Page last updated: 2024-08-23

paclitaxel and Nerve Degeneration

paclitaxel has been researched along with Nerve Degeneration in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (40.00)29.6817
2010's16 (53.33)24.3611
2020's2 (6.67)2.80

Authors

AuthorsStudies
Avizonis, D; Bergholz, JS; Chen, CY; de Sá Tavares Russo, M; DiAntonio, A; Hsueh, YP; Jiang, T; Ko, KW; Li, Y; Milbrandt, J; Pazyra-Murphy, MF; Segal, RA; Tang, S; Zhao, JJ; Zhu, J1
Bhattacharya, MRC1
Barclay, LA; Bird, GH; Fenstermacher, SJ; Fukuda, Y; Li, Y; Pazyra-Murphy, MF; Pease-Raissi, SE; Segal, RA; Wachter, F; Walensky, LD1
Au, NPB; Chine, VB; Kumar, G; Ma, CHE1
Boucher, M; Cook, JC; Fenyk-Melody, J; Liu, CN; Mechanic, J; Pardo, ID; Peng, Q; Schaevitz, L; Shoieb, A; Somps, C; Vitsky, A1
Chen, W; Höke, A; Mi, R; Reed, N; Zhou, C; Zhu, J1
Gornstein, E; Schwarz, TL1
Dittmann, J; King, AE; Southam, KA; Vickers, JC1
Höke, A; Ray, M1
Hsieh, YL; Hu, ME; Ko, MH; Lan, CT; Tseng, TJ1
Farah, MH; Rammelkamp, Z; Slusher, AB; Slusher, BS; Tasnim, A; Wozniak, K1
Bramley, JC; Buchser, WJ; Clark, KB; Collins, SV1
Höke, A; Hosmane, S; Siddique, R; Thakor, N; Yang, IH1
Bennett, GJ; Jin, HW; Liu, GK; Siau, C; Xiao, WH1
Shemesh, OA; Spira, ME1
Farah, MH; Ferraris, D; Griffin, JW; Hoffman, PN; Nguyen, T; Pan, BH; Price, DL; Slusher, BS; Tsukamoto, T; Wong, PC1
Bhattacharya, MR; DiAntonio, A; Ebstein, SY; Gerdts, J; Milbrandt, J; Naylor, SA; Royse, EX; Sasaki, Y1
Das, V; Miller, JH1
Fujiwara, T; Morimoto, K1
Culver, DG; Davis, AA; Glass, JD; Powers, JC; Wang, MS; Wang, Q1
Ansar, S; Audus, KL; Chen, Y; Georg, GI; Himes, RH; Michaelis, ML; Reiff, ER; Seyb, KI1
Feinstein, SC; Wilson, L1
Feng, J; Jiang, H; Jiang, Q; Liu, W; Ren, Y1
Lee, VM; Trojanowski, JQ1
Höke, A; Jack, C; Lambrinos, GL; Melli, G; Ringkamp, M1
Koike, T; Suzuki, K1
Bradke, F; Enes, J; Ertürk, A; Hellal, F1
Eguchi, K; Kato, H; Mimura, Y; Ogawa, T1
Braguer, D; Briand, C; Carles, G; Delacourte, A; Guise, S1
Cheema, SS; Kilpatrick, TJ; Lopes, EC; Phan, S; Reardon, K1

Reviews

4 review(s) available for paclitaxel and Nerve Degeneration

ArticleYear
The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions.
    Neuropharmacology, 2014, Volume: 76 Pt A

    Topics: Animals; Axons; Dose-Response Relationship, Drug; Humans; Microtubules; Nerve Degeneration; Paclitaxel

2014
Rodent models of chemotherapy-induced peripheral neuropathy.
    ILAR journal, 2014, Volume: 54, Issue:3

    Topics: Animals; Antineoplastic Agents; Axons; Boronic Acids; Bortezomib; Cisplatin; Disease Models, Animal; Mice; Nerve Degeneration; Paclitaxel; Peripheral Nervous System Diseases; Pyrazines; Rats; Vincristine

2014
Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death.
    Biochimica et biophysica acta, 2005, Jan-03, Volume: 1739, Issue:2-3

    Topics: Cell Death; Colchicine; Dementia; Humans; Microtubules; Models, Biological; Nerve Degeneration; Neurons; Paclitaxel; tau Proteins

2005
Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now.
    Journal of Alzheimer's disease : JAD, 2006, Volume: 9, Issue:3 Suppl

    Topics: Alzheimer Disease; Antineoplastic Agents, Phytogenic; Brain; Disease Progression; Humans; Nerve Degeneration; Neurofibrillary Tangles; Paclitaxel; tau Proteins

2006

Other Studies

26 other study(ies) available for paclitaxel and Nerve Degeneration

ArticleYear
Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN.
    The Journal of cell biology, 2022, 02-07, Volume: 221, Issue:2

    Topics: Animals; Armadillo Domain Proteins; Axons; Calcium; Calcium Channels; Cyclic ADP-Ribose; Cytoskeletal Proteins; Female; HEK293 Cells; Humans; Mice, Inbred C57BL; Nerve Degeneration; Paclitaxel; Peripheral Nervous System Diseases; Rats, Sprague-Dawley

2022
A Chemotherapy-Induced Peripheral Neuropathy Model in Drosophila melanogaster.
    Methods in molecular biology (Clifton, N.J.), 2020, Volume: 2143

    Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents; Axons; Dendrites; Disease Models, Animal; Dissection; Drosophila melanogaster; Female; Genotype; Larva; Male; Microscopy, Fluorescence; Nerve Degeneration; Paclitaxel; Peripheral Nervous System Diseases

2020
Paclitaxel Reduces Axonal Bclw to Initiate IP
    Neuron, 2017, Oct-11, Volume: 96, Issue:2

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Axons; Cells, Cultured; Female; Ganglia, Spinal; Inositol 1,4,5-Trisphosphate Receptors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley

2017
Targeting Axon Integrity to Prevent Chemotherapy-Induced Peripheral Neuropathy.
    Molecular neurobiology, 2019, Volume: 56, Issue:5

    Topics: Actin Depolymerizing Factors; Action Potentials; Animals; Antineoplastic Agents; Apoptosis; Axons; Caspase 3; Ganglia, Spinal; HSP27 Heat-Shock Proteins; Humans; Hyperalgesia; Male; Mice, Transgenic; Mitochondria; Mitochondrial Swelling; Myelin Sheath; Nerve Degeneration; Nerve Fibers; Neuroprotective Agents; Paclitaxel; Peripheral Nervous System Diseases; rhoA GTP-Binding Protein; Signal Transduction

2019
Circulating microRNA and automated motion analysis as novel methods of assessing chemotherapy-induced peripheral neuropathy in mice.
    PloS one, 2019, Volume: 14, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Automation; Behavior, Animal; Biomarkers; Circulating MicroRNA; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Movement; Nerve Degeneration; Paclitaxel; Peripheral Nervous System Diseases; Sciatic Nerve

2019
Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation.
    Annals of neurology, 2013, Volume: 74, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Cell Line; Drug Evaluation, Preclinical; Ethoxyquin; HSP90 Heat-Shock Proteins; Male; Mice; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Paclitaxel

2013
Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol.
    Acta neuropathologica communications, 2013, Sep-09, Volume: 1

    Topics: Animals; Axons; Caspase 3; Cells, Cultured; Cerebral Cortex; Cytoskeleton; Dendrites; Dose-Response Relationship, Drug; Kainic Acid; Mice; Microtubule-Associated Proteins; Microtubules; Nerve Degeneration; Neuroprotective Agents; Paclitaxel; Wallerian Degeneration

2013
Peptidergic intraepidermal nerve fibers in the skin contribute to the neuropathic pain in paclitaxel-induced peripheral neuropathy.
    Neuropeptides, 2014, Volume: 48, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Calcitonin Gene-Related Peptide; Epidermis; Male; Nerve Degeneration; Nerve Fibers; Neuralgia; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Substance P

2014
Paclitaxel causes degeneration of both central and peripheral axon branches of dorsal root ganglia in mice.
    BMC neuroscience, 2016, 07-11, Volume: 17, Issue:1

    Topics: Animals; Antineoplastic Agents; Axons; Disease Models, Animal; Female; Ganglia, Spinal; Male; Mice, Inbred C57BL; Microscopy, Electron; Nerve Degeneration; Paclitaxel; Peripheral Nervous System Diseases; Sciatic Nerve; Spinal Cord

2016
Avian axons undergo Wallerian degeneration after injury and stress.
    Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2016, Volume: 202, Issue:11

    Topics: Analysis of Variance; Animals; Axons; Axotomy; Calcium; Cells, Cultured; Disease Models, Animal; Finches; Microscopy, Confocal; Microscopy, Fluorescence; NAD; Nerve Degeneration; Paclitaxel; Pressure; Retinal Ganglion Cells; Stress, Physiological; Vincristine; Wallerian Degeneration

2016
Compartmentalized microfluidic culture platform to study mechanism of paclitaxel-induced axonal degeneration.
    Experimental neurology, 2009, Volume: 218, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Cell Count; Cells, Cultured; Embryo, Mammalian; Erythropoietin; Fluoresceins; Ganglia, Spinal; Microfluidics; Nerve Degeneration; Paclitaxel; Rats; Recombinant Proteins; Sensory Receptor Cells

2009
Terminal arbor degeneration--a novel lesion produced by the antineoplastic agent paclitaxel.
    The European journal of neuroscience, 2011, Volume: 33, Issue:9

    Topics: Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Epidermis; Male; Nerve Degeneration; Nerve Fibers; Neuralgia; Paclitaxel; Pain Measurement; Peripheral Nerves; Rats; Rats, Sprague-Dawley

2011
Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel.
    Neurobiology of disease, 2011, Volume: 43, Issue:1

    Topics: Alzheimer Disease; Animals; Aplysia; Cells, Cultured; Humans; Mitosis; Nerve Degeneration; Neurons; Paclitaxel; Protein Unfolding; tau Proteins; Tauopathies; Transduction, Genetic; Tubulin Modulators

2011
Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Apr-13, Volume: 31, Issue:15

    Topics: Acrylamide; Amyloid Precursor Protein Secretases; Animals; Antineoplastic Agents, Phytogenic; Aspartic Acid Endopeptidases; Axons; Biotin; Enzyme Inhibitors; Ganglia, Spinal; Immunohistochemistry; Infusion Pumps, Implantable; Mice; Mice, 129 Strain; Mice, Knockout; Microscopy, Electron; Myelin Sheath; Nerve Degeneration; Nerve Regeneration; Neuromuscular Junction; Paclitaxel; Peripheral Nervous System; Phagocytosis; Sciatic Nerve; Wallerian Degeneration

2011
A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Apr-11, Volume: 32, Issue:15

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Axons; Disease Models, Animal; Drosophila; Drosophila Proteins; Eye Proteins; Female; Ganglia, Spinal; Immunohistochemistry; Larva; Mice; Microscopy, Confocal; Nerve Degeneration; Neurotoxicity Syndromes; Paclitaxel; Peripheral Nerves; RNA Interference

2012
Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation.
    The European journal of neuroscience, 2012, Volume: 35, Issue:11

    Topics: Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Female; Lactones; Male; Microtubules; Nerve Degeneration; Neuroprotective Agents; Paclitaxel; Phosphorylation; Primary Cell Culture; Rats; Rats, Sprague-Dawley; tau Proteins; Tubulin Modulators

2012
Inhibition of p53 transactivation functionally interacts with microtubule stabilization to suppress excitotoxicity-induced axon degeneration.
    Biochemical and biophysical research communications, 2012, Oct-12, Volume: 427, Issue:1

    Topics: Animals; Axons; Benzothiazoles; Cells, Cultured; Dynactin Complex; Glutamic Acid; Hippocampus; Microtubule-Associated Proteins; Microtubules; Mitochondria; Mitochondrial Diseases; Nerve Degeneration; Neurotoxins; Paclitaxel; Rats; Rats, Wistar; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53

2012
Calpain inhibition protects against Taxol-induced sensory neuropathy.
    Brain : a journal of neurology, 2004, Volume: 127, Issue:Pt 3

    Topics: Animals; Antineoplastic Agents; Axons; Calpain; Caspases; Cell Death; Cell Line; Cells, Cultured; Dipeptides; Electrophysiology; Female; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microtubules; Nerve Degeneration; Neurons, Afferent; Paclitaxel; Rats; Rats, Inbred Strains

2004
{beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents, Phytogenic; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; JNK Mitogen-Activated Protein Kinases; Kinetics; Microtubules; Nerve Degeneration; Neurons; Neuroprotective Agents; Paclitaxel; Peptide Fragments; Rats; Rats, Sprague-Dawley

2005
Selective vulnerability of dopaminergic neurons to microtubule depolymerization.
    The Journal of biological chemistry, 2005, Oct-07, Volume: 280, Issue:40

    Topics: Cell Death; Colchicine; Cytosol; Dopamine; Humans; Microtubules; Nerve Degeneration; Nocodazole; Oxidative Stress; Paclitaxel; Parkinson Disease; Polymers; Receptors, Dopamine; Rotenone; Substantia Nigra; Uncoupling Agents

2005
Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration.
    Neurobiology of disease, 2006, Volume: 24, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Cells, Cultured; Dose-Response Relationship, Drug; Drug Carriers; Erythropoietin; Female; Ganglia, Spinal; Glycerol; Humans; Injections, Intraperitoneal; Mice; Nerve Degeneration; Neurons, Afferent; Neuroprotective Agents; Paclitaxel; Recombinant Proteins; Tubulin; Tyrosine

2006
Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation.
    Neuroscience, 2007, Jul-13, Volume: 147, Issue:3

    Topics: Acetylation; Analysis of Variance; Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Cerebellum; Colchicine; Fluoresceins; Gene Expression Regulation, Enzymologic; Mice; Nerve Degeneration; Neurons; Paclitaxel; RNA, Small Interfering; Sirtuin 2; Sirtuins; Time Factors; Transfection; Tubulin; Tubulin Modulators; Wallerian Degeneration

2007
Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Aug-22, Volume: 27, Issue:34

    Topics: Animals; Axons; Cells, Cultured; Central Nervous System; Cerebellum; Ganglia, Spinal; Green Fluorescent Proteins; Growth Cones; Luminescent Proteins; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Microtubules; Nerve Degeneration; Neurons; Nocodazole; Paclitaxel; Regeneration; Sciatic Neuropathy; Tubulin Modulators

2007
Schedule dependency of paclitaxel-induced neuropathy in mice: a morphological study.
    Neurotoxicology, 2000, Volume: 21, Issue:4

    Topics: Action Potentials; Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Body Weight; Electrophysiology; Ganglia, Spinal; Injections, Intraperitoneal; Male; Mice; Nerve Degeneration; Nerve Fibers; Neuropeptides; Neurotoxicity Syndromes; Paclitaxel; Pain Threshold; Sciatic Nerve

2000
Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells.
    Journal of neuroscience research, 2001, Feb-01, Volume: 63, Issue:3

    Topics: Alzheimer Disease; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Caspases; Doxorubicin; Humans; Microtubules; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neuroblastoma; Paclitaxel; Phosphorylation; tau Proteins; Tumor Cells, Cultured

2001
Leukaemia inhibitory factor abrogates Paclitaxel-induced axonal atrophy in the Wistar rat.
    Brain research, 2001, Aug-24, Volume: 911, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Calcitonin Gene-Related Peptide; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Growth Inhibitors; Immunohistochemistry; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Nerve Degeneration; Neural Conduction; Neurons, Afferent; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Substance P

2001