palmitic acid has been researched along with Cell Transformation, Neoplastic in 14 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "While the role of ras in malignancy is unclear, it is well-established that the association of ras protein with the inner surface of the plasma membrane is critical for triggering ras oncogenicity." | 2.38 | The ras/cholesterol connection: implications for ras oncogenicity. ( Cox, AD; Der, CJ, 1992) |
| "Obesity is a known risk factor for the development of gastroesophageal reflux disease (GERD), Barrett's Esophagus (BE) and the progression to esophageal adenocarcinoma." | 1.72 | Augmented CPT1A Expression Is Associated with Proliferation and Colony Formation during Barrett's Tumorigenesis. ( Altomare, DA; Andl, CD; Andl, T; Bernard, JN; Chinnaiyan, V; Le Bras, GF; Qureshi, MN, 2022) |
| "Furthermore, hematologic malignancies arising in NrasG12D/G12D,C181S compound heterozygous mice invariably acquired revertant mutations that restored cysteine 181." | 1.56 | Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. ( Cravatt, BF; Firestone, AJ; Haigis, KM; Huang, BJ; Inguva, A; Kogan, SC; Long, AM; Predovic, M; Remsberg, JR; Shannon, K; Suciu, RM; Wong, JC; Zambetti, NA, 2020) |
| "Fourteen breast cancer patients with a mean age of 61 years were recruited." | 1.39 | Carcinogenesis alters fatty acid profile in breast tissue. ( Azordegan, N; Fischer, G; Fraser, V; Hillyer, LM; Le, K; Ma, DW; Moghadasian, MH, 2013) |
| "No myristic acid was detected in fatty acids released from in vivo-labeled p21v-H-ras." | 1.27 | Direct identification of palmitic acid as the lipid attached to p21ras. ( Buss, JE; Sefton, BM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Bernard, JN | 1 |
| Chinnaiyan, V | 1 |
| Andl, T | 1 |
| Le Bras, GF | 1 |
| Qureshi, MN | 1 |
| Altomare, DA | 1 |
| Andl, CD | 1 |
| Zambetti, NA | 1 |
| Firestone, AJ | 1 |
| Remsberg, JR | 1 |
| Huang, BJ | 1 |
| Wong, JC | 1 |
| Long, AM | 1 |
| Predovic, M | 1 |
| Suciu, RM | 1 |
| Inguva, A | 1 |
| Kogan, SC | 1 |
| Haigis, KM | 1 |
| Cravatt, BF | 1 |
| Shannon, K | 1 |
| Cuiffo, B | 1 |
| Ren, R | 1 |
| Azordegan, N | 1 |
| Fraser, V | 1 |
| Le, K | 1 |
| Hillyer, LM | 1 |
| Ma, DW | 1 |
| Fischer, G | 1 |
| Moghadasian, MH | 1 |
| Chenette, EJ | 1 |
| Abo, A | 1 |
| Der, CJ | 2 |
| Meder, D | 1 |
| Simons, K | 1 |
| Sefton, BM | 3 |
| Trowbridge, IS | 1 |
| Cooper, JA | 1 |
| Scolnick, EM | 1 |
| Ponimaskin, E | 1 |
| Behn, H | 1 |
| Adarichev, V | 1 |
| Voyno-Yasenetskaya, TA | 1 |
| Offermanns, S | 1 |
| Schmidt, MF | 1 |
| Collett, ED | 1 |
| Davidson, LA | 1 |
| Fan, YY | 1 |
| Lupton, JR | 1 |
| Chapkin, RS | 1 |
| Cox, AD | 1 |
| Kanner, SB | 1 |
| Reynolds, AB | 1 |
| Parsons, JT | 1 |
| Buss, JE | 2 |
| Magee, AI | 1 |
| Courtneidge, SA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomised Controlled Trial of the Effects of Fish Oil Emulsion in Total Parenteral Nutrition Upon Tumour Vascularity in Patients With Hepatic Colorectal Metastases[NCT00942292] | Phase 2 | 20 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for palmitic acid and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
The ras/cholesterol connection: implications for ras oncogenicity.
Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cholesterol; Dimethylallyltranstransf | 1992 |
13 other studies available for palmitic acid and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Augmented CPT1A Expression Is Associated with Proliferation and Colony Formation during Barrett's Tumorigenesis.
Topics: Adenocarcinoma; Animals; Barrett Esophagus; Carcinogenesis; Carnitine; Carnitine O-Palmitoyltransfer | 2022 |
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Cell Transformation, Neoplastic; Cells, Cultured; G | 2020 |
Palmitoylation of oncogenic NRAS is essential for leukemogenesis.
Topics: Animals; Cell Membrane; Cell Transformation, Neoplastic; Disease Models, Animal; Farnesyltranstransf | 2010 |
Carcinogenesis alters fatty acid profile in breast tissue.
Topics: Arachidonic Acid; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Transformation, Neoplast | 2013 |
Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase.
Topics: Amino Acid Sequence; Animals; cdc42 GTP-Binding Protein; Cell Transformation, Neoplastic; GTP-Bindin | 2005 |
Cell biology. Ras on the roundabout.
Topics: Acylation; Animals; Cell Differentiation; Cell Membrane; Cell Proliferation; Cell Transformation, Ne | 2005 |
The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid.
Topics: Abelson murine leukemia virus; Animals; Avian Sarcoma Viruses; Carcinoma, Squamous Cell; Cell Line; | 1982 |
Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.
Topics: Actins; Acylation; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Cell Line; | 2000 |
n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes.
Topics: Alkyl and Aryl Transferases; Animals; Cell Division; Cell Line, Transformed; Cell Membrane; Cell Sur | 2001 |
Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells.
Topics: Animals; Antigens, Polyomavirus Transforming; Cell Line; Cell Transformation, Neoplastic; Chick Embr | 1991 |
Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Chro | 1985 |
Two classes of fatty acid acylated proteins exist in eukaryotic cells.
Topics: Acylation; Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cattle; Cell Transf | 1985 |
Direct identification of palmitic acid as the lipid attached to p21ras.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cysteine; Harvey murine sarcoma virus; Mi | 1986 |