Page last updated: 2024-10-19

palmitic acid and Cardiovascular Diseases

palmitic acid has been researched along with Cardiovascular Diseases in 21 studies

Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to determine the relative comparability of diets enriched in palmitic acid, stearic acid, and oleic acid on inflammation and coagulation markers, T lymphocyte proliferation/ex-vivo cytokine secretion, plasma cardiometabolic risk factors, and fecal bile acid concentrations."9.30Comparison of diets enriched in stearic, oleic, and palmitic acids on inflammation, immune response, cardiometabolic risk factors, and fecal bile acid concentrations in mildly hypercholesterolemic postmenopausal women-randomized crossover trial. ( Cohen, R; Dolnikowski, GG; Galluccio, JM; Li, L; Lichtenstein, AH; Matthan, NR; Meng, H; Rodríguez-Morató, J; Wu, D, 2019)
"The aim of this study was to determine the relative comparability of diets enriched in palmitic acid, stearic acid, and oleic acid on inflammation and coagulation markers, T lymphocyte proliferation/ex-vivo cytokine secretion, plasma cardiometabolic risk factors, and fecal bile acid concentrations."5.30Comparison of diets enriched in stearic, oleic, and palmitic acids on inflammation, immune response, cardiometabolic risk factors, and fecal bile acid concentrations in mildly hypercholesterolemic postmenopausal women-randomized crossover trial. ( Cohen, R; Dolnikowski, GG; Galluccio, JM; Li, L; Lichtenstein, AH; Matthan, NR; Meng, H; Rodríguez-Morató, J; Wu, D, 2019)
" Few studies have investigated the effects of palm oil per se, and the main reason why it has been associated with negative health effects is the relatively high content of saturated fatty acids (SFAs), particularly palmitic acid, which in turn have been associated with increased risk of coronary heart disease and some tumours."4.89Palm oil and palmitic acid: a review on cardiovascular effects and carcinogenicity. ( Fanelli, R; Fattore, E, 2013)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (19.05)29.6817
2010's15 (71.43)24.3611
2020's2 (9.52)2.80

Authors

AuthorsStudies
Gonçalinho, GHF1
Sampaio, GR1
Soares-Freitas, RAM1
Damasceno, NRT1
Lai, HTM1
de Oliveira Otto, MC1
Lee, Y1
Wu, JHY1
Song, X1
King, IB1
Psaty, BM1
Lemaitre, RN1
McKnight, B1
Siscovick, DS1
Mozaffarian, D1
Lee, DM1
Sevits, KJ1
Battson, ML1
Wei, Y1
Cox-York, KA1
Gentile, CL1
van Rooijen, MA1
Mensink, RP1
Fatima, S1
Hu, X1
Gong, RH1
Huang, C1
Chen, M1
Wong, HLX1
Bian, Z1
Kwan, HY1
Meng, H1
Matthan, NR1
Wu, D1
Li, L1
Rodríguez-Morató, J1
Cohen, R1
Galluccio, JM1
Dolnikowski, GG1
Lichtenstein, AH1
Fattore, E1
Fanelli, R1
Kien, CL1
Bunn, JY1
Stevens, R1
Bain, J1
Ikayeva, O1
Crain, K1
Koves, TR1
Muoio, DM1
Wang, J3
Chen, L2
Li, H1
Yang, J1
Gong, Z1
Wang, B1
Zhao, X1
Agostoni, C1
Moreno, L1
Shamir, R1
Bier, DM1
Mancini, A1
Imperlini, E1
Nigro, E1
Montagnese, C1
Daniele, A1
Orrù, S1
Buono, P1
Li, W1
Fang, Q1
Zhong, P1
Wang, L1
Zhang, Y1
Li, X1
Wang, Y1
Liang, G1
Zhao, L1
Ni, Y1
Ma, X1
Zhao, A1
Bao, Y1
Liu, J1
Chen, T1
Xie, G1
Panee, J1
Su, M1
Yu, H1
Wang, C1
Hu, C1
Jia, W2
Sepulveda, JL1
Tanhehco, YC1
Frey, M1
Guo, L1
Cropcho, LJ1
Gibson, KM1
Blair, HC1
Cocchi, M1
Tonello, L1
Karupaiah, T1
Tan, CH1
Chinna, K1
Sundram, K1
Ghosh, S1
An, D1
Pulinilkunnil, T1
Qi, D1
Lau, HC1
Abrahani, A1
Innis, SM1
Rodrigues, B1
Yao, D1
Shi, W1
Gou, Y1
Zhou, X1
Yee Aw, T1
Zhou, Y1
Liu, Z1
Pacheco, YM1
Bermúdez, B1
López, S1
Abia, R1
Villar, J1
Muriana, FJ1
Braam, B1
Verhaar, MC1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Dietary Fatty Acids on Cardiovascular Disease Risk Indicators and Inflammation.[NCT02145936]20 participants (Anticipated)Interventional2013-01-31Completed
Palmitate Metabolism and Insulin Resistance[NCT01612234]70 participants (Actual)Interventional2010-04-30Completed
Comparison of the Effect of Medium-Chain Fatty Acids and Long-Chain Fatty Acids on Postprandial Appetite and Lipemia[NCT05539742]26 participants (Actual)Interventional2022-06-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for palmitic acid and Cardiovascular Diseases

ArticleYear
Palmitic Acid Versus Stearic Acid: Effects of Interesterification and Intakes on Cardiometabolic Risk Markers - A Systematic Review.
    Nutrients, 2020, Feb-26, Volume: 12, Issue:3

    Topics: Biomarkers; Cardiovascular Diseases; Esterification; Humans; Metabolic Syndrome; Palmitic Acid; Risk

2020
Palmitic acid is an intracellular signaling molecule involved in disease development.
    Cellular and molecular life sciences : CMLS, 2019, Volume: 76, Issue:13

    Topics: Animals; Autophagy; Cardiovascular Diseases; Humans; Inflammation; Metabolic Syndrome; Neoplasms; Ne

2019
Palm oil and palmitic acid: a review on cardiovascular effects and carcinogenicity.
    International journal of food sciences and nutrition, 2013, Volume: 64, Issue:5

    Topics: Cardiovascular Diseases; Coronary Disease; Dietary Fats; Humans; Hypercholesterolemia; Neoplasms; Pa

2013
Saturated Fats and Cardiovascular Disease: Interpretations Not as Simple as They Once Were.
    Critical reviews in food science and nutrition, 2016, Sep-09, Volume: 56, Issue:12

    Topics: Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Diet; Dietary Fats; Fatty Acids; Humans

2016
Biological and Nutritional Properties of Palm Oil and Palmitic Acid: Effects on Health.
    Molecules (Basel, Switzerland), 2015, Sep-18, Volume: 20, Issue:9

    Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dietary Fats; Humans; Mice; Neoplasms;

2015
Understanding eNOS for pharmacological modulation of endothelial function: a translational view.
    Current pharmaceutical design, 2007, Volume: 13, Issue:17

    Topics: Animals; Atherosclerosis; Cardiovascular Agents; Cardiovascular Diseases; Endothelium, Vascular; Gen

2007

Trials

4 trials available for palmitic acid and Cardiovascular Diseases

ArticleYear
Comparison of diets enriched in stearic, oleic, and palmitic acids on inflammation, immune response, cardiometabolic risk factors, and fecal bile acid concentrations in mildly hypercholesterolemic postmenopausal women-randomized crossover trial.
    The American journal of clinical nutrition, 2019, 08-01, Volume: 110, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Bile Acids and Salts; Cardiovascular Diseases; Cross-Over Studies; F

2019
Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.
    The American journal of clinical nutrition, 2014, Volume: 99, Issue:3

    Topics: Adolescent; Adult; Cardiovascular Diseases; Carnitine; Cohort Studies; Cross-Over Studies; Dietary F

2014
The chain length of dietary saturated fatty acids affects human postprandial lipemia.
    Journal of the American College of Nutrition, 2011, Volume: 30, Issue:6

    Topics: Adult; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Coconut Oil; Corn Oil; Cross-Ove

2011
Ratio of oleic to palmitic acid is a dietary determinant of thrombogenic and fibrinolytic factors during the postprandial state in men.
    The American journal of clinical nutrition, 2006, Volume: 84, Issue:2

    Topics: Adult; Area Under Curve; Cardiovascular Diseases; Cross-Over Studies; Dietary Fats; Dietary Fats, Un

2006

Other Studies

11 other studies available for palmitic acid and Cardiovascular Diseases

ArticleYear
Stearic Acid, but not Palmitic Acid, is Associated with Inflammatory and Endothelial Dysfunction Biomarkers in Individuals at Cardiovascular Risk.
    Arquivos brasileiros de cardiologia, 2023, Volume: 120, Issue:8

    Topics: Adult; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Cross-Sectional Studies; Female; Hea

2023
Serial Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway and Total Mortality, Cause-Specific Mortality, and Cardiovascular Diseases in the Cardiovascular Health Study.
    Journal of the American Heart Association, 2019, 11-19, Volume: 8, Issue:22

    Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Cause of Death; Cohort Studies; Fatty Acids; Fatty

2019
Monounsaturated fatty acids protect against palmitate-induced lipoapoptosis in human umbilical vein endothelial cells.
    PloS one, 2019, Volume: 14, Issue:12

    Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Apoptosis; Cardiovascular Diseases; Cell Survival; Die

2019
Clopidogrel reduces apoptosis and promotes proliferation of human vascular endothelial cells induced by palmitic acid via suppression of the long non-coding RNA HIF1A-AS1 in vitro.
    Molecular and cellular biochemistry, 2015, Volume: 404, Issue:1-2

    Topics: Apoptosis; Cardiovascular Diseases; Cell Proliferation; China; Clopidogrel; Human Umbilical Vein End

2015
Palmitic Acid and Health: Introduction.
    Critical reviews in food science and nutrition, 2016, Sep-09, Volume: 56, Issue:12

    Topics: Cardiovascular Diseases; Cholesterol; Cholesterol, HDL; Dietary Fats; Health Promotion; Humans; Milk

2016
EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice.
    Scientific reports, 2016, Apr-18, Volume: 6

    Topics: Animals; Apolipoproteins E; Apoptosis; Cardiovascular Diseases; Cell Line; Diet, High-Fat; ErbB Rece

2016
A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals.
    Scientific reports, 2016, 06-27, Volume: 6

    Topics: 8,11,14-Eicosatrienoic Acid; Adult; Arachidonic Acid; Area Under Curve; Body Mass Index; Cardiovascu

2016
Variation in human erythrocyte membrane unsaturated Fatty acids: correlation with cardiovascular disease.
    Archives of pathology & laboratory medicine, 2010, Volume: 134, Issue:1

    Topics: Adult; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cholesterol, LDL; Erythrocyte Memb

2010
Bio molecular considerations in major depression and ischemic cardiovascular disease.
    Central nervous system agents in medicinal chemistry, 2010, Jun-01, Volume: 10, Issue:2

    Topics: Adult; Aged; Arachidonic Acid; Blood Platelets; Cardiovascular Diseases; Depressive Disorder, Major;

2010
Role of dietary fatty acids and acute hyperglycemia in modulating cardiac cell death.
    Nutrition (Burbank, Los Angeles County, Calif.), 2004, Volume: 20, Issue:10

    Topics: Animals; Apoptosis; Cardiovascular Diseases; Diabetes Mellitus, Experimental; Dietary Fats, Unsatura

2004
Fatty acid-mediated intracellular iron translocation: a synergistic mechanism of oxidative injury.
    Free radical biology & medicine, 2005, Nov-15, Volume: 39, Issue:10

    Topics: Animals; Antioxidants; Apoptosis; Biological Transport; Cardiovascular Diseases; Cell Death; Cell Su

2005