Page last updated: 2024-08-23

paclitaxel and Germinoblastoma

paclitaxel has been researched along with Germinoblastoma in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (34.29)18.2507
2000's14 (40.00)29.6817
2010's7 (20.00)24.3611
2020's2 (5.71)2.80

Authors

AuthorsStudies
Bahal, R; Chen, C; Gaddam, RR; Liu, Y; Malik, S; Nieh, MP; Shih, KC; Vikram, A; Wahane, A1
Cao, X; Dang, J; Epstein, AL; Feng, M; Gunes, EG; Querfeld, C; Rosen, ST; Sun, Z; Wang, J; Wang, Y; Zhang, W; Zhong, X1
Müller, F1
Franciosi, AI; Guérios, SD; Pezzini, PC; Silva, DM1
Bogdanova, LA; Kaledin, VI; Morozkova, TS; Nikolin, VP; Popova, NA; Pyshnaya, IA1
Chang, YF; Chen, TC; Chuang, HY; Hsu, FT; Hwang, JJ1
Otsuka, I; Shoji, K1
Chen, L; Chen, T; Honma, M; Mei, N; Moore, MM; Sawyer, JR; Wang, J1
Bagley, RG; Crawford, JL; Krumbholz, RD; Kurtzberg, LS; Roth, SD; Rouleau, C; Schmid, SM; Teicher, BA; Yao, M1
Doles, J; Hemann, MT1
Burckhardt, G; Gupta, S; Hagos, Y; Henjakovic, M; Koepsell, H; Wulf, G1
D'Orazio, A; Gibson, AD1
Chaudhry, M; Chaudhry, V; Crawford, TO; Griffin, JW; Simmons-O'Brien, E1
Chung, MK; Han, SS; Kim, EJ; Kim, JE; Kim, SN; Koh, WS; Kwon, J; Lee, M; Song, CW1
Dellon, AL; Livengood, MS; Maloney, CT; Swier, P; Werter, S1
An, J; Fisher, M; Rettig, MB; Sun, Y1
Armstrong, RC; Augeri, DJ; Belli, BA; Bruncko, M; Deckwerth, TL; Dinges, J; Elmore, SW; Fesik, SW; Hajduk, PJ; Joseph, MK; Kitada, S; Korsmeyer, SJ; Kunzer, AR; Letai, A; Li, C; Mitten, MJ; Nettesheim, DG; Ng, S; Nimmer, PM; O'Connor, JM; Oleksijew, A; Oltersdorf, T; Petros, AM; Reed, JC; Rosenberg, SH; Shen, W; Shoemaker, AR; Tahir, SK; Thompson, CB; Tomaselli, KJ; Wang, B; Wendt, MD; Zhang, H1
Corti, A; Curnis, F; Gallo-Stampino, C; Gasparri, A; Sacchi, A; Toma, S1
Arango, JI; Bradshaw, P; Callander, NS; Freytes, CO; Ochoa-Bayona, JL; Patterson, J; Restrepo, A; Restrepo, MI; Schneider, DL1
Arellano, M; Flowers, C; Heffner, LT; Hutcherson, D; Jo Lechowicz, M; Langston, A; Lonial, S; Waller, EK; Winton, E1
Asbury, R; Boros, L; Chang, AY; Garrow, G1
Bates, S; Berg, SL; Bryant, G; Fojo, A; Goldspiel, BR; Herdt, J; O'Shaughnessy, J; Steinberg, SM; Wilson, WH; Wittes, RE1
Parekh, H; Simpkins, H1
Chung, WK; Hunter, NR; Mason, KA; Milas, L; Milross, CG; Peters, LJ1
Hirose, Y; Takiguchi, T1
Ayoub, JP; Bachier, C; Cabanillas, F; Hagemeister, F; McLaughlin, P; North, L; Pate, O; Preti, A; Rodriguez, MA; Romaguera, J; Sarris, A; Younes, A1
Ayoub, JP; Cabanillas, F; Greer, J; North, L; Younes, A1
Rowinsky, EK1
Cherney, B; Fan, S; O'Connor, PM; Reinhold, W; Rucker, K1
Younes, A1
Bertucci, D; Goh, BC; Mani, S; Ratain, MJ; Vogelzang, NJ; Vokes, EE1
Burkes, R; Charpentier, D; Couture, F; Dulude, H; Glück, S; Goss, P; Kaizer, L; Klasa, R; Palmer, M; Stewart, AK; Tye, L1
Hobbs, ML; Meyn, RD; Munshi, A; Nguyen, LN; Story, MD1
Bilgrami, SA; Bona, RD; Clive, J; Edwards, RL; Feingold, JM; Naqvi, B; Tutschka, PJ1
Prasad, SB; Rosangkima, G1

Reviews

2 review(s) available for paclitaxel and Germinoblastoma

ArticleYear
Paclitaxel pharmacology and other tumor types.
    Seminars in oncology, 1997, Volume: 24, Issue:6 Suppl 19

    Topics: Alkylating Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Endometrial Neoplasms; Esophageal Neoplasms; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Lymphoma; Male; Neoplasms; Neoplasms, Unknown Primary; Paclitaxel; Platinum Compounds; Sarcoma, Kaposi; Stomach Neoplasms; Testicular Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Vinblastine; Vinorelbine

1997
Paclitaxel-based treatment of lymphoma.
    Seminars in oncology, 1999, Volume: 26, Issue:1 Suppl 2

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Paclitaxel

1999

Trials

7 trial(s) available for paclitaxel and Germinoblastoma

ArticleYear
Results of a clinical phase I dose-escalation study of cytarabine in combination with fixed-dose vinorelbine, paclitaxel, etoposide and cisplatin for the treatment of relapsed/refractory lymphoma.
    Leukemia & lymphoma, 2006, Volume: 47, Issue:10

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cytarabine; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Lymphoma; Male; Middle Aged; Paclitaxel; Recurrence; Stem Cells; Time Factors; Vinblastine; Vinorelbine

2006
Paclitaxel by 3-hour infusion followed by 96-hour infusion on failure in patients with refractory malignant disease.
    Seminars in oncology, 1995, Volume: 22, Issue:3 Suppl 6

    Topics: Adult; Aged; Breast Neoplasms; Drug Administration Schedule; Female; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Lung Neoplasms; Lymphoma; Male; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms; Paclitaxel; Remission Induction

1995
Paclitaxel in doxorubicin-refractory or mitoxantrone-refractory breast cancer: a phase I/II trial of 96-hour infusion.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:8

    Topics: Adult; Aged; Agranulocytosis; Breast Neoplasms; Doxorubicin; Drug Administration Schedule; Drug Resistance; Female; Humans; Lung Neoplasms; Lymphoma; Male; Middle Aged; Mitoxantrone; Mouth Mucosa; Paclitaxel; Stomatitis

1994
Paclitaxel (Taxol) for the treatment of lymphoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8 Suppl 1

    Topics: Antineoplastic Agents, Phytogenic; Drug Administration Schedule; Humans; Infusions, Intravenous; Lymphoma; Paclitaxel

1997
A Phase I study of raltitrexed and paclitaxel given every 3 weeks to patients with solid tumors.
    Cancer, 1999, Aug-01, Volume: 86, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Drug Administration Schedule; Drug Evaluation; Female; Humans; Lymphoma; Male; Middle Aged; Neoplasms; Neutropenia; Paclitaxel; Quinazolines; Thiophenes

1999
Combined results of two phase II studies of Taxol (paclitaxel) in patients with relapsed or refractory lymphomas.
    Leukemia & lymphoma, 1999, Volume: 34, Issue:3-4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Female; Humans; Lymphoma; Male; Middle Aged; Paclitaxel; Recurrence; Survival Rate

1999
Cytoreduction and stem cell mobilization with a regimen of paclitaxel, etoposide and cyclophosphamide followed by autologous transplantation using a preparative regimen of busulfan, etoposide and cyclophosphamide for patients with advanced lymphoma.
    Acta haematologica, 2001, Volume: 105, Issue:4

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child; Combined Modality Therapy; Cyclophosphamide; Etoposide; Female; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Male; Middle Aged; Paclitaxel; Salvage Therapy; Survival Analysis; Transplantation, Autologous

2001

Other Studies

26 other study(ies) available for paclitaxel and Germinoblastoma

ArticleYear
Dual-Modality Poly-l-histidine Nanoparticles to Deliver Peptide Nucleic Acids and Paclitaxel for In Vivo Cancer Therapy.
    ACS applied materials & interfaces, 2021, Sep-29, Volume: 13, Issue:38

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Carriers; Endocytosis; Female; Histidine; Humans; Lymphoma; Mice, Inbred NOD; MicroRNAs; Nanoparticles; Paclitaxel; Peptide Nucleic Acids; Polylactic Acid-Polyglycolic Acid Copolymer; Xenograft Model Antitumor Assays

2021
Targeting macrophages for enhancing CD47 blockade-elicited lymphoma clearance and overcoming tumor-induced immunosuppression.
    Blood, 2022, 06-02, Volume: 139, Issue:22

    Topics: CD47 Antigen; Humans; Immunosuppression Therapy; Immunotherapy; Lymphoma; Macrophages; Neoplasms; Paclitaxel; Phagocytosis; Tumor Microenvironment

2022
Synergistic immunotoxin-paclitaxel combination against lymphoma.
    Aging, 2017, Jun-13, Volume: 9, Issue:6

    Topics: Animals; Antineoplastic Agents; Bacterial Toxins; Drug Synergism; Exotoxins; Humans; Immunotoxins; Lymphoma; Paclitaxel

2017
Subcutaneous administration of paclitaxel in dogs with cancer: A preliminary study.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2015, Volume: 56, Issue:8

    Topics: Animals; Carcinoma; Dog Diseases; Dogs; Female; Injections, Subcutaneous; Lymphoma; Male; Mastocytoma; Paclitaxel; Sarcoma

2015
Effect of Paclitaxel on Antitumor Activity of Cyclophosphamide: Study on Two Transplanted Tumors in Mice.
    Bulletin of experimental biology and medicine, 2015, Volume: 160, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cyclophosphamide; Drug Interactions; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Lymphoma; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Paclitaxel

2015
Enhancement of adoptive T cell transfer with single low dose pretreatment of doxorubicin or paclitaxel in mice.
    Oncotarget, 2015, Dec-29, Volume: 6, Issue:42

    Topics: Adoptive Transfer; Animals; CD8-Positive T-Lymphocytes; Coculture Techniques; Dose-Response Relationship, Drug; Doxorubicin; Genes, Reporter; Granzymes; HEK293 Cells; Humans; Immunosuppressive Agents; Jurkat Cells; Luciferases, Firefly; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma; Male; Mice, Inbred C57BL; NF-kappa B; Paclitaxel; Promoter Regions, Genetic; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes, Regulatory; Time Factors; Transfection; Tumor Escape; Tumor Microenvironment

2015
Paraaortic node recurrence 25 years after removal of epithelial ovarian carcinoma.
    The journal of obstetrics and gynaecology research, 2016, Volume: 42, Issue:11

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Ovarian Epithelial; Female; Humans; Lymphoma; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Paclitaxel; Remission Induction; Treatment Outcome

2016
The mouse lymphoma assay detects recombination, deletion, and aneuploidy.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 109, Issue:1

    Topics: Aneuploidy; Animals; Antimetabolites; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Chromosomes, Mammalian; Cytogenetic Analysis; Gene Deletion; Gene Dosage; Loss of Heterozygosity; Lymphoma; Metaphase; Mice; Mitomycin; Mutagenicity Tests; Mutagens; Nucleic Acid Synthesis Inhibitors; Paclitaxel; Recombination, Genetic; Thymidine Kinase; Zidovudine

2009
Bone marrow CFU-GM and human tumor xenograft efficacy of three tubulin binding agents.
    Cancer chemotherapy and pharmacology, 2009, Volume: 64, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Body Weight; Bone Marrow Cells; Breast Neoplasms; Disease Progression; Female; Humans; Lymphoma; Male; Mice; Mice, Inbred BALB C; Multiple Myeloma; Oligopeptides; Paclitaxel; Prostatic Neoplasms; Tubulin; Tumor Stem Cell Assay; Vincristine; Xenograft Model Antitumor Assays

2009
Nek4 status differentially alters sensitivity to distinct microtubule poisons.
    Cancer research, 2010, Feb-01, Volume: 70, Issue:3

    Topics: Animals; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Female; Flow Cytometry; G2 Phase; Humans; Lymphoma; Mice; Mice, Inbred C57BL; Microtubules; Neoplasms, Experimental; NIMA-Related Kinases; Paclitaxel; Protein Kinases; Protein Serine-Threonine Kinases; RNA Interference; Survival Analysis; Tubulin Modulators; Vincristine

2010
Human organic cation transporter 1 is expressed in lymphoma cells and increases susceptibility to irinotecan and paclitaxel.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:1

    Topics: Animals; Camptothecin; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Lymphoma; Organic Cation Transporter 1; Paclitaxel

2012
VIII International Conference on malignant lymphoma. June 12-15, 2002 Lugano, Switzerland.
    Clinical lymphoma, 2002, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Etoposide; Humans; Lymphoma; Lymphoma, Mantle-Cell; Middle Aged; Paclitaxel; Prednisone; Rituximab; Time Factors; Topotecan; Treatment Outcome; Vincristine

2002
Toxic neuropathy in patients with pre-existing neuropathy.
    Neurology, 2003, Jan-28, Volume: 60, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Lupus Erythematosus, Discoid; Lymphoma; Male; Middle Aged; Neural Conduction; Oropharyngeal Neoplasms; Paclitaxel; Peripheral Nervous System Diseases; Severity of Illness Index; Thalidomide; Vincristine

2003
cDNA microarray gene expression profiling of hydroxyurea, paclitaxel, and p-anisidine, genotoxic compounds with differing tumorigenicity results.
    Environmental and molecular mutagenesis, 2003, Volume: 42, Issue:2

    Topics: Aniline Compounds; Animals; DNA Damage; Gene Expression Profiling; Hydroxyurea; Lymphoma; Mice; Oligonucleotide Array Sequence Analysis; Paclitaxel; Tumor Cells, Cultured

2003
Chemotherapy-induced neuropathy: treatment by decompression of peripheral nerves.
    Plastic and reconstructive surgery, 2004, Volume: 114, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carpal Tunnel Syndrome; Cisplatin; Decompression, Surgical; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Hand; Humans; Leg; Lung Neoplasms; Lymphoma; Male; Middle Aged; Neoplasms; Nerve Compression Syndromes; Neuralgia; Ovarian Neoplasms; Paclitaxel; Pain Measurement; Paresthesia; Peripheral Nervous System Diseases; Treatment Outcome; Vincristine; Wrist

2004
Antitumor effects of bortezomib (PS-341) on primary effusion lymphomas.
    Leukemia, 2004, Volume: 18, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Boronic Acids; Bortezomib; Cell Division; Dexamethasone; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Drug Synergism; Humans; Lymphoma; Membrane Glycoproteins; NF-kappa B; Paclitaxel; Pleural Effusion, Malignant; Pyrazines; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

2004
An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
    Nature, 2005, Jun-02, Volume: 435, Issue:7042

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Carcinoma, Small Cell; Cell Line, Tumor; Cytochromes c; Disease Models, Animal; Drug Synergism; Humans; Lymphoma; Magnetic Resonance Spectroscopy; Mice; Mitochondria; Models, Molecular; Neoplasms; Nitrophenols; Paclitaxel; Piperazines; Proto-Oncogene Proteins c-bcl-2; Structure-Activity Relationship; Sulfonamides; Survival Rate

2005
Synergistic antitumor activity of cisplatin, paclitaxel, and gemcitabine with tumor vasculature-targeted tumor necrosis factor-alpha.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Jan-01, Volume: 12, Issue:1

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Deoxycytidine; Drug Synergism; Female; Fibrosarcoma; Gemcitabine; Lymphoma; Mice; Neoplasm Transplantation; Neoplasms; Paclitaxel; Tumor Necrosis Factor-alpha

2006
Incidence of Clostridium difficile-associated diarrhea before and after autologous peripheral blood stem cell transplantation for lymphoma and multiple myeloma.
    Bone marrow transplantation, 2006, Volume: 37, Issue:5

    Topics: Adult; Aged; Cephalosporins; Clostridioides difficile; Diarrhea; Enterocolitis, Pseudomembranous; Female; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cell Mobilization; Humans; Incidence; Lymphoma; Male; Middle Aged; Multiple Myeloma; Paclitaxel; Peripheral Blood Stem Cell Transplantation; Retrospective Studies; Risk Factors; Transplantation, Autologous; Vancomycin

2006
Cross-resistance and collateral sensitivity to natural product drugs in cisplatin-sensitive and -resistant rat lymphoma and human ovarian carcinoma cells.
    Cancer chemotherapy and pharmacology, 1996, Volume: 37, Issue:5

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Survival; Cisplatin; Colchicine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Glutathione; Humans; Lymphoma; Methionine Sulfoximine; Mitosis; Ovarian Neoplasms; Paclitaxel; Rats; Tumor Cells, Cultured; Verapamil; Vinca Alkaloids

1996
Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel.
    Journal of the National Cancer Institute, 1996, Sep-18, Volume: 88, Issue:18

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Squamous Cell; Lymphoma; Male; Mice; Mice, Inbred C3H; Mitosis; Neoplasm Transplantation; Neoplasms, Experimental; Paclitaxel; Sarcoma, Experimental

1996
Microtubule changes in hematologic malignant cells treated with paclitaxel and comparison with vincristine cytotoxicity.
    Blood cells, molecules & diseases, 1995, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Female; Fluorescent Antibody Technique, Indirect; Humans; Leukemia; Lymphoma; Male; Microtubules; Middle Aged; Paclitaxel; Tubulin; Tumor Cells, Cultured; Vincristine

1995
Pulmonary changes in patients with lymphoma who receive paclitaxel.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Combined Modality Therapy; Female; Humans; Lung Diseases, Interstitial; Lymphoma; Paclitaxel

1997
Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Colonic Neoplasms; Dose-Response Relationship, Drug; Genes, p53; Humans; Lymphoma; Mutation; Paclitaxel; Radiation, Ionizing; Tumor Cells, Cultured; Vincristine

1998
Paclitaxel restores radiation-induced apoptosis in a bcl-2-expressing, radiation-resistant lymphoma cell line.
    International journal of radiation oncology, biology, physics, 2001, Mar-15, Volume: 49, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Survival; Dose-Response Relationship, Drug; Glutathione; Lymphoma; Mice; Neoplasm Proteins; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Radiation-Sensitizing Agents; Radiobiology; Radiotherapy Dosage; Time Factors; Tumor Cells, Cultured

2001
Antitumour activity of some plants from Meghalaya and Mizoram against murine ascites Dalton's lymphoma.
    Indian journal of experimental biology, 2004, Volume: 42, Issue:10

    Topics: Ageratum; Animals; Antineoplastic Agents, Phytogenic; Dilleniaceae; Glutathione; India; Lymphoma; Mice; Phytotherapy; Plant Extracts; Plants, Medicinal; Potentilla; Taxus

2004