paliperidone-palmitate and Neutropenia

Topics: Adolescent; Antipsychotic Agents; Delayed-Action Preparations; Female; Humans; Neutropenia; Paliperidone Palmitate; Risperidone; Schizophrenia

Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects.. We present a case study of a patient with schizoaffective disorder in a 50-year-old woman. We report a case of paliperidone extended-release (ER)-induced leukopenia and neutropenia in a female patient with schizoaffective disorder. Initiating lithium carbonate treatment and decreasing the dose of valproic acid improved the observed leukopenia and neutropenia. This treatment did not influence psychotic symptoms.. The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels. Lithium carbonate was successfully used to treat paliperidone ER-induced leukopenia and neutropenia.

Topics: Antipsychotic Agents; Delayed-Action Preparations; Female; Humans; Leukopenia; Lithium Carbonate; Middle Aged; Neutropenia; Paliperidone Palmitate; Psychotic Disorders; Treatment Outcome

Topics: Antipsychotic Agents; Humans; Isoxazoles; Lymphopenia; Male; Middle Aged; Neutropenia; Paliperidone Palmitate; Pyrimidines; Risperidone

Topics: Adult; Antipsychotic Agents; Female; Humans; Isoxazoles; Leukopenia; Neutropenia; Paliperidone Palmitate; Psychotic Disorders; Pyrimidines