paclitaxel has been researched along with Nerve Pain in 215 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.47) | 18.2507 |
| 2000's | 16 (7.44) | 29.6817 |
| 2010's | 121 (56.28) | 24.3611 |
| 2020's | 77 (35.81) | 2.80 |
| Authors | Studies |
|---|---|
| Dimas, K; Eleutheriades, A; Foscolos, GB; Georgakopoulou, S; Khan, H; Kourafalos, VN; Mantelas, A; Mirjolet, JF; Moutsos, VI; Papanastasiou, I; Pondiki, S; Prassa, M; Riganas, S; Serin, G; Theodoropoulou, M; Tsotinis, A; Vamvakides, A; Zaniou, A | 1 |
| Peng, Y; Ran, R; Wang, J; Xiao, Y; Zhang, X | 1 |
| Chen, JP; Chen, N; Ge, MM; Li, DY; Liu, DQ; Tian, YK; Wang, XM; Ye, DW; Zhou, YQ | 1 |
| Koizumi, S; Komatsu, R; Mizuno, K; Shibata, K; Takanashi, K | 1 |
| Arora, V; Asgar, J; Chung, MK; Kumari, S; Li, T; Wang, S | 1 |
| Khan, A; Khan, AU; Khan, S; Khan, SZ; Naveed, M; Rehman, ZU; Shal, B; Ullah, R | 1 |
| Cortez, IL; Cunha, TM; Dos Santos, JC; Gomes, FIF; Gomes, FV; Guimarães, FS; Lopes, AHP; Mechoulam, R; Silva, CEA; Silva, NR | 1 |
| Araldi, D; Bonet, IJM; Green, PG; Levine, JD; Staurengo-Ferrari, L | 1 |
| Albrecht, PJ; Carey, L; Dockum, M; Hillard, CJ; Hohmann, AG; Houk, G; Lin, X; Mackie, K; Makriyannis, A; Rice, FL; Romero, J; Ruggiero, E; Xu, Z | 1 |
| Adamek, P; Bhattacharyya, A; Heles, M; Palecek, J; Pontearso, M; Slepicka, J | 1 |
| Alexiou, A; Ashraf, GM; Baeesa, SS; Karmakar, V; Mohammad, FS; Sivakumar, SR | 1 |
| Feng, S; Mao, M; Wang, J; Wang, X; Zhang, S; Zhou, F | 1 |
| Ahsan Halim, S; Al-Harrasi, A; Ali, G; Khan, A; Rasheed, A; Subhan, F; Ullah, R | 1 |
| Arthur, P; Bagde, A; Kumar Kalvala, A; Kumar Surapaneni, S; Nathani, A; Ramesh, N; Singh, M | 1 |
| Adaralegbe, A; Bekker, A; Bono, J; Jia, S; Pan, Z; Tao, YX; Tenorio, C; Wang, B; Wei, G; Zheng, B | 1 |
| Kang, DW; Kim, HW; Lee, CJ; Lee, GS; Lee, SY; Neupane, C; Noh, C; Park, JB; Park, KD; Park, SE; Pham, TL; Sharma, R; Shin, HJ | 1 |
| El-Tanbouly, DM; El-Yamany, MF; Gendy, AM; Nasser, AH | 1 |
| Gao, SJ; Li, DY; Liu, DQ; Mei, W; Song, FH; Sun, J; Wu, JY; Zhang, LQ; Zhou, YQ | 1 |
| Abood, ME; Brenneman, DE; Kinney, WA; McDonnell, ME; Ward, SJ; Zhao, P | 1 |
| Ali, F; Faheem, M; Khan, AU; Khan, AW; Li, S; Saleem, MW; Shah, FA | 1 |
| Avagliano, C; Calignano, A; Cristiano, C; Cuozzo, M; Liguori, FM; Russo, R | 1 |
| Kulkarni, NP; Narula, AS; Sharma, SS; Vaidya, B | 1 |
| Adjafre, B; Alves-Filho, JC; Barroso-Sousa, R; Cunha, FQ; Cunha, TM; Gomes, FIF; Luiz, JPM; Maganin, AGM; Mendes, AS; Mota, JM; Nakaya, HI; Oliveira, FFB; Pigatto, GR; Quadros, AU; Restrepo, JLJ; Silva, CEA; Silva, CMS; Silva, GVL; Silva, NR; Speck-Hernandez, CA; Turaça, F; Wanderley, CWS | 1 |
| Chen, X; Jiang, Z; Xu, Y | 1 |
| Coffeen, U; Velasco-González, R | 1 |
| Cao, J; Guo, YX; Liu, JX; Liu, X; Wang, GY; Wang, XL; Zhao, S | 1 |
| Costa-Pereira, JT; Guadilla, I; Guillén, MJ; López-Larrubia, P; Oliveira, R; Tavares, I | 1 |
| He, L; Kume, M; Madsen, TM; Munro, G; Mwirigi, JM; Petersen, KA; Price, TJ; Sankaranarayanan, I; Tavares-Ferreira, D | 1 |
| Dang, D; Prater, C; Toro, G; Wu, Z; Xu, G; Yang, Q | 1 |
| Ai, W; Guo, J; He, Y; Huang, X; Jiang, C; Kuang, H; Li, L; Li, N; Li, P; Liu, T; Sun, W; Sun, Y; Wang, Z; Wu, Y; Xiao, L; Xiong, D; Zeng, Q; Zhou, Q | 1 |
| Cheng, JK; Cho, WL; Hsieh, MC; Lai, CY; Lin, KH; Lin, LT; Lin, TB; Nie, ST; Peng, HY; Wang, HH; Yang, PS; Yeh, CM | 1 |
| Burton, MD; Mejia, GL; Mwirigi, JM; Price, TJ; Sankaranarayanan, I; Tavares-Ferreira, D | 1 |
| Jia, L; Li, W; Shan, C; Wei, X; Zhang, S; Zhao, Y; Zhou, Y | 1 |
| Dos Santos, R; Elisei, L; Faccioli, L; Galdino, G; Netto, G; Sorgi, C; Veras, F | 1 |
| Liu, T; Pan, J; Su, CJ; Xu, DL; Zhang, JT; Zhao, FL | 1 |
| Guan, Y; He, SQ; Linderoth, B; Raja, SN; Sanchez, KR; Sivanesan, E; Stephens, KE; Zhang, C | 1 |
| Khan, A; Khan, MI; Khan, S; Li, CH; Luo, Y; Seo, EK; Shah, K; Wang, F; Zafar, S; Zhang, L | 1 |
| Bang, S; Bortsov, A; Breglio, A; Buchheit, T; Guo, R; Huh, Y; Ji, RR; Jun Huang, T; Matsuoka, Y; Reinecke, J; Wehling, P; Xu, J | 1 |
| Bustos-Quevedo, G; Constandil, L; Hernández, A; Lobos, N; Lux, S; Marcos, JL; Pelissier, T; Zepeda, RJ | 1 |
| Chen, H; Chen, SR; Huang, Y; Jin, D; Pan, HL | 1 |
| Chen, X; Gao, Y; Lin, P; Lu, Q; Mei, C; Miao, M; Ni, F; Pan, C; Wu, W; Xu, J; Xu, L; Xu, Y; Yu, Y | 1 |
| Bayram, C; Budak, H; Hacımüftüoğlu, A; Özkaraca, M; Sezen, S; Toraman, E | 1 |
| de Bruin, N; Geisslinger, G; Hahnefeld, L; Hausch, F; Heymann, T; Namendorf, C; Schmidt, MV; Schreiber, Y; Sisignano, M; Thomas, D; Uhr, M; Wedel, S | 1 |
| Araldi, D; Bonet, IJM; Green, PG; Levine, JD | 1 |
| Branca, JJV; Ciampi, C; Di Cesare Mannelli, L; Ghelardini, C; Leandri, M; Lucarini, E; Micheli, L; Pacini, A; Rajagopalan, P; Rajagopalan, R | 1 |
| Budak, H; Özkaraca, M; Toraman, A; Toraman, E | 1 |
| Ben-Salem, S; Bie, B; Borjini, N; Chen, J; Cheng, J; Dai, Y; Huang, P; Lin, F; Olman, M; Xu, J; Zhang, L | 1 |
| Giniatullin, R; Guo, Q; Jolkkonen, J; Li, Y; Lin, X; Liu, C; Liu, F; Liu, Z; Lv, C; Zhang, X; Zhao, C; Zhong, S; Zhou, Z | 1 |
| Braden, K; Chen, Z; Doyle, TM; Jacobson, KA; Salvemini, D; Samson, WK; Stockstill, K; Tosh, DK; Wahlman, C; Yosten, GL | 1 |
| Coraci, D; Fusco, A; Giovannini, S; Loreti, C; Padua, L | 1 |
| Du, J; Fang, J; Li, X; Li, Y; Liang, Y; Liu, B; Shao, X; Wang, J; Yin, C; Zheng, X | 1 |
| Gao, F; Huo, FQ; Liang, L; Padma Nagendra, BV; Tian, L; Wang, H; Wei, J; Xu, L; Zhang, J | 1 |
| Christensen, S; Giuvelis, D; Huynh, PN; McIntosh, JM; Tucker, KL | 1 |
| Adamson, T; Borneman, J; Cantin, EM; Corleto, J; Ermel, R; Logan, GD; McKemy, D; Mendonca, S; Peacock, BB; Ramakrishna, C; Ruegger, PM; Yamaki, S | 1 |
| Araldi, D; Ferrari, LF; Green, PG; Levine, JD | 1 |
| Bai, XH; Deng, J; Ding, HH; Liu, M; Luo, DX; Mai, JW; Ruan, XC; Xin, WJ; Xu, T; Yang, YL; Zhang, SB; Zhang, XQ; Zhang, XZ | 1 |
| Bai, X; Chen, X; Chen, Z; Han, Z; Huang, J; Nie, B; Ouyang, H; Zhang, S | 1 |
| Khanna, R; Stratton, H | 1 |
| Diallo, M; Kalynovska, N; Palecek, J; Sotakova-Kasparova, D | 1 |
| Chen, N; Chen, SP; Li, DY; Liu, DQ; Sun, J; Tian, YK; Wang, XM; Ye, DW; Zhou, YQ | 1 |
| Bellampalli, SS; Cai, S; Dorame, A; Gomez, K; Khanna, R; Kitamura, N; Luo, S; Ma, C; Molnar, G; Moutal, A; Patek, M; Perez-Miller, S; Ran, D; Streicher, JM; Tuohy, P; Wang, J; Yen Ngan Pham, N; Yu, J; Zhou, Y | 1 |
| Chen, D; Huang, J; Kang, S; Wu, S; Xie, J; Xing, W; Yan, F; Zeng, W | 1 |
| Finn, DP; Masocha, W; Okine, BN; Thomas, A | 1 |
| Abdi, S; Burish, MJ; Chen, Z; Chung, JM; Kim, E; Kim, HK; Koike, N; Lee, HK; Lee, SY; Wirianto, M; Yagita, K; Yoo, SH | 1 |
| Crystal, JD; Hohmann, AG; Iyer, V; Mackie, K; Slivicki, RA; Thomaz, AC | 1 |
| Bachmann, T; Bekker, A; Li, Z; Liang, L; Mao, Q; Tao, YX; Wen, J; Wu, S; Yang, Y; Zheng, B | 1 |
| Chen, YJ; Guo, RX; Li, B; Li, D; Liu, M; Luo, YX; Meng, Y; Xin, WJ; Xiong, YC; Yang, YL; Zhang, SB; Zhang, XZ | 1 |
| Ba, X; Hao, Y; Huang, Z; Jiang, C; Jin, G; Wang, J; Wu, J; Yang, S | 1 |
| Bennett, A; Chapman, V; Constantin-Teodosiu, D; Hathway, G; Meesawatsom, P | 1 |
| Abdi, S; Back, S; Bae, J; Cervantes, CL; Dougherty, PM; Hwang, SH; Jun, S; Jung, YS; Kim, HK; Kim, MJ; Kim, MS; Lee, H; Lee, SE; Lee, SH; Lee, SW; Park, JI | 1 |
| Aboulhosn, R; Adel, A; Bagdas, D; Caillaud, M; Contreras, KM; Damaj, MI; Khalefa, T; Mann, JA; Neddenriep, B; Roberts, JL; Toma, W; Ulker, E; White, AB | 1 |
| Pan, X; Wang, G; Xiao, Y; Zhang, X | 1 |
| Araldi, D; Bogen, O; Bonet, IJM; Levine, JD | 1 |
| Ahmad, N; Al-Harrasi, A; Ali, G; Halim, SA; Khan, A; Khan, J; Naveed, M; Subhan, F; Ullah, R | 1 |
| Li, D; Li, XJ; Ma, Y; Shen, YJ; Sun, L; Wang, H; Xia, J; Xiong, YC; Xu, Y | 1 |
| Chen, R; Du, J; Fang, J; He, X; Jiang, Y; Li, Y; Liang, Y; Liu, B; Nie, H; Wang, J; Yin, C; Zeng, D | 1 |
| Gao, J; Han, X; Hong, X; Li, X; Li, Z; Zhang, H; Zheng, A | 1 |
| Jo, S; Murthy, SN; Rangappa, S; Repka, MA; Shankar, VK | 1 |
| Choi, W; Go, EJ; Jeong, D; Kim, M; Kim, YH; Lee, H; Park, CK; Son, DB; Suh, JW | 1 |
| Carrino, D; Di Cesare Mannelli, L; Ghelardini, C; Lucarini, E; Micheli, L; Pacini, A; Parisio, C; Rajagopalan, P; Rajagopalan, R; Toti, A | 1 |
| Faingold, CL; Premkumar, LS; Samineni, VK | 1 |
| Allegretti, M; Antonosante, A; Benedetti, E; Brandolini, L; Castelli, V; Cimini, A; Cristiano, L; d'Angelo, M; Giordano, A; Ruffini, PA; Russo, R | 1 |
| King, KM; Myers, AM; Soroka-Monzo, AJ; Tallarida, RJ; Tuma, RF; Walker, EA; Ward, SJ | 1 |
| Adjei, S; Amoateng, P; Kretchy, IA; Kukuia, KKE; N'Guessan, BB; Osei-Safo, D; Sarkodie, JA | 1 |
| Calixto, JB; Costa, R; Freitas, CS; Manjavachi, MN; Matias, DO; Passos, GF; Segat, GC | 1 |
| Arsene, AL; Bastian, AE; Bild, V; ChiriŢă, C; Ciotu, IC; Ionică, FE; Negreş, S; Şeremet, OC; Ştefănescu, E; Tănase, AM; Zbârcea, CE | 1 |
| Colvin, L; Galley, HF; Lowes, DA; McCormick, B; Torsney, C; Wilson, KL | 1 |
| Berta, T; Chamessian, A; Decosterd, I; Ji, RR; Kato, AC; Liu, YC; Perrin, FE; Pertin, M; Tonello, R | 1 |
| Berman, BM; Lao, L; Li, A; Ren, K; Xin, J; Zhang, RX; Zhang, Y | 1 |
| Bai, X; Chen, X; Huang, Z; Liu, C; Nie, B; Ouyang, H; Wu, S; Xie, M; Xin, W; Xu, T; Zeng, W; Zhang, S | 1 |
| Chen, SR; Pan, HL; Xie, JD | 1 |
| Choi, J; Jang, JU; Jeon, C; Kim, SK; Kim, W; Lee, JH; Lee, K; Quan, FS | 1 |
| Blake, A; Chow, E; DeAngelis, C; Diaz, P; Lao, N; Malek, L; O'Hearn, S; Wan, BA | 1 |
| Bavencoffe, A; Cai, T; Dessauer, CW; Feng, J; Gong, X; Hu, H; Liu, S; Luo, J; Qian, A; Walters, ET; Yang, P; Yin, S; Yu, W | 1 |
| Cassidy, RM; Dougherty, PM; Edwards, DD; Harrison, DS; Johansson, CA; Li, Y; North, RY; Rao, G; Rhines, LD; Tatsui, CE; Zhang, H | 1 |
| Al-Mazidi, S; Alotaibi, M; Alzoghaibi, M; Chaudhary, A; Djouhri, L; Nedjadi, T | 1 |
| Legakis, LP; Negus, SS | 1 |
| Bigbee, JW; Legakis, LP; Negus, SS | 1 |
| Liang, X; Su, R; Yu, G | 1 |
| Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Tate, S; Yang, J; Yang, L; You, Z; Zhang, S | 1 |
| Beaumont, JL; Griffiths, C; Kwon, N; Paice, JA | 1 |
| Fox, DA; Huang, P; Li, Y; Lin, F; Rosenquist, R; Saunders, TL; Xie, M; Xu, J; Zhang, L | 1 |
| Bernal, L | 1 |
| Duggett, NA; Flatters, SJL; Griffiths, LA; Pitcher, AL | 1 |
| Ahmed, LA; Al-Massri, KF; El-Abhar, HS | 1 |
| Bellampalli, SS; Cai, S; Chefdeville, A; Chew, LA; Dorame, A; Gandini, MA; Gunatilaka, AAL; Ji, Y; Khanna, M; Khanna, R; Luo, S; Madura, CL; Molnar, G; Moutal, A; Streicher, JM; Wijeratne, EMK; Yu, J; Zamponi, GW | 1 |
| Ba, X; Hao, Y; Jin, G; Luo, X; Peng, Y; Wang, J; Yang, S; Zhou, S | 1 |
| Bie, B; Foss, JF; Hocevar, M; Naguib, M; Wu, J | 1 |
| Chen, H; Chen, SR; Chen, Y; Pan, HL; Zhang, J | 1 |
| Liu, L; Ma, X; Miao, H; Xu, D; Xu, J; Zhao, X | 1 |
| Ahmad, A; Barragán-Iglesias, P; Burton, MD; Campbell, ZT; Dougherty, PM; Dussor, G; Khoutorsky, A; Li, Y; Lou, TF; Megat, S; Moy, JK; North, RY; Pradhan, G; Price, TJ; Ray, PR; Sonenberg, N; Wanghzou, A; Webster, KR | 1 |
| Adamek, P; Heles, M; Palecek, J | 1 |
| Berta, T; Lee, SH; Tonello, R | 1 |
| Dang, D; Frost, JA; Li, J; Li, L; Yang, Q; Zuo, Y | 1 |
| Carey, LM; Dhopeshwarkar, AS; Hohmann, AG; Li, AL; Lin, X; Liu, Y; Mackie, K; Makriyannis, A; Nikas, SP; Thomaz, AC | 1 |
| Bhatia, A; Chakrabarti, A; Kumari, P; Saha, L; Singh, J; Singh, N | 1 |
| Arora, M; Deng, M; Ganugula, R; Kumar, MNVR; Pan, HL | 1 |
| Chen, J; Wang, R; Wu, Y | 1 |
| Bekker, A; Cao, J; Chen, L; Du, S; Gu, X; Mao, Q; Mo, K; Sun, L; Tao, YX; Wu, S | 1 |
| Chen, Y; Wu, P | 1 |
| Hohmann, AG; Mali, SS; Slivicki, RA; Xu, Z | 1 |
| Ha, JW; Kim, JW; Kwon, MS; Park, HS; You, MJ | 1 |
| Masocha, W; Thomas, A | 1 |
| Liu, L; Wang, G; Wang, Y; Zhang, Y; Zhao, X; Zhao, Y | 1 |
| Ishiuchi, K; Makino, T; Ohsawa, M; Tanimura, Y; Yoshida, M | 1 |
| Basbaum, AI; Braz, JM; Malik, R; Meda, KS; Patel, T; Seifikar, H; Sohal, VS; Turner, ML | 1 |
| Abdi, S; Hwang, SH; Kim, E; Kim, HK | 1 |
| Çetin, N; Demirci, U; Izgu, N; Karadas, C; Metin, ZG; Ozdemir, L | 1 |
| Bang, S; He, Q; Huh, Y; Ji, RR; Luo, X; Matsuda, M; Zhang, L | 1 |
| Braga, AV; Coelho, MM; Costa, SOAM; Machado, RR; Melo, ISF; Morais, MI; Rodrigues, FF | 1 |
| Baamonde, A; Hidalgo, A; Lastra, A; Menéndez, L; Pevida, M | 1 |
| Katsuyama, S; Kishikawa, Y; Nakamura, H; Sato, K; Yagi, T | 1 |
| Bennett, GJ; Bryant, L; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Ryerse, J; Salvemini, D | 1 |
| Anderson, EM; Bokrand-Donatelli, Y; Caudle, RM; Mustafa, G; Neubert, JK | 1 |
| Gao, M; Weng, HR; Yan, X | 1 |
| Kawamura, R; McAllister, SD; Murase, R; Neelakantan, H; Walker, EA; Ward, SJ | 1 |
| Mensah-Nyagan, AG; Meyer, L; Patte-Mensah, C; Taleb, O | 1 |
| Edafiogho, IO; Masocha, W; Thangamani, D | 1 |
| Bonanno, G; Di Cesare Mannelli, L; Fariello, RG; Farina, C; Ghelardini, C; Milanese, M; Misiano, P; Pittaluga, A | 1 |
| Baeyens, JM; Cañizares, FJ; Cendán, CM; Cubero, MA; Fernández-Segura, E; Nieto, FR; Vela, JM | 1 |
| Hsieh, YL; Hu, ME; Ko, MH; Lan, CT; Tseng, TJ | 1 |
| Deng, L; Hohmann, AG; Lai, YY; Makriyannis, A; Rahn, EJ; Thakur, GA; Vemuri, K; Zvonok, AM | 1 |
| Bieberich, E; Bryant, L; Chen, C; Chen, Z; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Kamocki, K; Li, C; Little, JW; Neumann, WL; Nicol, G; Obeid, L; Petrache, I; Salvemini, D; Snider, A | 1 |
| Cleeland, C; Heijnen, CJ; Huo, XJ; Kavelaars, A; Krukowski, K; Mao-Ying, QL; Price, TJ; Zhou, W | 1 |
| Berta, T; Ji, RR; Jiang, D; Liu, T; Liu, XJ; Park, CK; Xu, ZZ; Zhang, Y | 1 |
| Feng, Y; Li, J; Wu, Y; Zhou, J | 1 |
| Harumiya, M; Iwase, Y; Kanbara, T; Kanemasa, T; Komiya, S; Masumoto, A; Mori, T; Nakamura, A; Sakaguchi, G; Shibasaki, M; Suzuki, T | 1 |
| Cuzzocrea, S; Doyle, T; Esposito, E; Jacobson, KA; Janes, K; Salvemini, D; Tosh, DK | 1 |
| Chen, H; Chen, SR; Laumet, G; Pan, HL; Wen, L; Zhu, L | 1 |
| Fink, DJ; Mata, M; Wang, S; Wu, I; Wu, Z | 1 |
| Nagai, J; Uchida, H; Ueda, H | 1 |
| Choi, JG; Choi, JW; Kang, DW; Kang, SY; Kim, HW; Kim, SJ; Lee, SD; Park, JB; Ryu, YH | 1 |
| Masocha, W | 1 |
| Abed, A; Naji-Esfahani, H; Pilehvarian, AA; Rafieian-Kopaei, M; Safaeian, L; Vaseghi, G | 1 |
| Filipek, B; Sałat, K | 1 |
| Gao, M; Maixner, DW; Weng, HR; Yadav, R; Yan, X | 1 |
| Bartlett, MG; Gao, M; Li, P; Maixner, DW; Weng, HR; Yadav, R; Yan, X | 1 |
| Cornett, BL; Deng, L; Hohmann, AG; Mackie, K | 1 |
| Aki, M; Junpei, O; Kazumi, Y; Masato, H; Mika, F; Teruo, H; Tomohisa, M; Tsutomu, S | 1 |
| Liu, XG; Pang, RP; Shen, KF; Wei, XH; Xu, J; Zhu, HQ | 1 |
| Calò, G; Di Cesare Mannelli, L; Ghelardini, C; Guerrini, R; Micheli, L; Rizzi, A; Trapella, C | 1 |
| Bang, S; Berta, T; Ji, RR; Kim, YH; Oh, SB; Wang, F; Xu, ZZ; Zhang, Y | 1 |
| Kozachik, SL; Page, GG | 1 |
| Kanaoka, D; Kawabata, A; Kawaishi, Y; Kawakami, E; Kawara, Y; Ohkubo, T; Ozaki, T; Sekiguchi, F; Tomita, S; Tsubota, M; Yoshida, S | 1 |
| Huang, ZZ; Li, D; Liu, CC; Ma, C; Ou-Yang, HD; Wei, JY; Wu, SL; Xin, WJ; Xu, T; Zhang, XL | 1 |
| Chen, H; Chen, SR; Pan, HL; Xie, JD; Zeng, WA | 1 |
| Gao, W; Hu, XY; Huang, F; Wang, ZJ; Zan, Y | 1 |
| Cheng, G; Du, D; Lv, Y; Pu, S; Wu, J; Xu, Y; Zhang, X; Zhu, Y | 1 |
| Deng, L; Hohmann, AG; Lee, WH; Makriyannis, A; Xu, Z | 1 |
| Angioni, C; de Bruin, N; Geisslinger, G; Hofmann, M; Hohman, SW; Ji, RR; Jordan, H; Kuzikov, M; Liu, D; Lu, R; Meyer Dos Santos, S; Park, CK; Parnham, MJ; Schäfer, SM; Schmidt, M; Scholich, K; Schreiber, Y; Sisignano, M; Suo, J; Woolf, CJ; Yekkirala, AS; Zhang, DD; Zimmer, B; Zinn, S | 1 |
| Dougherty, PM; Eijkelkamp, N; Hack, CE; Heijnen, CJ; Kavelaars, A; Krukowski, K; Laumet, G; Li, Y | 1 |
| Colvin, L; Galley, HF; Lowes, DA; McCormick, B; Torsney, C | 1 |
| Brusco, I; Dalmolin, GD; de Almeida Cabrini, D; de Campos Velho Gewehr, C; Ferreira, J; Gomez, MV; La Rocca Tamiozzo, L; Oliveira, SM; Rigo, FK; Rossato, MF; Silva, CR; Tonello, R; Trevisan, G | 1 |
| Huang, ZZ; Li, ZY; Liu, CC; Ma, C; Nie, BL; Ou-Yang, HD; Wei, JY; Wu, SL; Xin, WJ; Xu, J; Xu, T; Zhang, XL | 1 |
| Butovsky, O; Duffy, SS; Goldstein, D; Lees, JG; Makker, PG; Moalem-Taylor, G; Park, SB; Perera, CJ; Tonkin, RS | 1 |
| Hayashi, S; Ikeda, H; Ikegami, M; Kai, M; Kamei, J; Nakanishi, Y; Sakai, A | 1 |
| Andoh, T; Kobayashi, N; Kuraishi, Y; Uta, D | 1 |
| Bravo-Caparrós, I; Nieto, FR | 1 |
| Hohmann, AG; Khanolkar, AD; Makriyannis, A; Rahn, EJ; Thakur, GA; Zvonok, AM | 1 |
| Astruc-Diaz, F; Brown, DL; Craig, S; Diaz, P; Naguib, M; Vivas-Mejia, P; Xu, JJ | 1 |
| Buzdar, A; Morrow, PK; Reyes-Gibby, CC; Shete, S | 1 |
| Bennett, GJ; Bordet, T; Pruss, RM; Xiao, WH; Zheng, FY | 1 |
| Beck, SL; Cohen, JA; Lavoie Smith, EM; Pett, MA | 1 |
| Bennett, GJ; Jin, HW; Liu, GK; Siau, C; Xiao, WH | 1 |
| Fukushima, N; Kanaoka, D; Kawabata, A; Matsunami, M; Ohkubo, T; Okubo, K; Sekiguchi, F; Takahashi, T; Yamazaki, J; Yoshida, S | 1 |
| Chen, Y; Wang, ZJ; Yang, C | 1 |
| Bennett, GJ; Xiao, WH; Zheng, H | 2 |
| Bennett, GJ; Meert, TF; Nuydens, R; Xiao, WH; Zheng, FY; Zheng, H | 1 |
| Bennett, GJ; Xiao, WH | 1 |
| Dougherty, PM; Yoon, SY; Zhang, H | 1 |
| Golan-Vered, Y; Pud, D | 1 |
| Bryant, L; Chen, Z; Cuzzocrea, S; Dagostino, C; Doyle, T; Esposito, E; Kamadulski, A; Muscoli, C; Neumann, WL; Rausaria, S; Ryerse, J; Salvemini, D | 1 |
| Ami, N; Okamoto, K; Oshima, H | 1 |
| Baulies, A; Bura, SA; Ruiz-Medina, J; Valverde, O | 1 |
| Carmeliet, P; Daniels, A; Dhondt, J; Lambrechts, D; Meert, T; Nuydens, R; Peeraer, E; Pintelon, I; Poesen, K; Timmermans, JP; Verheyen, A | 1 |
| Aoki, M; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Baeyens, JM; Cendán, CM; Cobos, EJ; Entrena, JM; Nieto, FR; Sánchez-Fernández, C; Tejada, MA; Vela, JM; Zamanillo, D | 1 |
| Hanani, M; Warwick, RA | 1 |
| Abe, K; Chiba, T; Hama, T; Katagiri, N; Kawakami, K; Saduka, M; Taguchi, K; Utsunomiya, I | 1 |
| Kawabata, A | 1 |
| Bennett, GJ; Flatters, SJ | 1 |
| Alessandri-Haber, N; Dina, OA; Levine, JD; Parada, CA; Reichling, DB; Yeh, JJ | 1 |
| Dellon, AL; Livengood, MS; Maloney, CT; Swier, P; Werter, S | 1 |
| Hohmann, AG | 1 |
| Dworkin, RH; Griggs, J; Herrmann, D; Jung, BF; Oaklander, AL | 1 |
| Goicoechea, C; Martín, MI; Pascual, D; Suardíaz, M | 1 |
| Bennett, GJ; Boroujerdi, A; Luo, ZD; Xiao, W | 1 |
| Baeyens, JM; Cendán, CM; Del Pozo, E; Entrena, JM; Nieto, FR; Vela, JM | 1 |
| Alessandri-Haber, N; Dina, OA; Green, PG; Khasar, SG; Levine, JD; Messing, RO | 1 |
| DeVore, R; Hande, KR; Johnson, DH; Paul, DM | 1 |
| Hirai, Y; Iwasaki, H; Matsui, H; Sekiya, S; Tate, S | 1 |
| Eisenberger, MA; Laufer, M; Schoenberg, MP | 1 |
| Authier, N; Coudore, F; Eschalier, A; Fialip, J; Gillet, JP | 1 |
| Du Nguyen, H; Horaguchi, Y; Kasanami, Y; Kawabata, A; Kitamura, S; Nishikawa, H; Okada, T; Sekiguchi, F; Toyooka, N; Tsubota, M; Yamaoka, S; Yoshida, S | 1 |
5 review(s) available for paclitaxel and Nerve Pain
| Article | Year |
|---|---|
Goshajinkigan attenuates paclitaxel-induced neuropathic pain via cortical astrocytes.
Topics: Animals; Antineoplastic Agents, Phytogenic; Astrocytes; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Somatosensory Cortex | 2021 |
Mechanisms underlying paclitaxel-induced neuropathic pain: Channels, inflammation and immune regulations.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Ganglia, Spinal; Humans; Hyperalgesia; Inflammation; Neuralgia; Paclitaxel | 2022 |
Neurophysiopathological Aspects of Paclitaxel-induced Peripheral Neuropathy.
Topics: Antineoplastic Agents; Docetaxel; Humans; Microtubules; Neuralgia; Oxidative Stress; Paclitaxel | 2022 |
Modulating the endocannabinoid pathway as treatment for peripheral neuropathic pain: a selected review of preclinical studies.
Topics: Animals; Antineoplastic Agents; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cisplatin; Disease Models, Animal; Endocannabinoids; Evaluation Studies as Topic; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Rats; Signal Transduction | 2017 |
Neuropathic pain associated with non-surgical treatment of breast cancer.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Disease Models, Animal; Female; Humans; Neuralgia; Paclitaxel; Peripheral Nerves; Peripheral Nervous System Diseases; Radiation Injuries; Radiotherapy; Rats | 2005 |
4 trial(s) available for paclitaxel and Nerve Pain
| Article | Year |
|---|---|
Cold therapy to prevent paclitaxel-induced peripheral neuropathy.
Topics: Adult; Aged; Breast Neoplasms; Cryotherapy; Female; Humans; Hypothermia, Induced; Middle Aged; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Surveys and Questionnaires; Treatment Outcome | 2018 |
Prevention of chemotherapy-induced peripheral neuropathy with classical massage in breast cancer patients receiving paclitaxel: An assessor-blinded randomized controlled trial.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Female; Follow-Up Studies; Humans; Massage; Middle Aged; Neuralgia; Paclitaxel; Prospective Studies; Quality of Life; Treatment Outcome | 2019 |
The validity of neuropathy and neuropathic pain measures in patients with cancer receiving taxanes and platinums.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carboplatin; Cisplatin; Comorbidity; Docetaxel; Female; Humans; Male; Middle Aged; Neoplasms; Neuralgia; Nursing Assessment; Oncology Nursing; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Pain Measurement; Reproducibility of Results; Risk Factors; Taxoids | 2011 |
Paclitaxel plus carboplatin in the treatment of patients with advanced lung cancer: a Vanderbilt University Cancer Center phase II trial (LUN-46).
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Arthralgia; Carboplatin; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Nausea; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Survival Rate; Thrombocytopenia; Treatment Outcome; Vomiting | 1996 |
206 other study(ies) available for paclitaxel and Nerve Pain
| Article | Year |
|---|---|
New adamantane phenylalkylamines with σ-receptor binding affinity and anticancer activity, associated with putative antagonism of neuropathic pain.
Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Proliferation; Female; Humans; Male; Mice; Mice, SCID; Molecular Structure; Neuralgia; Ovarian Neoplasms; Pancreatic Neoplasms; Piperidines; Prostatic Neoplasms; Protein Binding; Receptors, sigma; Structure-Activity Relationship; Tumor Cells, Cultured | 2012 |
FSC231 alleviates paclitaxel-induced neuralgia by inhibiting the interactions between PICK1 and GluA2 and activates GSK-3β and ERK1/2.
Topics: Animals; Carbamates; Cinnamates; Glycogen Synthase Kinase 3 beta; Neuralgia; Paclitaxel; Rats | 2021 |
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis.
Topics: Adrenergic beta-2 Receptor Agonists; Analgesics; Animals; Disease Models, Animal; DNA, Mitochondrial; Formoterol Fumarate; Male; Mitochondria; Neuralgia; Organelle Biogenesis; Paclitaxel; Pain Threshold; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Spinal Cord | 2021 |
Capsaicin-induced depolymerization of axonal microtubules mediates analgesia for trigeminal neuropathic pain.
Topics: Animals; Capsaicin; Chronic Pain; Hyperalgesia; Mice; Microtubules; Neuralgia; Paclitaxel; Trigeminal Neuralgia; TRPV Cation Channels; Tubulin | 2022 |
Anti-neuropathic pain activity of a cationic palladium (II) dithiocarbamate by suppressing the inflammatory mediators in paclitaxel-induced neuropathic pain model.
Topics: Analgesics; Animals; Antioxidants; Cytokines; Female; Hyperalgesia; Inflammation; Inflammation Mediators; Models, Animal; Neuralgia; Nitric Oxide Synthase Type II; Paclitaxel; Palladium; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2021 |
The Cannabidiol Analog PECS-101 Prevents Chemotherapy-Induced Neuropathic Pain via PPARγ Receptors.
Topics: Animals; Antineoplastic Agents; Cannabidiol; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Mice; Neuralgia; Paclitaxel; PPAR gamma | 2022 |
Second messengers mediating high-molecular-weight hyaluronan-induced antihyperalgesia in rats with chemotherapy-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents; Female; Hyaluronic Acid; Hyperalgesia; Male; Neuralgia; Oxaliplatin; Paclitaxel; Rats; Receptors, G-Protein-Coupled; RNA, Messenger; Second Messenger Systems; Type C Phospholipases | 2022 |
A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse.
Topics: Animals; Antineoplastic Agents; Cannabinoids; Cytokines; Hyperalgesia; Mice; Mice, Knockout; Neuralgia; Paclitaxel; Purines; Pyrans; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2022 |
Dual PI3Kδ/γ Inhibitor Duvelisib Prevents Development of Neuropathic Pain in Model of Paclitaxel-Induced Peripheral Neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Female; Hyperalgesia; Isoquinolines; Male; Mice; Neuralgia; Paclitaxel; Pain; Peripheral Nervous System Diseases; Phosphatidylinositol 3-Kinases; Purines; Rats | 2022 |
Effect of Cliothosa aurivilli on Paclitaxel-induced Peripheral Neuropathy in Experimental Animals.
Topics: Animals; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Pain Measurement; Porifera | 2022 |
Participation of transient receptor potential vanilloid 1 in the analgesic effect of duloxetine for paclitaxel induced peripheral neuropathic pain.
Topics: Analgesics; Animals; Antineoplastic Agents; Calcitonin Gene-Related Peptide; Duloxetine Hydrochloride; Ganglia, Spinal; Hyperalgesia; Neuralgia; Paclitaxel; Pain; Peripheral Nervous System Diseases; Rats; Spinal Cord Dorsal Horn; Substance P; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2022 |
The 7-Hydroxyflavone attenuates chemotherapy-induced neuropathic pain by targeting inflammatory pathway.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carrageenan; Cyclooxygenase 2; Cytokines; Edema; Flavonoids; Hyperalgesia; Inflammation Mediators; Mice; Neuralgia; NF-kappa B; Paclitaxel; Rats; Rats, Sprague-Dawley; Vincristine | 2022 |
Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-induced neuropathic pain in rodents.
Topics: Animals; Cannabidiol; Cannabinoids; Male; Mice; Mice, Inbred C57BL; Neuralgia; Paclitaxel; Rats; Rodentia | 2022 |
TET1 overexpression attenuates paclitaxel-induced neuropathic pain through rescuing K
Topics: Animals; Dioxygenases; Ganglia, Spinal; Hyperalgesia; Male; Neuralgia; Paclitaxel; Potassium Channels; Rats; Sensory Receptor Cells | 2022 |
Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model.
Topics: Analgesics; Animals; gamma-Aminobutyric Acid; Hyperalgesia; Mice; Monoamine Oxidase Inhibitors; Neuralgia; Paclitaxel; Reactive Oxygen Species; Spinal Cord | 2022 |
Upregulation of neuronal progranulin mediates the antinociceptive effect of trimetazidine in paclitaxel-induced peripheral neuropathy: Role of ERK1/2 signaling.
Topics: Analgesics; Animals; Axons; Humans; Hyperalgesia; MAP Kinase Signaling System; Neuralgia; Paclitaxel; Progranulins; Rats; Sciatic Nerve; Trimetazidine; Up-Regulation | 2022 |
Notch signaling activation contributes to paclitaxel-induced neuropathic pain via activation of A1 astrocytes.
Topics: Animals; Astrocytes; Hyperalgesia; Neuralgia; Paclitaxel; Platelet Aggregation Inhibitors; Rats; Signal Transduction; Spinal Cord | 2022 |
Anti-Inflammatory Properties of KLS-13019: a Novel GPR55 Antagonist for Dorsal Root Ganglion and Hippocampal Cultures.
Topics: Anti-Inflammatory Agents; Cannabinoids; Ganglia, Spinal; Hippocampus; Humans; Neuralgia; NLR Family, Pyrin Domain-Containing 3 Protein; Paclitaxel; Receptors, Cannabinoid | 2022 |
Neuroprotective Effect of Natural Compounds in Paclitaxel-Induced Chronic Inflammatory Pain.
Topics: 5-Methoxypsoralen; Chronic Pain; Humans; Neuralgia; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; Paclitaxel; Tumor Necrosis Factor-alpha | 2022 |
The Beneficial Effects of Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain and Associated Mood Disorders Induced by Paclitaxel in Mice.
Topics: Amides; Animals; Endocannabinoids; Ethanolamines; Mice; Neuralgia; Paclitaxel; Palmitic Acids; PPAR alpha | 2022 |
Caffeic Acid Phenethyl Ester (CAPE) Attenuates Paclitaxel-induced Peripheral Neuropathy: A Mechanistic Study.
Topics: Animals; Antineoplastic Agents; beta Catenin; Female; Matrix Metalloproteinase 2; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway | 2022 |
PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Humans; Mice; Neuralgia; Paclitaxel; Programmed Cell Death 1 Receptor; Rats; Rats, Sprague-Dawley | 2022 |
Inhibition of glutamatergic neurons in layer II/III of the medial prefrontal cortex alleviates paclitaxel-induced neuropathic pain and anxiety.
Topics: Animals; Anxiety; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Mice; Neuralgia; Neurons; Paclitaxel; Prefrontal Cortex | 2022 |
Neuroimaging uncovers neuronal and metabolic changes in pain modulatory brain areas in a rat model of chemotherapy-induced neuropathy - MEMRI and ex vivo spectroscopy studies.
Topics: Animals; Antineoplastic Agents; Brain; Magnetic Resonance Imaging; Male; Neuralgia; Paclitaxel; Rats; Rats, Wistar; Spectrum Analysis | 2023 |
Meteorin Alleviates Paclitaxel-Induced Peripheral Neuropathic Pain in Mice.
Topics: Analgesics; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Female; Humans; Hyperalgesia; Male; Mice; Neuralgia; Paclitaxel; Quality of Life | 2023 |
Paclitaxel Inhibits KCNQ Channels in Primary Sensory Neurons to Initiate the Development of Painful Peripheral Neuropathy.
Topics: Animals; Chronic Pain; Mice; Neuralgia; Paclitaxel; Rats; Sensory Receptor Cells | 2022 |
Up-regulation of oxytocin receptors on peripheral sensory neurons mediates analgesia in chemotherapy-induced neuropathic pain.
Topics: Analgesia; Analgesics; Animals; Antineoplastic Agents; Ganglia, Spinal; Mice; Neuralgia; Oxytocin; Paclitaxel; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin; Sensory Receptor Cells; Sodium; Up-Regulation | 2023 |
Phosphate NIMA-Related Kinase 2-Dependent Epigenetic Pathways in Dorsal Root Ganglion Neurons Mediates Paclitaxel-Induced Neuropathic Pain.
Topics: Animals; Antineoplastic Agents; Epigenesis, Genetic; Ganglia, Spinal; Histones; Humans; Hyperalgesia; Male; Neuralgia; Neurons; NIMA-Related Kinases; Paclitaxel; Phosphates; Quality of Life; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2023 |
Inducible co-stimulatory molecule (ICOS) alleviates paclitaxel-induced neuropathic pain via an IL-10-mediated mechanism in female mice.
Topics: Animals; Antineoplastic Agents; Female; Ganglia, Spinal; Humans; Hyperalgesia; Inducible T-Cell Co-Stimulator Protein; Interleukin-10; Mice; Neuralgia; Paclitaxel | 2023 |
Soluble Epoxide Hydrolase Inhibitor TPPU Alleviates Nab-Paclitaxel-Induced Peripheral Neuropathic Pain via Suppressing NF-
Topics: Animals; Cytokines; Epoxide Hydrolases; Male; Neuralgia; NF-kappa B; Paclitaxel; Rats; Rats, Sprague-Dawley; Spinal Cord | 2023 |
Cannabidiol prevents chemotherapy-induced neuropathic pain by modulating spinal TLR4 via endocannabinoid system activation.
Topics: Animals; Antineoplastic Agents; Cannabidiol; Cannabinoids; Cytokines; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Neuralgia; Paclitaxel; Receptor, Cannabinoid, CB2; Toll-Like Receptor 4 | 2023 |
Resolvin D1/N-formyl peptide receptor 2 ameliorates paclitaxel-induced neuropathic pain through the activation of IL-10/Nrf2/HO-1 pathway in mice.
Topics: Animals; Interleukin-10; Mice; Neuralgia; NF-E2-Related Factor 2; Paclitaxel; Receptors, Formyl Peptide | 2023 |
Spinal Cord Stimulation Increases Chemoefficacy and Prevents Paclitaxel-Induced Pain via CX3CL1.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Chemokine CX3CL1; Ganglia, Spinal; Humans; Lung Neoplasms; Male; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Stimulation | 2023 |
Daidzein attenuated paclitaxel-induced neuropathic pain via the down-regulation of TRPV1/P2Y and up-regulation of Nrf2/HO-1 signaling.
Topics: Antineoplastic Agents; Antioxidants; Down-Regulation; Heme Oxygenase-1; Humans; Hyperalgesia; Inflammation Mediators; Isoflavones; Neuralgia; NF-E2-Related Factor 2; Oxidative Stress; Paclitaxel; TRPV Cation Channels; Up-Regulation | 2023 |
Intrathecal administration of conditioned serum from different species resolves Chemotherapy-Induced neuropathic pain in mice via secretory exosomes.
Topics: Analgesics; Animals; Antineoplastic Agents; Exosomes; Female; Humans; Hyperalgesia; Male; Mice; Neuralgia; Paclitaxel; Rats; Spinal Cord | 2023 |
Rosuvastatin Synergistically Enhances the Antinociceptive Efficacy of Duloxetine in Paclitaxel-Induced Neuropathic Pain in Mice.
Topics: Analgesics; Animals; Duloxetine Hydrochloride; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Pain Measurement; Rosuvastatin Calcium | 2023 |
NMDA Receptors at Primary Afferent-Excitatory Neuron Synapses Differentially Sustain Chemotherapy- and Nerve Trauma-Induced Chronic Pain.
Topics: Animals; Antineoplastic Agents; Chronic Pain; Female; Male; Mice; Neuralgia; Neurons; Paclitaxel; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses | 2023 |
Trimethoxyflavanone relieves Paclitaxel-induced neuropathic pain via inhibiting expression and activation of P2X7 and production of CGRP in mice.
Topics: Animals; Antineoplastic Agents; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Hyperalgesia; Mice; Molecular Docking Simulation; Neuralgia; Paclitaxel | 2023 |
Parthenolide as a potential analgesic in the treatment of paclitaxel-induced neuropathic pain: the rat modeling.
Topics: Analgesics; Animals; Neuralgia; Paclitaxel; Rats; Sesquiterpenes | 2023 |
SAFit2 ameliorates paclitaxel-induced neuropathic pain by reducing spinal gliosis and elevating pro-resolving lipid mediators.
Topics: Animals; Gliosis; Lipids; Mice; Neuralgia; Neuroinflammatory Diseases; Paclitaxel | 2023 |
Topical coapplication of hyaluronan with transdermal drug delivery enhancers attenuates inflammatory and neuropathic pain.
Topics: Animals; Dimethyl Sulfoxide; Female; Hyaluronic Acid; Hyperalgesia; Male; Neuralgia; Paclitaxel; Protamines; Rats; Rats, Sprague-Dawley | 2023 |
Broad-spectrum neuroprotection exerted by DDD-028 in a mouse model of chemotherapy-induced neuropathy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Ganglia, Spinal; Mice; Neuralgia; Neuroprotection; Paclitaxel; Pregabalin; Sciatic Nerve | 2023 |
Evaluated periodontal tissues and oxidative stress in rats with neuropathic pain-like behavior.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alveolar Bone Loss; Animals; Antioxidants; Humans; Male; NAV1.7 Voltage-Gated Sodium Channel; Neuralgia; Oxidative Stress; Paclitaxel; Periodontal Ligament; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2023 |
Complement Receptor C3aR1 Contributes to Paclitaxel-Induced Peripheral Neuropathic Pain in Mice and Rats.
Topics: Animals; Complement System Proteins; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Potassium Iodide; Rats; Rats, Sprague-Dawley; Receptors, Complement; TRPV Cation Channels | 2023 |
Blockade of CCR5 suppresses paclitaxel-induced peripheral neuropathic pain caused by increased deoxycholic acid.
Topics: Breast Neoplasms; Deoxycholic Acid; Female; Humans; Maraviroc; Neuralgia; Paclitaxel; Receptors, CCR5 | 2023 |
Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents.
Topics: Adenosine A3 Receptor Antagonists; Analgesics, Opioid; Animals; Antineoplastic Agents; Bortezomib; Duloxetine Hydrochloride; Female; Fingolimod Hydrochloride; Male; Morphine; Neuralgia; Oxaliplatin; Paclitaxel; Rats; Receptor, Adenosine A3; Sex Factors; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Spinal Cord Dorsal Horn | 2020 |
Management of neuropathic pain: A graph theory-based presentation of literature review.
Topics: Breast Neoplasms; Gabapentin; Humans; Neuralgia; Paclitaxel | 2020 |
Electroacupuncture Alleviates Paclitaxel-Induced Peripheral Neuropathic Pain in Rats via Suppressing TLR4 Signaling and TRPV1 Upregulation in Sensory Neurons.
Topics: Animals; Antineoplastic Agents, Phytogenic; Electroacupuncture; Gene Expression Regulation; Male; Myeloid Differentiation Factor 88; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Toll-Like Receptor 4; TRPV Cation Channels | 2019 |
Paclitaxel Induces Sex-biased Behavioral Deficits and Changes in Gene Expression in Mouse Prefrontal Cortex.
Topics: Animals; Anxiety; Depression; Depressive Disorder; Gene Expression; Male; Maze Learning; Mice, Inbred C57BL; Neuralgia; Paclitaxel; Prefrontal Cortex | 2020 |
RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Conotoxins; Humans; Hyperalgesia; Male; Neuralgia; Nicotinic Antagonists; Paclitaxel; Rats; Rats, Sprague-Dawley | 2019 |
Dominant Role of the Gut Microbiota in Chemotherapy Induced Neuropathic Pain.
Topics: Animals; Antineoplastic Agents; Biodiversity; Brain; Disease Models, Animal; Female; Gastrointestinal Microbiome; Humans; Male; Mice; Microglia; Neuralgia; Paclitaxel; Spinal Cord | 2019 |
Marked sexual dimorphism in neuroendocrine mechanisms for the exacerbation of paclitaxel-induced painful peripheral neuropathy by stress.
Topics: Animals; Endocrine System; Female; Hyperalgesia; Male; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Sex Characteristics; Stress, Physiological | 2020 |
Upregulation of TRPC6 Mediated by PAX6 Hypomethylation Is Involved in the Mechanical Allodynia Induced by Chemotherapeutics in Dorsal Root Ganglion.
Topics: Animals; Antineoplastic Agents; Bortezomib; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Ganglia, Spinal; Gene Expression; Hyperalgesia; Male; Neuralgia; Oxaliplatin; Paclitaxel; PAX6 Transcription Factor; Rats; Rats, Sprague-Dawley; TRPC Cation Channels; Up-Regulation | 2020 |
Distinct roles of srGAP3-Rac1 in the initiation and maintenance phases of neuropathic pain induced by paclitaxel.
Topics: Animals; Dendritic Spines; GTPase-Activating Proteins; Maintenance; Neuralgia; Paclitaxel; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley | 2020 |
Just in time! Identification of a novel mechanism for treating PIPN.
Topics: Humans; Maintenance; Neuralgia; Paclitaxel; rac1 GTP-Binding Protein | 2020 |
Losartan attenuates neuroinflammation and neuropathic pain in paclitaxel-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Losartan; Macrophages; Male; Neuralgia; Paclitaxel; Pain Management; Rats | 2020 |
PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway.
Topics: Analgesics; Animals; Disease Models, Animal; Heme Oxygenase (Decyclizing); Hyperalgesia; Male; Neuralgia; NF-E2-Related Factor 2; Paclitaxel; Pain Perception; Pain Threshold; PPAR gamma; Rats, Sprague-Dawley; Rosiglitazone; Signal Transduction; Spinal Cord; Up-Regulation | 2020 |
A modulator of the low-voltage-activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Ganglia, Spinal; Glycoproteins; HIV Infections; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2020 |
JTC-801 alleviates mechanical allodynia in paclitaxel-induced neuropathic pain through the PI3K/Akt pathway.
Topics: Aminoquinolines; Analgesics; Animals; Behavior, Animal; Benzamides; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Inflammation Mediators; Interleukin-1beta; Male; Narcotic Antagonists; Neuralgia; Nociceptin Receptor; Paclitaxel; Pain Threshold; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, Opioid; Signal Transduction; Tumor Necrosis Factor-alpha | 2020 |
Peripheral deficiency and antiallodynic effects of 2-arachidonoyl glycerol in a mouse model of paclitaxel-induced neuropathic pain.
Topics: Analgesics; Animals; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Agonists; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Female; Glycerides; Hyperalgesia; Mice, Inbred BALB C; Monoacylglycerol Lipases; Neuralgia; Paclitaxel; Piperidines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Skin | 2020 |
Circadian regulation of chemotherapy-induced peripheral neuropathic pain and the underlying transcriptomic landscape.
Topics: Animals; Antineoplastic Agents, Phytogenic; ARNTL Transcription Factors; Circadian Rhythm; Disease Models, Animal; Ganglia, Spinal; Gene Expression; In Vitro Techniques; Mice; Neuralgia; Paclitaxel; Period Circadian Proteins; Peripheral Nerve Injuries; Rats; Spinal Cord Dorsal Horn | 2020 |
The cannabinoid CB
Topics: Analgesics; Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Conditioning, Operant; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Morphine Dependence; Neuralgia; Nociception; Paclitaxel; Purines; Pyrans; Receptor, Cannabinoid, CB2; Reward; Substance Withdrawal Syndrome | 2020 |
CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons.
Topics: Animals; Blotting, Western; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; DNA Methyltransferase 3A; Fluorescent Antibody Technique; Ganglia, Spinal; Male; Mice; Neuralgia; Paclitaxel; Sensory Receptor Cells; Transcriptional Activation; Up-Regulation | 2021 |
NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Base Sequence; Chemokines, CXC; Epigenesis, Genetic; Male; Neuralgia; NFATC Transcription Factors; Paclitaxel; Protein Binding; Rats; Rats, Sprague-Dawley; Up-Regulation | 2020 |
Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute neuropathic pain and suppresses spinal glial reactivity in rats.
Topics: Acute Pain; Allosteric Regulation; Animals; Benzhydryl Compounds; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord | 2021 |
Spinal neuronal excitability and neuroinflammation in a model of chemotherapeutic neuropathic pain: targeting the resolution pathways.
Topics: Animals; Antineoplastic Agents, Phytogenic; Docosahexaenoic Acids; Drug Delivery Systems; Inflammation Mediators; Male; Neuralgia; Paclitaxel; Pain Measurement; Posterior Horn Cells; Rats; Rats, Sprague-Dawley | 2020 |
Blockers of Wnt3a, Wnt10a, or β-Catenin Prevent Chemotherapy-Induced Neuropathic Pain In Vivo.
Topics: Animals; beta Catenin; Blotting, Western; Ganglia, Spinal; Humans; Hyperalgesia; Male; Mice; Mice, Transgenic; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Wnt Proteins; Wnt3A Protein | 2021 |
Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Phytogenic; Chronic Pain; Disease Models, Animal; Female; Freund's Adjuvant; Genotype; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Neuralgia; Nociceptive Pain; Paclitaxel; Peripheral Nerve Injuries; Running; Sex Factors | 2021 |
FSC231 can alleviate paclitaxel-induced neuralgia by inhibiting PICK1 and affecting related factors.
Topics: Analgesics; Animals; Carbamates; Cell Cycle Proteins; Cinnamates; Ganglia, Spinal; Inflammation Mediators; Male; Mice, Inbred C57BL; Neuralgia; Paclitaxel | 2021 |
Involvement of TACAN, a Mechanotransducing Ion Channel, in Inflammatory But Not Neuropathic Hyperalgesia in the Rat.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Inflammation; Ion Channels; Male; Mechanotransduction, Cellular; Neuralgia; Oxaliplatin; Paclitaxel; Pain Threshold; Rats; Rats, Sprague-Dawley | 2021 |
Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone.
Topics: Animals; Antineoplastic Agents, Phytogenic; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Drug Delivery Systems; Flavonoids; Inflammation Mediators; Male; Mice; Neuralgia; Nociception; Paclitaxel; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Substance P | 2021 |
DNMT3b SUMOylation Mediated MMP-2 Upregulation Contribute to Paclitaxel Induced Neuropathic Pain.
Topics: Animals; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Gene Knockdown Techniques; Hyperalgesia; Male; Matrix Metalloproteinase 2; Neuralgia; Paclitaxel; Promoter Regions, Genetic; Rats, Sprague-Dawley; RNA, Small Interfering; Spinal Cord Dorsal Horn; Sumoylation; Up-Regulation | 2021 |
Transcriptome profiling of long noncoding RNAs and mRNAs in spinal cord of a rat model of paclitaxel-induced peripheral neuropathy identifies potential mechanisms mediating neuroinflammation and pain.
Topics: Animals; Antineoplastic Agents, Phytogenic; Gene Expression Profiling; Gene Regulatory Networks; Male; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; RNA, Long Noncoding; RNA, Messenger; Spinal Cord | 2021 |
Lyophilization Serves as an Effective Strategy for Drug Development of the α9α10 Nicotinic Acetylcholine Receptor Antagonist α-Conotoxin GeXIVA[1,2].
Topics: Acute Pain; Analgesics; Animals; Conotoxins; Disease Models, Animal; Drug Development; Freeze Drying; Male; Neuralgia; Nicotinic Antagonists; Paclitaxel; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2021 |
Chemotherapeutic Agent-Induced Vulvodynia, an Experimental Model.
Topics: Analgesics; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Female; Gabapentin; Neuralgia; Paclitaxel; Pain Measurement; Rats; Rats, Sprague-Dawley; Vulvodynia | 2021 |
Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model.
Topics: Animals; Benzopyrans; Butyrates; Disease Models, Animal; Enzyme Activators; Humans; Hyperalgesia; Mice; Neuralgia; Paclitaxel | 2021 |
Pain Relieving and Neuroprotective Effects of Non-opioid Compound, DDD-028, in the Rat Model of Paclitaxel-Induced Neuropathy.
Topics: Analgesics, Non-Narcotic; Animals; Antineoplastic Agents, Phytogenic; Azepines; Carbolines; Dose-Response Relationship, Drug; Male; Neuralgia; Neuroprotective Agents; Paclitaxel; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2021 |
Neuropathic pain-induced enhancement of spontaneous and pain-evoked neuronal activity in the periaqueductal gray that is attenuated by gabapentin.
Topics: Action Potentials; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Male; Neuralgia; Neuronal Plasticity; Neurons; Paclitaxel; Periaqueductal Gray; Rats; Rats, Sprague-Dawley | 2017 |
CXCR1/2 pathways in paclitaxel-induced neuropathic pain.
Topics: Animals; Antineoplastic Agents, Phytogenic; Interleukin-8; Male; Neuralgia; Paclitaxel; Rats; Rats, Wistar; Receptors, Interleukin-8A; Receptors, Interleukin-8B | 2017 |
Single and combined effects of Δ
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Cannabidiol; Disease Models, Animal; Dronabinol; Drug Therapy, Combination; Hyperalgesia; Male; Mice, Inbred C57BL; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Vincristine | 2017 |
Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats.
Topics: Analgesics; Animals; Asteraceae; Ethanol; Hyperalgesia; Injections, Intraperitoneal; Neuralgia; Paclitaxel; Plant Extracts; Pregabalin; Rats, Sprague-Dawley | 2017 |
Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Cannabinoid Receptor Modulators; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Indoles; Male; Neuralgia; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Piperidines; Polycyclic Sesquiterpenes; Pyrazoles; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sesquiterpenes; Spinal Cord | 2017 |
Therapeutic potential of certain drug combinations on paclitaxel-induced peripheral neuropathy in rats.
Topics: Animals; Disease Models, Animal; Drug Combinations; Male; Neuralgia; Paclitaxel; Rats; Rats, Wistar | 2017 |
Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Female; Humans; Hyperalgesia; Male; Melatonin; Mitochondria; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley | 2017 |
Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain.
Topics: Animals; Biopsy; Caspase 6; Computational Biology; Disease Models, Animal; Ganglia, Spinal; Gene Expression Profiling; Humans; Immunohistochemistry; Mice; Mice, Knockout; Neuralgia; Nociceptors; Paclitaxel; Rats; Skin; Spinal Nerves; Transcriptome | 2017 |
Electroacupuncture alleviates chemotherapy-induced pain through inhibiting phosphorylation of spinal CaMKII in rats.
Topics: Acupuncture Points; Animals; Antineoplastic Agents, Phytogenic; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Electroacupuncture; Hyperalgesia; Male; Neuralgia; Paclitaxel; Phosphorylation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2018 |
AKAP150 involved in paclitaxel-induced neuropathic pain via inhibiting CN/NFAT2 pathway and downregulating IL-4.
Topics: A Kinase Anchor Proteins; Animals; Calcineurin; Cytokines; Down-Regulation; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Interleukin-4; Male; Neuralgia; NFATC Transcription Factors; Paclitaxel; Rats; Rats, Sprague-Dawley; Spinal Cord; Up-Regulation | 2018 |
Presynaptic mGluR5 receptor controls glutamatergic input through protein kinase C-NMDA receptors in paclitaxel-induced neuropathic pain.
Topics: Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Cells, Cultured; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Injections, Spinal; Male; Nerve Tissue Proteins; Neuralgia; Neurons, Afferent; Paclitaxel; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Resorcinols; Spinal Cord Dorsal Horn; Synaptosomes | 2017 |
Suppressive Effects of Bee Venom Acupuncture on Paclitaxel-Induced Neuropathic Pain in Rats: Mediation by Spinal α₂-Adrenergic Receptor.
Topics: Acupuncture Therapy; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Bee Venoms; Hyperalgesia; Idazoxan; Male; Melitten; Neuralgia; Paclitaxel; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord | 2017 |
Zinc Inhibits TRPV1 to Alleviate Chemotherapy-Induced Neuropathic Pain.
Topics: Animals; Antineoplastic Agents, Phytogenic; Female; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Paclitaxel; TRPV Cation Channels; Zinc Acetate | 2018 |
DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain.
Topics: Action Potentials; Animals; Antineoplastic Agents, Phytogenic; Calcitonin Gene-Related Peptide; Female; Ganglia, Spinal; Humans; Hyperalgesia; Male; NAV1.7 Voltage-Gated Sodium Channel; Neuralgia; Paclitaxel; Patch-Clamp Techniques; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Spider Venoms; Up-Regulation | 2018 |
Blocking of cytokines signalling attenuates evoked and spontaneous neuropathic pain behaviours in the paclitaxel rat model of chemotherapy-induced neuropathy.
Topics: Animals; Cytokines; Disease Models, Animal; Etanercept; Interleukin 1 Receptor Antagonist Protein; Male; Neuralgia; Paclitaxel; Rats; Rats, Wistar; Signal Transduction; Up-Regulation | 2018 |
Repeated Morphine Produces Sensitization to Reward and Tolerance to Antiallodynia in Male and Female Rats with Chemotherapy-Induced Neuropathy.
Topics: Animals; Antineoplastic Agents; Female; Hyperalgesia; Male; Morphine; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Reward; Time Factors | 2018 |
Lack of paclitaxel effects on intracranial self-stimulation in male and female rats: comparison to mechanical sensitivity.
Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Electric Stimulation; Female; Male; Medial Forebrain Bundle; Neuralgia; Paclitaxel; Pain; Pain Management; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Stimulation | 2018 |
Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents; Blood Pressure; Cyclohexanecarboxylic Acids; Disease Models, Animal; Fluorobenzenes; Gabapentin; gamma-Aminobutyric Acid; Heart Rate; Locomotion; Male; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Peripheral Nervous System; Rats; Rats, Sprague-Dawley | 2018 |
Cognitive impairment in a rat model of neuropathic pain: role of hippocampal microtubule stability.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Learning; Long-Term Potentiation; Male; Memory; Microtubules; Neuralgia; Nocodazole; Paclitaxel; Rats; Rats, Sprague-Dawley; Tubulin Modulators | 2018 |
Role of Complement in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy.
Topics: Animals; Complement System Proteins; Disease Models, Animal; Hyperalgesia; Immunity, Innate; Nerve Fibers; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Quality of Life; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 2018 |
Insights into the Contribution of Voltage-Gated Sodium Channel 1.7 to Paclitaxel-Induced Neuropathy.
Topics: Animals; Humans; NAV1.7 Voltage-Gated Sodium Channel; Neuralgia; Paclitaxel; Rats; Sodium | 2018 |
Evoked and Ongoing Pain-Like Behaviours in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Hyperalgesia; Male; Motor Activity; Neuralgia; Paclitaxel; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Psychomotor Performance; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Time Factors | 2018 |
Pregabalin and lacosamide ameliorate paclitaxel-induced peripheral neuropathy via inhibition of JAK/STAT signaling pathway and Notch-1 receptor.
Topics: Animals; Hyperalgesia; Lacosamide; Male; Neuralgia; Paclitaxel; Pregabalin; Rats, Wistar; Receptors, Notch; Sciatic Nerve; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2018 |
Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Betulinic Acid; Calcium Channels, N-Type; Calcium Channels, T-Type; CHO Cells; Cricetulus; Diprenorphine; Disease Models, Animal; Female; Ganglia, Spinal; HIV Infections; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; Neuralgia; Neurons; Paclitaxel; Pentacyclic Triterpenes; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Triterpenes; Tritium | 2019 |
Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats.
Topics: Amphibian Venoms; Animals; Astrocytes; Cytokines; Hyperalgesia; Inflammation; Male; Neuralgia; Neuroprotective Agents; Paclitaxel; Rats, Sprague-Dawley; Spinal Cord; TRPV Cation Channels; Up-Regulation | 2018 |
Cannabinoid Type 2 Receptor System Modulates Paclitaxel-Induced Microglial Dysregulation and Central Sensitization in Rats.
Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Agonists; Central Nervous System Sensitization; Epigenesis, Genetic; Hyperalgesia; Inflammation; Male; Microglia; Neuralgia; Paclitaxel; Piperidines; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Spinal Cord Dorsal Horn | 2019 |
Increased α2δ-1-NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy-induced neuropathic pain.
Topics: Animals; Antineoplastic Agents; Male; Mice; Mice, Knockout; Neuralgia; Paclitaxel; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2019 |
Nociceptive behavior induced by chemotherapeutic paclitaxel and beneficial role of antioxidative pathways.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Male; Neuralgia; Nociception; Paclitaxel; Pain Measurement; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.
Topics: Animals; Antineoplastic Agents, Phytogenic; Eukaryotic Initiation Factor-4E; Female; Gene Expression Profiling; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Mice, Transgenic; Monomeric GTP-Binding Proteins; NAV1.8 Voltage-Gated Sodium Channel; Neuralgia; Nociceptors; Paclitaxel; Pain Measurement; Protein Serine-Threonine Kinases; Ribosomes; Signal Transduction | 2019 |
Mechanical allodynia and enhanced responses to capsaicin are mediated by PI3K in a paclitaxel model of peripheral neuropathy.
Topics: Animals; Capsaicin; Excitatory Postsynaptic Potentials; Hyperalgesia; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neuralgia; Oncogene Protein v-akt; Paclitaxel; Peptide Fragments; Phosphatidylinositol 3-Kinases; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Signal Transduction; Spinal Cord; Toll-Like Receptor 4; Transient Receptor Potential Channels; TRPV Cation Channels | 2019 |
Monoclonal Antibody Targeting the Matrix Metalloproteinase 9 Prevents and Reverses Paclitaxel-Induced Peripheral Neuropathy in Mice.
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Immunologic Factors; Male; Matrix Metalloproteinase 9; Mice; Neuralgia; Neurons; Neuroprotective Agents; Paclitaxel; Peripheral Nervous System Diseases | 2019 |
Activation of KCNQ Channels Prevents Paclitaxel-Induced Peripheral Neuropathy and Associated Neuropathic Pain.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carbamates; Cell Line, Tumor; Drug Repositioning; Humans; KCNQ Potassium Channels; Male; Neuralgia; Neurons; Neuroprotective Agents; Paclitaxel; Peripheral Nervous System Diseases; Phenylenediamines; Random Allocation; Rats, Sprague-Dawley | 2019 |
Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal.
Topics: Analgesics, Opioid; Animals; Cannabinoids; Cell Line; Chromones; Dronabinol; Drug Tolerance; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Neuralgia; Paclitaxel; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Signal Transduction | 2019 |
Study of nuclear factor-2 erythroid related factor-2 activator, berberine, in paclitaxel induced peripheral neuropathy pain model in rats.
Topics: Animals; Berberine; Glutathione; Lipid Peroxidation; Male; Malondialdehyde; Models, Animal; Neuralgia; NF-E2-Related Factor 2; Oxidative Stress; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Wistar; RNA, Messenger; Sciatic Nerve; Superoxide Dismutase | 2019 |
Polyester Nanoparticle Encapsulation Mitigates Paclitaxel-Induced Peripheral Neuropathy.
Topics: Animals; Ganglia, Spinal; Hyperalgesia; Nanoparticles; Neuralgia; Paclitaxel; Polyesters; Rats, Sprague-Dawley | 2019 |
Puerarin suppresses TRPV1, calcitonin gene-related peptide and substance P to prevent paclitaxel-induced peripheral neuropathic pain in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Calcitonin Gene-Related Peptide; Isoflavones; Male; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Substance P; TRPV Cation Channels | 2019 |
DNMT3a-triggered downregulation of K
Topics: Animals; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Down-Regulation; Ganglia, Spinal; Humans; Hyperalgesia; Male; Mice, Knockout; Neuralgia; Paclitaxel; Patch-Clamp Techniques; Potassium Channels, Tandem Pore Domain; RNA Interference; Sensory Receptor Cells | 2019 |
Evodiamine ameliorates paclitaxel-induced neuropathic pain by inhibiting inflammation and maintaining mitochondrial anti-oxidant functions.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cytokines; Disease Models, Animal; Ganglia, Spinal; Humans; Inflammation Mediators; Male; Membrane Potential, Mitochondrial; Mitochondria; Neuralgia; Oxidative Stress; Paclitaxel; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phytotherapy; Quinazolines; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Cells, Cultured; Uncoupling Protein 2 | 2019 |
Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor
Topics: Amidohydrolases; Analgesics; Animals; Antineoplastic Agents; Benzamides; Benzoxazines; Brain; Cannabinoids; Carbamates; Cell Line, Tumor; Cell Survival; Drug Synergism; Drug Tolerance; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neuralgia; Paclitaxel; Substance-Related Disorders | 2019 |
Differential effect of LPS and paclitaxel on microglial functional phenotypes and circulating cytokines: the possible role of CX3CR1 and IL-4/10 in blocking persistent inflammation.
Topics: Animals; Antineoplastic Agents, Phytogenic; CX3C Chemokine Receptor 1; Disease Models, Animal; Inflammation; Interleukin-10; Interleukin-4; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Neuralgia; Paclitaxel; Phenotype | 2019 |
Indomethacin plus minocycline coadministration relieves chemotherapy and antiretroviral drug-induced neuropathic pain in a cannabinoid receptors-dependent manner.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Retroviral Agents; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Female; Indomethacin; Mice, Inbred BALB C; Minocycline; Neuralgia; Paclitaxel; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Zalcitabine | 2019 |
Electroacupuncture enhances antioxidative signal pathway and attenuates neuropathic pain induced by chemotherapeutic paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Electroacupuncture; Ganglia, Spinal; Male; Neuralgia; Paclitaxel; Pain Measurement; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats.
Topics: Aconitine; Aconitum; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Hyperalgesia; Male; Mice; Neuralgia; Paclitaxel; Peripheral Nerve Injuries; Plant Roots; Rats, Wistar; Sciatic Nerve | 2019 |
Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion.
Topics: Animals; Antineoplastic Agents, Phytogenic; Avoidance Learning; Basolateral Nuclear Complex; Chronic Pain; Excitatory Postsynaptic Potentials; Gyrus Cinguli; Male; Mediodorsal Thalamic Nucleus; Mice; Neural Pathways; Neuralgia; Paclitaxel; Patch-Clamp Techniques; Sciatic Nerve | 2019 |
Losartan, an Angiotensin II Type 1 Receptor Antagonist, Alleviates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain by Inhibiting Inflammatory Cytokines in the Dorsal Root Ganglia.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cytokines; Disease Models, Animal; Ganglia, Spinal; Glial Fibrillary Acidic Protein; Hyperalgesia; Hypnotics and Sedatives; Inflammation Mediators; Losartan; Male; Neuralgia; Neurons; NF-kappa B; Paclitaxel; Phosphorylation; Rats, Sprague-Dawley | 2019 |
Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice.
Topics: Animals; Antineoplastic Agents; Female; Hyperalgesia; Macrophages; Male; Mice; Neuralgia; Paclitaxel; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Toll-Like Receptor 9 | 2019 |
Thiamine, riboflavin, and nicotinamide inhibit paclitaxel-induced allodynia by reducing TNF-α and CXCL-1 in dorsal root ganglia and thalamus and activating ATP-sensitive potassium channels.
Topics: Animals; Chemokine CXCL1; Ganglia, Spinal; Hyperalgesia; KATP Channels; Male; Mice; Neuralgia; Niacinamide; Paclitaxel; Riboflavin; Thalamus; Thiamine; Tumor Necrosis Factor-alpha; Vitamin B Complex | 2020 |
Spinal CCL2 and microglial activation are involved in paclitaxel-evoked cold hyperalgesia.
Topics: Animals; Chemokine CCL2; Cold Temperature; Hyperalgesia; Male; Mice; Microglia; Minocycline; Neuralgia; Paclitaxel; Receptors, CCR2; Spinal Cord | 2013 |
Effects of repeated milnacipran and fluvoxamine treatment on mechanical allodynia in a mouse paclitaxel-induced neuropathic pain model.
Topics: Animals; Cyclopropanes; Disease Models, Animal; Fluvoxamine; Hyperalgesia; Male; Mice; Milnacipran; Neuralgia; Paclitaxel | 2013 |
Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Axons; Boronic Acids; Bortezomib; Energy Metabolism; Hyperalgesia; Male; Mitochondria; Neoplasm Transplantation; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Peripheral Nerves; Peroxynitrous Acid; Physical Stimulation; Protein Processing, Post-Translational; Pyrazines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Superoxide Dismutase | 2013 |
Anti-nociceptive effect of a conjugate of substance P and light chain of botulinum neurotoxin type A.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Botulinum Toxins, Type A; Cells, Cultured; Conditioning, Operant; Facial Pain; Female; Hot Temperature; Immunohistochemistry; Male; Mice; Mice, Hairless; Neuralgia; Neurons; Paclitaxel; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reward; Substance P; Synaptosomal-Associated Protein 25 | 2013 |
Inhibition of glycogen synthase kinase 3β activity with lithium prevents and attenuates paclitaxel-induced neuropathic pain.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Lithium; Male; Neuralgia; Paclitaxel; Posterior Horn Cells; Rats; Rats, Sprague-Dawley | 2013 |
Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Brain; Breast Neoplasms; Cannabidiol; Cell Line, Tumor; Cell Survival; Conditioning, Operant; Drug Synergism; Female; Humans; Memory; Mice; Mice, Inbred C57BL; Neuralgia; Neurons; Neuroprotective Agents; Paclitaxel; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists | 2014 |
Neurosteroid 3α-androstanediol efficiently counteracts paclitaxel-induced peripheral neuropathy and painful symptoms.
Topics: Action Potentials; Androstane-3,17-diol; Animals; Antineoplastic Agents, Phytogenic; Hyperalgesia; Male; Nerve Fibers; Neural Conduction; Neuralgia; Neuroprotective Agents; Paclitaxel; Pain; Pain Measurement; Peripheral Nerves; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley | 2013 |
The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclohexanes; Female; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mice; Mice, Inbred BALB C; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley | 2013 |
Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain.
Topics: Analysis of Variance; Animals; Anti-Retroviral Agents; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Hyperalgesia; Imidazoles; Male; Neuralgia; Osteoarthritis, Knee; Paclitaxel; Pain Measurement; Pain Threshold; Physical Stimulation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Vincristine; Weight-Bearing | 2014 |
Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice.
Topics: Animals; Axons; Behavior, Animal; Female; Gene Silencing; Mice; Mice, Knockout; Mitochondria; Myelin Sheath; Neuralgia; Paclitaxel; Piperazines; Receptors, sigma; Sensory Receptor Cells; Sigma-1 Receptor | 2014 |
Peptidergic intraepidermal nerve fibers in the skin contribute to the neuropathic pain in paclitaxel-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Calcitonin Gene-Related Peptide; Epidermis; Male; Nerve Degeneration; Nerve Fibers; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Substance P | 2014 |
Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Motor Activity; Neuralgia; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Cord | 2014 |
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Topics: Anilides; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Enzyme Activation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Lysophospholipids; Male; Neuralgia; Organophosphonates; Oxadiazoles; Paclitaxel; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles; Thiophenes | 2014 |
The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model.
Topics: Animals; Cisplatin; Disease Models, Animal; Hyperalgesia; Hypoglycemic Agents; Metformin; Mice, Inbred C57BL; Nerve Fibers; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Protective Agents | 2014 |
Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter.
Topics: Adaptive Immunity; Animals; Antineoplastic Agents, Phytogenic; CD11b Antigen; CD8-Positive T-Lymphocytes; Ganglia, Spinal; Immunity, Innate; Killer Cells, Natural; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; Neuralgia; Nociceptors; Paclitaxel; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells | 2014 |
Dynamic long-term microstructural and ultrastructural alterations in sensory nerves of rats of paclitaxel-induced neuropathic pain.
Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Male; Microtubules; Mitochondria; Neuralgia; Paclitaxel; Random Allocation; Rats; Rats, Sprague-Dawley | 2014 |
Establishment of opioid-induced rewarding effects under oxaliplatin- and Paclitaxel-induced neuropathy in rats.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Fentanyl; Male; Morphine; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Oxycodone; Paclitaxel; Rats, Sprague-Dawley; Receptors, Opioid, mu; Substance-Related Disorders | 2014 |
A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Hyperalgesia; Male; NADP; Neuralgia; Neuroglia; NF-kappa B; Oxidation-Reduction; Paclitaxel; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Tumor Necrosis Factor-alpha | 2014 |
Increased spinal cord Na⁺-K⁺-2Cl⁻ cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain.
Topics: Animals; Cell Membrane; Electrophysiology; Endosomes; Homeostasis; Kinesins; Male; Microtubules; Neuralgia; Neuronal Plasticity; Nociception; Paclitaxel; Rats; Rats, Sprague-Dawley; Solute Carrier Family 12, Member 2; Spinal Cord; Synapses; Tubulin Modulators | 2014 |
Activation of TLR-4 to produce tumour necrosis factor-α in neuropathic pain caused by paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Ganglia, Spinal; Male; Neuralgia; Neuroglia; Paclitaxel; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Satellite Cells, Perineuronal; Toll-Like Receptor 4; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Up-Regulation | 2015 |
Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Dizocilpine Maleate; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuralgia; Paclitaxel; Pain Measurement; Phospholipases A2; Piperidines; Receptors, Lysophosphatidic Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spinal Cord Dorsal Horn; Time Factors | 2014 |
Analgesic effect of electroacupuncture on paclitaxel-induced neuropathic pain via spinal opioidergic and adrenergic mechanisms in mice.
Topics: Acupuncture Points; Animals; Antineoplastic Agents, Phytogenic; Electroacupuncture; Mice, Inbred ICR; Neuralgia; Paclitaxel; Peptide Fragments; Phosphorylation; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord | 2015 |
Comprehensive analysis of the GABAergic system gene expression profile in the anterior cingulate cortex of mice with Paclitaxel-induced neuropathic pain.
Topics: Animals; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gyrus Cinguli; Humans; Mice; Neuralgia; Paclitaxel; Receptors, GABA-A; RNA, Messenger; Transcriptome | 2015 |
Gender differences in a mouse model of chemotherapy-induced neuropathic pain.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cisplatin; Disease Models, Animal; Female; Injections, Intraperitoneal; Male; Mice; Neuralgia; Paclitaxel; Sex Factors | 2016 |
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
Topics: Acetanilides; Analgesics; Animals; Benzamides; Capsaicin; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; Isothiocyanates; Male; Mice; Neuralgia; Oximes; Paclitaxel; Pain Measurement; Purines; Thiophenes; Touch; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels | 2015 |
Blocking the GABA transporter GAT-1 ameliorates spinal GABAergic disinhibition and neuropathic pain induced by paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Disease Models, Animal; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn | 2015 |
Paclitaxel induces acute pain via directly activating toll like receptor 4.
Topics: Acute Pain; Animals; Antineoplastic Agents, Phytogenic; Ganglia, Spinal; Male; Neuralgia; Paclitaxel; Pain Measurement; Pain Threshold; Rats, Sprague-Dawley; Toll-Like Receptor 4 | 2015 |
CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain.
Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Male; Mice; Mice, Knockout; Neuralgia; Paclitaxel; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Treatment Outcome | 2015 |
Possible involvement of the Sigma-1 receptor chaperone in chemotherapeutic-induced neuropathic pain.
Topics: Animals; Anisoles; Antineoplastic Agents; Blotting, Western; CHO Cells; Cricetulus; Hyperalgesia; Male; Microscopy, Fluorescence; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Piperazines; Propylamines; Rats, Sprague-Dawley; Receptors, sigma; Sensory System Agents; Sigma-1 Receptor; Spinal Cord; Touch; Transfection | 2015 |
Bulleyaconitine A depresses neuropathic pain and potentiation at C-fiber synapses in spinal dorsal horn induced by paclitaxel in rats.
Topics: Aconitine; Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Hyperalgesia; In Vitro Techniques; Male; Nerve Fibers, Unmyelinated; Neuralgia; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Synaptic Potentials; Time Factors | 2015 |
Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Hyperalgesia; Injections, Spinal; Male; Neuralgia; Nociceptin Receptor; Opioid Peptides; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2015 |
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
Topics: Adult; Aged; Anesthetics, Local; Animals; Antineoplastic Agents; Capsaicin; Diabetic Neuropathies; Female; Flagellin; Ganglia, Spinal; Humans; Hyperalgesia; Lidocaine; Male; Mice; Mice, Knockout; Middle Aged; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neuralgia; Neurofilament Proteins; Neurons; Paclitaxel; Peripheral Nerve Injuries; Sensory System Agents; Toll-Like Receptor 5 | 2015 |
A Hyperresponsive HPA Axis May Confer Resilience Against Persistent Paclitaxel-Induced Mechanical Hypersensitivity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Female; Hyperalgesia; Hypothalamo-Hypophyseal System; Male; Neuralgia; Paclitaxel; Pituitary-Adrenal System; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Stress, Physiological | 2016 |
Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Female; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Neuralgia; Nociception; Paclitaxel; Rats; Rats, Wistar; Visceral Pain | 2016 |
mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain.
Topics: Action Potentials; Animals; Antagomirs; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Down-Regulation; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperalgesia; Inhibitory Postsynaptic Potentials; Male; MicroRNAs; Neuralgia; Paclitaxel; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Transcription Activator-Like Effector Nucleases | 2016 |
Presynaptic N-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ganglia, Spinal; Male; Neuralgia; Paclitaxel; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2016 |
Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Dose-Response Relationship, Drug; Ganglia, Spinal; Histamine Release; Mast Cells; Mice, Inbred ICR; Neuralgia; Paclitaxel; Protein Kinase C-epsilon; Quercetin; Rats, Sprague-Dawley; Spinal Cord; TRPV Cation Channels | 2016 |
Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel-evoked neuropathic pain.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Astrocytes; Blotting, Western; Cell Line, Tumor; Cell Survival; Citrates; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Humans; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Neuralgia; Neuroglia; Paclitaxel; Pain Measurement; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn | 2016 |
Prophylactic treatment with the tricyclic antidepressant desipramine prevents development of paclitaxel-induced neuropathic pain through activation of endogenous analgesic systems.
Topics: Animals; Antidepressive Agents, Tricyclic; Antineoplastic Agents, Phytogenic; Desipramine; Hyperalgesia; Male; Neuralgia; Paclitaxel; Rats, Sprague-Dawley; Receptors, Cannabinoid; Signal Transduction | 2016 |
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antineoplastic Agents, Phytogenic; Benzimidazoles; Benzoates; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Ganglia, Spinal; Gene Expression Regulation, Enzymologic; HEK293 Cells; Humans; Linoleic Acids; Male; Mice, Inbred C57BL; Molecular Targeted Therapy; Neuralgia; Paclitaxel; Pain Threshold; Telmisartan | 2016 |
CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain.
Topics: Animals; Antineoplastic Agents; CD8-Positive T-Lymphocytes; Interleukin-10; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Paclitaxel; Pain Measurement; Pain Perception | 2016 |
MitoVitE, a mitochondria-targeted antioxidant, limits paclitaxel-induced oxidative stress and mitochondrial damage in vitro, and paclitaxel-induced mechanical hypersensitivity in a rat pain model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Disease Models, Animal; Hyperalgesia; In Vitro Techniques; Male; Mitochondria; Neuralgia; Organophosphorus Compounds; Oxidative Stress; Paclitaxel; Rats; Rats, Sprague-Dawley; Ubiquinone | 2016 |
Potentiation of Paclitaxel-Induced Pain Syndrome in Mice by Angiotensin I Converting Enzyme Inhibition and Involvement of Kinins.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antineoplastic Agents; Bradykinin; Drug Synergism; Male; Mice; Neuralgia; Paclitaxel; Pain Measurement; Receptors, Bradykinin | 2017 |
Epigenetic upregulation of CXCL12 expression mediates antitubulin chemotherapeutics-induced neuropathic pain.
Topics: Animals; Antibodies; Chemokine CXCL12; Disease Models, Animal; Evoked Potentials; Excitatory Postsynaptic Potentials; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; RNA, Small Interfering; Spinal Cord; STAT3 Transcription Factor; Time Factors; Tubulin; Up-Regulation; Vincristine | 2017 |
Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy.
Topics: Activating Transcription Factor 3; Animals; Antineoplastic Agents; CD8-Positive T-Lymphocytes; Chemokine CCL2; Chemokine CCL3; Ganglia, Spinal; Gene Expression; Hyperalgesia; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neuralgia; Neurofilament Proteins; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Receptors, Purinergic P2Y12; Sensory Receptor Cells; Spinal Cord; Spleen; T-Lymphocytes, Regulatory | 2017 |
Rikkunshito prevents paclitaxel-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice.
Topics: Animals; Drugs, Chinese Herbal; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Neuroprotective Agents; NF-kappa B; Paclitaxel; Peripheral Nervous System Diseases; Phosphorylation; Signal Transduction; Spinal Cord | 2017 |
Prophylactic topical paeoniflorin prevents mechanical allodynia caused by paclitaxel in mice through adenosine A
Topics: Administration, Topical; Animals; Antineoplastic Agents; Benzoates; Demyelinating Diseases; Glucosides; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Monoterpenes; Neuralgia; Paclitaxel; Paeonia; Phytotherapy; Plant Extracts; Receptor, Adenosine A1 | 2017 |
Roles for CD8
Topics: Antineoplastic Agents, Phytogenic; CD8-Positive T-Lymphocytes; Interleukin-10; Neuralgia; Paclitaxel | 2017 |
Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cannabinoids; Chromones; Dimethyl Sulfoxide; Male; Morphine; Neuralgia; Paclitaxel; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Stereoisomerism | 2008 |
MDA7: a novel selective agonist for CB2 receptors that prevents allodynia in rat neuropathic pain models.
Topics: Analgesics; Animals; Benzofurans; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Ligation; Motor Activity; Neuralgia; Paclitaxel; Pain Measurement; Piperidines; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Species Specificity; Spinal Nerves | 2008 |
Chemotherapy-induced peripheral neuropathy as a predictor of neuropathic pain in breast cancer patients previously treated with paclitaxel.
Topics: Analgesics; Analysis of Variance; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Comorbidity; Female; Follow-Up Studies; Humans; Logistic Models; Multivariate Analysis; Neuralgia; Odds Ratio; Paclitaxel; Patient Acceptance of Health Care; Peripheral Nervous System Diseases; Risk Factors | 2009 |
Olesoxime (cholest-4-en-3-one, oxime): analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel.
Topics: Analysis of Variance; Animals; Area Under Curve; Cholestenones; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Evoked Potentials; Hyperalgesia; Male; Nerve Fibers; Neuralgia; Neuroprotective Agents; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Ubiquitin Thiolesterase | 2009 |
Terminal arbor degeneration--a novel lesion produced by the antineoplastic agent paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Epidermis; Male; Nerve Degeneration; Nerve Fibers; Neuralgia; Paclitaxel; Pain Measurement; Peripheral Nerves; Rats; Rats, Sprague-Dawley | 2011 |
Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Blotting, Western; Calcium Channels, T-Type; Cyclopropanes; Enzyme Inhibitors; HEK293 Cells; Humans; Hydrogen Sulfide; Hyperalgesia; Male; Naphthalenes; Neuralgia; Paclitaxel; Patch-Clamp Techniques; Rats; Rats, Wistar | 2011 |
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
Topics: Analysis of Variance; Anilides; Animals; Ankyrins; Antineoplastic Agents, Phytogenic; Capsaicin; Carbazoles; Central Nervous System; Cinnamates; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Oligopeptides; Paclitaxel; Pain Measurement; Physical Stimulation; Protein Kinase C; Pyrroles; Pyrrolidinones; Receptor, PAR-2; Sulfonamides; Time Factors; TRPV Cation Channels; Tryptases; Type C Phospholipases | 2011 |
Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Cell Respiration; Chronic Pain; Citrate (si)-Synthase; Electron Transport Complex I; Electron Transport Complex II; Male; Mitochondria; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Oxygen; Paclitaxel; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sensory Receptor Cells | 2011 |
Mitochondrial abnormality in sensory, but not motor, axons in paclitaxel-evoked painful peripheral neuropathy in the rat.
Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Cell Respiration; Male; Microscopy, Electron, Transmission; Mitochondria; Motor Neurons; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells | 2011 |
Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel.
Topics: Animals; Antineoplastic Agents; Axons; Hyperalgesia; Male; Neural Conduction; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Rats; Rats, Sprague-Dawley; Sural Nerve; Tibial Nerve | 2012 |
Effects of mitochondrial poisons on the neuropathic pain produced by the chemotherapeutic agents, paclitaxel and oxaliplatin.
Topics: Animals; Antineoplastic Agents; Antirheumatic Agents; Auranofin; Behavior, Animal; Drug Interactions; Hyperalgesia; Male; Mitochondria; Nerve Fibers; Neuralgia; Oligomycins; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Rotenone; Time Factors; Uncoupling Agents | 2012 |
Evidence that spinal astrocytes but not microglia contribute to the pathogenesis of Paclitaxel-induced painful neuropathy.
Topics: Animals; Antineoplastic Agents; Astrocytes; Blotting, Western; Disease Models, Animal; Immunohistochemistry; Male; Microglia; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord | 2012 |
Chemotherapy-induced neuropathic pain and its relation to cluster symptoms in breast cancer patients treated with paclitaxel.
Topics: Adult; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cluster Analysis; Depression; Fatigue; Female; Humans; Middle Aged; Neuralgia; Paclitaxel; Pain Measurement; Severity of Illness Index; Sleep Wake Disorders | 2013 |
Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain.
Topics: Animals; Antineoplastic Agents; Cytokines; Drug Delivery Systems; Male; Neuralgia; Paclitaxel; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord | 2012 |
Analgesic effect of magnetic stimulation on paclitaxel-induced peripheral neuropathic pain in mice.
Topics: Analgesia; Analgesics; Animals; Hyperalgesia; Magnetic Field Therapy; Male; Mice; Mice, Inbred ICR; Neuralgia; Paclitaxel; Pain Measurement; Peripheral Nervous System Diseases | 2012 |
Paclitaxel-induced neuropathic pain is age dependent and devolves on glial response.
Topics: Age Factors; Animals; Antineoplastic Agents, Phytogenic; Astrocytes; Calcium-Binding Proteins; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Mice; Mice, Inbred Strains; Microfilament Proteins; Microglia; Neuralgia; Nociceptors; Paclitaxel; Physical Stimulation; Spinal Cord | 2013 |
Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy.
Topics: Animals; Antibodies, Neutralizing; Behavior, Animal; Ganglia, Spinal; Indoles; Mice; Mice, Transgenic; Neuralgia; Neurons; Paclitaxel; Pain Measurement; Polyneuropathies; Protein Kinase Inhibitors; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats.
Topics: Analgesics; Animals; Antineoplastic Agents; Behavior, Animal; Calcitonin; Cold Temperature; Hyperalgesia; Isothiocyanates; Male; Menthol; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Rats; Rats, Sprague-Dawley | 2012 |
Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Blotting, Western; Brain; Cold Temperature; Female; Hyperalgesia; MAP Kinase Signaling System; Membranes; Mice; Mice, Knockout; Morpholines; Narcotics; Neuralgia; Paclitaxel; Pain Measurement; Pentazocine; Physical Stimulation; Piperazines; Postural Balance; Pyrazoles; Receptors, sigma; Sigma-1 Receptor | 2012 |
The contribution of satellite glial cells to chemotherapy-induced neuropathic pain.
Topics: Animals; Antineoplastic Agents; Carbenoxolone; Ganglia, Spinal; Gap Junctions; Glial Fibrillary Acidic Protein; Mice; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Pain Threshold; Satellite Cells, Perineuronal | 2013 |
Paclitaxel increases high voltage-dependent calcium channel current in dorsal root ganglion neurons of the rat.
Topics: Action Potentials; Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Size; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Male; Nerve Tissue Proteins; Neuralgia; Neurons; Neurotoxicity Syndromes; Paclitaxel; Rats; Rats, Wistar; Up-Regulation | 2012 |
[Targeting Ca(v)3.2 T-type calcium channels as a therapeutic strategy for chemotherapy-induced neuropathic pain].
Topics: Animals; Antineoplastic Agents; Ascorbic Acid; Calcium Channels, T-Type; Dinoprostone; Humans; Hydrogen Sulfide; Molecular Targeted Therapy; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases | 2013 |
Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy.
Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Ethosuximide; Excitatory Amino Acid Antagonists; Male; Morphine; Narcotics; Neuralgia; Paclitaxel; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Time Factors; Vincristine | 2004 |
Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat.
Topics: Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Calcium; Cation Transport Proteins; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Hypotonic Solutions; Integrins; Ion Channels; Male; Neuralgia; Nociceptors; Oligonucleotides, Antisense; Paclitaxel; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Signal Transduction; src-Family Kinases; TRPV Cation Channels | 2004 |
Chemotherapy-induced neuropathy: treatment by decompression of peripheral nerves.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carpal Tunnel Syndrome; Cisplatin; Decompression, Surgical; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Hand; Humans; Leg; Lung Neoplasms; Lymphoma; Male; Middle Aged; Neoplasms; Nerve Compression Syndromes; Neuralgia; Ovarian Neoplasms; Paclitaxel; Pain Measurement; Paresthesia; Peripheral Nervous System Diseases; Treatment Outcome; Vincristine; Wrist | 2004 |
A cannabinoid pharmacotherapy for chemotherapy-evoked painful peripheral neuropathy.
Topics: Animals; Antineoplastic Agents; Cannabinoids; Humans; Neoplasms; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases | 2005 |
A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Benzoxazines; Cannabinoids; Disease Models, Animal; Hot Temperature; Humans; Hyperalgesia; Male; Morpholines; Naphthalenes; Neuralgia; Paclitaxel; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Wistar; Sensory Thresholds; Touch; Treatment Outcome | 2005 |
Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Gene Expression Regulation; Male; Motor Activity; Neuralgia; Paclitaxel; Pain Measurement; Protein Subunits; Rats; Rats, Sprague-Dawley; Time Factors; Vincristine | 2007 |
Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice.
Topics: Anesthetics, Local; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Hyperalgesia; Mice; Neuralgia; Paclitaxel; Pain Measurement; Tetrodotoxin | 2008 |
Alcohol-induced stress in painful alcoholic neuropathy.
Topics: Adrenalectomy; Alcoholic Neuropathy; Alcohols; Analysis of Variance; Animals; Drug Interactions; Epinephrine; Hormone Antagonists; Hyperalgesia; Male; Mifepristone; Neuralgia; Oligonucleotides, Antisense; Paclitaxel; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Receptors, Glucocorticoid; Stress, Physiological; Time Factors; Zalcitabine | 2008 |
[Evaluation of adverse effects including neurotoxicity of combination chemotherapy with paclitaxel and carboplatin].
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carboplatin; Female; Humans; Hypesthesia; Nausea; Neuralgia; Ovarian Neoplasms; Paclitaxel; Pain Measurement; Sensation Disorders; Surveys and Questionnaires | 2000 |
Paclitaxel-induced stomal neuropathy: a unique cause of pain in a patient with ileal conduit.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Transitional Cell; Humans; Ileum; Male; Middle Aged; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Postoperative Complications; Surgical Stomas; Urinary Bladder Neoplasms; Urinary Diversion | 2000 |
Description of a short-term Taxol-induced nociceptive neuropathy in rats.
Topics: Animals; Hair; Hand Strength; Hot Temperature; Hyperalgesia; Male; Motor Activity; Neural Conduction; Neuralgia; Nociceptors; Paclitaxel; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Somatosensory Disorders | 2000 |
Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.
Topics: Action Potentials; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Drug Design; Flavonoids; HEK293 Cells; Humans; Inhibitory Concentration 50; Male; Mice; Neuralgia; Patch-Clamp Techniques; Structure-Activity Relationship | 2018 |