paclitaxel has been researched along with Polyploid in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (12.82) | 18.2507 |
| 2000's | 16 (41.03) | 29.6817 |
| 2010's | 17 (43.59) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Allard, M; Bastida-Ruiz, D; Cohen, M; Dietrich, PY; Petignat, P; Yart, L | 1 |
| Liu, J; Mercado-Uribe, I; Niu, N | 1 |
| He, W; Huang, S; Ji, D; Lan, H; Li, L; Li, Z; Liu, X; Wang, Y; Wu, Z; Xu, J; Yang, F; Zhang, W; Zhou, W | 1 |
| Daugel-Dauge, NO; Durnev, AD; Kulakova, AV; Pligina, KL; Zhanataev, AK | 1 |
| Cheney, EM; Clifton, EM; Dawson, MR; Ghosh, D; Xuan, B | 1 |
| Adachi, J; Horiuchi, M; Kuga, T; Nagano, M; Nakayama, Y; Saito, Y; Tomonaga, T; Yamaguchi, N | 1 |
| Liu, J; Mercado-Uribe, I; Zhang, S | 1 |
| Bush, TL; Chung, G; Friberg, G; Hanestad, K; Heller, S; Kendall, RL; Loberg, R; Payton, M; Radinsky, R; Rottman, JB; Saffran, D | 1 |
| Gong, H; Huang, K; Huang, L; Ji, K; Liu, X; Peng, A; Petersen, RB; Zheng, L; Zhou, Y | 1 |
| Chumduri, C; Daniel, PT; Gillissen, B; Milojkovic, A; Müller, A; Overkamp, T; Pott, C; Richter, A | 1 |
| Bhakta, A; Demirjian, JA; Hahn, S; Havas, AP; Rodrigues, KB; Scavello, M; Schmelz, M; Smith, CL; Tran, J; Tula-Sanchez, AA; Zeng, Y | 1 |
| Andrzej Szczepanski, M; Gackowska, L; Grzanka, A; Grzanka, D; Helmin-Basa, A; Stepien, A | 1 |
| Akasaka, K; Akinaga, S; Honda, S; Ichikawa, S; Iida, S; Ishida, H; Kusaka, H; Murakata, C; Nakai, R; Nitta, M; Okamoto, S; Saya, H; Takada, C; Takahashi, T; Tsujita, T; Yamashita, Y | 1 |
| Devineni, S; Ghebre, R; Ghosh, G; Jing, Y; Joshi, HP; Ramakrishnan, S; Subramanian, IV; Truskinovsky, AM | 1 |
| Anderson, DJ; Belmont, LD; Chiu, ML; Dixit, VM; Dueber, EC; Eby, M; Ernst, JA; Fairbrother, WJ; Helgason, E; Huang, DC; Jackson, PK; Johnson, AR; Kaminker, JS; Kohli, PB; Kusam, S; Lam, C; Leong, KG; Lill, JR; Liu, J; Ludlam, MJ; Maecker, H; O'Rourke, KM; Okamoto, T; Pujara, K; Sandoval, W; Seshagiri, S; Wertz, IE | 1 |
| Abdulkadir, SA; Roh, M; van der Meer, R | 1 |
| Llovera, L; Mansilla, S; Portugal, J | 1 |
| Guan, H; Huang, B; Li, B; Liu, XD; Rang, WQ; Shang, ZF; Tu, WZ; Wang, Y; Yu, L; Zhou, PK | 1 |
| Hao, J; Liu, GY; Wang, DH; Xu, YF; Yu, J; Yuan, BB | 1 |
| Cole, RW; Hauf, S; Heckel, A; LaTerra, S; Peters, JM; Rieder, CL; Schnapp, G; van Meel, J; Walter, R; Zimmer, C | 1 |
| Baek, KH; Cho, JH; Choi, YH; Lee, CW; McKeon, F; Shin, HJ; Sung, YC; Yoo, JK | 1 |
| Cammer, M; Chen, JG; Horwitz, SB; Yang, CP | 1 |
| Fujikawa-Yamamoto, K; Han, JF; Katsuda, S; Matsui, S; Zong, ZP | 1 |
| Gossé, F; Raul, F; Schleiffer, R; Schneider, Y; Seiler, N | 1 |
| Muehlbauer, PA; Schuler, MJ | 1 |
| Dijkhuis, AJ; Jacobs, S; Kamps, W; Klappe, K; Kok, JW; Kroesen, BJ; Sietsma, H | 1 |
| Blagosklonny, MV | 1 |
| Hiratsuka, M; Inoue, T; Ito, H; Katoh, M; Kishimoto, I; Nakano, S; Osaki, M; Oshimura, M; Yamada, H; Yamaguchi, S | 1 |
| Allday, MJ; Anderton, E; Leao, M; Meekings, K; Wade, M | 1 |
| Clarke, A; Dikovskaya, D; Jamieson, TJ; Kroboth, K; Meniel, V; Näthke, IS; Newton, IP; Oakley, A; Sansom, O; Schiffmann, D | 1 |
| Ozalpan, A; Ozcan Arican, G | 1 |
| Altieri, D; Fuks, Z; Kolesnick, R | 1 |
| Ahmed, AA; Brenton, JD; Chang, J; Downward, J; Elustondo, F; Kelly, G; Marani, M; Nicke, B; Pardo, O; Sahai, E; Swanton, C; Temple, J; Warne, PH | 1 |
| Erusalimsky, JD; Hancock, V; Hong, Y; Martin, JF; van der Loo, B | 1 |
| Andreassen, PR; Margolis, RL; Martineau, SN | 1 |
| Chen, J; Donovan, S; Hong, FD; Nisen, PD; Schneider, N | 1 |
| Chang, YG; Fujikawa-Yamamoto, K; Ishikawa, Y; Li, AL; Murakami, M; Yamaguchi, N; Zong, ZP | 1 |
| Cabral, TF; Chandra, J; Mcconker, J; Multani, AS; Pathak, S; Sen, S | 1 |
| Allison, DC; Donehower, RC; Roberts, JR; Rowinsky, EK | 1 |
39 other study(ies) available for paclitaxel and Polyploid
| Article | Year |
|---|---|
Linking unfolded protein response to ovarian cancer cell fusion.
Topics: Carcinoma, Ovarian Epithelial; Cell Fusion; Cell Line, Tumor; Female; Humans; Hypoxia; Neoplasm Recurrence, Local; Ovarian Neoplasms; Paclitaxel; Polyploidy; Unfolded Protein Response | 2022 |
Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells.
Topics: Blastomeres; Carcinogenesis; Cell Differentiation; Cell Line, Tumor; Drug Resistance, Neoplasm; Embryonic Stem Cells; Female; Giant Cells; Humans; Neoplastic Stem Cells; Ovarian Neoplasms; Paclitaxel; Polyploidy; Signal Transduction | 2017 |
CyclinG1 Amplification Enhances Aurora Kinase Inhibitor-Induced Polyploid Resistance and Inhibition of Bcl-2 Pathway Reverses the Resistance.
Topics: Adult; Aniline Compounds; Antineoplastic Agents, Phytogenic; bcl-X Protein; Benzamides; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin G1; Drug Resistance, Neoplasm; Female; Humans; MCF-7 Cells; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Paclitaxel; Polyploidy; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; RNA Interference; Sulfonamides; Triple Negative Breast Neoplasms | 2017 |
Induced Aneugenic Effects in Mouse Oocytes In Vivo.
Topics: Aneugens; Aneuploidy; Animals; Cisplatin; Colchicine; Doxorubicin; Etoposide; Melphalan; Mice; Oocytes; Paclitaxel; Polyploidy | 2017 |
Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells.
Topics: Actin Cytoskeleton; Antineoplastic Agents, Phytogenic; Biophysical Phenomena; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Female; Giant Cells; Humans; Neoplastic Stem Cells; Paclitaxel; Polyploidy; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Triple Negative Breast Neoplasms | 2018 |
The tyrosine kinase v-Src causes mitotic slippage by phosphorylating an inhibitory tyrosine residue of Cdk1.
Topics: Antineoplastic Agents, Phytogenic; CDC2 Protein Kinase; Cell Proliferation; HeLa Cells; Humans; Microtubules; Mitosis; Oncogene Protein pp60(v-src); Paclitaxel; Phosphoproteins; Phosphorylation; Polyploidy; Protein Kinase Inhibitors; Pyrimidines; RNA, Small Interfering; Time-Lapse Imaging | 2018 |
Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Humans; Mice; Mice, Nude; Paclitaxel; Polyploidy; Stromal Cells | 2014 |
AMG 900, a small-molecule inhibitor of aurora kinases, potentiates the activity of microtubule-targeting agents in human metastatic breast cancer models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aurora Kinases; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; Epothilones; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Metastasis; Paclitaxel; Phosphorylation; Phthalazines; Polyploidy; Protein Kinase Inhibitors; Triple Negative Breast Neoplasms; Tubulin Modulators; Xenograft Model Antitumor Assays | 2013 |
MPHOSPH1: a potential therapeutic target for hepatocellular carcinoma.
Topics: Adenoviridae; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Kinesins; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Paclitaxel; Polyploidy; RNA, Small Interfering; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2014 |
Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.
Topics: Animals; Apoptosis; Burkitt Lymphoma; Caspase Inhibitors; Caspases; Cell Line; DNA Fragmentation; Flow Cytometry; Gene Knockout Techniques; Humans; Mice; Mice, Knockout; Mitosis; Nocodazole; Paclitaxel; Ploidies; Polyploidy; Proto-Oncogene Proteins c-bcl-2; Tubulin Modulators; Vincristine | 2015 |
Belinostat and vincristine demonstrate mutually synergistic cytotoxicity associated with mitotic arrest and inhibition of polyploidy in a preclinical model of aggressive diffuse large B cell lymphoma.
Topics: Apoptosis; Cell Line, Tumor; Cytotoxins; Drug Evaluation, Preclinical; Drug Synergism; G2 Phase Cell Cycle Checkpoints; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lymphoma, Large B-Cell, Diffuse; Mitosis; Models, Biological; Paclitaxel; Polyploidy; Sulfonamides; Tubulin Modulators; Up-Regulation; Vincristine | 2016 |
Taxol-induced polyploidy and cell death in CHO AA8 cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Transport; Cell Cycle; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; DNA Fragmentation; Flow Cytometry; Fluorescent Antibody Technique; In Situ Nick-End Labeling; Microscopy, Fluorescence; Paclitaxel; Phosphatidylserines; Polyploidy | 2010 |
K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.
Topics: Animals; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Death; Cell Nucleus; Colorectal Neoplasms; HCT116 Cells; Humans; Kinesins; Mad2 Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubules; Mitosis; Paclitaxel; Polyploidy; Repressor Proteins; Spindle Apparatus; Thiadiazoles; Xenograft Model Antitumor Assays | 2009 |
AAV-P125A-endostatin and paclitaxel treatment increases endoreduplication in endothelial cells and inhibits metastasis of breast cancer.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; beta Catenin; Breast Neoplasms; Cells, Cultured; Endostatins; Endothelium, Vascular; Female; Genetic Therapy; Humans; Lung Neoplasms; Mice; Mutant Proteins; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Paclitaxel; Polyploidy; Recombinant Proteins | 2011 |
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.
Topics: Animals; Apoptosis; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; F-Box Proteins; F-Box-WD Repeat-Containing Protein 7; Fibroblasts; Humans; Mice; Mitosis; Myeloid Cell Leukemia Sequence 1 Protein; Paclitaxel; Pharmacogenetics; Phosphorylation; Polyploidy; Proteasome Endopeptidase Complex; Protein Binding; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Tubulin; Tubulin Modulators; Ubiquitin-Protein Ligases; Vincristine | 2011 |
Tumorigenic polyploid cells contain elevated ROS and ARE selectively targeted by antioxidant treatment.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Cell Line; Drug Resistance, Neoplasm; Epithelial Cells; Female; Humans; Hydrogen Peroxide; Male; Mammary Glands, Human; Mitochondria; Mitosis; Paclitaxel; Polyploidy; Prostate; Reactive Oxygen Species | 2012 |
Apoptotic-like death occurs through a caspase-independent route in colon carcinoma cells undergoing mitotic catastrophe.
Topics: Apoptosis; Caspases; Cell Cycle; Cell Death; Colonic Neoplasms; Endoreduplication; HCT116 Cells; Humans; Mitosis; Paclitaxel; Polyploidy; Tubulin Modulators; Tumor Suppressor Protein p53 | 2012 |
4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1.
Topics: Adaptor Proteins, Signal Transducing; Cell Cycle Proteins; Centrosome; Chromosomes, Human; DNA, Neoplasm; Drug Screening Assays, Antitumor; Genomic Instability; HeLa Cells; Hep G2 Cells; Humans; Mitosis; Paclitaxel; Phosphoproteins; Phosphorylation; Polo-Like Kinase 1; Polyploidy; Protein Binding; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Spindle Apparatus | 2012 |
[Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole].
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Docetaxel; Down-Regulation; Drug Resistance, Neoplasm; Epirubicin; Etoposide; Female; Fluorouracil; Gene Knockdown Techniques; Humans; Inhibitory Concentration 50; Nocodazole; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Polyploidy; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; RNA, Small Interfering; Taxoids; Vincristine | 2012 |
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.
Topics: Anaphase; Aneugens; Animals; Aurora Kinase B; Aurora Kinases; Cell Cycle Proteins; Chromosome Segregation; Endopeptidases; Eukaryotic Cells; Genes, cdc; HeLa Cells; Humans; Indoles; Kinetochores; Microtubules; Mitosis; Nocodazole; Paclitaxel; Phenotype; Polyploidy; Protein Kinases; Protein Serine-Threonine Kinases; Pyrimidines; RNA, Small Interfering; Separase; Spindle Apparatus; Sulfonamides; Thiones | 2003 |
p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest.
Topics: Animals; Cell Cycle Proteins; Cells, Cultured; Chromosomes; DNA; Female; Humans; Jurkat Cells; Kinetics; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Knockout; Mitosis; Mutation; Nocodazole; Paclitaxel; Phosphorylation; Polyploidy; Protein Kinases; Protein Serine-Threonine Kinases; Spindle Apparatus; T-Lymphocytes; Tumor Suppressor Protein p53 | 2003 |
Gene expression and mitotic exit induced by microtubule-stabilizing drugs.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epothilones; Gene Expression; Gene Expression Profiling; Humans; Lung Neoplasms; Microtubules; Mitosis; Oligonucleotide Array Sequence Analysis; Paclitaxel; Polyploidy; RNA, Messenger | 2003 |
Phorbol myristate induces apoptosis of taxol-resistant sarcoma cells in vitro.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Caspases; Cell Cycle; Cell Line, Tumor; DNA; Drug Resistance, Neoplasm; Drug Synergism; Flow Cytometry; G1 Phase; Genes, bcl-2; Genes, p53; Male; Mice; Mice, Inbred BALB C; Mitosis; Oncogene Protein p21(ras); Paclitaxel; Polyploidy; Resting Phase, Cell Cycle; S Phase; Sarcoma, Experimental; Survival; Tetradecanoylphorbol Acetate | 2004 |
Polyploidisation of metastatic colon carcinoma cells by microtubule and tubulin interacting drugs: effect on proteolytic activity and invasiveness.
Topics: Cell Division; Cell Line, Tumor; Colchicine; Colonic Neoplasms; Humans; Matrix Metalloproteinase 7; Microtubules; Neoplasm Invasiveness; Paclitaxel; Polyploidy; Tissue Plasminogen Activator; Tubulin | 2004 |
Detection of numerical chromosomal aberrations by flow cytometry: a novel process for identifying aneugenic agents.
Topics: Adult; Aneugens; Cells, Cultured; Chromosome Aberrations; Etoposide; Female; Flow Cytometry; Griseofulvin; Humans; Lymphocytes; Male; Mitomycin; Mitosis; Mutagenicity Tests; Paclitaxel; Polyploidy | 2005 |
PDMP sensitizes neuroblastoma to paclitaxel by inducing aberrant cell cycle progression leading to hyperploidy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; CDC2 Protein Kinase; Cell Cycle; Ceramides; Cyclin-Dependent Kinase 2; Down-Regulation; Drug Resistance, Neoplasm; Fatty Acids, Monounsaturated; Lipid Metabolism; Mice; Morpholines; Neuroblastoma; Paclitaxel; Polyploidy; Sphingolipids | 2006 |
Prolonged mitosis versus tetraploid checkpoint: how p53 measures the duration of mitosis.
Topics: Antineoplastic Agents; Docetaxel; Gene Expression Regulation; Humans; Mitosis; Paclitaxel; Phosphorylation; Polyploidy; Taxoids; Tumor Suppressor Protein p53; Vinca Alkaloids | 2006 |
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
Topics: Cell Line, Tumor; Chromosomal Instability; Chromosomes, Human; Glioma; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Mitosis; Nocodazole; Paclitaxel; Polyploidy; Sirtuin 2; Sirtuins; Stress, Physiological; Tubulin; Ultraviolet Rays; X-Rays | 2007 |
Epstein-barr virus-induced resistance to drugs that activate the mitotic spindle assembly checkpoint in Burkitt's lymphoma cells.
Topics: Antineoplastic Agents; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Burkitt Lymphoma; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Epstein-Barr Virus Nuclear Antigens; Gamma Rays; Herpesvirus 4, Human; Humans; Membrane Proteins; Mitosis; Nocodazole; Paclitaxel; Phenotype; Polyploidy; Proto-Oncogene Proteins; Spindle Apparatus; Tubulin Modulators; Viral Proteins; Virus Latency | 2007 |
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.
Topics: Adenomatous Polyposis Coli Protein; Animals; Apoptosis; beta Catenin; Caspase 3; Cell Cycle Proteins; Cell Line, Tumor; Chromatin; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Fibroblasts; HCT116 Cells; Histones; Humans; Intestinal Mucosa; Intestines; Mice; Mice, Transgenic; Mitosis; Models, Biological; Nocodazole; Paclitaxel; Polyploidy; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Small Interfering; Spindle Apparatus; Staurosporine | 2007 |
Evaluation of the effect of paclitaxel, epirubicin and tamoxifen by cell kinetics parameters in estrogen-receptor-positive ehrlich ascites tumor (eat) cells growing in vitro.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Survival; Epirubicin; Kinetics; Male; Mice; Mice, Inbred BALB C; Mitotic Index; Paclitaxel; Polyploidy; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured | 2007 |
A CERTain role for ceramide in taxane-induced cell death.
Topics: Bridged-Ring Compounds; Cell Death; Ceramides; Chromosomal Instability; Drug Resistance, Neoplasm; Humans; Mitosis; Paclitaxel; Polyploidy; Protein Folding; Protein Serine-Threonine Kinases; RNA, Small Interfering; Spindle Apparatus; Taxoids; Tumor Cells, Cultured | 2007 |
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.
Topics: Cell Line, Tumor; Cell Survival; Ceramides; Chromosomal Instability; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Mitosis; Ovarian Neoplasms; Paclitaxel; Polyploidy; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Small Interfering | 2007 |
Antimicrotubule agents induce polyploidization of human leukaemic cell lines with megakaryocytic features.
Topics: Cell Division; Colchicine; Demecolcine; DNA; Flow Cytometry; Humans; Leukemia; Lumicolchicines; Megakaryocytes; Microtubules; Nocodazole; Paclitaxel; Polyploidy; Tumor Cells, Cultured | 1993 |
Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state.
Topics: 2-Aminopurine; Aneuploidy; Animals; Cell Cycle; CHO Cells; Cricetinae; Cytochalasin B; Diketopiperazines; Enzyme Inhibitors; Microtubules; Mitosis; Nocodazole; Paclitaxel; Piperazines; Polyploidy; Protein Kinase Inhibitors; Topoisomerase II Inhibitors | 1996 |
Taxol, vincristine or nocodazole induces lethality in G1-checkpoint-defective human astrocytoma U373MG cells by triggering hyperploid progression.
Topics: Astrocytoma; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Division; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Humans; Hydroxyurea; Karyotyping; Microtubule-Associated Proteins; Nocodazole; Paclitaxel; Phosphorylation; Polyploidy; Retinoblastoma Protein; Thymidine; Tumor Cells, Cultured; Tumor Suppressor Proteins; Vincristine | 1999 |
Involvement of protein kinase C in taxol-induced polyploidization in a cultured sarcoma cell line.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Carcinogens; Cell Cycle; DNA, Neoplasm; Drug Synergism; Flow Cytometry; Fluorescent Antibody Technique; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Paclitaxel; Polyploidy; Protein Kinase C; Sarcoma, Experimental; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured | 2000 |
Cell death in paclitaxel-dependent chinese hamster ovary cells is initiated by the loss of telomeric DNA repeats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Southern; Cell Death; CHO Cells; Chromosomes; Cricetinae; DNA; DNA Fragmentation; In Situ Hybridization, Fluorescence; Metaphase; Micronuclei, Chromosome-Defective; Mutation; Paclitaxel; Polyploidy; Repetitive Sequences, Nucleic Acid; Telomere; Time Factors | 1999 |
Development of polyploidization in taxol-resistant human leukemia cells in vitro.
Topics: Alkaloids; Cell Cycle; DNA, Neoplasm; Drug Resistance; Humans; Interphase; Leukemia; Paclitaxel; Polyploidy; Spindle Apparatus; Time Factors; Tumor Cells, Cultured | 1990 |