palmitic acid has been researched along with Carcinoma, Hepatocellular in 47 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the potential of GB as a material for the mitigation of NAFLD, we investigated the effects of GB hydrolysates on the hepatic lipid accumulation, inflammation, and endoplasmic reticulum (ER) stress in human hepatoma G2 (Hep G2) cells treated with palmitic acid (PA)." | 8.12 | Gryllus bimaculatus De Geer hydrolysates alleviate lipid accumulation, inflammation, and endoplasmic reticulum stress in palmitic acid-treated human hepatoma G2 cells. ( Jeong, Y; Jo, EB; Jung, S; Kim, N; Lee, E; Yoon, S, 2022) |
| "The experiments were conducted on hepatocellular carcinoma cells (HepG2) incubated with RSV and/or Palmitic Acid (PA) at the concentration of 0." | 7.91 | Influence of Resveratrol on Sphingolipid Metabolism in Hepatocellular Carcinoma Cells in Lipid Overload State. ( Berk, K; Chabowski, A; Charytoniuk, T; Drygalski, K; Harasim-Symbor, E; Konstantynowicz-Nowicka, K; Polak, A, 2019) |
| "Non-alcoholic fatty liver (NAFLD) is a widespread disease with various complications including Non-alcoholic steatohepatitis (NASH) that could lead to cirrhosis and ultimately hepatocellular carcinoma (HCC)." | 5.91 | Rhamnetin ameliorates non-alcoholic steatosis and hepatocellular carcinoma in vitro. ( El-Derany, MO; El-Mesallamy, HO; Gibriel, AA; Shatta, MA, 2023) |
| "Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases worldwide." | 5.72 | PREX1 depletion ameliorates high-fat diet-induced non-alcoholic fatty liver disease in mice and mitigates palmitic acid-induced hepatocellular injury via suppressing the NF-κB signaling pathway. ( Gong, W; Li, Z; Wang, H; Wang, P; Wu, K; Zou, Y, 2022) |
| "Toyocamycin was recently reported to attenuate the activation of XBP-1, possibly by inducing a conformational change in IRE1α." | 5.46 | Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice. ( Akazawa, Y; Eguchi, S; Kanda, Y; Kido, Y; Matsuda, K; Miyaaki, H; Nakao, K; Nakashima, M; Ohnita, K; Sakai, Y; Tabuchi, M; Takahara, I; Takeshima, F; Taura, N, 2017) |
| "To evaluate the potential of GB as a material for the mitigation of NAFLD, we investigated the effects of GB hydrolysates on the hepatic lipid accumulation, inflammation, and endoplasmic reticulum (ER) stress in human hepatoma G2 (Hep G2) cells treated with palmitic acid (PA)." | 4.12 | Gryllus bimaculatus De Geer hydrolysates alleviate lipid accumulation, inflammation, and endoplasmic reticulum stress in palmitic acid-treated human hepatoma G2 cells. ( Jeong, Y; Jo, EB; Jung, S; Kim, N; Lee, E; Yoon, S, 2022) |
| " In this study, we found, for the first time, that oleic acid/palmitic acid (OA/PA)-induced lipid accumulation was largely abrogated by DDX17 overexpression in both HepG2 (a human hepatocellular carcinoma line) and Hep1-6 (a murine hepatocellular carcinoma line) cells, and this effect was due to a marked reduction in cellular triglyceride (TG) content." | 4.12 | DDX17 protects hepatocytes against oleic acid/palmitic acid-induced lipid accumulation. ( An, T; Dou, L; Huang, X; Li, H; Li, J; Man, Y; Shen, T; Tang, W; Zhang, X, 2022) |
| " The study was carried out on human hepatocellular carcinoma cells (HepG2) incubated with VK2 and/or palmitic acid (PA)." | 4.02 | Vitamin K2 as a New Modulator of the Ceramide De Novo Synthesis Pathway. ( Bzdęga, W; Chabowski, A; Harasim-Symbor, E; Konstantynowicz-Nowicka, K; Kołakowski, A; Kurzyna, PF; Żywno, H, 2021) |
| "The experiments were conducted on hepatocellular carcinoma cells (HepG2) incubated with RSV and/or Palmitic Acid (PA) at the concentration of 0." | 3.91 | Influence of Resveratrol on Sphingolipid Metabolism in Hepatocellular Carcinoma Cells in Lipid Overload State. ( Berk, K; Chabowski, A; Charytoniuk, T; Drygalski, K; Harasim-Symbor, E; Konstantynowicz-Nowicka, K; Polak, A, 2019) |
| "Non-alcoholic fatty liver (NAFLD) is a widespread disease with various complications including Non-alcoholic steatohepatitis (NASH) that could lead to cirrhosis and ultimately hepatocellular carcinoma (HCC)." | 1.91 | Rhamnetin ameliorates non-alcoholic steatosis and hepatocellular carcinoma in vitro. ( El-Derany, MO; El-Mesallamy, HO; Gibriel, AA; Shatta, MA, 2023) |
| "Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases worldwide." | 1.72 | PREX1 depletion ameliorates high-fat diet-induced non-alcoholic fatty liver disease in mice and mitigates palmitic acid-induced hepatocellular injury via suppressing the NF-κB signaling pathway. ( Gong, W; Li, Z; Wang, H; Wang, P; Wu, K; Zou, Y, 2022) |
| "Furthermore, we assayed migration of hepatoma cells and saw a 2-fold increase in the number of migrating cells towards CXCL1." | 1.56 | An Autocrine Role for CXCL1 in Progression of Hepatocellular Carcinoma. ( Dahlquist, KJV; Fee, AJ; Stoeckman, AK; Voth, LC, 2020) |
| "The biological function of OGT in NAFLD-HCC was determined by gain- or loss- of OGT functional assays in vitro and in nude mice." | 1.46 | O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress. ( Chen, GG; Fu, L; Lai, PB; Liu, D; Liu, K; Wong, N; Wu, JL; Xu, W; Yu, J; Zhang, X, 2017) |
| "Toyocamycin was recently reported to attenuate the activation of XBP-1, possibly by inducing a conformational change in IRE1α." | 1.46 | Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice. ( Akazawa, Y; Eguchi, S; Kanda, Y; Kido, Y; Matsuda, K; Miyaaki, H; Nakao, K; Nakashima, M; Ohnita, K; Sakai, Y; Tabuchi, M; Takahara, I; Takeshima, F; Taura, N, 2017) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in parallel with the prevalence of obesity." | 1.42 | GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance. ( Isobe, K; Nishio, N, 2015) |
| "We used hepatocyte suspensions, hepatoma monolayers, and perfused rat livers to quantitate the transport of purified [(3)H]palmitate ([(3)H]PA) and 12-(N-methyl)-N-[(7-nitrobenz-2oxa-1,3-diazol-4yl-)amino]octadecanoicacid (12-NBDS) from solutions with a constant unbound LCFA concentration with varying bovine serum albumin (BSA) concentrations and in the presence and absence of antisera raised against cytosolic liver fatty acid binding protein (L-FABP)." | 1.33 | Membrane binding proteins are the major determinants for the hepatocellular transmembrane flux of long-chain fatty acids bound to albumin. ( Burczynski, FJ; Hung, D; Rajaraman, G; Roberts, MS; Wang, GQ, 2005) |
| "Treatment with palmitic acid (PA), oleic acid (OA), linoleic acid (LA), LNA, and DHA resulted in respective cellular FA concentrations of C16:0 (43." | 1.32 | Differential effects of dietary fatty acids on the regulation of CYP2E1 and protein kinase C in human hepatoma HepG2 cells. ( Kim, I; Lee, M; Park, M; Sung, M; Whang, Y, 2004) |
| "However, hepatoma cells had a 2-fold higher fatty acid uptake and a 2-fold lower fatty acid oxidation as compared with primary hepatocytes." | 1.32 | Glucose and fatty acid metabolism in McA-RH7777 hepatoma cells vs. rat primary hepatocytes: responsiveness to nutrient availability. ( Asztély, AK; Clapham, JC; Hansson, PK; Schreyer, SA, 2004) |
| "Palmitic acid was the most representative saturated FFA (which together accounted for 2." | 1.29 | Free fatty acid analysis in ascitic fluid improves diagnosis in malignant abdominal tumors. ( Gasbarrini, G; Greco, AV; Mingrone, G, 1995) |
| "Using both hepatoma cells (Hep G2) and human erythrocytes, which have poor oxidative capacity and metabolize glucose primarily anaerobically, we have demonstrated a unique stimulatory effect of FFA on glycolysis." | 1.28 | A stimulatory effect of FFA on glycolysis unmasked in cells with impaired oxidative capacity. ( Blackard, WG; Clore, JN; Powers, LP, 1990) |
| "Utilizing the human hepatoma cell line HEP-G2, we have established that, in addition to proteolytic processing, secreted nascent apo-A-I is acylated with palmitate." | 1.27 | Human apolipoprotein A-I. Post-translational modification by fatty acid acylation. ( Brewer, HB; Fairwell, T; Hoeg, JM; Meng, MS; Ronan, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (8.51) | 18.7374 |
| 1990's | 5 (10.64) | 18.2507 |
| 2000's | 13 (27.66) | 29.6817 |
| 2010's | 10 (21.28) | 24.3611 |
| 2020's | 15 (31.91) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, N | 1 |
| Jung, S | 1 |
| Lee, E | 1 |
| Jo, EB | 1 |
| Yoon, S | 1 |
| Jeong, Y | 1 |
| Zhang, X | 4 |
| An, T | 1 |
| Shen, T | 1 |
| Li, H | 2 |
| Dou, L | 1 |
| Huang, X | 1 |
| Man, Y | 1 |
| Tang, W | 1 |
| Li, J | 1 |
| Li, Z | 1 |
| Wu, K | 1 |
| Zou, Y | 1 |
| Gong, W | 1 |
| Wang, P | 1 |
| Wang, H | 1 |
| Saha, S | 1 |
| Verma, R | 1 |
| Kumar, C | 1 |
| Kumar, B | 1 |
| Dey, AK | 1 |
| Surjit, M | 1 |
| Mylavarapu, SVS | 1 |
| Maiti, TK | 1 |
| Seong, MS | 1 |
| Hwang, HJ | 1 |
| Jang, EA | 1 |
| Jang, JA | 1 |
| Aung, WW | 1 |
| Kyaw, YY | 1 |
| Cheong, J | 1 |
| Shatta, MA | 2 |
| El-Derany, MO | 2 |
| Gibriel, AA | 2 |
| El-Mesallamy, HO | 2 |
| Schilcher, K | 1 |
| Dayoub, R | 1 |
| Kubitza, M | 1 |
| Riepl, J | 1 |
| Klein, K | 1 |
| Buechler, C | 1 |
| Melter, M | 1 |
| Weiss, TS | 1 |
| Parra-Robert, M | 1 |
| Casals, E | 1 |
| Massana, N | 1 |
| Zeng, M | 1 |
| Perramón, M | 1 |
| Fernández-Varo, G | 1 |
| Morales-Ruiz, M | 1 |
| Puntes, V | 1 |
| Jiménez, W | 1 |
| Casals, G | 1 |
| Xue, J | 1 |
| Cao, Z | 1 |
| Cheng, Y | 1 |
| Wang, J | 1 |
| Liu, Y | 1 |
| Yang, R | 1 |
| Jiang, W | 1 |
| Li, G | 1 |
| Zhao, W | 1 |
| Gu, L | 1 |
| Zhu, Y | 1 |
| Lin, X | 1 |
| Tan, X | 1 |
| Lu, B | 1 |
| Li, Y | 1 |
| Grünig, D | 1 |
| Szabo, L | 1 |
| Marbet, M | 1 |
| Krähenbühl, S | 1 |
| Dahlquist, KJV | 1 |
| Voth, LC | 1 |
| Fee, AJ | 1 |
| Stoeckman, AK | 1 |
| Buratta, S | 1 |
| Shimanaka, Y | 1 |
| Costanzi, E | 1 |
| Ni, S | 1 |
| Urbanelli, L | 1 |
| Kono, N | 1 |
| Morena, F | 1 |
| Sagini, K | 1 |
| Giovagnoli, S | 1 |
| Romani, R | 1 |
| Gargaro, M | 1 |
| Arai, H | 1 |
| Emiliani, C | 1 |
| Yu, J | 2 |
| Liu, S | 1 |
| Chen, L | 1 |
| Wu, B | 1 |
| Amorim, R | 1 |
| Simões, ICM | 1 |
| Veloso, C | 1 |
| Carvalho, A | 1 |
| Simões, RF | 1 |
| Pereira, FB | 1 |
| Thiel, T | 1 |
| Normann, A | 1 |
| Morais, C | 1 |
| Jurado, AS | 1 |
| Wieckowski, MR | 1 |
| Teixeira, J | 1 |
| Oliveira, PJ | 1 |
| Kołakowski, A | 1 |
| Kurzyna, PF | 1 |
| Żywno, H | 1 |
| Bzdęga, W | 1 |
| Harasim-Symbor, E | 2 |
| Chabowski, A | 2 |
| Konstantynowicz-Nowicka, K | 2 |
| Xu, W | 1 |
| Wu, JL | 1 |
| Fu, L | 1 |
| Liu, K | 1 |
| Liu, D | 1 |
| Chen, GG | 1 |
| Lai, PB | 1 |
| Wong, N | 1 |
| Ahn, SB | 1 |
| Wu, WH | 1 |
| Lee, JH | 1 |
| Jun, DW | 1 |
| Kim, J | 1 |
| Kim, R | 1 |
| Lee, TB | 1 |
| Jun, JH | 1 |
| Charytoniuk, T | 1 |
| Polak, A | 1 |
| Drygalski, K | 1 |
| Berk, K | 1 |
| Li, SX | 1 |
| Tang, GS | 1 |
| Zhou, DX | 1 |
| Pan, YF | 1 |
| Tan, YX | 1 |
| Zhang, J | 1 |
| Zhang, B | 2 |
| Ding, ZW | 1 |
| Liu, LJ | 1 |
| Jiang, TY | 1 |
| Hu, HP | 1 |
| Dong, LW | 1 |
| Wang, HY | 1 |
| Lou, J | 1 |
| Wang, Y | 2 |
| Wang, X | 1 |
| Jiang, Y | 1 |
| Nishio, N | 1 |
| Isobe, K | 1 |
| Lin, L | 1 |
| Ding, Y | 1 |
| Wang, Z | 1 |
| Yin, X | 1 |
| Yan, G | 1 |
| Zhang, L | 2 |
| Yang, P | 1 |
| Shen, H | 1 |
| Takahara, I | 1 |
| Akazawa, Y | 1 |
| Tabuchi, M | 1 |
| Matsuda, K | 1 |
| Miyaaki, H | 1 |
| Kido, Y | 1 |
| Kanda, Y | 1 |
| Taura, N | 1 |
| Ohnita, K | 1 |
| Takeshima, F | 1 |
| Sakai, Y | 1 |
| Eguchi, S | 1 |
| Nakashima, M | 1 |
| Nakao, K | 1 |
| Ruddock, MW | 1 |
| Stein, A | 1 |
| Landaker, E | 1 |
| Park, J | 1 |
| Cooksey, RC | 1 |
| McClain, D | 1 |
| Patti, ME | 1 |
| Vock, C | 2 |
| Gleissner, M | 2 |
| Klapper, M | 2 |
| Döring, F | 2 |
| Jain, V | 1 |
| Nath, B | 1 |
| Gupta, GK | 1 |
| Shah, PP | 1 |
| Siddiqui, MA | 1 |
| Pant, AB | 1 |
| Mishra, PR | 1 |
| Lausada, N | 1 |
| de Gómez Dumm, IN | 1 |
| Raimondi, JC | 1 |
| de Alaniz, MJ | 1 |
| Chavez-Tapia, NC | 1 |
| Rosso, N | 1 |
| Tiribelli, C | 1 |
| SATO, S | 1 |
| AMIZUKA, T | 1 |
| SATO, K | 1 |
| BLOCH-FRANKENTHAL, L | 1 |
| LANGAN, J | 1 |
| MORRIS, HP | 1 |
| WEINHOUSE, S | 1 |
| Isozaki, T | 2 |
| Numata, K | 2 |
| Kiba, T | 1 |
| Hara, K | 1 |
| Morimoto, M | 2 |
| Sakaguchi, T | 1 |
| Sekihara, H | 1 |
| Kubota, T | 1 |
| Shimada, H | 1 |
| Morizane, T | 2 |
| Tanaka, K | 2 |
| Sung, M | 1 |
| Kim, I | 1 |
| Park, M | 1 |
| Whang, Y | 1 |
| Lee, M | 1 |
| Hansson, PK | 1 |
| Asztély, AK | 1 |
| Clapham, JC | 1 |
| Schreyer, SA | 1 |
| Ji, J | 1 |
| Zhu, XY | 1 |
| Wu, YY | 1 |
| Yu, H | 1 |
| Li, XL | 1 |
| Sun, XZ | 1 |
| Rajaraman, G | 1 |
| Roberts, MS | 1 |
| Hung, D | 1 |
| Wang, GQ | 1 |
| Burczynski, FJ | 1 |
| Sugimori, K | 1 |
| Kunisaki, R | 1 |
| Gómez-Lechón, MJ | 1 |
| Donato, MT | 1 |
| Martínez-Romero, A | 1 |
| Jiménez, N | 1 |
| Castell, JV | 1 |
| O'Connor, JE | 1 |
| Greco, AV | 1 |
| Mingrone, G | 1 |
| Gasbarrini, G | 1 |
| Srivastava, RA | 1 |
| Ito, H | 1 |
| Hess, M | 1 |
| Srivastava, N | 1 |
| Schonfeld, G | 1 |
| Zeng, FY | 1 |
| Oka, JA | 1 |
| Weigel, PH | 1 |
| Lligona-Trulla, L | 1 |
| Arduini, A | 1 |
| Aldaghlas, TA | 1 |
| Calvani, M | 1 |
| Kelleher, JK | 1 |
| Martínez-Cayuela, M | 1 |
| García-Pelayo, MC | 1 |
| Linares, A | 1 |
| García-Peregrín, E | 1 |
| Blackard, WG | 1 |
| Clore, JN | 1 |
| Powers, LP | 1 |
| Magee, AI | 1 |
| Siddle, K | 1 |
| Hoeg, JM | 1 |
| Meng, MS | 1 |
| Ronan, R | 1 |
| Fairwell, T | 1 |
| Brewer, HB | 1 |
47 other studies available for palmitic acid and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Gryllus bimaculatus De Geer hydrolysates alleviate lipid accumulation, inflammation, and endoplasmic reticulum stress in palmitic acid-treated human hepatoma G2 cells.
Topics: Carcinoma, Hepatocellular; Endoplasmic Reticulum Stress; Hep G2 Cells; Hepatocytes; Humans; Inflamma | 2022 |
DDX17 protects hepatocytes against oleic acid/palmitic acid-induced lipid accumulation.
Topics: Animals; Carcinoma, Hepatocellular; DEAD-box RNA Helicases; Hep G2 Cells; Hepatocytes; Humans; Lipid | 2022 |
PREX1 depletion ameliorates high-fat diet-induced non-alcoholic fatty liver disease in mice and mitigates palmitic acid-induced hepatocellular injury via suppressing the NF-κB signaling pathway.
Topics: Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Guanine Nucleotide Exchange Factors; Inflammatio | 2022 |
Proteomic analysis reveals USP7 as a novel regulator of palmitic acid-induced hepatocellular carcinoma cell death.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Line; Humans; Liver Neoplasms; Palmitic Acid; | 2022 |
Core promoter mutation of nucleotides A1762T and G1764A of hepatitis B virus increases core promoter transactivation by hepatocyte nuclear factor 1.
Topics: Carcinoma, Hepatocellular; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Hepatocyte Nuclear Fac | 2022 |
Rhamnetin ameliorates non-alcoholic steatosis and hepatocellular carcinoma in vitro.
Topics: Carcinoma, Hepatocellular; Flavonoids; Humans; Liver Neoplasms; Non-alcoholic Fatty Liver Disease; P | 2023 |
Rhamnetin ameliorates non-alcoholic steatosis and hepatocellular carcinoma in vitro.
Topics: Carcinoma, Hepatocellular; Flavonoids; Humans; Liver Neoplasms; Non-alcoholic Fatty Liver Disease; P | 2023 |
Rhamnetin ameliorates non-alcoholic steatosis and hepatocellular carcinoma in vitro.
Topics: Carcinoma, Hepatocellular; Flavonoids; Humans; Liver Neoplasms; Non-alcoholic Fatty Liver Disease; P | 2023 |
Rhamnetin ameliorates non-alcoholic steatosis and hepatocellular carcinoma in vitro.
Topics: Carcinoma, Hepatocellular; Flavonoids; Humans; Liver Neoplasms; Non-alcoholic Fatty Liver Disease; P | 2023 |
Saturated Fat-Mediated Upregulation of IL-32 and CCL20 in Hepatocytes Contributes to Higher Expression of These Fibrosis-Driving Molecules in MASLD.
Topics: Carcinoma, Hepatocellular; Chemokine CCL20; Chemokines; Fats, Unsaturated; Fatty Liver; Hepatocytes; | 2023 |
Beyond the Scavenging of Reactive Oxygen Species (ROS): Direct Effect of Cerium Oxide Nanoparticles in Reducing Fatty Acids Content in an In Vitro Model of Hepatocellular Steatosis.
Topics: Carcinoma, Hepatocellular; Cell Survival; Cerium; Fatty Acid Desaturases; Fatty Acid Elongases; Fatt | 2019 |
Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression.
Topics: Acetylation; alpha-Fetoproteins; Amino Acid Sequence; Animals; Apoptosis; Carcinoma, Hepatocellular; | 2020 |
Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis.
Topics: Acetyl-CoA C-Acetyltransferase; Acetylation; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; F | 2020 |
Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms.
Topics: Animals; Apolipoprotein B-100; Apoptosis; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tu | 2020 |
An Autocrine Role for CXCL1 in Progression of Hepatocellular Carcinoma.
Topics: Animals; Apoptosis; Autocrine Communication; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movem | 2020 |
Lipotoxic stress alters the membrane lipid profile of extracellular vesicles released by Huh-7 hepatocarcinoma cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Endoplasmic Reticulum Stress; Extracellular Vesicles; F | 2021 |
Combined effects of arsenic and palmitic acid on oxidative stress and lipid metabolism disorder in human hepatoma HepG2 cells.
Topics: Arsenic; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Lipid Metabolism; Lipid Metabolism Disorde | 2021 |
Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells.
Topics: Carcinoma, Hepatocellular; Cell Death; Data Analysis; Diet, High-Fat; Dietary Carbohydrates; Fatty A | 2021 |
Vitamin K2 as a New Modulator of the Ceramide De Novo Synthesis Pathway.
Topics: Biosynthetic Pathways; Carcinoma, Hepatocellular; Ceramides; Chromatography, High Pressure Liquid; G | 2021 |
O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Stre | 2017 |
Fermented Soymilk Alleviates Lipid Accumulation by Inhibition of SREBP-1 and Activation of NRF-2 in the Hepatocellular Steatosis Model.
Topics: Bioreactors; Carcinoma, Hepatocellular; Cell Proliferation; Estrogens; Fatty Liver; Fermentation; Ge | 2018 |
Influence of Resveratrol on Sphingolipid Metabolism in Hepatocellular Carcinoma Cells in Lipid Overload State.
Topics: Carcinoma, Hepatocellular; Caspase 3; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Lipid | 2019 |
Prognostic significance of cytoskeleton-associated membrane protein 4 and its palmitoyl acyltransferase DHHC2 in hepatocellular carcinoma.
Topics: Acyltransferases; Adult; Aged; Biomarkers, Tumor; Blotting, Western; Carcinoma, Hepatocellular; Chin | 2014 |
Uncoupling protein 2 regulates palmitic acid-induced hepatoma cell autophagy.
Topics: Apoptosis; Autophagy; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Gene Expression Regula | 2014 |
GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance.
Topics: Adipogenesis; Aging; Animals; Body Weight; Carcinoma, Hepatocellular; CHO Cells; Cricetinae; Cricetu | 2015 |
Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Disease Models, Animal; Gluco | 2017 |
Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Cells, Cultured; Diet, H | 2017 |
Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling.
Topics: Aminoimidazole Carboxamide; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Activation; | 2008 |
Oleate regulates genes controlled by signaling pathways of mitogen-activated protein kinase, insulin, and hypoxia.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Gene Expression Regulation; Humans; Hypoxia; | 2008 |
Galactose-grafted chylomicron-mimicking emulsion: evaluation of specificity against HepG-2 and MCF-7 cell lines.
Topics: Antineoplastic Agents, Phytogenic; Asialoglycoprotein Receptor; Breast Neoplasms; Carcinoma, Hepatoc | 2009 |
Effect of cyclosporine and sirolimus on fatty acid desaturase activities in cultured HEPG2 cells.
Topics: Arachidonic Acids; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclosporine; Fatty Acid Desaturases | 2009 |
Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytokines; Dose-Response Relationship, Drug; | 2012 |
THE INTERRELATIONSHIP BETWEEN GLUCOSE AND PALMITIC ACID OXIDATION IN VITRO BY ASCITES HEPATOMA, AH 130.
Topics: Ascites; Carbohydrate Metabolism; Carcinoma, Hepatocellular; Glucose; Glycolysis; In Vitro Technique | 1964 |
FATTY ACID OXIDATION AND KETOGENESIS IN TRANSPLANTABLE LIVER TUMORS.
Topics: Acetoacetates; Butyrates; Carbon Dioxide; Carbon Isotopes; Carcinoma, Hepatocellular; Fatty Acids; L | 1965 |
Differential diagnosis of hepatic tumors by using contrast enhancement patterns at US.
Topics: Carcinoma, Hepatocellular; Contrast Media; Diagnosis, Differential; Female; Galactose; Hemangioma; H | 2003 |
Differential effects of dietary fatty acids on the regulation of CYP2E1 and protein kinase C in human hepatoma HepG2 cells.
Topics: Carcinoma, Hepatocellular; Cell Membrane; Cytochrome P-450 CYP2E1; Dietary Fats, Unsaturated; Docosa | 2004 |
Glucose and fatty acid metabolism in McA-RH7777 hepatoma cells vs. rat primary hepatocytes: responsiveness to nutrient availability.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Fatty A | 2004 |
[Palmitic acid induces apoptosis in human hepatoma cell line, HepG2 cells].
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell | 2004 |
Membrane binding proteins are the major determinants for the hepatocellular transmembrane flux of long-chain fatty acids bound to albumin.
Topics: Albumins; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Fatty Acid-Binding Proteins; Fatty A | 2005 |
Prospective study of differential diagnosis of hepatic tumors by pattern-based classification of contrast-enhanced sonography.
Topics: Aged; Carcinoma, Hepatocellular; Contrast Media; Diagnosis, Differential; Female; Galactose; Hemangi | 2006 |
A human hepatocellular in vitro model to investigate steatosis.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, D | 2007 |
Identification of palmitate-regulated genes in HepG2 cells by applying microarray analysis.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; | 2007 |
Free fatty acid analysis in ascitic fluid improves diagnosis in malignant abdominal tumors.
Topics: Adult; Aged; Albumins; Arachidonic Acid; Ascitic Fluid; Carcinoma, Hepatocellular; Fatty Acids, None | 1995 |
Regulation of low density lipoprotein receptor gene expression in HepG2 and Caco2 cells by palmitate, oleate, and 25-hydroxycholesterol.
Topics: Blood; Caco-2 Cells; Carcinoma, Hepatocellular; Gene Expression Regulation; Humans; Hydroxycholester | 1995 |
The human asialoglycoprotein receptor is palmitoylated and fatty deacylation causes inactivation of state 2 receptors.
Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Carcinoma, Hepatocellular; Cell Line; Chromatograp | 1996 |
Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis.
Topics: 3T3 Cells; Acetates; Acetylcarnitine; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cholester | 1997 |
Metabolism of palmitic and docosahexaenoic acids in Reuber H35 hepatoma cells.
Topics: Carcinoma, Hepatocellular; Cell Membrane; Culture Media; Docosahexaenoic Acids; Fatty Acids; Humans; | 2000 |
A stimulatory effect of FFA on glycolysis unmasked in cells with impaired oxidative capacity.
Topics: Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Glucagon; Gluc | 1990 |
Insulin and IGF-1 receptors contain covalently bound palmitic acid.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Humans; Insulin-Like Growth Factor I; Kinetics; Liver | 1988 |
Human apolipoprotein A-I. Post-translational modification by fatty acid acylation.
Topics: Acylation; Apolipoprotein A-I; Apolipoproteins A; Carcinoma, Hepatocellular; Cell Line; Electrophore | 1986 |