pai-039 and Kidney-Diseases

Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of fibrinolysis and regulates cell migration and fibrosis. Preclinical studies using genetically altered mice and biological or small molecule inhibitors have elucidated a role for PAI-1 in the pathogenesis of thrombosis, vascular remodeling, renal injury, and initiation of diabetes. Inhibition of PAI-1 is a potential therapeutic strategy in these diseases.

Topics: Animals; Atherosclerosis; Fibrinolysis; Humans; Indoleacetic Acids; Kidney Diseases; Plasminogen Activator Inhibitor 1; Pulmonary Fibrosis; Thrombosis