palmitic acid has been researched along with Cardiac Hypertrophy in 24 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We observed that palmitic acid treatment in cardiac-derived H9c2 cells induced a significant increase in reactive oxygen species, inflammation, apoptosis, fibrosis and hypertrophy." | 3.83 | Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity. ( Chen, G; Chen, X; Li, X; Liang, G; Lu, K; Peng, K; Qian, Y; Xu, Z; Zhang, Y; Zhong, P, 2016) |
| "Although mutations in the gamma-subunit of AMP-activated protein kinase (AMPK) can result in excessive glycogen accumulation and cardiac hypertrophy, the mechanisms by which this occurs have not been well defined." | 3.74 | The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes. ( Allard, MF; Dyck, JR; Folmes, KD; Witters, LA; Young, ME, 2007) |
| "Palmitic acid did not activate AMPKα but increased expression of the FA translocase CD36 (FAT/CD36) to 163 ± 23% and adipose-differentiation-related-protein (ADRP), a sensitive marker of lipid accumulation, to 168 ± 42%." | 1.46 | AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes. ( Adrian, L; Böhm, M; Heeren, J; Laufs, U; Lenski, M; Tödter, K, 2017) |
| "Metabolic changes in cardiac hypertrophy include suppression of fatty acid oxidation and enhancement of glucose utilization, which could result in lipid accumulation in the heart." | 1.42 | Mouse SIRT3 attenuates hypertrophy-related lipid accumulation in the heart through the deacetylation of LCAD. ( Bu, P; Chen, T; Li, J; Li, N; Liu, H; Liu, J; Wang, S; Zhang, Y, 2015) |
| " Long-term administration of propionyl-L-carnitine normalized the degree of reduction of mitochondrial pyridine nucleotides and improved the kinetics of mitochondrial ATP production in volume-overloaded hearts." | 1.30 | Control of oxidative metabolism in volume-overloaded rat hearts: effect of propionyl-L-carnitine. ( El Alaoui-Talibi, Z; Guendouz, A; Moravec, J; Moravec, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 11 (45.83) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, P | 3 |
| Wu, H | 3 |
| Gu, Y | 3 |
| Li, L | 3 |
| Hu, R | 3 |
| Ma, W | 3 |
| Bian, Z | 3 |
| Liu, N | 3 |
| Yang, D | 3 |
| Chen, X | 4 |
| Adrian, L | 1 |
| Lenski, M | 1 |
| Tödter, K | 1 |
| Heeren, J | 1 |
| Böhm, M | 1 |
| Laufs, U | 1 |
| Ceylan-Isik, AF | 1 |
| Kandadi, MR | 1 |
| Xu, X | 2 |
| Hua, Y | 2 |
| Chicco, AJ | 1 |
| Ren, J | 2 |
| Nair, S | 2 |
| Liang, L | 1 |
| Shou, XL | 1 |
| Zhao, HK | 1 |
| Ren, GQ | 1 |
| Wang, JB | 1 |
| Wang, XH | 1 |
| Ai, WT | 1 |
| Maris, JR | 1 |
| Hueckstaedt, LK | 1 |
| Ma, AQ | 1 |
| Zhang, Y | 4 |
| Ravassa, S | 1 |
| Beaumont, J | 1 |
| Huerta, A | 1 |
| Barba, J | 1 |
| Coma-Canella, I | 1 |
| González, A | 1 |
| López, B | 1 |
| Díez, J | 1 |
| Chen, T | 1 |
| Liu, J | 2 |
| Li, N | 1 |
| Wang, S | 2 |
| Liu, H | 1 |
| Li, J | 1 |
| Bu, P | 1 |
| Qian, Y | 1 |
| Zhong, P | 1 |
| Peng, K | 1 |
| Xu, Z | 1 |
| Lu, K | 1 |
| Chen, G | 1 |
| Li, X | 1 |
| Liang, G | 1 |
| Luo, M | 1 |
| Zhang, Z | 1 |
| Gu, J | 1 |
| Chen, J | 1 |
| Payne, KM | 1 |
| Tan, Y | 1 |
| Wang, Y | 1 |
| Yin, X | 1 |
| Zhang, X | 1 |
| Liu, GC | 1 |
| Wintergerst, K | 1 |
| Liu, Q | 1 |
| Zheng, Y | 1 |
| Cai, L | 1 |
| O'Donnell, JM | 3 |
| Fields, A | 1 |
| Chowdhury, SA | 1 |
| Geenen, DL | 1 |
| Bi, J | 1 |
| Wang, P | 1 |
| Li, Y | 1 |
| Wu, S | 1 |
| Luo, J | 1 |
| Yang, H | 1 |
| Subbiah, R | 1 |
| Chatham, J | 1 |
| Zhelyabovska, O | 1 |
| Yang, Q | 1 |
| Riquelme, CA | 1 |
| Magida, JA | 1 |
| Harrison, BC | 1 |
| Wall, CE | 1 |
| Marr, TG | 1 |
| Secor, SM | 1 |
| Leinwand, LA | 1 |
| Lewandowski, ED | 2 |
| Fischer, SK | 1 |
| Fasano, M | 1 |
| Banke, NH | 1 |
| Walker, LA | 1 |
| Huqi, A | 1 |
| Wang, X | 1 |
| Lopaschuk, GD | 2 |
| Dolence, J | 1 |
| Shi, GP | 1 |
| Sorokina, N | 1 |
| McKinney, RD | 1 |
| Pound, KM | 1 |
| Woldegiorgis, G | 1 |
| LaNoue, KF | 1 |
| Ballal, K | 1 |
| Taegtmeyer, H | 1 |
| Buttrick, PM | 1 |
| Folmes, KD | 1 |
| Witters, LA | 1 |
| Allard, MF | 2 |
| Young, ME | 1 |
| Dyck, JR | 1 |
| Lesniak, W | 1 |
| Schaefer, C | 1 |
| Grueninger, S | 1 |
| Chiesi, M | 1 |
| Schönekess, BO | 1 |
| Henning, SL | 1 |
| English, DR | 1 |
| Ben Cheikh, R | 1 |
| Guendouz, A | 2 |
| Moravec, J | 3 |
| El Alaoui-Talibi, Z | 2 |
| Moravec, M | 1 |
| Van Der Lee, KA | 1 |
| Willemsen, PH | 1 |
| Van Der Vusse, GJ | 1 |
| Van Bilsen, M | 1 |
| Barger, PM | 1 |
| Brandt, JM | 1 |
| Leone, TC | 1 |
| Weinheimer, CJ | 1 |
| Kelly, DP | 1 |
| Zahabi, A | 1 |
| Deschepper, CF | 1 |
| Landormy, S | 1 |
| Loireau, A | 1 |
| Whitmer, JT | 1 |
24 other studies available for palmitic acid and Cardiac Hypertrophy
| Article | Year |
|---|---|
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Carnitine O-Palmitoyltransferase; Fatty Acids; Mice; Mitochondr | 2023 |
AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiomegaly; Cell Li | 2017 |
Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction.
Topics: Adipokines; Animals; Apelin; Autophagy; Body Weight; Cardiomegaly; Cells, Cultured; Diet, High-Fat; | 2013 |
Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKKβ-AMPK-dependent regulation of autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Autophagy; Calcium; Cardiomegaly; Catalase; Di | 2015 |
Association of low GLP-1 with oxidative stress is related to cardiac disease and outcome in patients with type 2 diabetes mellitus: a pilot study.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Animals; Antioxidants; Atrial Remodeling; Cardiomegaly; Cardiovas | 2015 |
Mouse SIRT3 attenuates hypertrophy-related lipid accumulation in the heart through the deacetylation of LCAD.
Topics: Acetylation; Acyl-CoA Dehydrogenase, Long-Chain; Animals; Cardiomegaly; Down-Regulation; Lipid Metab | 2015 |
Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity.
Topics: Animals; Apoptosis; Blood Glucose; Cardiomegaly; Cell Line; Diet, High-Fat; Fibrosis; Heart Injuries | 2016 |
Zinc deficiency exacerbates while zinc supplement attenuates cardiac hypertrophy in high-fat diet-induced obese mice through modulating p38 MAPK-dependent signaling.
Topics: Animals; Cardiomegaly; Cells, Cultured; Chelating Agents; Deficiency Diseases; Diet, High-Fat; Dieta | 2016 |
Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo.
Topics: Adenosine Triphosphate; Adenoviridae; Adrenergic beta-Agonists; Animals; Calcium-Binding Proteins; C | 2008 |
Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart.
Topics: Aging; Animals; Antioxidants; Cardiomegaly; Cells, Cultured; DNA, Mitochondrial; Energy Metabolism; | 2010 |
Fatty acids identified in the Burmese python promote beneficial cardiac growth.
Topics: Animals; Animals, Newborn; Biological Transport; Boidae; Cardiomegaly; Cell Size; Fasting; Fatty Aci | 2011 |
Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy.
Topics: Acetyl-CoA Carboxylase; Animals; Atrial Natriuretic Factor; Carboxy-Lyases; Cardiomegaly; Carnitine | 2013 |
Cathepsin K knockout mitigates high-fat diet-induced cardiac hypertrophy and contractile dysfunction.
Topics: Animals; Apoptosis; Calcium; Cardiomegaly; Cathepsin K; Cell Line; Cytochromes c; Cytoplasm; Diet, H | 2013 |
Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts.
Topics: Animals; Cardiomegaly; Carnitine O-Palmitoyltransferase; Citric Acid Cycle; Energy Metabolism; Gluco | 2007 |
The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes.
Topics: Active Transport, Cell Nucleus; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Cardiomega | 2007 |
Effect of alpha adrenergic stimulation and carnitine palmitoyl transferase I inhibition on hypertrophying adult rat cardiomyocytes in culture.
Topics: Animals; Atrial Natriuretic Factor; Base Sequence; Cardiomegaly; Cell Division; Cells, Cultured; DNA | 1995 |
Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts.
Topics: Adenosine Triphosphate; Animals; Body Weight; Cardiomegaly; Energy Metabolism; Glucose; Glycolysis; | 1994 |
Control of oxidative metabolism in volume-overloaded rat hearts: effects of different lipid substrates.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Caprylates; Cardiomegaly; Creatine; Energy M | 1994 |
Control of oxidative metabolism in volume-overloaded rat hearts: effect of propionyl-L-carnitine.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Pressure; Body Weight; Cardiomegaly; C | 1997 |
Effects of fatty acids on uncoupling protein-2 expression in the rat heart.
Topics: Aging; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Diabetes Mellitus, Experimental; Em | 2000 |
Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Cardiomegaly; Carnitine O-Palmitoyltransferase; Cell | 2000 |
Long-chain fatty acids modify hypertrophic responses of cultured primary neonatal cardiomyocytes.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cell Size; Cells, Cultured; Cult | 2001 |
Fatty acid oxidation and mechanical performance of volume-overloaded rat hearts.
Topics: Animals; Blood Volume; Carbon Dioxide; Cardiomegaly; Fatty Acids; Heart; Heart Rate; Mitochondria, H | 1992 |
Energy metabolism and mechanical function in perfused hearts of Syrian hamsters with dilated or hypertrophic cardiomyopathy.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cardiomegaly; Carnitine; Coenzyme A; Coronary Circu | 1986 |