palmitic acid has been researched along with Cardiomegaly in 24 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We observed that palmitic acid treatment in cardiac-derived H9c2 cells induced a significant increase in reactive oxygen species, inflammation, apoptosis, fibrosis and hypertrophy." | 3.83 | Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity. ( Chen, G; Chen, X; Li, X; Liang, G; Lu, K; Peng, K; Qian, Y; Xu, Z; Zhang, Y; Zhong, P, 2016) |
| "Although mutations in the gamma-subunit of AMP-activated protein kinase (AMPK) can result in excessive glycogen accumulation and cardiac hypertrophy, the mechanisms by which this occurs have not been well defined." | 3.74 | The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes. ( Allard, MF; Dyck, JR; Folmes, KD; Witters, LA; Young, ME, 2007) |
| "Palmitic acid did not activate AMPKα but increased expression of the FA translocase CD36 (FAT/CD36) to 163 ± 23% and adipose-differentiation-related-protein (ADRP), a sensitive marker of lipid accumulation, to 168 ± 42%." | 1.46 | AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes. ( Adrian, L; Böhm, M; Heeren, J; Laufs, U; Lenski, M; Tödter, K, 2017) |
| "Metabolic changes in cardiac hypertrophy include suppression of fatty acid oxidation and enhancement of glucose utilization, which could result in lipid accumulation in the heart." | 1.42 | Mouse SIRT3 attenuates hypertrophy-related lipid accumulation in the heart through the deacetylation of LCAD. ( Bu, P; Chen, T; Li, J; Li, N; Liu, H; Liu, J; Wang, S; Zhang, Y, 2015) |
| " Long-term administration of propionyl-L-carnitine normalized the degree of reduction of mitochondrial pyridine nucleotides and improved the kinetics of mitochondrial ATP production in volume-overloaded hearts." | 1.30 | Control of oxidative metabolism in volume-overloaded rat hearts: effect of propionyl-L-carnitine. ( El Alaoui-Talibi, Z; Guendouz, A; Moravec, J; Moravec, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 11 (45.83) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, P | 3 |
| Wu, H | 3 |
| Gu, Y | 3 |
| Li, L | 3 |
| Hu, R | 3 |
| Ma, W | 3 |
| Bian, Z | 3 |
| Liu, N | 3 |
| Yang, D | 3 |
| Chen, X | 4 |
| Adrian, L | 1 |
| Lenski, M | 1 |
| Tödter, K | 1 |
| Heeren, J | 1 |
| Böhm, M | 1 |
| Laufs, U | 1 |
| Ceylan-Isik, AF | 1 |
| Kandadi, MR | 1 |
| Xu, X | 2 |
| Hua, Y | 2 |
| Chicco, AJ | 1 |
| Ren, J | 2 |
| Nair, S | 2 |
| Liang, L | 1 |
| Shou, XL | 1 |
| Zhao, HK | 1 |
| Ren, GQ | 1 |
| Wang, JB | 1 |
| Wang, XH | 1 |
| Ai, WT | 1 |
| Maris, JR | 1 |
| Hueckstaedt, LK | 1 |
| Ma, AQ | 1 |
| Zhang, Y | 4 |
| Ravassa, S | 1 |
| Beaumont, J | 1 |
| Huerta, A | 1 |
| Barba, J | 1 |
| Coma-Canella, I | 1 |
| González, A | 1 |
| López, B | 1 |
| Díez, J | 1 |
| Chen, T | 1 |
| Liu, J | 2 |
| Li, N | 1 |
| Wang, S | 2 |
| Liu, H | 1 |
| Li, J | 1 |
| Bu, P | 1 |
| Qian, Y | 1 |
| Zhong, P | 1 |
| Peng, K | 1 |
| Xu, Z | 1 |
| Lu, K | 1 |
| Chen, G | 1 |
| Li, X | 1 |
| Liang, G | 1 |
| Luo, M | 1 |
| Zhang, Z | 1 |
| Gu, J | 1 |
| Chen, J | 1 |
| Payne, KM | 1 |
| Tan, Y | 1 |
| Wang, Y | 1 |
| Yin, X | 1 |
| Zhang, X | 1 |
| Liu, GC | 1 |
| Wintergerst, K | 1 |
| Liu, Q | 1 |
| Zheng, Y | 1 |
| Cai, L | 1 |
| O'Donnell, JM | 3 |
| Fields, A | 1 |
| Chowdhury, SA | 1 |
| Geenen, DL | 1 |
| Bi, J | 1 |
| Wang, P | 1 |
| Li, Y | 1 |
| Wu, S | 1 |
| Luo, J | 1 |
| Yang, H | 1 |
| Subbiah, R | 1 |
| Chatham, J | 1 |
| Zhelyabovska, O | 1 |
| Yang, Q | 1 |
| Riquelme, CA | 1 |
| Magida, JA | 1 |
| Harrison, BC | 1 |
| Wall, CE | 1 |
| Marr, TG | 1 |
| Secor, SM | 1 |
| Leinwand, LA | 1 |
| Lewandowski, ED | 2 |
| Fischer, SK | 1 |
| Fasano, M | 1 |
| Banke, NH | 1 |
| Walker, LA | 1 |
| Huqi, A | 1 |
| Wang, X | 1 |
| Lopaschuk, GD | 2 |
| Dolence, J | 1 |
| Shi, GP | 1 |
| Sorokina, N | 1 |
| McKinney, RD | 1 |
| Pound, KM | 1 |
| Woldegiorgis, G | 1 |
| LaNoue, KF | 1 |
| Ballal, K | 1 |
| Taegtmeyer, H | 1 |
| Buttrick, PM | 1 |
| Folmes, KD | 1 |
| Witters, LA | 1 |
| Allard, MF | 2 |
| Young, ME | 1 |
| Dyck, JR | 1 |
| Lesniak, W | 1 |
| Schaefer, C | 1 |
| Grueninger, S | 1 |
| Chiesi, M | 1 |
| Schönekess, BO | 1 |
| Henning, SL | 1 |
| English, DR | 1 |
| Ben Cheikh, R | 1 |
| Guendouz, A | 2 |
| Moravec, J | 3 |
| El Alaoui-Talibi, Z | 2 |
| Moravec, M | 1 |
| Van Der Lee, KA | 1 |
| Willemsen, PH | 1 |
| Van Der Vusse, GJ | 1 |
| Van Bilsen, M | 1 |
| Barger, PM | 1 |
| Brandt, JM | 1 |
| Leone, TC | 1 |
| Weinheimer, CJ | 1 |
| Kelly, DP | 1 |
| Zahabi, A | 1 |
| Deschepper, CF | 1 |
| Landormy, S | 1 |
| Loireau, A | 1 |
| Whitmer, JT | 1 |
24 other studies available for palmitic acid and Cardiomegaly
| Article | Year |
|---|---|
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiomegaly; Cell Li | 2017 |
Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction.
Topics: Adipokines; Animals; Apelin; Autophagy; Body Weight; Cardiomegaly; Cells, Cultured; Diet, High-Fat; | 2013 |
Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKKβ-AMPK-dependent regulation of autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Autophagy; Calcium; Cardiomegaly; Catalase; Di | 2015 |
Association of low GLP-1 with oxidative stress is related to cardiac disease and outcome in patients with type 2 diabetes mellitus: a pilot study.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Animals; Antioxidants; Atrial Remodeling; Cardiomegaly; Cardiovas | 2015 |
Mouse SIRT3 attenuates hypertrophy-related lipid accumulation in the heart through the deacetylation of LCAD.
Topics: Acetylation; Acyl-CoA Dehydrogenase, Long-Chain; Animals; Cardiomegaly; Down-Regulation; Lipid Metab | 2015 |
Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity.
Topics: Animals; Apoptosis; Blood Glucose; Cardiomegaly; Cell Line; Diet, High-Fat; Fibrosis; Heart Injuries | 2016 |
Zinc deficiency exacerbates while zinc supplement attenuates cardiac hypertrophy in high-fat diet-induced obese mice through modulating p38 MAPK-dependent signaling.
Topics: Animals; Cardiomegaly; Cells, Cultured; Chelating Agents; Deficiency Diseases; Diet, High-Fat; Dieta | 2016 |
Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo.
Topics: Adenosine Triphosphate; Adenoviridae; Adrenergic beta-Agonists; Animals; Calcium-Binding Proteins; C | 2008 |
Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart.
Topics: Aging; Animals; Antioxidants; Cardiomegaly; Cells, Cultured; DNA, Mitochondrial; Energy Metabolism; | 2010 |
Fatty acids identified in the Burmese python promote beneficial cardiac growth.
Topics: Animals; Animals, Newborn; Biological Transport; Boidae; Cardiomegaly; Cell Size; Fasting; Fatty Aci | 2011 |
Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy.
Topics: Acetyl-CoA Carboxylase; Animals; Atrial Natriuretic Factor; Carboxy-Lyases; Cardiomegaly; Carnitine | 2013 |
Cathepsin K knockout mitigates high-fat diet-induced cardiac hypertrophy and contractile dysfunction.
Topics: Animals; Apoptosis; Calcium; Cardiomegaly; Cathepsin K; Cell Line; Cytochromes c; Cytoplasm; Diet, H | 2013 |
Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts.
Topics: Animals; Cardiomegaly; Carnitine O-Palmitoyltransferase; Citric Acid Cycle; Energy Metabolism; Gluco | 2007 |
The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes.
Topics: Active Transport, Cell Nucleus; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Cardiomega | 2007 |
Effect of alpha adrenergic stimulation and carnitine palmitoyl transferase I inhibition on hypertrophying adult rat cardiomyocytes in culture.
Topics: Animals; Atrial Natriuretic Factor; Base Sequence; Cardiomegaly; Cell Division; Cells, Cultured; DNA | 1995 |
Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts.
Topics: Adenosine Triphosphate; Animals; Body Weight; Cardiomegaly; Energy Metabolism; Glucose; Glycolysis; | 1994 |
Control of oxidative metabolism in volume-overloaded rat hearts: effects of different lipid substrates.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Caprylates; Cardiomegaly; Creatine; Energy M | 1994 |
Control of oxidative metabolism in volume-overloaded rat hearts: effect of propionyl-L-carnitine.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Pressure; Body Weight; Cardiomegaly; C | 1997 |
Effects of fatty acids on uncoupling protein-2 expression in the rat heart.
Topics: Aging; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Diabetes Mellitus, Experimental; Em | 2000 |
Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Cardiomegaly; Carnitine O-Palmitoyltransferase; Cell | 2000 |
Long-chain fatty acids modify hypertrophic responses of cultured primary neonatal cardiomyocytes.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cell Size; Cells, Cultured; Cult | 2001 |
Fatty acid oxidation and mechanical performance of volume-overloaded rat hearts.
Topics: Animals; Blood Volume; Carbon Dioxide; Cardiomegaly; Fatty Acids; Heart; Heart Rate; Mitochondria, H | 1992 |
Energy metabolism and mechanical function in perfused hearts of Syrian hamsters with dilated or hypertrophic cardiomyopathy.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cardiomegaly; Carnitine; Coenzyme A; Coronary Circu | 1986 |