Page last updated: 2024-10-19

palmitic acid and Atherogenesis

palmitic acid has been researched along with Atherogenesis in 32 studies

Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.

Research Excerpts

ExcerptRelevanceReference
"The development of atherosclerosis is closely related to excessive endoplasmic reticulum stress (ERs)."5.43Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells. ( Hu, Q; Mi, M; Qin, L; Shi, L; Zhang, Q; Zhang, T, 2016)
"These results suggest that elevated level of palmitic acid may contribute to development of atherosclerosis through enhanced uptake of oxLDL via upregulation of LOX-1 in macrophages."3.76Palmitic acid enhances lectin-like oxidized LDL receptor (LOX-1) expression and promotes uptake of oxidized LDL in macrophage cells. ( Ishiyama, J; Murakami, K; Taguchi, R; Yamamoto, A, 2010)
"Despite the lower lipemia following the SFA-rich fats, increased proatherogenic large triacylglycerol-rich lipoprotein remnant and small LDL particles following the SFA-rich fats relative to RO adds a new postprandial dimension to the mechanistic evidence linking SFAs to cardiovascular disease risk."3.01Palmitic acid-rich oils with and without interesterification lower postprandial lipemia and increase atherogenic lipoproteins compared with a MUFA-rich oil: A randomized controlled trial. ( Bapir, M; Berry, SE; Fielding, BA; Gray, R; Hall, WL; Harding, SV; Mandalari, G; Mills, CE; Salt, LJ; Wilde, PJ, 2021)
"The development of atherosclerosis is closely related to excessive endoplasmic reticulum stress (ERs)."1.43Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells. ( Hu, Q; Mi, M; Qin, L; Shi, L; Zhang, Q; Zhang, T, 2016)
"Insulin sensitivity was assessed by the minimal model analysis."1.36Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. ( Avogaro, A; Bortoluzzi, A; Ceolotto, G; Cobelli, C; Dalla Man, C; de Kreutzenberg, SV; Fadini, GP; Papparella, I; Semplicini, A, 2010)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (9.38)29.6817
2010's23 (71.88)24.3611
2020's6 (18.75)2.80

Authors

AuthorsStudies
Luo, R1
Zhao, L1
Li, S2
Chen, P1
Yu, H1
Cai, K1
Yu, Q1
Tian, W2
Wang, M2
Liu, F2
Fang, B1
Huo, Q1
Yang, Y1
Liu, Q1
Cheng, Z1
Huang, B1
Luo, S1
Guo, Y1
Zhan, W1
Zhang, W1
Tian, H1
Sun, T1
Lee, J1
Yoo, JH1
Kim, HS1
Cho, YK1
Lee, Y1
Lee, WJ1
Park, JY1
Jung, CH1
Mills, CE1
Harding, SV1
Bapir, M1
Mandalari, G1
Salt, LJ1
Gray, R1
Fielding, BA1
Wilde, PJ1
Hall, WL1
Berry, SE1
Lu, Z1
Li, Y2
Brinson, CW1
Lopes-Virella, MF1
Huang, Y1
Karbasforush, S1
Nourazarian, A2
Darabi, M1
Rahbarghazi, R2
Khaki-Khatibi, F2
Biray Avci, Ç1
Salimi, L1
Goker Bagca, B1
Novin Bahador, T1
Rezabakhsh, A1
Khaksar, M1
Novinbahador, T1
Asgharzadeh, M1
Avci, ÇB1
Bagca, BG1
Ozates, NP1
Karbasforoush, S1
Kutryb-Zajac, B1
Koszalka, P1
Slominska, EM1
Smolenski, RT1
Namgaladze, D1
Kemmerer, M1
von Knethen, A1
Brüne, B1
Titov, VN2
Vostrov, IA1
Kaba, SI1
Ameliushkina, VA1
Shiriaeva, IuK2
Song, Y1
Zhang, LJ1
Li, H1
Gu, Y1
Li, FF1
Jiang, LN1
Ye, J1
Li, Q1
Zhao, Y1
Feng, G1
Wang, Y1
Yue, Y1
Zhao, W1
Perdomo, L1
Beneit, N1
Otero, YF1
Escribano, Ó1
Díaz-Castroverde, S1
Gómez-Hernández, A1
Benito, M1
Qiu, L1
Xu, R1
Wang, S1
Sheng, H1
Wu, J1
Qu, Y1
Reddy, MA1
Das, S1
Zhuo, C1
Jin, W1
Lanting, L1
Natarajan, R1
Liu, Y1
Tian, X1
Liu, D1
Liu, M1
Zhang, X1
Zhang, Q2
Yan, C1
Han, Y1
Afonso, MS1
Lavrador, MS1
Koike, MK1
Cintra, DE1
Ferreira, FD1
Nunes, VS1
Castilho, G1
Gioielli, LA1
Paula Bombo, R1
Catanozi, S1
Caldini, EG1
Damaceno-Rodrigues, NR1
Passarelli, M1
Nakandakare, ER1
Lottenberg, AM1
Slusher, AL1
Mischo, AB1
Acevedo, EO1
Zhang, T1
Hu, Q1
Shi, L1
Qin, L1
Mi, M1
Ishiyama, J1
Taguchi, R1
Yamamoto, A1
Murakami, K1
de Kreutzenberg, SV1
Ceolotto, G1
Papparella, I1
Bortoluzzi, A1
Semplicini, A1
Dalla Man, C1
Cobelli, C1
Fadini, GP1
Avogaro, A1
Song, J1
Ren, P1
Zhang, L1
Wang, XL1
Chen, L1
Shen, YH1
Cho, KH1
Hong, JH1
Lee, KT1
Karaman, IuK1
Novgorodtseva, TP1
Kantur, TA1
Antoniuk, MV1
Zhukova, NV1
Krylin, VV1
Gao, D1
Pararasa, C1
Dunston, CR1
Bailey, CJ1
Griffiths, HR1
Lamers, D1
Schlich, R1
Horrighs, A1
Cramer, A1
Sell, H1
Eckel, J1
Mattern, HM1
Hardin, CD1
Malmberg, P1
Börner, K1
Chen, Y1
Friberg, P1
Hagenhoff, B1
Månsson, JE1
Nygren, H1
Braam, B1
Verhaar, MC1

Reviews

3 reviews available for palmitic acid and Atherogenesis

ArticleYear
[Low and very low density lipoproteins: pathogenetic and clinical significance].
    Klinicheskaia meditsina, 2013, Volume: 91, Issue:1

    Topics: Atherosclerosis; Humans; Lipoproteins, LDL; Lipoproteins, VLDL; Metabolic Syndrome; Palmitic Acid

2013
[Prevention of atherosclerosis. Excess of palmitic acid in food--a cause of hypercholesterolemia, inflammatory syndrome, insulin resistance in myocytes, and apoptosis].
    Klinicheskaia laboratornaia diagnostika, 2011, Issue:2

    Topics: Apoptosis; Atherosclerosis; Dietary Fats; Humans; Hypercholesterolemia; Inflammation; Insulin Resist

2011
Understanding eNOS for pharmacological modulation of endothelial function: a translational view.
    Current pharmaceutical design, 2007, Volume: 13, Issue:17

    Topics: Animals; Atherosclerosis; Cardiovascular Agents; Cardiovascular Diseases; Endothelium, Vascular; Gen

2007

Trials

1 trial available for palmitic acid and Atherogenesis

ArticleYear
Palmitic acid-rich oils with and without interesterification lower postprandial lipemia and increase atherogenic lipoproteins compared with a MUFA-rich oil: A randomized controlled trial.
    The American journal of clinical nutrition, 2021, 05-08, Volume: 113, Issue:5

    Topics: Aged; Apolipoprotein B-48; Atherosclerosis; Chylomicrons; Cross-Over Studies; Dietary Fats, Unsatura

2021

Other Studies

28 other studies available for palmitic acid and Atherogenesis

ArticleYear
Curcumin Alleviates Palmitic Acid-Induced LOX-1 Upregulation by Suppressing Endoplasmic Reticulum Stress in HUVECs.
    BioMed research international, 2021, Volume: 2021

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Atherosclerosis; Cell Survival; Cells, Cultured; Curcumin;

2021
Proteome-scale profiling reveals MAFF and MAFG as two novel key transcription factors involved in palmitic acid-induced umbilical vein endothelial cell apoptosis.
    BMC cardiovascular disorders, 2021, 09-17, Volume: 21, Issue:1

    Topics: Apoptosis; Atherosclerosis; Cells, Cultured; Chromatography, Liquid; Gene Expression Regulation; Hum

2021
Palmitic acid promotes endothelial-to-mesenchymal transition via activation of the cytosolic DNA-sensing cGAS-STING pathway.
    Archives of biochemistry and biophysics, 2022, 09-30, Volume: 727

    Topics: Atherosclerosis; DNA, Mitochondrial; Endothelial Cells; Humans; Interferons; Membrane Proteins; Nucl

2022
ANGPTL4 attenuates palmitic acid-induced endothelial cell injury by increasing autophagy.
    Cellular signalling, 2022, Volume: 98

    Topics: Angiopoietin-Like Protein 4; Animals; Atherosclerosis; Autophagy; Endothelial Cells; Mice; Palmitic

2022
C1q/TNF-related protein-9 attenuates palmitic acid-induced endothelial cell senescence via increasing autophagy.
    Molecular and cellular endocrinology, 2021, 02-05, Volume: 521

    Topics: Adiponectin; AMP-Activated Protein Kinases; Atherosclerosis; Autophagosomes; Autophagy; Cellular Sen

2021
Cooperative stimulation of atherogenesis by lipopolysaccharide and palmitic acid-rich high fat diet in low-density lipoprotein receptor-deficient mice.
    Atherosclerosis, 2017, Volume: 265

    Topics: Animals; Atherosclerosis; Diet, High-Fat; Fatty Acids; Lipopolysaccharides; Male; Mice; Palmitic Aci

2017
Docosahexaenoic acid reversed atherosclerotic changes in human endothelial cells induced by palmitic acid in vitro.
    Cell biochemistry and function, 2018, Volume: 36, Issue:4

    Topics: Atherosclerosis; Cell Survival; Cells, Cultured; Docosahexaenoic Acids; Dose-Response Relationship,

2018
Docosahexaenoic acid attenuates the detrimental effect of palmitic acid on human endothelial cells by modulating genes from the atherosclerosis signaling pathway.
    Journal of cellular biochemistry, 2018, Volume: 119, Issue:12

    Topics: Apoptosis; Atherosclerosis; Cell Survival; Docosahexaenoic Acids; Gene Expression Regulation; Granul

2018
The effects of pro- and anti-atherosclerotic factors on intracellular nucleotide concentration in murine endothelial cells.
    Nucleosides, nucleotides & nucleic acids, 2018, Volume: 37, Issue:11

    Topics: Adenosine Triphosphate; Animals; Atherosclerosis; Atorvastatin; Blood Vessels; Cell Line; Cytokines;

2018
AICAR inhibits PPARγ during monocyte differentiation to attenuate inflammatory responses to atherogenic lipids.
    Cardiovascular research, 2013, Jun-01, Volume: 98, Issue:3

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Anti-Inflammatory Agents; Atherosclerosis

2013
Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members.
    Lipids in health and disease, 2013, Jul-23, Volume: 12

    Topics: Acyltransferases; Apoptosis Regulatory Proteins; Atherosclerosis; Cell Line; Cell Survival; Choleste

2013
A key mediator, PTX3, of IKK/IκB/NF-κB exacerbates human umbilical vein endothelial cell injury and dysfunction.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:11

    Topics: Apoptosis; Atherosclerosis; C-Reactive Protein; Cell Survival; Human Umbilical Vein Endothelial Cell

2014
Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process.
    Cardiovascular diabetology, 2015, Jun-10, Volume: 14

    Topics: Angiotensin II; Animals; Apoptosis; Atherosclerosis; Blotting, Western; Cell Line; Cell Proliferatio

2015
Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IκB/NF-κB, in atherosclerotic cell model.
    Experimental & molecular medicine, 2015, Jul-03, Volume: 47

    Topics: Apoptosis; Atherosclerosis; Biphenyl Compounds; C-Reactive Protein; Down-Regulation; Drugs, Chinese

2015
Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504.
    Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:5

    Topics: Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Cell Movement; Cell Proliferation; Cells

2016
Up-Regulation of CREG Expression by the Transcription Factor GATA1 Inhibits High Glucose- and High Palmitate-Induced Apoptosis in Human Umbilical Vein Endothelial Cells.
    PloS one, 2016, Volume: 11, Issue:5

    Topics: Apoptosis; Atherosclerosis; Base Sequence; Diabetes Mellitus; Dose-Response Relationship, Drug; GATA

2016
Dietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammation.
    The Journal of nutritional biochemistry, 2016, Volume: 32

    Topics: Animals; Aorta; Atherosclerosis; Biomarkers; Cholesterol; Cytokines; Diet, High-Fat; Endothelium, Va

2016
Pentraxin 3 is an anti-inflammatory protein associated with lipid-induced interleukin 10 in vitro.
    Cytokine, 2016, Volume: 86

    Topics: Adult; Atherosclerosis; C-Reactive Protein; Cells, Cultured; Cytokines; Humans; Inflammation; Interl

2016
Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Activating Transcription Factor 6; Animals; Aorta; Apolipoproteins E; Apoptosis; Atherosclerosis; Ch

2016
Palmitic acid enhances lectin-like oxidized LDL receptor (LOX-1) expression and promotes uptake of oxidized LDL in macrophage cells.
    Atherosclerosis, 2010, Volume: 209, Issue:1

    Topics: Animals; Atherosclerosis; Cell Line, Tumor; Down-Regulation; Humans; Interleukin-1 Receptor-Associat

2010
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.
    Diabetes, 2010, Volume: 59, Issue:4

    Topics: Angiogenesis Inhibitors; Atherosclerosis; Carotid Arteries; Down-Regulation; Glucose; Glucose Tolera

2010
Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4.
    Biochemical and biophysical research communications, 2010, Feb-26, Volume: 393, Issue:1

    Topics: Atherosclerosis; Carnitine O-Palmitoyltransferase; Cell Line, Tumor; Down-Regulation; Fatty Acid-Bin

2010
Monoacylglycerol (MAG)-oleic acid has stronger antioxidant, anti-atherosclerotic, and protein glycation inhibitory activities than MAG-palmitic acid.
    Journal of medicinal food, 2010, Volume: 13, Issue:1

    Topics: Antioxidants; Apolipoproteins; Aryldialkylphosphatase; Atherosclerosis; Cell Line; Cholesterol, LDL;

2010
[The role of modification of fatty acid composition of erythrocyte lipids in pathogenesis of arterial hypertension].
    Kardiologiia, 2010, Volume: 50, Issue:7

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Atherosclerosis; Biological Transport, Active; Carbon

2010
Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis.
    Free radical biology & medicine, 2012, Aug-15, Volume: 53, Issue:4

    Topics: Animals; Aorta; Atherosclerosis; CD11b Antigen; CD36 Antigens; Cell Adhesion; Cell Line; Cell Prolif

2012
Differential impact of oleate, palmitate, and adipokines on expression of NF-κB target genes in human vascular smooth muscle cells.
    Molecular and cellular endocrinology, 2012, Oct-15, Volume: 362, Issue:1-2

    Topics: Activins; Adipocytes; Adipokines; Angiopoietins; Apoptosis Regulatory Proteins; Atherosclerosis; Cel

2012
Vascular metabolic dysfunction and lipotoxicity.
    Physiological research, 2007, Volume: 56, Issue:2

    Topics: Albumins; Animals; Aorta; Apoptosis; Atherosclerosis; Boron Compounds; Carotid Arteries; Cell Line;

2007
Localization of lipids in the aortic wall with imaging TOF-SIMS.
    Biochimica et biophysica acta, 2007, Volume: 1771, Issue:2

    Topics: Animals; Aorta; Atherosclerosis; Cholesterol; Fatty Acids, Monounsaturated; Freeze Drying; Humans; L

2007