paliperidone-palmitate and Arrhythmias--Cardiac

Fatal cases with the use of atypical antipsychotic drug paliperidone have been reported; however, there was no clinical report describing paliperidone-induced torsade de pointes. In this study we assessed its electropharmacological effects together with its proarrhythmic potential in intravenous doses of 0.03, 0.3 and 3 mg/kg using the halothane-anesthetized dogs (n = 5), which could provide approximately 2, 20 and 200 times higher peak plasma drug concentrations than its therapeutic level, respectively. Paliperidone exerted potent vasodilator effect resulting in hypotension, which may be largely explained by its α

Topics: Adrenergic alpha-1 Receptor Antagonists; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Antipsychotic Agents; Arrhythmias, Cardiac; Dogs; Dose-Response Relationship, Drug; Electrophysiologic Techniques, Cardiac; Ether-A-Go-Go Potassium Channels; Female; Halothane; Infusions, Intravenous; Myocardium; Paliperidone Palmitate; Sodium Channel Blockers; Vasodilator Agents