palmitic acid has been researched along with Alloxan Diabetes in 92 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Curcumin improves muscular insulin resistance by increasing oxidation of fatty acid and glucose, which is, at least in part, mediated through LKB1-AMPK pathway." | 7.77 | Curcumin improves insulin resistance in skeletal muscle of rats. ( Kong, T; Li, R; Li, Y; Liu, LY; Na, LX; Sun, CH; Zhang, YL, 2011) |
| " To simulate a similar in-vivo condition, we persuaded insulin resistance in H9c2 cells by palmitic acid (PA) treatment." | 4.12 | Empagliflozin prohibits high-fructose diet-induced cardiac dysfunction in rats via attenuation of mitochondria-driven oxidative stress. ( Alam, MJ; Arava, S; Banerjee, SK; Bugga, P; Katare, P; Maulik, SK; Meghwani, H; Mohammed, SA, 2022) |
| " Here, we report that KIM-1 mediates PT uptake of palmitic acid (PA)-bound albumin, leading to enhanced tubule injury with DNA damage, PT cell-cycle arrest, interstitial inflammation and fibrosis, and secondary glomerulosclerosis." | 4.02 | KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. ( Ajay, AK; Bonventre, JV; Brooks, CR; Chang, JH; Galichon, P; Hawkins, J; Henderson, JM; Ichimura, T; Kishi, S; Kuchroo, VK; Li, J; Li, L; Mori, Y; Mou, S; Palmer, SC; Sabbisetti, VS; Woo, HM; Xiao, S; Zhao, H, 2021) |
| "In the present experiment, we used HepG2 cells, a human hepatoma cell line, and a MSC-HepG2 transwell culturing system to investigate the anti-inflammatory mechanism of human umbilical cord-derived MSCs (UC-MSCs) under palmitic acid (PA) and lipopolysaccharide (LPS)-induced insulin resistance in vitro." | 3.85 | Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats. ( Dong, L; Han, Q; Han, W; Hao, H; Liu, J; Mu, Y; Song, X; Sun, X, 2017) |
| "APS treatment ameliorated hyperglycemia, hyperlipidemia, and insulin resistance and decreased the elevation of myostatin expression and malondialdehyde production in skeletal muscle of noninsulin-dependent diabetic KKAy mice." | 3.79 | Astragalus polysaccharide suppresses skeletal muscle myostatin expression in diabetes: involvement of ROS-ERK and NF-κB pathways. ( Hao, Y; Liu, M; Luo, J; Luo, T; Qin, J; Wei, L, 2013) |
| "Curcumin improves muscular insulin resistance by increasing oxidation of fatty acid and glucose, which is, at least in part, mediated through LKB1-AMPK pathway." | 3.77 | Curcumin improves insulin resistance in skeletal muscle of rats. ( Kong, T; Li, R; Li, Y; Liu, LY; Na, LX; Sun, CH; Zhang, YL, 2011) |
| "Palmitic acid was used to stimulate cardiomyocytes to establish a myocardial lipotoxicity model." | 1.62 | Ophiopogonin D alleviates diabetic myocardial injuries by regulating mitochondrial dynamics. ( Chen, H; Guo, W; Ji, L; Li, W; Lu, R; Shan, X; Tang, W; Tian, J; Xu, M; Zhang, C; Zhao, P, 2021) |
| "We recently published that type 2 diabetes promotes cell centrosome amplification via upregulation of Rho-associated protein kinase 1 (ROCK1) and 14-3-3 protein-σ (14-3-3σ)." | 1.56 | Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4. ( He, QJ; Lee, SC; Li, YF; Liu, QQ; Wang, J; Wang, P; Wu, QG, 2020) |
| " The decrease in nitric oxide (NO) bioavailability is the hallmark of endothelial dysfunction, and it leads to attenuated vascular relaxation and atherosclerosis followed by a decrease in blood flow." | 1.39 | Coronary endothelial dysfunction and mitochondrial reactive oxygen species in type 2 diabetic mice. ( Basu, A; Cho, YE; Dai, A; Heldak, M; Makino, A, 2013) |
| "Overt type 2 diabetes is associated with diminished islet expression of SCD and Elovl6, and this can disrupt desaturation of saturated FAs to MUFAs, rendering β-cells more susceptible to saturated FA-induced ER stress and apoptosis." | 1.37 | Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6. ( Green, CD; Olson, LK, 2011) |
| " BI (oral I) containing SBE had greater reduction of blood glucose than BII (oral II) ,showing that SBE increased the bioavailability of insulin." | 1.35 | Evaluation of the pharmacodynamic activity of insulin from bilosomal formulation. ( Attama, AA; Ayogu, IJ; Ayolugbe, CI; Ogbonna, O, 2009) |
| "Both diabetes and hypergalactosemia are believed to cause vascular dysfunction via a common biochemical mechanism." | 1.29 | Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. ( Engerman, RL; Inoguchi, T; Kern, TS; King, GL; Oates, PJ; Xia, P, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (23.91) | 18.7374 |
| 1990's | 12 (13.04) | 18.2507 |
| 2000's | 15 (16.30) | 29.6817 |
| 2010's | 29 (31.52) | 24.3611 |
| 2020's | 14 (15.22) | 2.80 |
| Authors | Studies |
|---|---|
| Bugga, P | 1 |
| Mohammed, SA | 1 |
| Alam, MJ | 1 |
| Katare, P | 1 |
| Meghwani, H | 1 |
| Maulik, SK | 1 |
| Arava, S | 1 |
| Banerjee, SK | 1 |
| Xie, S | 1 |
| Zhang, M | 1 |
| Shi, W | 1 |
| Xing, Y | 1 |
| Huang, Y | 1 |
| Fang, WX | 1 |
| Liu, SQ | 1 |
| Chen, MY | 1 |
| Zhang, T | 1 |
| Chen, S | 1 |
| Zeng, X | 1 |
| Wang, S | 1 |
| Deng, W | 1 |
| Tang, Q | 1 |
| Alka, K | 1 |
| Mohammad, G | 1 |
| Kowluru, RA | 1 |
| Jamil, S | 1 |
| Dastagir, G | 1 |
| Foudah, AI | 1 |
| Alqarni, MH | 1 |
| Yusufoglu, HS | 1 |
| Alkreathy, HM | 1 |
| Ertürk, Ö | 1 |
| Shah, MAR | 1 |
| Khan, RA | 1 |
| Du, Q | 1 |
| Wu, X | 1 |
| Ma, K | 1 |
| Liu, W | 1 |
| Liu, P | 1 |
| Hayashi, T | 1 |
| Mizuno, K | 1 |
| Hattori, S | 1 |
| Fujisaki, H | 1 |
| Ikejima, T | 1 |
| He, QJ | 2 |
| Wang, P | 3 |
| Liu, QQ | 2 |
| Wu, QG | 1 |
| Li, YF | 1 |
| Wang, J | 1 |
| Lee, SC | 3 |
| Wu, Q | 1 |
| Chen, X | 2 |
| He, Q | 2 |
| Lang, L | 1 |
| Xu, P | 1 |
| Wen, XH | 1 |
| Guo, QL | 1 |
| Guo, JC | 1 |
| Huang, JS | 1 |
| Guo, BB | 1 |
| Wang, GH | 1 |
| Zeng, LM | 1 |
| Hu, YH | 1 |
| Wang, T | 1 |
| Wang, HY | 1 |
| Hu, HQ | 1 |
| Qiao, JT | 1 |
| Liu, FQ | 1 |
| Wang, JB | 1 |
| Sha, S | 1 |
| Cui, C | 1 |
| Song, J | 1 |
| Zang, N | 1 |
| Wang, LS | 1 |
| Sun, Z | 1 |
| Chen, L | 2 |
| Hou, XG | 1 |
| Li, W | 2 |
| Ji, L | 1 |
| Tian, J | 1 |
| Tang, W | 1 |
| Shan, X | 1 |
| Zhao, P | 1 |
| Chen, H | 1 |
| Zhang, C | 2 |
| Xu, M | 2 |
| Lu, R | 1 |
| Guo, W | 1 |
| Zhang, N | 1 |
| Liu, C | 1 |
| Zhang, Y | 2 |
| Xu, D | 1 |
| Gui, L | 1 |
| Lu, Y | 1 |
| Zhang, Q | 1 |
| Mori, Y | 1 |
| Ajay, AK | 1 |
| Chang, JH | 1 |
| Mou, S | 1 |
| Zhao, H | 1 |
| Kishi, S | 1 |
| Li, J | 1 |
| Brooks, CR | 1 |
| Xiao, S | 1 |
| Woo, HM | 1 |
| Sabbisetti, VS | 1 |
| Palmer, SC | 1 |
| Galichon, P | 1 |
| Li, L | 1 |
| Henderson, JM | 1 |
| Kuchroo, VK | 1 |
| Hawkins, J | 1 |
| Ichimura, T | 1 |
| Bonventre, JV | 1 |
| Zhang, B | 1 |
| Li, X | 4 |
| Liu, G | 1 |
| Zhang, X | 1 |
| Shen, Q | 1 |
| Sun, G | 1 |
| Sun, X | 2 |
| Rumora, AE | 1 |
| Lentz, SI | 1 |
| Hinder, LM | 1 |
| Jackson, SW | 1 |
| Valesano, A | 1 |
| Levinson, GE | 1 |
| Feldman, EL | 1 |
| Skarbaliene, J | 1 |
| Rigbolt, KT | 1 |
| Fosgerau, K | 1 |
| Billestrup, N | 1 |
| Wang, L | 1 |
| Fan, S | 1 |
| Song, S | 1 |
| Min, H | 1 |
| Wu, Y | 1 |
| He, X | 1 |
| Liang, Q | 1 |
| Wang, Y | 3 |
| Yi, L | 1 |
| Gao, Q | 1 |
| Hao, H | 1 |
| Han, Q | 1 |
| Song, X | 1 |
| Liu, J | 2 |
| Dong, L | 1 |
| Han, W | 1 |
| Mu, Y | 1 |
| He, Y | 1 |
| Zhou, L | 1 |
| Fan, Z | 1 |
| Liu, S | 2 |
| Fang, W | 1 |
| Wu, XM | 1 |
| Ren, T | 1 |
| Liu, JF | 1 |
| Liu, YJ | 1 |
| Yang, LC | 1 |
| Jin, X | 1 |
| Jin, SJ | 1 |
| Su, J | 1 |
| Li, XX | 1 |
| Ruan, JS | 1 |
| Lin, JK | 1 |
| Kuo, YY | 1 |
| Chen, YW | 1 |
| Chen, PC | 1 |
| Liu, Q | 1 |
| Huan, Y | 1 |
| Li, R | 2 |
| Li, C | 3 |
| Sun, S | 1 |
| Guo, N | 1 |
| Yang, M | 1 |
| Shen, Z | 1 |
| Fu, J | 1 |
| Zhang, G | 1 |
| Tong, X | 1 |
| Zhang, H | 1 |
| Ding, J | 1 |
| Ma, Y | 1 |
| Cheng, R | 1 |
| Hou, S | 1 |
| An, S | 1 |
| Ma, S | 1 |
| Ma, R | 1 |
| Hamad, ARA | 1 |
| Sadasivam, M | 1 |
| Rabb, H | 1 |
| Syed, I | 1 |
| Rubin de Celis, MF | 1 |
| Mohan, JF | 1 |
| Moraes-Vieira, PM | 1 |
| Vijayakumar, A | 1 |
| Nelson, AT | 1 |
| Siegel, D | 1 |
| Saghatelian, A | 1 |
| Mathis, D | 1 |
| Kahn, BB | 1 |
| Zhao, Y | 1 |
| Tan, Y | 1 |
| Xi, S | 1 |
| Li, Y | 2 |
| Cui, J | 1 |
| Yan, X | 1 |
| Wang, G | 1 |
| Cai, L | 1 |
| Bi, L | 1 |
| Chiang, JY | 1 |
| Ding, WX | 1 |
| Dunn, W | 1 |
| Roberts, B | 1 |
| Li, T | 1 |
| Cho, YE | 1 |
| Basu, A | 1 |
| Dai, A | 1 |
| Heldak, M | 1 |
| Makino, A | 1 |
| Wei, X | 1 |
| Song, H | 1 |
| Semenkovich, CF | 1 |
| Liu, M | 2 |
| Qin, J | 2 |
| Hao, Y | 1 |
| Luo, J | 1 |
| Luo, T | 1 |
| Wei, L | 1 |
| Fang, N | 1 |
| Lou, J | 1 |
| Zhang, W | 1 |
| Xu, S | 1 |
| Liu, H | 1 |
| Fang, Q | 1 |
| Wang, Z | 2 |
| Men, X | 1 |
| Peng, L | 1 |
| Wu, W | 1 |
| Xu, H | 1 |
| Mao, Y | 1 |
| Yuan, L | 1 |
| Luo, W | 1 |
| Cui, Z | 1 |
| Cui, T | 1 |
| Wang, XL | 1 |
| Shen, YH | 1 |
| Wang, X | 1 |
| Gupta, J | 1 |
| Kerslake, M | 1 |
| Rayat, G | 1 |
| Proctor, SD | 1 |
| Chan, CB | 1 |
| Kuwagata, S | 1 |
| Kume, S | 1 |
| Chin-Kanasaki, M | 1 |
| Araki, H | 1 |
| Araki, S | 1 |
| Nakazawa, J | 1 |
| Sugaya, T | 1 |
| Koya, D | 1 |
| Haneda, M | 1 |
| Maegawa, H | 1 |
| Uzu, T | 1 |
| Li, Q | 1 |
| Kim, YR | 1 |
| Vikram, A | 1 |
| Kumar, S | 1 |
| Kassan, M | 1 |
| Gabani, M | 1 |
| Lee, SK | 1 |
| Jacobs, JS | 1 |
| Irani, K | 1 |
| Kim, MS | 1 |
| Wang, F | 1 |
| Puthanveetil, P | 1 |
| Kewalramani, G | 1 |
| Hosseini-Beheshti, E | 1 |
| Ng, N | 1 |
| Kumar, U | 1 |
| Innis, S | 1 |
| Proud, CG | 1 |
| Abrahani, A | 2 |
| Rodrigues, B | 2 |
| Larade, K | 1 |
| Jiang, Z | 1 |
| Wang, W | 1 |
| Bonner-Weir, S | 1 |
| Zhu, H | 1 |
| Bunn, HF | 1 |
| Ayogu, IJ | 1 |
| Ogbonna, O | 1 |
| Ayolugbe, CI | 1 |
| Attama, AA | 1 |
| Juan, YC | 1 |
| Tsai, WJ | 1 |
| Lin, YL | 1 |
| Wang, GJ | 1 |
| Cheng, JJ | 1 |
| Yang, HY | 1 |
| Hsu, CY | 1 |
| Liu, HK | 1 |
| Na, LX | 1 |
| Zhang, YL | 1 |
| Liu, LY | 1 |
| Kong, T | 1 |
| Sun, CH | 1 |
| Green, CD | 1 |
| Olson, LK | 1 |
| Kulkarni, SS | 1 |
| Karlsson, HK | 1 |
| Szekeres, F | 1 |
| Chibalin, AV | 1 |
| Krook, A | 1 |
| Zierath, JR | 1 |
| Lee, J | 2 |
| Lee, C | 2 |
| Kim, I | 1 |
| Moon, HR | 2 |
| Kim, TH | 2 |
| Oh, KT | 2 |
| Lee, ES | 2 |
| Lee, KC | 2 |
| Youn, YS | 2 |
| Chi, SC | 1 |
| Maslov, DL | 1 |
| Lokhov, PG | 1 |
| Abakumova, OY | 1 |
| Tsvetkova, TA | 1 |
| Prozorovskiy, VN | 1 |
| Zendzian-Piotrowska, M | 1 |
| Górska, M | 1 |
| Zabielski, P | 1 |
| LOSSOW, WJ | 2 |
| BROWN, GW | 1 |
| CHAIKOFF, IL | 3 |
| HILL, R | 1 |
| SOSS, AW | 1 |
| OSTMAN, J | 2 |
| SHICHIRI, M | 1 |
| TARRANT, ME | 1 |
| MAHLER, R | 1 |
| ASHMORE, J | 1 |
| JONES, JA | 1 |
| BLECHER, M | 1 |
| STRISOWER, EH | 1 |
| WEINMAN, EO | 1 |
| Pari, L | 1 |
| Venkateswaran, S | 1 |
| Ghosh, S | 1 |
| An, D | 1 |
| Pulinilkunnil, T | 1 |
| Qi, D | 1 |
| Lau, HC | 1 |
| Innis, SM | 1 |
| Alba-Loureiro, TC | 1 |
| Hirabara, SM | 1 |
| Mendonça, JR | 1 |
| Curi, R | 1 |
| Pithon-Curi, TC | 1 |
| Gerber, LK | 1 |
| Aronow, BJ | 1 |
| Matlib, MA | 1 |
| King, KL | 1 |
| Young, ME | 1 |
| Kerner, J | 1 |
| Huang, H | 1 |
| O'Shea, KM | 1 |
| Alexson, SE | 1 |
| Hoppel, CL | 1 |
| Stanley, WC | 1 |
| Onay-Besikci, A | 1 |
| Guner, S | 1 |
| Arioglu, E | 1 |
| Ozakca, I | 1 |
| Ozcelikay, AT | 1 |
| Altan, VM | 1 |
| Sharma, V | 1 |
| Dhillon, P | 1 |
| Wambolt, R | 1 |
| Parsons, H | 1 |
| Brownsey, R | 1 |
| Allard, MF | 1 |
| McNeill, JH | 1 |
| Murthy, VK | 1 |
| Bauman, MD | 1 |
| Shipp, JC | 1 |
| Dahlkvist, HH | 2 |
| Arnqvist, HJ | 2 |
| Norrby, K | 2 |
| Pieper, GM | 2 |
| Murray, WJ | 2 |
| Salhany, JM | 2 |
| Wu, ST | 2 |
| Eliot, RS | 2 |
| Ohgaku, S | 2 |
| Brady, PS | 2 |
| Schumann, WC | 2 |
| Bartsch, GE | 2 |
| Margolis, JM | 2 |
| Kumaran, K | 2 |
| Landau, SB | 1 |
| Landau, BR | 2 |
| Scofield, RF | 1 |
| Horvat, A | 1 |
| Mann, S | 1 |
| Chen, V | 1 |
| Bagby, GJ | 1 |
| Spitzer, JJ | 1 |
| Pouliot, JF | 1 |
| Béliveau, R | 1 |
| Xia, P | 1 |
| Inoguchi, T | 1 |
| Kern, TS | 1 |
| Engerman, RL | 1 |
| Oates, PJ | 1 |
| King, GL | 1 |
| Sener, A | 1 |
| Giroix, MH | 1 |
| Malaisse-Lagae, F | 1 |
| Bailbe, D | 1 |
| Leclercq-Meyer, V | 1 |
| Portha, B | 1 |
| Malaisse, WJ | 1 |
| Myers, SR | 1 |
| Yakubu-Madus, FE | 1 |
| Johnson, WT | 1 |
| Baker, JE | 1 |
| Cusick, TS | 1 |
| Williams, VK | 1 |
| Tinsley, FC | 1 |
| Kriauciunas, A | 1 |
| Manetta, J | 1 |
| Chen, VJ | 1 |
| Abdel-aleem, S | 1 |
| Karim, AM | 1 |
| Zarouk, WA | 1 |
| Taylor, DA | 1 |
| el-Awady, MK | 1 |
| Lowe, JE | 1 |
| Smith, JM | 1 |
| Solar, SM | 1 |
| Paulson, DJ | 2 |
| Hill, NM | 1 |
| Broderick, TL | 1 |
| Van Der Lee, KA | 1 |
| Willemsen, PH | 1 |
| Van Der Vusse, GJ | 1 |
| Van Bilsen, M | 1 |
| Sakamoto, J | 1 |
| Barr, RL | 1 |
| Kavanagh, KM | 1 |
| Lopaschuk, GD | 3 |
| Chatham, JC | 1 |
| Des Rosiers, C | 1 |
| Forder, JR | 1 |
| Saddik, M | 1 |
| Barr, R | 1 |
| Huang, L | 1 |
| Barker, CC | 1 |
| Muzyka, RA | 1 |
| Mathews, R | 1 |
| Bowman, J | 1 |
| Zhao, J | 1 |
| Hartvig, P | 1 |
| Waldenström, A | 1 |
| Wikström, G | 1 |
| Zielinski, T | 1 |
| Martinussen, HJ | 1 |
| Carlsten, J | 1 |
| Voipio-Pulkki, LM | 1 |
| Lundqvist, H | 1 |
| Bjurling, P | 1 |
| Någren, K | 1 |
| Engström, E | 1 |
| Haglund, A | 1 |
| Eriksson, UJ | 1 |
| Wang, PY | 1 |
| Mokuda, O | 1 |
| Sakamoto, Y | 1 |
| Ikeda, T | 1 |
| Mashiba, H | 1 |
| Thomas, CR | 1 |
| Evans, JL | 1 |
| Lowy, C | 1 |
| Minnich, A | 1 |
| Zilversmit, DB | 1 |
| Burke, JP | 1 |
| Fenton, MR | 1 |
| Tsang, H | 1 |
| Kaiser, KP | 1 |
| Feinendegen, LE | 2 |
| Beckurts, TE | 1 |
| Shreeve, WW | 1 |
| Schieren, R | 1 |
92 other studies available for palmitic acid and Alloxan Diabetes
| Article | Year |
|---|---|
Empagliflozin prohibits high-fructose diet-induced cardiac dysfunction in rats via attenuation of mitochondria-driven oxidative stress.
Topics: Animals; Benzhydryl Compounds; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mel | 2022 |
Long-Term Activation of Glucagon-like peptide-1 receptor by Dulaglutide Prevents Diabetic Heart Failure and Metabolic Remodeling in Type 2 Diabetes.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2022 |
Regulation of serine palmitoyl-transferase and Rac1-Nox2 signaling in diabetic retinopathy.
Topics: Animals; Ceramides; Cytosine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic R | 2022 |
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Bilirubin; Blood Glucose; Carduus; Creatinine; Diabete | 2022 |
Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ferroptosis; Glucose; Mitophagy | 2023 |
Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
Topics: 14-3-3 Proteins; Animals; Biomarkers, Tumor; Blood Glucose; Centrosome; Diabetes Mellitus, Experimen | 2020 |
Resveratrol attenuates diabetes-associated cell centrosome amplification via inhibiting the PKCα-p38 to c-myc/c-jun pathway.
Topics: Animals; Centrosome; Colon; Diabetes Mellitus, Experimental; Gene Knockdown Techniques; Glucose; HCT | 2020 |
Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism.
Topics: Aging; Animals; Behavior, Animal; Blood Glucose; Body Weight; Brain; Brain-Derived Neurotrophic Fact | 2020 |
DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis.
Topics: Animals; Apoptosis; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2021 |
The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes.
Topics: Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ins | 2020 |
Ophiopogonin D alleviates diabetic myocardial injuries by regulating mitochondrial dynamics.
Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Calcineurin; Calcium; Cardiotonic Agents; Cell Line; | 2021 |
Liraglutide regulates lipid metabolism via FGF21- LKB1- AMPK- ACC1 pathway in white adipose tissues and macrophage of type 2 diabetic mice.
Topics: Acetyl-CoA Carboxylase; Adipocytes; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; B | 2021 |
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease.
Topics: Animals; Benzamides; Cell Cycle Checkpoints; Diabetes Mellitus, Experimental; Diabetic Nephropathies | 2021 |
Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy.
Topics: Animals; Apoptosis; Cell Line; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Dose-Resp | 2021 |
Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Dyslipidemias; Energy Metabolism; Ganglia | 2018 |
In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes.
Topics: Amino Acid Sequence; Animals; Apoptosis; Blood Glucose; Body Weight; Cell Proliferation; Cytokines; | 2017 |
Puerarin acts on the skeletal muscle to improve insulin sensitivity in diabetic rats involving μ-opioid receptor.
Topics: Animals; Cell Membrane; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucose; Glucos | 2018 |
Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats.
Topics: Animals; Caspase 3; Coculture Techniques; Diabetes Mellitus, Experimental; Female; Fetal Blood; Gene | 2017 |
Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N‑acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress.
Topics: Acetylcysteine; Animals; Apoptosis; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Stress; G | 2018 |
Vernonia amygdalina Delile extract inhibits the hepatic gluconeogenesis through the activation of adenosine-5'monophosph kinase.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme Activ | 2018 |
Acid Sphingomyelinase Down-regulation Alleviates Vascular Endothelial Insulin Resistance in Diabetic Rats.
Topics: Amitriptyline; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Down-Regulation; End | 2018 |
Chronic palmitic acid-induced lipotoxicity correlates with defective trafficking of ATP sensitive potassium channels in pancreatic β cells.
Topics: Animals; Cell Line, Tumor; Diabetes Mellitus, Experimental; Glyburide; Insulin-Secreting Cells; Insu | 2018 |
Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Caspase | 2018 |
Crucial Roles of 5-HT and 5-HT2 Receptor in Diabetes-Related Lipid Accumulation and Pro-Inflammatory Cytokine Generation in Hepatocytes.
Topics: Animals; Cytokines; Diabetes Mellitus, Experimental; GTP-Binding Protein alpha Subunits, Gq-G11; Hep | 2018 |
PPARγ promotes diabetes-associated centrosome amplification via increasing the expression of SKA1 directly at the transcriptional level.
Topics: Animals; Centrosome; Chromosomal Proteins, Non-Histone; Colon; Diabetes Mellitus, Experimental; Fema | 2019 |
Hybrid lipids, peptides, and lymphocytes: new era in type 1 diabetes research.
Topics: Animals; Cell Survival; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Esters; Hydroxy | 2019 |
PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.
Topics: Adult; Aged; Animals; Cell Survival; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Est | 2019 |
A novel mechanism by which SDF-1β protects cardiac cells from palmitate-induced endoplasmic reticulum stress and apoptosis via CXCR7 and AMPK/p38 MAPK-mediated interleukin-6 generation.
Topics: Adenylate Kinase; Animals; Apoptosis; Benzylamines; Cell Line; Chemokine CXCL12; Cyclams; Diabetes M | 2013 |
Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Diabetes Mellitus, Experimental; Down-Regulation; Dy | 2013 |
Coronary endothelial dysfunction and mitochondrial reactive oxygen species in type 2 diabetic mice.
Topics: Acetylcholine; Animals; Coronary Vessels; Culture Media; Diabetes Mellitus, Experimental; Endothelia | 2013 |
Insulin-regulated protein palmitoylation impacts endothelial cell function.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Cattle; Cell Membrane; Cell Movement; Chlor | 2014 |
Astragalus polysaccharide suppresses skeletal muscle myostatin expression in diabetes: involvement of ROS-ERK and NF-κB pathways.
Topics: Animals; Blood Glucose; Body Weight; Cell Line; Diabetes Mellitus, Experimental; Extracellular Signa | 2013 |
TRB3 is involved in free fatty acid-induced INS-1-derived cell apoptosis via the protein kinase C δ pathway.
Topics: Animals; Apoptosis; Caspase 3; Caspase 7; Cell Cycle Proteins; Cell Line; Diabetes Mellitus, Experim | 2014 |
PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury.
Topics: Animals; Autophagy; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelial Cells; Endothelium | 2015 |
Trans-11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro.
Topics: Aged; Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, | 2016 |
MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells.
Topics: Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Experimental; Glucose; Hypoxia; JNK Mitogen- | 2016 |
P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.
Topics: Animals; Antioxidants; Aorta; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Angiopathie | 2016 |
Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Glucose; Heat-Shock Proteins; HSP27 Heat- | 2008 |
Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes.
Topics: Animals; Apoptosis; Cell Survival; Cytochrome-B(5) Reductase; Diabetes Mellitus, Experimental; Fatty | 2008 |
Evaluation of the pharmacodynamic activity of insulin from bilosomal formulation.
Topics: Administration, Oral; Animals; Biological Availability; Blood Glucose; Chemistry, Pharmaceutical; Ch | 2009 |
The novel anti-hyperglycemic effect of Paeoniae radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK).
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetophenones; Animals; Benzoates; Bridged-Ring Compounds; C | 2010 |
Curcumin improves insulin resistance in skeletal muscle of rats.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Biological Transport; Cell Line; Curcumin; Deoxygluco | 2011 |
Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.
Topics: Acetyltransferases; Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes M | 2011 |
Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Gene Expression Regulation; | 2011 |
Preparation and evaluation of palmitic acid-conjugated exendin-4 with delayed absorption and prolonged circulation for longer hypoglycemia.
Topics: Absorption; Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus; Diabetes Mellitu | 2012 |
Pulmonary administered palmitic-acid modified exendin-4 peptide prolongs hypoglycemia in type 2 diabetic db/db mice.
Topics: Administration, Inhalation; Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, | 2012 |
New peptidomimetics of insulin.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; DNA; Dose-Response Relationship, Drug; Gluc | 2002 |
Effect of diabetes and contractile activity on incorporation of the plasma-borne fatty acids into skeletal muscle lipids.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Fatty Acids; Lipids; Male; Muscle | 2002 |
The action of insulin in sparing fatty acid oxidation: a study with palmitic acid-1-C14 and octanoate-1-C14.
Topics: Animals; Caprylates; Diabetes Mellitus, Experimental; Fatty Acids; Insulin; Lipid Metabolism; Oxidat | 1956 |
Extrahepatic oxidation of albumin-bound palmitic acid in the diabetic rat; its regulation by insulin.
Topics: Albumins; Animals; Diabetes Mellitus, Experimental; Fatty Acids; Insulin; Lipid Metabolism; Oxidatio | 1958 |
EFFECT OF NICOTINIC ACID ON THE FATTY ACID METABOLISM OF ADIPOSE TISSUE IN ALLOXAN DIABETIC RATS.
Topics: Adipose Tissue; Alloxan; Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Epididymis; Fatt | 1964 |
BIOCHEMICAL STUDIES ON PERIPHERAL NERVES IN ALLOXAN DIABETIC ANIMALS. 3. METABOLISM OF PALMITATE-1-C14 IN PERIPHERAL NERVES.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Metabolism; Palmitates; Palmitic Acid; Peripheral | 1964 |
STUDIES IN EXPERIMENTAL DIABETES. IV. FREE FATTY ACID MOBILIZATION.
Topics: Adipose Tissue; Animals; Blood Glucose; Carbon Isotopes; Diabetes Mellitus; Diabetes Mellitus, Exper | 1964 |
ON THE MECHANISM OF BETA-OXIDATION OF LONG CHAIN FATTY ACIDS BY LIVER MITOCHONDRIA FROM NORMAL AND ALLOXAN-DIABETIC RATS.
Topics: Alloxan; Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Fatty Acids; Liver; Mitochondria | 1965 |
INHIBITORY EFFECT OF NICOTINIC ACID ON FFA MOBILIZATION IN ALLOXAN-DIABETIC RATS. II. A COMPARISON OF THE EFFECT OF NICOTINIC ACID AND SALICYLATE ON THE FATTY ACID METABOLISM AND GLUCOSE UPTAKE BY ADIPOSE TISSUE IN VITRO.
Topics: Adipose Tissue; Alloxan; Animals; Carbohydrate Metabolism; Carbon Isotopes; Diabetes Mellitus, Exper | 1965 |
Conversion of C14-palmitic acid to glucose. I. Normal and diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Fatty Acids; Glucose; Lipid Metabolism; Palmitic Acid; Rat | 1951 |
Protective role of Phaseolus vulgaris on changes in the fatty acid composition in experimental diabetes.
Topics: alpha-Linolenic Acid; Animals; Arachidonic Acid; Blood Glucose; Brain Chemistry; Cholesterol; Diabet | 2004 |
Role of dietary fatty acids and acute hyperglycemia in modulating cardiac cell death.
Topics: Animals; Apoptosis; Cardiovascular Diseases; Diabetes Mellitus, Experimental; Dietary Fats, Unsatura | 2004 |
Diabetes causes marked changes in function and metabolism of rat neutrophils.
Topics: Animals; Blood Glucose; Cells, Cultured; Citrate (si)-Synthase; Diabetes Mellitus, Experimental; Glu | 2006 |
Activation of a novel long-chain free fatty acid generation and export system in mitochondria of diabetic rat hearts.
Topics: Animals; Atractyloside; Biological Transport; Cell Respiration; Diabetes Mellitus, Experimental; Enz | 2006 |
Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart.
Topics: Animals; Diabetes Mellitus, Experimental; Fenofibrate; Ion Channels; Male; Mitochondria, Heart; Mito | 2007 |
The effects of chronic trimetazidine treatment on mechanical function and fatty acid oxidation in diabetic rat hearts.
Topics: Acetyl-CoA C-Acyltransferase; Animals; Body Mass Index; Cardiac Output; Coronary Circulation; Diabet | 2007 |
Metoprolol improves cardiac function and modulates cardiac metabolism in the streptozotocin-diabetic rat.
Topics: Acetyl-CoA Carboxylase; Adenosine Triphosphate; Adrenergic beta-Antagonists; AMP-Activated Protein K | 2008 |
Regulation of triacylglycerol lipolysis in the perfused hearts of normal and diabetic rats.
Topics: Acetates; Animals; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; In Vitro Techniques; Insu | 1983 |
Effect of elevated substrates on substrate oxidation in normal and diabetic aorta.
Topics: 3-Hydroxybutyric Acid; Animals; Aorta; Diabetes Mellitus, Experimental; Glucose; Hydroxybutyrates; M | 1983 |
Salient effects of L-carnitine on adenine-nucleotide loss and coenzyme A acylation in the diabetic heart perfused with excess palmitic acid. A phosphorus-31 NMR and chemical extract study.
Topics: Acyl Coenzyme A; Adenine Nucleotides; Adenosine Triphosphate; Animals; Carnitine; Diabetes Mellitus, | 1984 |
Lipid-mediated impairment of normal energy metabolism in the isolated perfused diabetic rat heart studied by phosphorus-31 NMR and chemical extraction.
Topics: Acyl Coenzyme A; Adenosine Triphosphate; Animals; Carnitine; Coenzyme A; Diabetes Mellitus, Experime | 1984 |
A method for quantitating the contributions of the pathways of acetoacetate formation and its application to diabetic ketosis in vivo.
Topics: Acetoacetates; Acetyl Coenzyme A; Acyl Coenzyme A; Animals; Chemical Phenomena; Chemistry; Diabetes | 1982 |
Pathways of acetoacetate's formation in liver and kidney.
Topics: Acetoacetates; Acetyl Coenzyme A; Acyl Coenzyme A; Animals; Chemical Phenomena; Chemistry; Diabetes | 1982 |
Exogenous substrate utilization by isolated myocytes from chronically diabetic rats.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Diabetes Mellitus, Experimental; Glycolysis; In Vitr | 1983 |
Influence of diabetes on oxidation of exogenous substrates in rat aorta.
Topics: 3-Hydroxybutyric Acid; Animals; Aorta; Diabetes Mellitus, Experimental; Glucose; Hydroxybutyrates; I | 1981 |
Palmitoylation of the glucose transporter in blood-brain barrier capillaries.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Blood Glucose; Blood-Brain Barrier; Blotting, We | 1995 |
Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia.
Topics: Animals; Aorta; Arachidonic Acid; Cell Membrane; Cells, Cultured; Cytosol; Diabetes Mellitus, Experi | 1994 |
Metabolic response to nonglucidic nutrient secretagogues and enzymatic activities in pancreatic islets of adult rats after neonatal streptozotocin administration.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Animals, Newborn; Caproates; Carbon Dioxide; Diabetes Mel | 1993 |
Acylation of human insulin with palmitic acid extends the time action of human insulin in diabetic dogs.
Topics: Acylation; Animals; Blood Glucose; Chromatography, Gel; Diabetes Mellitus, Experimental; Disease Mod | 1997 |
Reduced effects of L-carnitine on glucose and fatty acid metabolism in myocytes isolated from diabetic rats.
Topics: Acetyl Coenzyme A; Acetylcarnitine; Animals; Carbon Radioisotopes; Carnitine; Citric Acid Cycle; Dia | 1997 |
Effect of palmitate on carbohydrate utilization and Na/K-ATPase activity in aortic vascular smooth muscle from diabetic rats.
Topics: Animals; Aorta, Thoracic; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; In Vitro Techniq | 1999 |
Effects of fatty acids on uncoupling protein-2 expression in the rat heart.
Topics: Aging; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Diabetes Mellitus, Experimental; Em | 2000 |
Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Blood Glucose; Body Weight; Carboxy- | 2000 |
Evidence of separate pathways for lactate uptake and release by the perfused rat heart.
Topics: Alanine; Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Glucose; Heart; Lactates; Magnet | 2001 |
Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats.
Topics: Adenosine Triphosphate; Animals; Coronary Disease; Diabetes Mellitus, Experimental; Diabetic Angiopa | 1992 |
Metabolic effects of treadmill exercise training on the diabetic heart.
Topics: Animals; Blood Glucose; Body Weight; Carbon Dioxide; Diabetes Mellitus, Experimental; Diabetic Angio | 1992 |
Metabolism of [1-11C]palmitate in the diabetic heart studied in a porcine model using positron emission tomography.
Topics: Animals; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Myocardium; Palmitic Acid; Palmitic | 1991 |
Effects of maternal diabetes or in vitro hyperglycemia on uptake of palmitic and arachidonic acid by rat embryos.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Diabetes Mellitus, Experimental; Embr | 1991 |
Palmitic acid as an excipient in implants for sustained release of insulin.
Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Delayed-Action Preparations; Diabet | 1991 |
Effects of anoxia and low free fatty acid on myocardial energy metabolism in streptozotocin-diabetic rats.
Topics: Adenosine Triphosphate; Aerobiosis; Animals; Diabetes Mellitus, Experimental; Energy Metabolism; Fat | 1990 |
The effect of alloxan induced diabetes in the rabbit on placental transfer of glucose and non-esterified fatty acids.
Topics: Animals; Blood Glucose; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Female; Fetal Blood; | 1989 |
Impaired triacylglycerol catabolism in hypertriglyceridemia of the diabetic, cholesterol-fed rabbit: a possible mechanism for protection from atherosclerosis.
Topics: Animals; Arteriosclerosis; Cholesterol, Dietary; Diabetes Mellitus, Experimental; Female; Heparin; H | 1989 |
Plasma and cellular zinc levels and membrane lipid composition in streptozotocin diabetic rats.
Topics: Animals; Cell Membrane; Cytosol; Diabetes Mellitus, Experimental; Fatty Acids, Unsaturated; Female; | 1989 |
Metabolism of palmitate in isolated working hearts from spontaneously diabetic "BB" Wistar rats.
Topics: Animals; Coenzyme A; Diabetes Mellitus, Experimental; Heart; Heart Rate; Insulin; Kinetics; Myocardi | 1987 |
[Planar scintigraphy versus PET in measuring fatty acid metabolism of the heart].
Topics: Animals; Carbon Radioisotopes; Coronary Disease; Diabetes Mellitus, Experimental; Fatty Acids; Human | 1987 |
Kinetics of different 123I- and 14C-labelled fatty acids in normal and diabetic rat myocardium in vivo.
Topics: Animals; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Fatty Acids; Iodine Radioisotopes; I | 1985 |