2021 |
The Hepatotoxicity of Palmitic Acid in Zebrafish Involves the Intestinal Microbiota.
Topics: Animal Feed; Animals; Caspase 12; Chemical and Drug Induced Liver Injury; Dietary Fats; Endoplasmic | 2018 |
Palmitic Acid-Enriched Diet Induces Hepatic Steatosis and Injury in Adult Zebrafish.
Topics: Animal Feed; Animals; Chemical and Drug Induced Liver Injury; Diet; Endoplasmic Reticulum Stress; Fa | 2019 |
Ethanol promotes saturated fatty acid-induced hepatoxicity through endoplasmic reticulum (ER) stress response.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Caspase 3; Chemical and Drug Induced Liver In | 2015 |
Ghrelin protects against palmitic acid or lipopolysaccharide-induced hepatocyte apoptosis through inhibition of MAPKs/iNOS and restoration of Akt/eNOS pathways.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Cell Proliferation; Chemical and Drug Induced L | 2016 |
Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease.
Topics: Animals; Cell Death; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Diet; Endoplasmic Ret | 2011 |
LIVER LIPIDS IN A CASE OF HYPERVITAMINOSIS A.
Topics: Chemical and Drug Induced Liver Injury; Cholesterol; Chromatography; Fatty Acids; Fatty Acids, Essen | 1965 |
PLASMA FREE FATTY ACID TURNOVER IN CARBON TETRACHLORIDE-TREATED RATS.
Topics: Blood Volume; Body Weight; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug I | 1965 |
Role of nutritional fatty acid and L-carnitine in the final outcome of thioacetamide hepatotoxicity.
Topics: Analysis of Variance; Animals; Carnitine; Cell Division; Chemical and Drug Induced Liver Injury; Die | 1994 |
Role of nutrition in the survival after hepatotoxic injury.
Topics: Administration, Oral; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Diet; Drinking; Gl | 1996 |
Amineptine, a tricyclic antidepressant, inhibits the mitochondrial oxidation of fatty acids and produces microvesicular steatosis of the liver in mice.
Topics: Acetyl Coenzyme A; Animals; Antidepressive Agents, Tricyclic; Breath Tests; Chemical and Drug Induce | 1988 |