paclitaxel has been researched along with Colonic Neoplasms in 243 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 49 (20.16) | 18.2507 |
| 2000's | 79 (32.51) | 29.6817 |
| 2010's | 89 (36.63) | 24.3611 |
| 2020's | 26 (10.70) | 2.80 |
| Authors | Studies |
|---|---|
| Christ, WJ; Habgood, GJ; Kishi, Y; Littlefield, BA; Wang, Y; Yu, MJ | 1 |
| Chai, H; Cordell, GA; Farnsworth, NR; Hollingshead, MG; Kardono, LB; Kinghorn, AD; Lantvit, D; Lee, IS; Mayo, JG; Mi, Q; Ngassapa, O; Peraza-Sánchez, S; Pezzuto, JM; Reyes-Lim, E; Riswan, S; Zhao, W | 1 |
| Howarth, J; Kenny, P; McDonnell, S; O'Connor, A | 1 |
| Bibby, MC; Cooper, PA; Gill, JH; Millington, NJ; Shnyder, SD | 1 |
| Hansch, C; Verma, RP | 1 |
| Baba, K; Harada, T; Hirata, Y; Kawaratani, Y; Nagaoka, Y; Shibano, M; Taniguchi, M; Tanimura, S; Uesato, S; Yasuda, M | 1 |
| Chai, HB; González-Cestari, TF; Kinghorn, AD; Li, C; McKay, DB; Ninh, TN; Pan, L; Pavlovicz, RE; Soejarto, DD; Still, PC; Yi, B | 1 |
| Abdel-Aziz, HA; El-Hussieny, EA; Fakhr, IM; Gamal-Eldeen, AM; Hamdy, NA | 1 |
| Chen, L; He, L; Liu, Y; Ma, L; Nie, C; Pu, Y; Shao, M; Wang, F; Wu, W; Wu, Y; Yang, Z; Yu, K | 1 |
| Bai, R; Betancourt, T; Dasari, R; Frail, SK; Frolova, LV; Hamel, E; Hill, RM; Kornienko, A; LaBarbera, DV; Medellin, DC; Ontiveros, SJ; Pelly, SC; Rogelj, S; Scott, R; Shuster, CB; van Otterlo, WA; Zhou, Q | 1 |
| Ali, T; Chai, HB; Inagaki, M; Rakotondraibe, LH; Rapplye, C; Wieboldt, T | 1 |
| Dymock, BW; Kitagawa, M; Lee, KH; Lee, SH; Liao, PJ; See, CS; Wong, J | 2 |
| Liang, M; Ma, X; Sun, ZJ; Xiao, Y; Xu, Z; Yang, LL; Yang, QC; Yang, SC; Zhang, T | 1 |
| Duarte, D; Vale, N | 1 |
| Condello, M; Gallo, FR; Meschini, S; Multari, G; Pellegrini, E; Vecchiotti, D; Zazzeroni, F | 1 |
| Casciano, F; Marchesi, E; Melloni, E; Navacchia, ML; Perrone, D; Preti, L; Rimondi, E; Romani, A; Secchiero, P | 1 |
| Amorim, I; Duarte, D; Rêma, A; Vale, N | 1 |
| Chen, L; Duan, H; Gao, Z; Hou, Y; Huang, W; Jin, J; Jin, M; Liu, C | 1 |
| Bagiński, M; Bartoszewski, R; Dąbrowska, AM; Filip-Psurska, B; Gawrońska, M; Krzymiński, K; Milczarek, M; Moszyńska, A; Psurski, M; Świtalska, M; Wietrzyk, J | 1 |
| Duarte, D; Nunes, M; Ricardo, S; Vale, N | 1 |
| Mata, R; Nakkala, JR; Sadras, SR | 1 |
| Alsadooni, JFK; Barzegar, A; Feizi, MAH; Haghi, M | 1 |
| Anandan, A; Manogaran, P; Vijaya Padma, V | 1 |
| Abd El-Sadek, I; Lichtenegger, A; Makita, S; Matsusaka, S; Mori, T; Mukherjee, P; Shen, LT; Yasuno, Y | 1 |
| Pham, DT; Saelim, N; Tiyaboonchai, W | 1 |
| Chen, F; Jeevarathinam, AS; Jokerst, JV; Lemaster, JE; Zhao, E | 1 |
| Bracci, L; Brunetti, J; Cipriani, G; Depau, L; Falciani, C; Fragai, M; Menichetti, S; Piantini, S; Pini, A; Scali, S | 1 |
| Jemaà, M; Kifagi, C; Massoumi, R; Serrano, SS | 1 |
| Ahamad, N; Banerjee, R; Deshmukh, A; Joshi, N; Shanmugam, T | 1 |
| Chang, N; Ge, N; Qian, L; Zhao, Y | 1 |
| Geng, Z; He, L; Liu, L; Wen, X | 1 |
| Arjona-Sanchez, A; Aziz, O; Briceño, J; Casado-Adam, A; Esquivel, J; Glehen, O; Nedelcut, DS; Passot, G; Piso, P; Rodriguez-Ortiz, L; Rufian-Peña, S; Salti, G; Sanchez-Hidalgo, JM; Selvasekar, CR; Sommariva, A; Turaga, K; Van der Speeten, K; Yonemura, Y | 1 |
| Abdullah Sani, MS; Amid, A; Daddiouaissa, D; Elnour, AAM | 1 |
| Amiri, FT; Ghadi, M; Hosseinimehr, SJ; Mardanshahi, A; Noaparast, Z | 1 |
| Li, HX; Xiao, ZS; Yin, ZH; Zhang, XN; Zhao, L | 1 |
| Gu, W; Hu, Y; Ji, X; Jiang, T; Li, F; Li, L; Niu, X; Pang, L; Qi, Y; Wang, C; Xu, Z; Zhang, K; Zhao, W; Zheng, X; Zhu, X; Zou, H | 1 |
| Ahn, KS; Baek, SH; Ha, IJ; Um, JY; Yang, MH | 1 |
| Cardoso, A; Duarte, D; Vale, N | 1 |
| Gao, T; Lei, Q; Song, X; Wang, N; Xia, Y; Xiong, M; Ye, T; You, X; Yu, L; Zhang, L | 1 |
| Rubinstein, A; Tirosh, B; Tiwari, S | 1 |
| Dai, C; Fu, C; Jia, X; Liu, S; Shen, R; Teng, F; Wu, J; Xu, J | 1 |
| Cao, D; Lei, M; Liang, L; Sun, J; Sun, Z; Wang, M; Wei, Y; Xu, Y | 1 |
| Chen, Y; Dehvari, K; Lin, KS; Tsai, YH; Tseng, SH | 1 |
| Du, Y; Guo, X; Kong, F; Li, Q; Li, W; Luo, L; Wang, Z; Yang, J; You, J; Zhang, H; Zhu, C | 1 |
| Cao, L; Gong, Z; Wang, L; Xi, C; Ye, H; Yu, J | 1 |
| Ambudkar, SV; Cai, CY; Chen, ZS; Gupta, P; Ji, N; Kong, D; Lei, ZN; Shukla, S; Wang, JQ; Yang, Y | 1 |
| Sabatier, P; Saei, AA; Wang, S; Zubarev, RA | 1 |
| Chen, ZS; De Vera, AA; Gupta, P; Lei, Z; Liao, D; Narayanan, S; Reznik, SE; Teng, Q | 1 |
| Bister, B; Ishiguro, N; Nakanishi, T; Tamai, I; Washio, I | 1 |
| Chen, Y; Chen, ZS; Gao, W; Jiang, Y; Lin, Z; Wang, B; Wu, S; Yang, X | 1 |
| Bio, M; Figg, WD; Kindrick, J; Li, M; Nguyen, L; Peer, CJ; Subramaniyan, B; Woo, S; You, Y | 1 |
| Chen, J; Chen, Y; Wang, X; Wu, S | 1 |
| Baidoo, KE; Brechbiel, MW; Milenic, DE; Yong, KJ | 2 |
| Johnston, DS; Sheets, TP; Uzgare, RP | 1 |
| Bae, YH; Na, K; Park, SJ; Yim, H | 1 |
| Evers, BM; Gemeinhart, RA; Hollis, CP; Leggas, M; Li, T; Weiss, HL | 1 |
| Park, K | 1 |
| Brons, S; Combs, SE; Debus, J; Haberer, T; Schlaich, F; Weber, KJ | 1 |
| Banerjee, R; Deshmukh, A; Joshi, N; Shanmugam, T | 1 |
| Du, QG; Guo, XY; Han, S; Hao, ZM; Liu, GS; Lv, YF; Wang, P; Zhu, SM | 1 |
| Hong, JT; Im, SA; Kim, K; Lee, CK; Lee, YH; Lee, YR; Park, CS; Song, S; Whang, BY | 1 |
| Kim, M; Kim, MK; Kim, SY; Lee, DH; Lee, DK; Lee, H; Yang, SG | 1 |
| Guo, WH; Lv, K; Xie, ZY; Xiong, Y | 1 |
| Arulvasu, C; Gokul Raj, K; Manikandan, R; Pandi, M | 1 |
| Bender, S; Broggini-Tenzer, A; Hug, D; Nytko, KJ; O'Reilly, T; Orlowski, K; Pruschy, M; Sharma, A; Vuong, V | 1 |
| Cromarty, D; Koot, D | 1 |
| Chen, Y; Ding, J; Huan, XJ; Miao, ZH; Song, SS; Sun, YM; Tian, QT; Wang, W; Wang, YQ; Yang, CH; Yi, JM; Zhang, XF | 1 |
| Abbruzzese, C; Alcaro, S; Amato, R; Artese, A; Botta, L; Costa, G; D'Antona, L; Dattilo, V; Gigliotti, F; Iuliano, R; Menniti, M; Musumeci, F; Ortuso, F; Paggi, MG; Perrotti, N; Schenone, S; Talarico, C; Trapasso, F | 1 |
| Chen, Y; Chen, ZS; El Sayed, KA; Jain, S; Li, J; Vispute, SG; Wang, YJ; Youssef, DT; Zhang, Y; Zhang, YK | 1 |
| Bishr, AM; Deme, D; Nizar, J; Telekes, A | 1 |
| Bechi, B; Bennett, A; Cleveland, DW; Huels, D; Littler, S; Ly, P; Nelson, L; Procter, DJ; Ridgway, RA; Sansom, OJ; Schandl, C; Sloss, O; Sun, Y; Taylor, SS; Tighe, A; Topham, C | 1 |
| Abasolo, I; Arango, D; Arranja, A; de Sousa Rafael, DF; Fernández, Y; Fort, NB; Gener, P; Gouveia, LP; Ortega, JS; Prieto, RM; Sabat, GR; Schwartz, S; Videira, M | 1 |
| Gao, X; Gong, C; Huang, N; Men, K; Shi, H; Wang, B; Wei, X; Wei, Y; Wu, Q; Zheng, F | 1 |
| Dai, Y; Ishibashi, O; Kondo, T; Maeda, M; Ohkohchi, N; Watanabe, M | 1 |
| Chen, Y; He, L; Jin, Q; Li, S; Liu, Y; Ren, K; Song, X; Tan, X; Wang, F; Xia, S; Xu, B; Yao, S; Yu, T; Zeng, J | 1 |
| Garcia Carcedo, I; Gu, W; Li, L; Monteiro, M; Xu, ZP; Zou, H | 1 |
| Choi, HG; Jeon, CK; Kang, HR; Kim, SH; Lim, SJ | 1 |
| Cao, L; Li, W; Pan, W; Qin, J; Wang, J; Wang, Q; Wu, F; Xu, G; Zhang, N; Zhang, Y | 1 |
| Chen, C; Huang, Z; Li, X; Su, F; Zhang, M | 1 |
| Greish, K; Highton, AJ; Kemp, RA; Nehoff, H; Norton, SE; Parayath, NN; Taurin, S | 1 |
| Boissenot, T; Bordat, A; Chacun, H; Fattal, E; Gueutin, C; Houvenagel, S; Tsapis, N; Valette, J | 1 |
| Ghaidi, F; Joshi, B; Kojic, LD; Nabi, IR; Nedev, H; Saragovi, HU; Wiseman, SM | 1 |
| Bezdetnaya, L; Bressenot, A; Garrier, J; Guillemin, F; Marchal, S; Plénat, F | 1 |
| Fujimoto, H; Harada, E; Horiuchi, N; Iwasaka, N; Kashima, M; Kimura, S; Masuda, K; Matsushita, T; Nakamura, S; Oshima, Y; Shichijo, K; Shinomiya, S; Takeichi, T; Tamaki, Y; Yoshida, S | 1 |
| Kawakami, I; Kobayashi, Y; Kohyama, N; Ohbayashi, M; Yamamoto, T; Yasuda, M | 1 |
| Jiang, H; Pan, S; Sun, X; Tao, W; Zhang, M | 1 |
| Akiyoshi, T; Katano, M; Koga, K; Mibu, R; Nagai, S; Nakamura, M; Sato, N; Wada, J; Xu, R; Yanai, K | 1 |
| Bastians, H; Ertych, N; Kienitz, A; Schneider, V; Stolz, A; Vogel, C; Yu, H | 1 |
| Choi, SS; Han, SB; Hong, JT; Kim, SM; Kim, Y; Lee, SY; Moon, DC; Oh, KW; Yuk, DY | 1 |
| Kameda, C; Katano, M; Kubo, M; Kuroki, S; Nakamura, M; Sato, N; Tanaka, H; Tanaka, M | 1 |
| Chen, Z; Chivukula, P; Gough, D; Liu, C; Liu, J; Ma, N; Okada, K; Perelman, L; Yu, L; Zhao, G | 1 |
| Blaskó, G; Nagy, Z; Turcsik, V | 1 |
| Mager, DE; Straubinger, RM; Yang, J | 1 |
| Ahn, YG; Kim, KH; Kim, MS; Kim, SW; Kwak, JO; Lee, GS; Lee, JH; Lee, MG; Lee, SH | 1 |
| Colombo, V; D'Incalci, M; Falcetta, F; Forestieri, D; Lupi, M; Ubezio, P | 1 |
| Adiseshaiah, PP; Clogston, JD; Dobrovolskaia, M; Lim, J; Lo, ST; Patri, AK; Simanek, EE; Stern, S; Sun, X; Zheng, J | 1 |
| Cohen, K; Koffler, J; Margalit, R; Melikhov, D; Peer, D; Rivkin, I | 1 |
| Akyol, A; Fearon, ER; Hinoi, T; Kawaguchi, Y; Ohdan, H; Okajima, M; Oue, N; Sasada, T; Takakura, Y; Yasui, W | 1 |
| Ho, PC; Lim, LY; Wang, C | 1 |
| Hiro, J; Inoue, Y; Kusunoki, M; Miki, C; Mohri, Y; Tanaka, K; Toiyama, Y; Yoshiyama, S | 1 |
| Alvarez, PJ; Aranega, A; Burgos, M; Hita, F; Melguizo, C; Ortiz, R; Prados, J; Rama, AR; Ramos, JL; Rodríguez-Serrano, F | 1 |
| Kaneno, FM; Kaneno, R; Luo, J; Naiditch, H; Shurin, GV; Shurin, MR | 1 |
| Chen, Y; Kong, F; Li, J; Zhang, Y; Zhao, J | 2 |
| Higaki, K; Kimura, T; Kono, Y; Ogawara, K; Yoshizawa, Y | 1 |
| Hong, GY; Jeong, YI; Lee, E; Lee, HC; Lee, SJ; Oh, JS | 1 |
| Gupta, R; Krissansen, GW; Kuhn-Sherlock, B; Macgibbon, AK; Sun, X; Zhang, J | 1 |
| Andelković, T; Banković, J; Pešić, M; Podolski-Renić, A; Ruždijić, S; Tanić, N | 1 |
| Pishko, MV; Yu, X | 1 |
| Aranda Aguilar, E; de la Haba-Rodríguez, JR; Gómez-España, MA; Ortiz-Morales, MJ | 1 |
| Baker, JH; Kyle, AH; Minchinton, AI | 1 |
| Dasanu, CA; Kaur, A | 1 |
| Choi, JH; Kim, SY; Kim, TH; Kuh, HJ; Lee, KC; Lee, SJ; Park, KD | 1 |
| Li, J; Liu, W; Wang, G; Yu, H; Zhao, Y | 1 |
| Aracil, M; Arguelaguet, E; Hernández-Losa, J; Jimeno, J; Marés, R; Pons, B; Ramón Y Cajal, S; Somoza, R; Teixidó, C | 1 |
| Hong, GY; Jeong, YI; Kang, MS; Lee, HC; Lee, SJ; Oh, JS; Song, CE | 1 |
| Joseph, IB; Kelly, R; Michaelson, JS; Wortham, K; Yang, L; Zhang, X | 1 |
| Kanwar, JR; Kanwar, RK; Mahidhara, G | 1 |
| Feng, LX; Li, M; Li, YX; Yang, XY; Zhang, L; Zhang, N | 1 |
| Araki, T; Higaki, K; Kimura, T; Kono, Y; Ogawara, K; Ono, T; Watanabe, T | 1 |
| Llovera, L; Mansilla, S; Portugal, J | 1 |
| Abbott, NJ; D'Emanuele, A; Najlah, M; Teow, HM; Yusof, SR; Zhou, Z | 1 |
| Agosti, V; Amato, R; Colao, E; Costanzo, FS; Cuda, G; D'Antona, L; Di Sanzo, M; Faniello, MC; Iuliano, R; Lang, F; Lavia, P; Malatesta, P; Menniti, M; Mileo, AM; Paggi, MG; Perrotti, N; Scumaci, D; Zingone, A | 1 |
| Bertin, R; Bolcato, J; Caparrotta, L; Chen, Z; Froldi, G; Montopoli, M | 1 |
| Abe, S; Araki, T; Fushimi, A; Higaki, K; Ishikawa, K; Kimura, T; Molema, G; Ogawara, K; Yoshizawa, Y | 1 |
| Chen, J; Chen, Y; Chen, Z | 1 |
| Anitha, A; Furuike, T; Jayakumar, R; Nair, SV; Smitha, KT; Tamura, H | 1 |
| Brasky, J; Ehrenpreis, ED; Shah, DA; Sherid, M; Sifuentes, H | 1 |
| Krüger, I; Lindenfelser, R; Scherwitz, P | 1 |
| Banskota, AH; Kadota, S; Kouda, K; Nguyen, NT; Tezuka, Y; Usia, T | 1 |
| Friess, T; Osl, F; Scheuer, WV; Schneider, T; Stockinger, H | 1 |
| Pan, JX; Sun, L; Yang, HL; Yeung, SC | 1 |
| Bombardelli, E; Cassinelli, G; D'Incalci, M; Frapolli, R; Laccabue, D; Lanzi, C; Morazzoni, P; Pratesi, G; Riva, A; Supino, R; Zucchetti, M; Zunino, F | 1 |
| Eberwein, DJ; Ingram, AC; Knick, VC; Murray, DM; Ryan, CH; Stimmel, JB; Thurmond, LM; Witherspoon, SM | 1 |
| Mayor, S | 1 |
| Sawabu, N | 1 |
| Bottone, MG; Brison, O; Ciomei, M; Gorrini, C; Lazzè, MC; Pellicciari, C; Scovassi, AI; Soldani, C; Tognon, G | 1 |
| Bellucci, A; Calvani, M; Camerini, B; Carminati, P; Castorina, M; Cavaletti, G; Cicuzza, S; Galbiati, S; Laccabue, D; Lo Giudice, P; Marmiroli, P; Nicolini, G; Pacifici, L; Pisano, C; Pratesi, G; Tredici, G; Vesci, L; Zunino, F | 1 |
| Cammia, C; Croci, V; De Nicolao, G; Germani, M; Magni, P; Pesenti, E; Poggesi, I; Rocchetti, M; Simeoni, M | 1 |
| C -Gaudreault, R; Côté, MF; Deschesnes, RG; Janvier, R; Lacroix, J; Legault, J; Madelmont, JC; Marquis, C; Miot-Noirault, E; Mounetou, E; Petitclerc, E | 1 |
| Avunie-Masala, R; Elkabets, M; Fich, A; Gheber, L; Leizerman, I | 1 |
| Gossé, F; Raul, F; Schleiffer, R; Schneider, Y; Seiler, N | 1 |
| Rosenberg, SH; Semizarov, D; Sowin, TJ; Xiao, Z; Xue, J; Zhang, H | 1 |
| Carvajal, D; Heimbrook, DC; Tovar, C; Vassilev, LT; Vu, BT; Yang, H | 1 |
| Goda, R; Hamaguchi, T; Kakizoe, T; Kataoka, K; Matsumura, Y; Nakamura, I; Nakatomi, I; Shimizu, K; Suzuki, M; Yokoyama, M | 1 |
| Chen, SZ; Jiang, M; Zhen, YS | 1 |
| Basson, MD; Thamilselvan, V | 1 |
| Ezumi, K; Fujie, Y; Hayashi, T; Ikeda, M; Matsuura, N; Monden, M; Ngan, CY; Sekimoto, M; Suzuki, R; Takagi, A; Takemasa, I; Yamamoto, H | 1 |
| El-Zawahry, A; Hannun, YA; Voelkel-Johnson, C | 1 |
| Fujio, N; Fukuda, Y; Ihara, T; Koyama, I; Osugi, H; Takatori, H; Tsukazaki, T; Tsukazaki, Y | 1 |
| Chen, L; Fields, AP; Ko, TC; Liu, Y; Thompson, EA | 1 |
| Alexandre, J; Batteux, F; Chéreau, C; Goldwasser, F; Laurent, A; Nicco, C; Weill, B | 1 |
| Bates, SE; Fojo, T; Kayastha, GL; Piekarz, RL; Robey, RW; Zhan, Z | 1 |
| Matsui, H; Matsuzaki, Y; Miyazaki, K; Nakahara, A; Sato, D; Shibahara, T; Suzuki, H; Uchida, K; Yanaka, A | 1 |
| Dabholkar, RD; Devarajan, PV; Mongayt, DA; Sawant, RM; Torchilin, VP | 1 |
| Kajiki, M; Kobayashi, TR; Kuriyama, H; Sugahara, S | 2 |
| Golemis, EA; Khazak, V; Menon, S; Skobeleva, N; Weber, L | 1 |
| Corrado, G; Samaritani, R; Sbiroli, C; Vizza, E | 1 |
| Goshima, F; Kasuya, H; Kodera, Y; Nakao, A; Nishiyama, Y; Shimoyama, S; Teshigahara, O | 1 |
| Bartlett, DL; Brown, CK; Demarco, RA; Dong, Xda E; Ito, N; Lotze, MT; Popovic, P; Shand, SH; Watkins, S; Winikoff, S; Zeh, HJ | 1 |
| Meyer, TF; Rudel, T; Wang, JA | 1 |
| Ishizu, K; Makuuchi, H; Sadahiro, S; Sunose, N; Tsuruo, T; Yamazaki, K; Yamori, T | 1 |
| Carstens, MG; Crommelin, DJ; de Jong, PH; de Leede, LG; Hennink, WE; Kemmink, J; van Nostrum, CF; Verrijk, R | 1 |
| Azuma, H; Hayasaki, H; Horie, S; Inamoto, T; Katsuoka, Y; Kiyama, S; Kotake, Y; Morishita, R; Otsuki, Y; Sakamoto, T; Segawa, N; Takahara, K; Takahara, S; Tanigawa, N; Tomita, N | 1 |
| Alami, N; Belanger, S; Grieshaber, CK; Juste, S; Leyland-Jones, B; Paterson, J | 1 |
| Andriambeloson, E; Callizot, N; Cirillo, R; Dreano, M; Ferro, P; Glass, J; Revel, M; Vitte, PA | 1 |
| Allegrini, PR; Brueggen, J; Floersheimer, A; Maira, M; McSheehy, PM; O'Reilly, T; Wartmann, M | 1 |
| Bissery, MC; Dykes, DJ; Harrison, SD; Waud, WR | 1 |
| Beijnen, JH; Boesen, JJ; Huizing, MT; Nooijen, WJ; Sparreboom, A; van Tellingen, O | 1 |
| Ariyoshi, K; Fogler, WE; Longo, DL; Pearson, JW; Riggs, CW; Volker, K; Watabe, H; Wiltrout, RH | 1 |
| Armour, EP; Corry, PM; Lee, YJ; Martinez, AA; Stromberg, JS | 1 |
| Braguer, D; Briand, C; Carles, G; Garcia, P | 1 |
| Cook, JA; Fisher, J; Liebmann, JE; Lipschultz, C; Mitchell, JB; Teague, D | 1 |
| Fairchild, CR; Long, BH | 1 |
| Gabel, M; Khil, MS; Kim, JH; Kim, SH; Lee, YJ; Ryu, S | 1 |
| Taguchi, T | 1 |
| Karantanis, E; Morris, DL; Nicholson, S | 1 |
| Carboni, JM; Farina, V; Hauck, SI; Horwitz, SB; Rao, S; Ringel, I | 1 |
| Bissery, MC; Lavelle, F; Vrignaud, P | 1 |
| Haskill, JS; Lee, LF; Lofquist, AK; Martin, BK; Schuerer-Maly, CC; Ting, JP; van Haaften-Day, C; White, CM | 1 |
| Akutsu, M; Kano, Y; Miura, Y; Suzuki, K; Tsunoda, S; Yazawa, Y | 1 |
| Braguer, D; Briand, C; Carles, G; Marvaldi, J; Roccabianca, M; Rognoni, JB | 1 |
| Bernacki, RJ; Ojima, I; Sharma, A; Straubinger, RM | 1 |
| Adachi, K; Akutsu, M; Ando, J; Ikeda, T; Inoue, Y; Kano, Y; Matsui, J; Suzuki, K; Tsunoda, S | 1 |
| Crilly, R; Fromm, D; Kessel, D; Luo, Y; Webber, J | 1 |
| Bates, S; Fojo, T; Hose, C; Monks, A; Scala, S; Zhan, Z | 1 |
| Bibby, MC; Nicholson, KM; Phillips, RM | 1 |
| Greco, WR; Levasseur, LM; Rustum, YM; Slocum, HK | 1 |
| Aebi, S; de las Alas, MM; Fink, D; Howell, SB; Los, G | 1 |
| Valero, V | 1 |
| Day, BW; Giannakakou, P; Gunasekera, SP; Hamel, E; Kowalski, RJ; Longley, RE | 1 |
| Berkowitz, R; Bunnell, CA; Buswell, L; Muto, M; Sheets, E; Shulman, LN; Thompson, L | 1 |
| Banan, A; Kokoska, ER; Miller, TA; Rieckenberg, CL; Smith, GS | 1 |
| Carboni, JM; Casazza, AM; Cornell, LA; Fairchild, CR; Fenical, W; Jensen, PR; Lindel, T; Long, BH; Wasserman, AJ | 1 |
| Fukase, Y; Ishikawa, T; Ishitsuka, H; Nishida, M; Sawada, N; Yoshikubo, T | 1 |
| Cherney, B; Fan, S; O'Connor, PM; Reinhold, W; Rucker, K | 1 |
| Agrawal, S; Bianco, AR; Bianco, R; Caputo, R; Ciardiello, F; Damiano, V; Jiang, Z; Pepe, S; Pomatico, G; Tortora, G | 1 |
| Germain, GS; Horton, JK; Houghton, PJ; Jayashree, BS; Thimmaiah, KN | 1 |
| Braguer, D; Briand, C; Carles, G; Sabeur, G | 1 |
| Akutsu, M; Ando, J; Furuta, M; Kano, Y; Tsunoda, S; Yazawa, Y | 1 |
| Bombardelli, E; Polizzi, D; Pratesi, G; Riva, A; Supino, R; Tortoreto, M; Zunino, F | 1 |
| Bacon, KD; Crass, RC; Deveney, CW; Deveney, KE; Land, J; Leonetti, PO; Meichsner, CL; Rutten, MJ; Sheppard, BC; Trunkey, DD | 1 |
| Boquet, P; d'Andrea, L; Far, DF; Guzman, E; Hofman, P; Le Negrate, G; Lemichez, E; Rossi, B; Selva, E | 1 |
| Mays, D; Pietenpol, JA; Stewart, ZA | 1 |
| Emiliani, E; Marangolo, M; Monti, G; Niero, A; Pironi, F; Turci, L; Valenti, AM | 1 |
| Akutsu, M; Kano, Y; Mori, K; Suzuki, K; Tsunoda, S; Yazawa, Y | 1 |
| Chi, CW; Lin, HL; Liu, TY; Wu, CW | 1 |
| Aikou, T; Akiyama, S; Chen, ZS; Furukawa, T; Kitazono, M; Nagayama, S; Sumizawa, T; Takao, S; Takebayashi, Y; Tani, A | 1 |
| Akutsu, M; Ando, J; Kano, Y; Suzuki, K; Tsunoda, S | 1 |
| Bianchi, AB; Girit, E; Hellström, I; Hellström, KE; Henderson, AJ; Lasch, S; Trail, PA; TrailSmith, MD; Willner, D | 1 |
| Arakawa, H; Kodera, T; Morishima, H; Morita, M; Nishimura, S; Ohkubo, M; Okura, A | 1 |
| Holton, RA; Wang, HJ; Yang, LX | 1 |
| Bates, S; Blagosklonny, MV; Fojo, T; Robey, R | 1 |
| Baguley, BC; Ding, L; Galettis, P; Haddad, GG; McKeage, MJ; Screnci, D; Zhuang, L | 1 |
| Chambers, TC; Drake, RR; Jones, KE; McMasters, RA; Moyer, MP; Pitlyk, K; Saylors, RL; Wilbert, TN | 1 |
| Filipeanu, CM; Klappe, K; Kok, JW; Koning, H; Müller, M; Veldman, RJ | 1 |
| Bianco, AR; Bianco, R; Ciardiello, F; Damiano, V; De Placido, S; Fontanini, G; Tortora, G | 1 |
| Cherian, SP; Collins, N; Han, EK; Ng, SC; Tahir, SK | 1 |
| Edatsugi, H; Matsuba, Y; Matsunaga, A; Mita, I; Nakanishi, O | 1 |
| Bhupalam, L; Fleming, DR; Glisson, SD; Goldsmith, GH; LaRocca, RV; Michelson, GD | 1 |
| Golik, J; Kadow, J; Lee, FY; Rose, WC | 1 |
| Aziz, S; Bowers, M; Brown, R; Chapman, R; Ramachandran, S; Sharma, N; Yegappan, M; Yu, BW | 1 |
| André, N; Braguer, D; Briand, C; Carles, G; Gonçalves, A; Prevôt, C | 1 |
| Kanaeda, T; Kurihara, M; Masaoka, N; Nagai, N; Ohtani, K; Sakamoto, H; Satoh, K; Shimada, K | 1 |
| Kobayashi, T; Morikawa, J; Sawa, H; Shiku, H; Zhang, W | 1 |
| Fairchild, C; Lee, FY; Rose, WC | 1 |
| Beijnen, JH; Koopman, FJ; Mandjes, IA; Meerum Terwogt, JM; Rocchetti, M; Rosing, H; Schellens, JH; Schot, M; ten Bokkel Huinink, WW; Zurlo, MG | 1 |
| Borzilleri, R; Fairchild, CR; Kim, SH; Kramer, RA; Lee, FY; Long, BH; Reventos-Suarez, C; Rose, WC; Vite, GD | 1 |
| Goehle, S; Lamb, JR; Ludlow, C; Simon, JA | 1 |
| Debus, G; Schuhmacher, I | 1 |
| Baccino, FM; Bonelli, G; Castino, R; Cesaro, P; Démoz, M; Isidoro, C; Raiteri, E | 1 |
| Blackburn, A; Buchanan, A; Cunningham, C; Edelman, G; Kirn, D; Maples, P; Nemunaitis, J; Netto, G; Olson, S; Randlev, B; Tong, A | 1 |
| Huang, S; Johnson, TD; Kadow, JF; Vyas, DM; Walker, MA | 1 |
| Donaldson, KL; Mixan, BJ; Siegall, CB; Trail, PA; Wahl, AF | 1 |
| Bernacki, RJ; Cabral, F; Greco, WR; Kanter, P; Kee, K; Ojima, I; Pera, P; Sharma, A; Veith, J; Vredenburg, MR | 1 |
| Bahadori, HR; Catapano, CV; Green, MR | 1 |
| Chen, X; Han, R; He, W; Kong, M; Li, J; Li, Y; Si, Y; Wu, H | 1 |
| Guo, J; Liang, X; Yao, F | 1 |
| Bissery, MC; Guénard, D; Guéritte-Voegelein, F; Lavelle, F | 1 |
| Baker, JR; Donehower, RC; Gralla, RJ; Leyland-Jones, B; Ohnuma, T; Trump, DL; Van Echo, DA; Von Hoff, DD; Weiss, RB; Wiernik, PH | 1 |
3 review(s) available for paclitaxel and Colonic Neoplasms
| Article | Year |
|---|---|
Clinical and endoscopic features of angiosarcoma of the colon: two case reports and a review of the literature.
Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Benzamides; Colonic Neoplasms; Endoscopy, Digestive System; Female; Gastrointestinal Hemorrhage; Hemangiosarcoma; Humans; Imatinib Mesylate; Paclitaxel; Piperazines; Pyrimidines; Review Literature as Topic; Treatment Outcome | 2013 |
[Recent advances in chemotherapy for digestive cancers with special references to gastric and colonic cancers].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Docetaxel; Drug Administration Schedule; Drug Combinations; Drug Delivery Systems; Fluorouracil; Humans; Irinotecan; Oxonic Acid; Paclitaxel; Pyridines; Stomach Neoplasms; Taxoids; Tegafur | 2003 |
Cooperative antitumor effect of mixed backbone oligonucleotides targeting protein kinase A in combination with cytotoxic drugs or biologic agents.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Division; Cisplatin; Colonic Neoplasms; Combined Modality Therapy; Cyclic AMP-Dependent Protein Kinases; Doxorubicin; Drug Design; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Fluorouracil; Genetic Therapy; Humans; Methotrexate; Oligonucleotides, Antisense; Ovarian Neoplasms; Paclitaxel; Structure-Activity Relationship; Thionucleotides; Tumor Cells, Cultured; Vincristine | 1998 |
8 trial(s) available for paclitaxel and Colonic Neoplasms
| Article | Year |
|---|---|
The effect of LMWH (Nadroparin) on tumor progression.
Topics: Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Disease Progression; Epirubicin; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Leucovorin; Male; Nadroparin; Neoplasm Staging; Ovarian Neoplasms; Paclitaxel; Pilot Projects; Retrospective Studies; Survival Analysis; Time Factors | 2009 |
Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).
Topics: Acetylation; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Carcinoma, Renal Cell; Colonic Neoplasms; Depsipeptides; Didanosine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Hippocalcin; Histones; Humans; Kidney; Kidney Neoplasms; Leukocytes, Mononuclear; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Neoplastic Cells, Circulating; Paclitaxel; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sezary Syndrome; Tumor Cells, Cultured | 2006 |
[An early phase II clinical study of RP56976 (docetaxel) in patients with cancer of the gastrointestinal tract].
Topics: Adenocarcinoma; Adult; Aged; Alopecia; Anorexia; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Docetaxel; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Leukopenia; Male; Middle Aged; Neutropenia; Paclitaxel; Pancreatic Neoplasms; Stomach Neoplasms; Taxoids | 1994 |
Combination docetaxel/cyclophosphamide in patients with advanced solid tumors.
Topics: Adenocarcinoma; Adult; Aged; Antiemetics; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Cyclophosphamide; Dexamethasone; Docetaxel; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fever; Granulocyte Colony-Stimulating Factor; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Middle Aged; Neoplasms; Neutropenia; Paclitaxel; Premedication; Remission Induction; Sarcoma; Taxoids | 1997 |
A Phase I trial of ifosfamide and paclitaxel with granulocyte-colony stimulating factor in the treatment of patients with refractory solid tumors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Female; Granulocyte Colony-Stimulating Factor; Humans; Ifosfamide; Lung Neoplasms; Male; Mesna; Middle Aged; Neoplasms; Neutropenia; Ovarian Neoplasms; Paclitaxel | 1998 |
Phase I study of paclitaxel and day 1/day 8 gemcitabine in patients with solid malignancies.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Deoxycytidine; Diarrhea; Esophageal Neoplasms; Exanthema; Female; Gemcitabine; Humans; Lung Neoplasms; Male; Middle Aged; Nausea; Neoplasm Staging; Neoplasms, Unknown Primary; Neutropenia; Paclitaxel; Pancreatic Neoplasms; Paresthesia; Urinary Bladder Neoplasms; Vomiting | 2000 |
Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel.
Topics: Adult; Aged; Anemia; Area Under Curve; Breast Neoplasms; Carcinoma, Small Cell; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Carriers; Female; Gastrointestinal Diseases; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Maximum Tolerated Dose; Methacrylates; Middle Aged; Nervous System Diseases; Ovarian Neoplasms; Paclitaxel; Polymers; Prodrugs; Remission Induction; Skin Neoplasms; Solubility; Taxoids | 2001 |
Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoviridae; Adrenal Gland Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma; Carcinoma, Papillary; Carcinoma, Squamous Cell; Colonic Neoplasms; Feasibility Studies; Female; Genetic Therapy; Genetic Vectors; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Osteosarcoma; Paclitaxel; Thyroid Neoplasms | 2001 |
232 other study(ies) available for paclitaxel and Colonic Neoplasms
| Article | Year |
|---|---|
Structure-activity relationships of halichondrin B analogues: modifications at C.30-C.38.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Ethers, Cyclic; Humans; Leukemia; Macrolides; Mice; Structure-Activity Relationship; Tumor Cells, Cultured | 2000 |
Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests.
Topics: Animals; Biological Factors; Colonic Neoplasms; Diosgenin; Disease Models, Animal; Diterpenes; Drug Screening Assays, Antitumor; Female; Heterocyclic Compounds, 3-Ring; HL-60 Cells; Humans; Inhibitory Concentration 50; KB Cells; Leukemia P388; Male; Melanoma; Mice; Molecular Structure; Naphthoquinones; Ovarian Neoplasms; Paclitaxel; Polymers; Prostatic Neoplasms; Triterpenes; Tumor Cells, Cultured | 2002 |
The design and synthesis of guanosine compounds with in vitro activity against the colon cancer cell line SW480: non-taxane derived mimics of taxol?
Topics: Antineoplastic Agents, Phytogenic; Bridged-Ring Compounds; Cell Line, Tumor; Colonic Neoplasms; Drug Design; Drug Screening Assays, Antitumor; Guanosine; Humans; Microtubules; Paclitaxel; Structure-Activity Relationship; Taxoids | 2003 |
Sodium pancratistatin 3,4-o-cyclic phosphate, a water-soluble synthetic derivative of pancratistatin, is highly effective in a human colon tumor model.
Topics: Amaryllidaceae Alkaloids; Antineoplastic Agents, Phytogenic; Benzimidazoles; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Isoquinolines; Microtubules; Models, Biological; Molecular Structure; Solubility; Tumor Cells, Cultured; Water | 2008 |
QSAR modeling of taxane analogues against colon cancer.
Topics: Antineoplastic Agents; Colonic Neoplasms; Inhibitory Concentration 50; Models, Molecular; Quantitative Structure-Activity Relationship; Taxoids | 2010 |
New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group.
Topics: Acetates; Animals; Aspirin; Benzoates; Carbamates; Cell Division; Cell Line, Tumor; Colonic Neoplasms; G2 Phase; Humans; Indoles; Mice; Mice, Nude; Nitrates; Nitro Compounds; Structure-Activity Relationship; Transplantation, Heterologous; Tubulin; Tubulin Modulators; Vincristine | 2011 |
Alkaloids from Microcos paniculata with cytotoxic and nicotinic receptor antagonistic activities.
Topics: Alkaloids; Bridged Bicyclo Compounds, Heterocyclic; Colonic Neoplasms; HT29 Cells; Humans; Malvaceae; Molecular Structure; Nicotinic Antagonists; Piperidines; Plant Leaves; Receptors, Nicotinic; Vietnam | 2013 |
Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; MCF-7 Cells; Models, Molecular; Molecular Structure; Pyrazoles; Pyridines; Pyrimidines; Pyrimidinones; Structure-Activity Relationship; Tumor Cells, Cultured | 2014 |
Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity.
Topics: Angiogenesis Inhibitors; Animals; Antimitotic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line, Tumor; Cell Movement; Colchicine; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred BALB C; Protein Binding; Stilbenes; Structure-Activity Relationship; Thiazoles; Tubulin Modulators; Xenograft Model Antitumor Assays | 2015 |
Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colchicine; Colonic Neoplasms; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Marine Toxins; Mice; Mice, Nude; Models, Molecular; Molecular Docking Simulation; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Xanthines | 2016 |
Halogenated Compounds from Directed Fermentation of Penicillium concentricum, an Endophytic Fungus of the Liverwort Trichocolea tomentella.
Topics: Benzyl Alcohols; Colonic Neoplasms; Epoxy Compounds; Ethylene Glycols; Fermentation; Halogenation; Hepatophyta; HT29 Cells; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; MCF-7 Cells; Molecular Structure; Penicillium; Xanthones | 2017 |
Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131).
Topics: Acrylonitrile; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitosis; Neoplasms; Rats | 2018 |
Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer.
Topics: Acrylonitrile; Administration, Oral; Animals; Antineoplastic Agents; Colonic Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Indoles; Isoquinolines; Mice; Molecular Structure; Neoplasms, Experimental; Paclitaxel; Prodrugs; Solubility; Structure-Activity Relationship | 2019 |
Microenvironment-Responsive Prodrug-Induced Pyroptosis Boosts Cancer Immunotherapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Drug Liberation; Female; Glutathione; Immunotherapy; Mice; Mice, Inbred BALB C; Paclitaxel; Photochemotherapy; Photosensitizing Agents; Prodrugs; Pyroptosis; Reactive Oxygen Species; Tumor Microenvironment | 2021 |
Synergistic Interaction of CPP2 Coupled with Thiazole Derivates Combined with Clotrimazole and Antineoplastic Drugs in Prostate and Colon Cancer Cell Lines.
Topics: Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell-Penetrating Peptides; Clotrimazole; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Male; Paclitaxel; Prostatic Neoplasms; Thiazoles | 2021 |
A natural product, voacamine, sensitizes paclitaxel-resistant human ovarian cancer cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Ibogaine; Molecular Structure; Ovarian Neoplasms; Paclitaxel | 2022 |
Synthesis and Biological Investigation of Bile Acid-Paclitaxel Hybrids.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Bile Acids and Salts; Cell Line; Cell Survival; Colonic Neoplasms; Deoxycholic Acid; Humans; Leukemia; Mice; Paclitaxel | 2022 |
Drug Combinations: A New Strategy to Extend Drug Repurposing and Epithelial-Mesenchymal Transition in Breast and Colon Cancer Cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Drug Combinations; Drug Repositioning; Epithelial-Mesenchymal Transition; Female; Humans; MCF-7 Cells; Paclitaxel | 2022 |
Targeted therapeutic effects of oral inulin-modified double-layered nanoparticles containing chemotherapeutics on orthotopic colon cancer.
Topics: Cell Line, Tumor; Colonic Neoplasms; Drug Delivery Systems; Humans; Hyaluronic Acid; Inulin; Nanoparticles; Paclitaxel | 2022 |
Combined anticancer therapy with imidazoacridinone analogue C-1305 and paclitaxel in human lung and colon cancer xenografts-Modulation of tumour angiogenesis.
Topics: Acridines; Apoptosis; Colonic Neoplasms; Heterografts; Humans; Lung; Lung Neoplasms; Paclitaxel; Triazoles | 2022 |
Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action.
Topics: Adenosine Diphosphate; Antimalarials; Antineoplastic Agents; Artesunate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benztropine; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Colonic Neoplasms; Containment of Biohazards; Doxorubicin; Drug Resistance, Neoplasm; Female; Fluorouracil; Fluoxetine; Fluphenazine; Humans; Ki-67 Antigen; MCF-7 Cells; Michigan; NF-kappa B; Paclitaxel; Poly(ADP-ribose) Polymerase Inhibitors; Ribose; Sertraline; Thioridazine | 2022 |
Therapeutic role of biogenic silver and gold nanoparticles against a DMH-induced colon cancer model.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Gold; Metal Nanoparticles; Paclitaxel; Rats; Rats, Wistar; Silver | 2023 |
The effect of chitosan hydrogel containing gold nanoparticle complex with paclitaxel on colon cancer cell line.
Topics: Cell Line, Tumor; Chitosan; Colonic Neoplasms; Gold; Humans; Hydrogels; Metal Nanoparticles; Nanoparticles; Paclitaxel | 2023 |
Isoliensinine augments the therapeutic potential of paclitaxel in multidrug-resistant colon cancer stem cells and induced mitochondria-mediated cell death.
Topics: Apoptosis; Cell Death; Cell Line, Tumor; Cisplatin; Colonic Neoplasms; Drug Resistance, Neoplasm; Humans; Mitochondria; Neoplastic Stem Cells; Paclitaxel | 2023 |
Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography.
Topics: Algorithms; Breast Neoplasms; Colonic Neoplasms; Drug Evaluation; Female; Humans; Irinotecan; Paclitaxel; Tomography, Optical Coherence | 2023 |
Paclitaxel loaded EDC-crosslinked fibroin nanoparticles: a potential approach for colon cancer treatment.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bombyx; Caco-2 Cells; Cell Proliferation; Cell Survival; Colonic Neoplasms; Drug Compounding; Ethyldimethylaminopropyl Carbodiimide; Fibroins; Humans; MCF-7 Cells; Nanoparticles; Paclitaxel; Particle Size | 2020 |
Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye-Labeled Cargo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Drug Carriers; Drug Liberation; Drug Screening Assays, Antitumor; Fluorescent Dyes; Methylene Blue; Mice; Mice, Nude; Molecular Structure; Nanoparticles; Neoplasms, Experimental; Oxidation-Reduction; Paclitaxel; Particle Size; Photoacoustic Techniques; Polylactic Acid-Polyglycolic Acid Copolymer; Surface Properties | 2020 |
A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment.
Topics: Adenocarcinoma; Colonic Neoplasms; Drug Delivery Systems; HT29 Cells; Humans; Paclitaxel; Peptides; Quantum Dots | 2020 |
Preferential Killing of Tetraploid Colon Cancer Cells by Targeting the Mitotic Kinase PLK1.
Topics: Antimitotic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Colchicine; Colonic Neoplasms; Drug Synergism; Humans; Microtubules; Mitochondria; Mitosis; Paclitaxel; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; RNA, Small Interfering; Tetraploidy; Tubulin Modulators; Vincristine | 2020 |
Enhanced absorption, and efficacy of oral self-assembled paclitaxel nanocochleates in multi-drug resistant colon cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Delayed-Action Preparations; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HCT116 Cells; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Nude; Nanoparticles; Paclitaxel; Phosphatidylserines; Rats; Rats, Wistar; Xenograft Model Antitumor Assays | 2020 |
A pH/ROS cascade-responsive and self-accelerating drug release nanosystem for the targeted treatment of multi-drug-resistant colon cancer.
Topics: Animals; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Dextrans; Drug Carriers; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Histidine; Humans; Hydrogen-Ion Concentration; Mice; Nanoparticles; Naphthoquinones; Paclitaxel; Prodrugs; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2020 |
Application of Taxol Nanomicelles with Lyp-1 Target in Targeted 805-813 Therapy of Colon Cancer.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Mice; MicroRNAs; Nanoparticles; Paclitaxel; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Transfection | 2021 |
Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for limited peritoneal metastasis. The PSOGI international collaborative registry.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Colonic Neoplasms; Cytoreduction Surgical Procedures; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Hyperthermic Intraperitoneal Chemotherapy; Laparoscopy; Length of Stay; Male; Mesothelioma; Middle Aged; Mitomycin; Neoadjuvant Therapy; Neoplasm, Residual; Ovarian Neoplasms; Oxaliplatin; Paclitaxel; Peritoneal Neoplasms; Pseudomyxoma Peritonei; Registries; Severity of Illness Index; Survival Rate; Tumor Burden | 2021 |
Evaluation of metabolomics behavior of human colon cancer HT29 cell lines treated with ionic liquid graviola fruit pulp extract.
Topics: Annona; Antineoplastic Agents, Phytogenic; Cell Proliferation; Colonic Neoplasms; Fruit; HT29 Cells; Humans; Ionic Liquids; Metabolome; Paclitaxel; Plant Extracts; Principal Component Analysis | 2021 |
Itraconazole synergistically increases therapeutic effect of paclitaxel and
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; Colonic Neoplasms; Drug Synergism; Female; HT29 Cells; Humans; Itraconazole; Mice, Nude; Paclitaxel; Radiopharmaceuticals; Technetium Tc 99m Sestamibi; Tissue Distribution; Whole Body Imaging; Xenograft Model Antitumor Assays | 2021 |
Effect of rs67085638 in long non-coding RNA (CCAT1) on colon cancer chemoresistance to paclitaxel through modulating the microRNA-24-3p and FSCN1.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Carrier Proteins; Cell Movement; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microfilament Proteins; MicroRNAs; Middle Aged; Paclitaxel; Prognosis; RNA, Long Noncoding; Survival Rate; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2021 |
Synergistic Inhibition of Drug-Resistant Colon Cancer Growth with PI3K/mTOR Dual Inhibitor BEZ235 and Nano-Emulsioned Paclitaxel via Reducing Multidrug Resistance and Promoting Apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Count; Cell Line, Tumor; Cell Proliferation; Cell Shape; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Emulsions; Female; Humans; Imidazoles; Inhibitory Concentration 50; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasm Proteins; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinolines; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2021 |
Brassinin enhances the anticancer actions of paclitaxel by targeting multiple signaling pathways in colorectal cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Humans; Indoles; Paclitaxel; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiocarbamates; TOR Serine-Threonine Kinases | 2021 |
Synergistic Growth Inhibition of HT-29 Colon and MCF-7 Breast Cancer Cells with Simultaneous and Sequential Combinations of Antineoplastics and CNS Drugs.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antipsychotic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Humans; Paclitaxel; Tumor Cells, Cultured | 2021 |
Mannosylated liposomes improve therapeutic effects of paclitaxel in colon cancer models.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colonic Neoplasms; Drug Delivery Systems; Female; Humans; Lectins, C-Type; Liposomes; Mannose; Mannose Receptor; Mannose-Binding Lectins; Mice; Mice, Inbred BALB C; Paclitaxel; Receptors, Cell Surface | 2017 |
Increasing the affinity of cationized polyacrylamide-paclitaxel nanoparticles towards colon cancer cells by a surface recognition peptide.
Topics: Acrylic Resins; Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Humans; Nanoparticles; Paclitaxel; Peptides | 2017 |
Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biomarkers, Tumor; Cell Line, Tumor; Cisplatin; Colonic Neoplasms; Computational Biology; Databases, Genetic; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epirubicin; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Ovarian Neoplasms; Paclitaxel; RNA, Long Noncoding | 2018 |
Tumor associated macrophages and angiogenesis dual-recognizable nanoparticles for enhanced cancer chemotherapy.
Topics: Animals; Annexin A1; Antineoplastic Agents; Cell Proliferation; Colonic Neoplasms; Drug Delivery Systems; Humans; Macrophages; Mice; Mice, Nude; Nanoparticles; Neovascularization, Pathologic; Paclitaxel; Peptide Fragments; Tumor Cells, Cultured; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2018 |
Superparamagnetic Iron Oxide Nanorod Carriers for Paclitaxel Delivery in the Treatment and Imaging of Colon Cancer in Mice.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mice; Mice, Inbred BALB C; Nanotubes; Paclitaxel; Theranostic Nanomedicine | 2016 |
Suppress orthotopic colon cancer and its metastasis through exact targeting and highly selective drug release by a smart nanomicelle.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cell Line, Tumor; Colonic Neoplasms; Drug Delivery Systems; Drug Liberation; HT29 Cells; Humans; Hyaluronic Acid; Male; Mice; Micelles; NIH 3T3 Cells; Paclitaxel | 2018 |
Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer.
Topics: Animals; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Colonic Neoplasms; Drug Resistance; Drug Synergism; Eukaryotic Initiation Factor-4E; Female; Fluorouracil; Humans; Mice; Paclitaxel; Ribavirin; Uterine Cervical Neoplasms | 2018 |
Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells.
Topics: Adenosine Triphosphatases; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HEK293 Cells; Humans; Lung Neoplasms; MAP Kinase Kinase Kinase 5; Mitoxantrone; Models, Molecular; Neoplasm Proteins; Neoplasms; Paclitaxel; Protein Kinase Inhibitors | 2019 |
Dynamic Proteomics Reveals High Plasticity of Cellular Proteome: Growth-Related and Drug-Induced Changes in Cancer Cells are Comparable.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Plasticity; Cell Proliferation; Colonic Neoplasms; Humans; Methotrexate; Paclitaxel; Proteome; Tumor Cells, Cultured | 2018 |
Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Binding Sites; Class Ib Phosphatidylinositol 3-Kinase; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; LLC-PK1 Cells; Male; Mice, Nude; Molecular Docking Simulation; Neoplasm Proteins; Paclitaxel; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Signal Transduction; Swine; Xenograft Model Antitumor Assays | 2019 |
Effect of endogenous multidrug resistance 1 and P-glycoprotein expression on anticancer drug resistance in colon cancer cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Colonic Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mitoxantrone; Paclitaxel; Vinorelbine | 2019 |
A personalized and long-acting local therapeutic platform combining photothermal therapy and chemotherapy for the treatment of multidrug-resistant colon tumor.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Combined Modality Therapy; Drug Liberation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Elastic Modulus; Gold; Humans; Hydrogels; Hyperthermia, Induced; Inhibitory Concentration 50; Male; Mice, Nude; Micelles; Nanoparticles; Nanotubes; Neoplasm Recurrence, Local; Paclitaxel; Phototherapy; Polyethylene Glycols; Temperature; Time Factors; Vitamin E | 2018 |
PBPK modeling-based optimization of site-specific chemo-photodynamic therapy with far-red light-activatable paclitaxel prodrug.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colonic Neoplasms; Mice; Models, Biological; Paclitaxel; Photochemotherapy; Prodrugs; Time Factors | 2019 |
Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells.
Topics: Animals; Antineoplastic Agents; Autophagy; Blotting, Western; CD24 Antigen; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; HCT116 Cells; Homeodomain Proteins; Humans; Hyaluronan Receptors; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; Neoplastic Stem Cells; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; RNA Interference; Signal Transduction; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2013 |
212Pb-radioimmunotherapy potentiates paclitaxel-induced cell killing efficacy by perturbing the mitotic spindle checkpoint.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Death; Cell Line, Tumor; Colonic Neoplasms; Combined Modality Therapy; Female; Humans; Lead Radioisotopes; M Phase Cell Cycle Checkpoints; Mice; Mice, Nude; Paclitaxel; Radioimmunotherapy; Treatment Outcome; Xenograft Model Antitumor Assays | 2013 |
Evaluation of melphalan, oxaliplatin, and paclitaxel in colon, liver, and gastric cancer cell lines in a short-term exposure model of chemosaturation therapy by percutaneous hepatic perfusion.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Adhesion; Cell Proliferation; Cells, Cultured; Colonic Neoplasms; Flow Cytometry; Hepatic Artery; Hepatocytes; Humans; Liver Neoplasms; Melphalan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Perfusion; Stomach Neoplasms | 2013 |
Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Drug Resistance, Neoplasm; Male; Mice; Mice, Inbred BALB C; Nanogels; Nanoparticles; Necrosis; Paclitaxel; Polyethylene Glycols; Polyethyleneimine; Xenograft Model Antitumor Assays | 2013 |
Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colonic Neoplasms; Drug Delivery Systems; Female; Humans; Mice; Mice, Nude; Nanoparticles; Optical Imaging; Paclitaxel; Permeability; Tissue Distribution | 2013 |
Questions on the role of the EPR effect in tumor targeting.
Topics: Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Female; Humans; Nanoparticles; Paclitaxel | 2013 |
Comparison of the effects of photon versus carbon ion irradiation when combined with chemotherapy in vitro.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carbon; Cell Cycle; Cell Line, Tumor; Cell Separation; Chemoradiotherapy; Cisplatin; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; Flow Cytometry; Gemcitabine; Glioblastoma; Humans; Ions; Lung Neoplasms; Paclitaxel; Pancreatic Neoplasms; Photons; Propidium; Radiotherapy; Relative Biological Effectiveness; Time Factors | 2013 |
Apoptotic cascade inspired lipid nanovesicles show synergism with encapsulated paclitaxel in chemoresistant colon carcinoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Chemistry, Pharmaceutical; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Female; Hemolysis; Humans; Mice; Mice, Nude; Nanocapsules; Nanomedicine; Nanotechnology; Paclitaxel; Phosphatidylserines; Protein Binding; Rats; Rats, Wistar | 2014 |
Paclitaxel and gemcitabine combinational drug-loaded mucoadhesive delivery system in the treatment of colon cancers.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cell Survival; Chitosan; Colonic Neoplasms; Deoxycytidine; Drug Carriers; Drug Liberation; Drug Therapy, Combination; Gemcitabine; Humans; Mice; Nanoparticles; Paclitaxel; Succinic Anhydrides; Survival Rate; Xenograft Model Antitumor Assays | 2015 |
Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Female; Male; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Mice, Nude; Myeloid Cells; Paclitaxel; Reactive Oxygen Species; T-Lymphocytes; Taxoids | 2014 |
Paclitaxel-eluting nanofiber-covered self-expanding nonvascular stent for palliative chemotherapy of gastrointestinal cancer and its related stenosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Coated Materials, Biocompatible; Colonic Neoplasms; Constriction, Pathologic; Drug-Eluting Stents; Humans; Mice; Mice, Inbred BALB C; Nanofibers; Paclitaxel; Palliative Care | 2014 |
Impact of α-targeted radiation therapy on gene expression in a pre-clinical model for disseminated peritoneal disease when combined with paclitaxel.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis Regulatory Proteins; Cell Cycle Proteins; Colonic Neoplasms; Combined Modality Therapy; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Repair Enzymes; Drug Evaluation, Preclinical; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Injections, Intraperitoneal; Lead Radioisotopes; Mice; Mice, Nude; Oligonucleotide Array Sequence Analysis; Paclitaxel; Peritoneal Neoplasms; Radioimmunotherapy; Trastuzumab; Xenograft Model Antitumor Assays | 2014 |
ABCG2-meditated multidrug resistance and tumor-initiating capacity of side population cells from colon cancer.
Topics: Adult; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biomarkers, Tumor; Cisplatin; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Neoplasm Proteins; Neoplasm Transplantation; Neoplastic Stem Cells; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Real-Time Polymerase Chain Reaction; Side-Population Cells | 2014 |
Anti-proliferative effect of fungal taxol extracted from Cladosporium oxysporum against human pathogenic bacteria and human colon cancer cell line HCT 15.
Topics: Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Bacteria; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cladosporium; Colonic Neoplasms; Humans; Microbial Sensitivity Tests; Paclitaxel; Proton Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 2015 |
Combined treatment strategies for microtubule stabilizing agent-resistant tumors.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Epothilones; Everolimus; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Mice; Mice, Nude; Microtubules; Paclitaxel; Real-Time Polymerase Chain Reaction; RNA, Neoplasm; Sirolimus; TOR Serine-Threonine Kinases; Tubulin Modulators; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2015 |
Anticancer efficacy and toxicokinetics of a novel paclitaxel-clofazimine nanoparticulate co-formulation.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Clofazimine; Colonic Neoplasms; Drug Carriers; Drug Combinations; Drug Compounding; Drug Stability; Female; Humans; Mice, Inbred BALB C; Mice, Nude; Micelles; Nanoparticles; Paclitaxel; Phosphatidylethanolamines; Polyethylene Glycols; Tissue Distribution; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition.
Topics: Animals; Apoptosis; Binding Sites; Binding, Competitive; Carbolines; Cell Line, Tumor; Colchicine; Colonic Neoplasms; DNA Breaks, Double-Stranded; DNA Topoisomerases, Type II; DNA, Neoplasm; DNA, Superhelical; Drug Interactions; Drug Screening Assays, Antitumor; Etoposide; Humans; Inhibitory Concentration 50; Metaphase; Mice; Mice, Nude; Microtubules; Molecular Structure; Neoplasm Proteins; Paclitaxel; Topoisomerase II Inhibitors; Tubulin; Tubulin Modulators; Vincristine | 2015 |
SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; G1 Phase Cell Cycle Checkpoints; Humans; Immediate-Early Proteins; Insulin; MCF-7 Cells; Necrosis; Paclitaxel; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Stability; Proto-Oncogene Proteins c-mdm2; Pyrazoles; Pyrimidines; Tumor Suppressor Protein p53 | 2015 |
Esters of the marine-derived triterpene sipholenol A reverse P-GP-mediated drug resistance.
Topics: Absorption, Physiological; Acetates; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Callyspongia; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Esterification; HEK293 Cells; Humans; Isonicotinic Acids; Molecular Conformation; Molecular Docking Simulation; Paclitaxel; Recombinant Proteins; Triterpenes | 2015 |
[Individualized therapy of synchronous ovarian and colon cancers with lymph].
Topics: Abdominal Pain; Adenocarcinoma; Adenocarcinoma, Papillary; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Administration Schedule; Female; Fever; Fluorouracil; Humans; Immunohistochemistry; Keratin-20; Keratin-7; Laparotomy; Leucovorin; Lymphatic Metastasis; Neoplasms, Multiple Primary; Organoplatinum Compounds; Ovarian Neoplasms; Paclitaxel; Precision Medicine; Treatment Outcome | 2015 |
MYC Is a Major Determinant of Mitotic Cell Fate.
Topics: Animals; Antimitotic Agents; Apoptosis; bcl-X Protein; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Early Growth Response Protein 1; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mitochondrial Membrane Transport Proteins; Mitosis; Molecular Sequence Data; Neoplasms; Ovarian Neoplasms; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc | 2015 |
Fluorescent CSC models evidence that targeted nanomedicines improve treatment sensitivity of breast and colon cancer stem cells.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; ErbB Receptors; Female; Fluorescent Dyes; Genes, Reporter; Humans; Hyaluronan Receptors; Micelles; Microscopy, Fluorescence; Nanomedicine; Neoplastic Stem Cells; Paclitaxel; Polyethylene Glycols; Polyglactin 910; Retinal Dehydrogenase | 2015 |
Combined Delivery and Anti-Cancer Activity of Paclitaxel and Curcumin Using Polymeric Micelles.
Topics: Animals; Antineoplastic Agents; Apoptosis; Colonic Neoplasms; Curcumin; Drug Carriers; Drug Delivery Systems; Female; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Micelles; Microcirculation; Microscopy, Fluorescence; Neovascularization, Pathologic; NF-kappa B; Paclitaxel; Polymers; Zebrafish | 2015 |
[A Case of Gastrointestinal Metastases of Breast Cancer Effectively Treated with Gemcitabine and Paclitaxel Combination Chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Deoxycytidine; Female; Gemcitabine; Humans; Intestinal Obstruction; Middle Aged; Paclitaxel; Stomach Neoplasms | 2015 |
Polymeric Nanomedicine for Combined Gene/Chemotherapy Elicits Enhanced Tumor Suppression.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Cycle; Cell Movement; Cell Proliferation; Colonic Neoplasms; Combined Modality Therapy; Drug Delivery Systems; Eye Proteins; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Nanomedicine; Nanoparticles; Nerve Growth Factors; Paclitaxel; Polymers; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serpins; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Synergistic inhibition of colon cancer cell growth with nanoemulsion-loaded paclitaxel and PI3K/mTOR dual inhibitor BEZ235 through apoptosis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Colonic Neoplasms; Drug Delivery Systems; Emulsions; HCT116 Cells; HT29 Cells; Humans; Imidazoles; Nanocomposites; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolines; TOR Serine-Threonine Kinases | 2016 |
Butyrate-mediated acquisition of chemoresistance by human colon cancer cells.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; bcl-X Protein; Butyrates; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; HCT116 Cells; Humans; Hydroxamic Acids; Multidrug Resistance-Associated Proteins; Neoplasm Invasiveness; Neoplasm Proteins; Paclitaxel | 2016 |
Verteporfin can Reverse the Paclitaxel Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Humans; Inhibitory Concentration 50; Microscopy, Confocal; Paclitaxel; Phosphoproteins; Photosensitizing Agents; Porphyrins; RNA Interference; Transcription Factors; Verteporfin; YAP-Signaling Proteins | 2016 |
Knockdown of Hypoxia-Inducible Factor 1α Improved the Efficacy of Low-Dose Metronomic Chemotherapy of Paclitaxel in Human Colon Cancer Xenografts.
Topics: Administration, Metronomic; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Neovascularization, Pathologic; Paclitaxel; RNA Interference; RNA, Small Interfering; Xenograft Model Antitumor Assays | 2017 |
Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Body Weight; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Drug Liberation; Female; Humans; Maleates; Maximum Tolerated Dose; Mice, Inbred BALB C; Micelles; Microvessels; Neovascularization, Physiologic; Paclitaxel; Polystyrenes; Static Electricity; Toxicity Tests | 2016 |
Paclitaxel-loaded PEGylated nanocapsules of perfluorooctyl bromide as theranostic agents.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Survival; Colonic Neoplasms; Cryoelectron Microscopy; Drug Carriers; Drug Delivery Systems; Female; Fluorocarbons; Hydrocarbons, Brominated; Inhibitory Concentration 50; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Microscopy, Electron, Transmission; Nanocapsules; Neoplasm Transplantation; Paclitaxel; Particle Size; Polyethylene Glycols; Theranostic Nanomedicine | 2016 |
Raft-dependent endocytosis of autocrine motility factor/phosphoglucose isomerase: a potential drug delivery route for tumor cells.
Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Delivery Systems; Endocytosis; Glucose-6-Phosphate Isomerase; HCT116 Cells; HT29 Cells; Humans; Melanoma; Membrane Microdomains; Mice; Neoplasms; Paclitaxel; Receptors, Autocrine Motility Factor; Receptors, Cytokine; Ubiquitin-Protein Ligases | 2008 |
Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Colonic Neoplasms; Humans; Immunohistochemistry; Mesoporphyrins; Mice; Mice, Nude; Neoplasm Transplantation; Paclitaxel; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Spheroids, Cellular; Transplantation, Heterologous; Triazenes | 2009 |
[A case of peritonitis carcinomatosa from goblet cell carcinoid of the appendix treated by intraperitoneal paclitaxel and systemic S-1 chemotherapy].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Colonic Neoplasms; Colonoscopy; Drug Combinations; Female; Humans; Injections, Intraperitoneal; Oxonic Acid; Paclitaxel; Peritonitis; Tegafur; Tomography, X-Ray Computed; Treatment Failure | 2008 |
Effect of interleukins response to ECM-induced acquisition of drug resistance in MCF-7 cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Camptothecin; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; Extracellular Matrix; Female; Fluorescent Antibody Technique; Humans; Interleukins; Lung Neoplasms; Paclitaxel | 2008 |
Low-dose metronomic chemotherapy of paclitaxel synergizes with cetuximab to suppress human colon cancer xenografts.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Division; Cetuximab; Colonic Neoplasms; Drug Administration Schedule; Drug Synergism; Endothelial Cells; Female; Humans; Leukopenia; Mice; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Random Allocation; Retinal Vessels; Thrombospondin 1; Xenograft Model Antitumor Assays | 2009 |
Enhancement of paclitaxel-induced apoptosis by inhibition of mitogen-activated protein kinase pathway in colon cancer cells.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Flavonoids; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Paclitaxel; RNA, Small Interfering | 2009 |
Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells.
Topics: Apoptosis; Aurora Kinase B; Aurora Kinases; Carbazoles; Chromosome Aberrations; Colonic Neoplasms; Drug Synergism; Enzyme Inhibitors; HCT116 Cells; Humans; Mitosis; Nocodazole; Paclitaxel; Protein Serine-Threonine Kinases; Spindle Apparatus | 2009 |
Inhibition of NF-kappaB by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Proteins; Cell Proliferation; Cisplatin; Colonic Neoplasms; Docetaxel; Dose-Response Relationship, Drug; Doxorubicin; Ginsenosides; HCT116 Cells; Humans; Inhibitory Concentration 50; NF-kappa B; Paclitaxel; Taxoids | 2009 |
The Hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24-/low subpopulation and the side population of breast cancer cells.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Breast Neoplasms; Carcinoma, Pancreatic Ductal; CD24 Antigen; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Flow Cytometry; Hedgehog Proteins; Humans; Hyaluronan Receptors; Mice; Mice, Inbred NOD; Mice, SCID; Paclitaxel; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Trans-Activators; Transcription Factors; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1 | 2009 |
Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel.
Topics: AC133 Antigen; Adjuvants, Pharmaceutic; Antigens, CD; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cations; Cell Line, Tumor; Colonic Neoplasms; Cross-Linking Reagents; Drug Compounding; Drug Delivery Systems; Glycoproteins; Humans; Lipids; Luciferases; Molecular Weight; Paclitaxel; Particle Size; Peptides; Polyethylene Glycols; Polymers; RNA, Small Interfering; Solubility; Transfection; Water | 2009 |
Comparison of two pharmacodynamic transduction models for the analysis of tumor therapeutic responses in model systems.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Computer Simulation; Mice; Models, Biological; Paclitaxel | 2010 |
Selective inhibition of MDR1 (ABCB1) by HM30181 increases oral bioavailability and therapeutic efficacy of paclitaxel.
Topics: Administration, Oral; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Benzopyrans; Biological Availability; Cell Line; Colonic Neoplasms; Dogs; Humans; Isoquinolines; Male; Mice; Multidrug Resistance-Associated Protein 2; Paclitaxel; Rats; Rats, Sprague-Dawley; Substrate Specificity; Tetrazoles; Treatment Outcome; Xenograft Model Antitumor Assays | 2010 |
Chemotherapeutic activity of silymarin combined with doxorubicin or paclitaxel in sensitive and multidrug-resistant colon cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biological Transport; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Doxorubicin; Drug Antagonism; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Paclitaxel; Silymarin | 2011 |
Biological assessment of triazine dendrimer: toxicological profiles, solution behavior, biodistribution, drug release and efficacy in a PEGylated, paclitaxel construct.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cell Line, Tumor; Chromatography, Gel; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dendrimers; Fractionation, Field Flow; Hep G2 Cells; Humans; Male; Mice; Mice, SCID; Models, Chemical; Molecular Weight; Paclitaxel; Polyethylene Glycols; Prostatic Neoplasms; Rats; Swine; Triazines; Xenograft Model Antitumor Assays | 2010 |
Paclitaxel-clusters coated with hyaluronan as selective tumor-targeted nanovectors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Colonic Neoplasms; Cytokines; Drug Delivery Systems; Hyaluronic Acid; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Paclitaxel | 2010 |
CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; CDX2 Transcription Factor; Colon; Colonic Neoplasms; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; HT29 Cells; Humans; Paclitaxel; Verapamil; Vincristine | 2010 |
Wheat germ agglutinin-conjugated PLGA nanoparticles for enhanced intracellular delivery of paclitaxel to colon cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Biological Transport; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Colonic Neoplasms; Drug Delivery Systems; Drug Screening Assays, Antitumor; Endocytosis; Humans; Lactic Acid; Nanoparticles; Paclitaxel; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Wheat Germ Agglutinins | 2010 |
Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer.
Topics: Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Fluorouracil; Humans; Paclitaxel; Radiation-Sensitizing Agents | 2010 |
E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carboplatin; Carcinoma; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Genetic Therapy; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Paclitaxel; Transfection; Viral Proteins | 2010 |
Chemotherapeutic agents in low noncytotoxic concentrations increase immunogenicity of human colon cancer cells.
Topics: Antigen Presentation; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Calmodulin; Cell Survival; Cells, Cultured; Coculture Techniques; Colonic Neoplasms; Cysteine Endopeptidases; Cytotoxicity, Immunologic; Dendritic Cells; Dose-Response Relationship, Drug; Doxorubicin; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Membrane Transport Proteins; Oligonucleotide Array Sequence Analysis; Paclitaxel; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic | 2011 |
miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Northern; Blotting, Western; Cell Proliferation; Colonic Neoplasms; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Mutation; Paclitaxel; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2011 |
PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Carriers; Drug Compounding; Emulsions; Inhibitory Concentration 50; Liposomes; Male; Mice; Mice, Inbred BALB C; Nanospheres; Paclitaxel; Polyethylene Glycols; Rats; Rats, Wistar; Survival Analysis; Tissue Distribution; Tumor Burden | 2011 |
Combination of paclitaxel- and retinoic acid-incorporated nanoparticles for the treatment of CT-26 colon carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Synergism; Humans; Microscopy, Electron, Transmission; Nanoparticles; Neoplasm Invasiveness; Paclitaxel; Particle Size; Surface Properties; Tretinoin | 2011 |
Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; Gene Expression Regulation; HCT116 Cells; HT29 Cells; Humans; MicroRNAs; Mutation; Paclitaxel; PTEN Phosphohydrolase; Signal Transduction; Tumor Suppressor Protein p53 | 2011 |
Dairy milk fat augments paclitaxel therapy to suppress tumour metastasis in mice, and protects against the side-effects of chemotherapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cachexia; Colonic Neoplasms; Dietary Fats; Dietary Supplements; Female; gamma-Glutamyltransferase; Mice; Mice, Inbred BALB C; Milk; Neoplasm Metastasis; Neovascularization, Pathologic; Paclitaxel; Soybean Oil; Time Factors | 2011 |
The role of paclitaxel in the development and treatment of multidrug resistant cancer cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Death; Cell Line, Tumor; Colonic Neoplasms; Disease Progression; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glioblastoma; Glutathione; Humans; Inactivation, Metabolic; Paclitaxel; Rhodamine 123; RNA, Messenger; Vascular Endothelial Growth Factor A | 2011 |
Nanoparticle-based biocompatible and targeted drug delivery: characterization and in vitro studies.
Topics: Antineoplastic Agents, Phytogenic; Biocompatible Materials; Caco-2 Cells; Cell Survival; Chitosan; Colonic Neoplasms; Dextran Sulfate; Drug Carriers; Drug Compounding; Fluorescence; Humans; Kinetics; Microscopy, Electron, Scanning; Molecular Targeted Therapy; Nanoparticles; Paclitaxel; Particle Size; Photoelectron Spectroscopy; Polyethylene Glycols; Surface Properties; Wheat Germ Agglutinins | 2011 |
[ABCB1 polymorphisms in patients with Charcot-Marie-Tooth disease. A possible relationship with neurotoxicity due to cytostatic treatment].
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Charcot-Marie-Tooth Disease; Colonic Neoplasms; Cytostatic Agents; Disease Susceptibility; Female; Genotype; Humans; Multidrug Resistance-Associated Proteins; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Peripheral Nervous System Diseases; Polymorphism, Single Nucleotide | 2012 |
Targeting quiescent tumor cells via oxygen and IGF-I supplementation.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Culture Techniques; Cell Hypoxia; Cell Proliferation; Cell Survival; Colonic Neoplasms; Deoxycytidine; Drug Synergism; Gemcitabine; HCT116 Cells; HT29 Cells; Humans; Insulin; Insulin-Like Growth Factor I; Mice; Mice, Inbred NOD; Mice, SCID; Oxygen; Paclitaxel; Receptor, IGF Type 1; Xenograft Model Antitumor Assays | 2012 |
Rapidly progressive colonic dysplasia/neoplasia in a series of treated lung cancer patients: Is paclitaxel involved?
Topics: Aged, 80 and over; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Colonic Polyps; Female; Humans; Immunosuppressive Agents; Lung Neoplasms; Male; Middle Aged; Neoplasms, Second Primary; Paclitaxel; Precancerous Conditions | 2013 |
Evaluation of interstitial protein delivery in multicellular layers model.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Biological Transport; Cell Membrane Permeability; Cetuximab; Colonic Neoplasms; Drug Carriers; HT29 Cells; Humans; Immunoglobulin G; Microscopy, Fluorescence; Molecular Weight; Nanogels; Paclitaxel; Polyethylene Glycols; Polyethyleneimine; Proteins; Ribonuclease, Pancreatic; TNF-Related Apoptosis-Inducing Ligand | 2012 |
Synthesis and characterization of a novel polydepsipeptide contained tri-block copolymer (mPEG-PLLA-PMMD) as self-assembly micelle delivery system for paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Calorimetry, Differential Scanning; Cell Survival; Chemistry, Pharmaceutical; Colonic Neoplasms; Depsipeptides; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Stability; Half-Life; HCT116 Cells; Humans; Injections, Intravenous; Magnetic Resonance Spectroscopy; Male; Metabolic Clearance Rate; Micelles; Paclitaxel; Particle Size; Polyesters; Polyethylene Glycols; Polymers; Rats; Rats, Wistar; Solubility; Surface Properties; Technology, Pharmaceutical | 2012 |
ErbB3 expression predicts sensitivity to elisidepsin treatment: in vitro synergism with cisplatin, paclitaxel and gemcitabine in lung, breast and colon cancer cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Neoplasms; Deoxycytidine; Depsipeptides; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Gemcitabine; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mitogen-Activated Protein Kinases; Paclitaxel; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4 | 2012 |
Paclitaxel-incorporated nanoparticles of hydrophobized polysaccharide and their antitumor activity.
Topics: Acetic Anhydrides; Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cell Line, Tumor; Chemical Precipitation; Colonic Neoplasms; Delayed-Action Preparations; Drug Delivery Systems; Glucans; Humans; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron; Nanoparticles; Paclitaxel; Particle Size; Polysaccharides; Time Factors | 2012 |
The anti-Fn14 antibody BIIB036 inhibits tumor growth in xenografts and patient derived primary tumor models and enhances efficacy of chemotherapeutic agents in multiple xenograft models.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carboplatin; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Female; Fluorouracil; Half-Life; Humans; Lung Neoplasms; Mice; Mice, Nude; Mice, SCID; Paclitaxel; Receptors, Tumor Necrosis Factor; Stomach Neoplasms; Tumor Burden; TWEAK Receptor; Xenograft Model Antitumor Assays | 2012 |
Novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy.
Topics: Administration, Oral; Alginates; Animals; Antineoplastic Agents; Calcium Phosphates; Cattle; Chitosan; Colonic Neoplasms; Endocytosis; Glucuronic Acid; Hexuronic Acids; Humans; Iron; Lactoferrin; Mice; Nanoparticles; Paclitaxel; Xenograft Model Antitumor Assays | 2012 |
Hyaluronic acid-coated nanostructured lipid carriers for targeting paclitaxel to cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Female; HCT116 Cells; Humans; Hyaluronic Acid; Lipids; Melanoma, Experimental; Mice; Nanostructures; Paclitaxel; Random Allocation | 2013 |
Formulation and evaluation of paclitaxel-loaded polymeric nanoparticles composed of polyethylene glycol and polylactic acid block copolymer.
Topics: Administration, Intravenous; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Lactic Acid; Liver; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Paclitaxel; Particle Size; Polyesters; Polyethylene Glycols; Polymers; Spleen | 2012 |
Apoptotic-like death occurs through a caspase-independent route in colon carcinoma cells undergoing mitotic catastrophe.
Topics: Apoptosis; Caspases; Cell Cycle; Cell Death; Colonic Neoplasms; Endoreduplication; HCT116 Cells; Humans; Mitosis; Paclitaxel; Polyploidy; Tubulin Modulators; Tumor Suppressor Protein p53 | 2012 |
Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Biological Transport; Blood-Brain Barrier; Brain; Caco-2 Cells; Colonic Neoplasms; Dendrimers; Drug Carriers; Drug Delivery Systems; Endothelial Cells; Humans; Nanoparticles; Paclitaxel; Permeability; Swine | 2013 |
Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells.
Topics: Apoptosis; Carcinoma; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Immediate-Early Proteins; Nuclear Proteins; Paclitaxel; Phosphorylation; Protein Serine-Threonine Kinases; Proteomics; RNA Interference; Sp1 Transcription Factor; Transcription, Genetic | 2013 |
Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Croton; HT29 Cells; Humans; Melanoma; Paclitaxel; Plant Extracts; Vinblastine | 2012 |
Deeper penetration into tumor tissues and enhanced in vivo antitumor activity of liposomal paclitaxel by pretreatment with angiogenesis inhibitor SU5416.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Humans; Immunoenzyme Techniques; Indoles; Liposomes; Male; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Paclitaxel; Pericytes; Polyethylene Glycols; Pyrroles; Solubility; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
MiR-125a/b regulates the activation of cancer stem cells in paclitaxel-resistant colon cancer.
Topics: Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Myeloid Cell Leukemia Sequence 1 Protein; Neoplastic Stem Cells; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Up-Regulation | 2013 |
In vitro evaluation of paclitaxel loaded amorphous chitin nanoparticles for colon cancer drug delivery.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Cell Survival; Chitin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Screening Assays, Antitumor; Flow Cytometry; HT29 Cells; Humans; Nanoparticles; Paclitaxel; Particle Size; Structure-Activity Relationship; Surface Properties; Tumor Cells, Cultured | 2013 |
[Localization of primary small cell carcinoma with liver metastasis: a rare combination of colonic adenocarcinoma and undifferentiated small cell carcinoma].
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Small Cell; Colectomy; Colon; Colonic Neoplasms; Docetaxel; Doxorubicin; Etoposide; Female; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Neoplasms, Multiple Primary; Neoplasms, Unknown Primary; Paclitaxel; Taxoids; Time Factors; Vincristine | 2002 |
Three new C-14 oxygenated taxanes from the wood of Taxus yunnanensis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bridged-Ring Compounds; Cell Survival; Colonic Neoplasms; Diterpenes; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Fibrosarcoma; Humans; Hydrolysis; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Paclitaxel; Plants, Medicinal; Stereoisomerism; Taxoids; Taxus; Trees; Tumor Cells, Cultured | 2002 |
Quantification of human Alu sequences by real-time PCR--an improved method to measure therapeutic efficacy of anti-metastatic drugs in human xenotransplants.
Topics: Alu Elements; Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Colonic Neoplasms; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Mice; Mice, SCID; Neoplasms; Paclitaxel; Pancreatic Neoplasms; Piperazines; Polymerase Chain Reaction; Pyrimidines; Sensitivity and Specificity; Transplantation, Heterologous; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2002 |
p21 Waf-1 (Cip-1) enhances apoptosis induced by manumycin and paclitaxel in anaplastic thyroid cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspases; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Gene Expression; Humans; Mutagenesis; Oligonucleotide Array Sequence Analysis; Paclitaxel; Polyenes; Polyunsaturated Alkamides; Thyroid Neoplasms; Transfection; Tumor Cells, Cultured; Zinc | 2003 |
IDN 5390: an oral taxane candidate for protracted treatment schedules.
Topics: Administration, Oral; Animals; Brain Neoplasms; Bridged-Ring Compounds; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Female; Glioblastoma; Humans; Injections, Subcutaneous; Mice; Mice, Nude; Neoplasms, Experimental; Ovarian Neoplasms; Paclitaxel; Taxoids; Transplantation, Heterologous | 2003 |
Adenocarcinoma cells exposed in vitro to Navelbine or Taxol increase Ep-CAM expression through a novel mechanism.
Topics: Adenocarcinoma; Animals; Antigens, Neoplasm; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Cell Adhesion Molecules; Cell Survival; Chromium; Colonic Neoplasms; Epithelial Cell Adhesion Molecule; Female; G2 Phase; Humans; In Vitro Techniques; Lutetium; Male; Mice; Mice, Nude; Mitosis; Paclitaxel; Prostatic Neoplasms; Tumor Cells, Cultured; Vinblastine; Vinorelbine | 2003 |
NICE recommends new treatment for breast and bowel cancer.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Colonic Neoplasms; Deoxycytidine; Docetaxel; Female; Fluorouracil; Humans; Paclitaxel; Practice Guidelines as Topic; Taxoids; Tegafur; Uracil | 2003 |
Multiple effects of paclitaxel are modulated by a high c-myc amplification level.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma; Cell Compartmentation; Cell Division; Cell Nucleus; Colonic Neoplasms; Eukaryotic Cells; Gene Amplification; Gene Dosage; Genes, myc; Humans; Neoplasms; Paclitaxel; Phosphorylation; Tumor Cells, Cultured; Up-Regulation | 2003 |
Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Neoplasms; Female; Ganglia, Spinal; HeLa Cells; Humans; Lung Neoplasms; Male; Models, Animal; Neurotoxins; Ovarian Neoplasms; Paclitaxel; Prostatic Neoplasms; Rats; Rats, Wistar | 2003 |
Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents.
Topics: Antineoplastic Agents; Camptothecin; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Female; Fluorouracil; HCT116 Cells; Humans; Irinotecan; Models, Biological; Ovarian Neoplasms; Paclitaxel | 2004 |
Antiangiogenic and antitumoral activity of phenyl-3-(2-chloroethyl)ureas: a class of soft alkylating agents disrupting microtubules that are unaffected by cell adhesion-mediated drug resistance.
Topics: Actins; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Cell Division; Cell Line, Tumor; Cells, Cultured; Chick Embryo; Colchicine; Colonic Neoplasms; Cricetinae; Cytoskeleton; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Endothelium, Vascular; Extracellular Matrix; Humans; Mice; Mice, Inbred BALB C; Microtubules; Paclitaxel; Tubulin; Urea | 2004 |
Differential effects of monastrol in two human cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Colonic Neoplasms; G2 Phase; HT29 Cells; Humans; Kinesins; Microtubules; Mitosis; Paclitaxel; Pyrimidines; Stomach Neoplasms; Thiones | 2004 |
Polyploidisation of metastatic colon carcinoma cells by microtubule and tubulin interacting drugs: effect on proteolytic activity and invasiveness.
Topics: Cell Division; Cell Line, Tumor; Colchicine; Colonic Neoplasms; Humans; Matrix Metalloproteinase 7; Microtubules; Neoplasm Invasiveness; Paclitaxel; Polyploidy; Tissue Plasminogen Activator; Tubulin | 2004 |
Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cell Line, Tumor; Checkpoint Kinase 1; Colonic Neoplasms; Enzyme Inhibitors; HeLa Cells; Humans; Lung Neoplasms; Mitosis; Oligonucleotide Array Sequence Analysis; Paclitaxel; Protein Kinases; RNA, Small Interfering | 2005 |
Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Proliferation; Colonic Neoplasms; Female; G1 Phase; G2 Phase; Humans; Imidazoles; Mitosis; Mutation; Nuclear Proteins; Paclitaxel; Piperazines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2005 |
NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Chemistry, Pharmaceutical; Colonic Neoplasms; Humans; Mice; Nanostructures; Nervous System; Paclitaxel; Transplantation, Heterologous | 2005 |
HERG K+ channel expression-related chemosensitivity in cancer cells and its modulation by erythromycin.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Biomarkers; Breast Neoplasms; Camptothecin; Carcinoma; Colonic Neoplasms; Coloring Agents; Drug Interactions; Drug Resistance, Neoplasm; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression Profiling; Humans; Lung Neoplasms; Paclitaxel; Potassium Channels, Voltage-Gated; Tetrazolium Salts; Thiazoles; Transfection; Vincristine | 2005 |
The role of the cytoskeleton in differentially regulating pressure-mediated effects on malignant colonocyte focal adhesion signaling and cell adhesion.
Topics: Cell Adhesion; Cell Line, Tumor; Cells, Cultured; Colchicine; Colon; Colonic Neoplasms; Cytochalasin D; Cytoskeleton; Dimethyl Sulfoxide; Humans; Integrins; Models, Biological; Paclitaxel; Phalloidine; Pressure; Signal Transduction | 2005 |
Oxaliplatin, a potent inhibitor of survivin, enhances paclitaxel-induced apoptosis and mitotic catastrophe in colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Cysteine Proteinase Inhibitors; Drug Synergism; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Mitosis; Neoplasm Proteins; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Survivin; Tumor Suppressor Protein p53 | 2005 |
Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspases; Ceramides; Colonic Neoplasms; Down-Regulation; Drug Combinations; Enzyme Activation; Flow Cytometry; Glucose; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Membrane Glycoproteins; Paclitaxel; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2005 |
[A case of advanced gastric cancer with direct invasion of the transverse colon responding to paclitaxel/5'-DFUR combined therapy].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Colon, Transverse; Colonic Neoplasms; Drug Administration Schedule; Floxuridine; Humans; Ileus; Male; Middle Aged; Neoplasm Invasiveness; Paclitaxel; Peritoneal Neoplasms; Quality of Life; Stomach Neoplasms | 2005 |
Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; DNA-Binding Proteins; Drug Resistance, Neoplasm; Humans; Intestinal Mucosa; Oncogene Protein v-akt; Paclitaxel; Phosphatidylinositol 3-Kinases; Proto-Oncogenes; Rats; Signal Transduction; Transcription Factors; Transcriptional Activation; Transforming Growth Factor beta | 2006 |
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Catalase; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Confidence Intervals; Drug Synergism; Edetic Acid; Female; Fluorouracil; Glutathione Reductase; Humans; Hydrogen Peroxide; Leukocytes; Mice; Mice, Inbred BALB C; Organoplatinum Compounds; Oxaliplatin; Oxidative Stress; Paclitaxel; Pyridoxal Phosphate; Reactive Oxygen Species; Staphylococcal Infections; Staphylococcus aureus; Superoxide Dismutase; Superoxides | 2006 |
Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Caco-2 Cells; Camptothecin; Cell Line, Tumor; Cisplatin; Colonic Neoplasms; Cytokines; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; HT29 Cells; Humans; Interferons; Ligands; Mitomycin; Orotate Phosphoribosyltransferase; Paclitaxel; RNA, Messenger; Thymidine Phosphorylase; Thymidylate Synthase | 2006 |
Polyethylene glycol-phosphatidylethanolamine conjugate (PEG-PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Acids and Salts; Caco-2 Cells; Colonic Neoplasms; Humans; Hydrogen-Ion Concentration; Micelles; Paclitaxel; Phosphatidylethanolamines; Polyethylene Glycols; Solubility | 2006 |
Complete regression of xenografted human carcinomas by a paclitaxel-carboxymethyl dextran conjugate (AZ10992).
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carbohydrate Sequence; Carcinoma; Cell Line, Tumor; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dextrans; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molecular Weight; Neoplasm Transplantation; Paclitaxel; Tissue Distribution | 2007 |
In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors.
Topics: 3T3 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Docetaxel; Drug Synergism; Enzyme Inhibitors; Humans; In Vitro Techniques; Lung Neoplasms; Male; Mice; Mice, Nude; Mice, SCID; Microtubules; Mitogen-Activated Protein Kinases; Paclitaxel; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Taxoids; Transcriptional Activation; Tumor Cells, Cultured; Vincristine; Xenograft Model Antitumor Assays | 2007 |
Cyclophosphamide "metronomic" chemotherapy for palliative treatment of a young patient with advanced epithelial ovarian cancer.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Colonic Neoplasms; Colostomy; Cyclophosphamide; Cystadenocarcinoma, Serous; Disease-Free Survival; Drug Administration Schedule; Drug Evaluation; Drug Resistance, Neoplasm; Epoetin Alfa; Erythropoietin; Fatal Outcome; Female; Follow-Up Studies; Hemorrhage; Humans; Intestinal Obstruction; Karnofsky Performance Status; Laparotomy; Ovarian Neoplasms; Ovariectomy; Paclitaxel; Palliative Care; Peritoneal Neoplasms; Recombinant Proteins; Salvage Therapy; Topotecan; Urinary Bladder Neoplasms; Vitamins | 2007 |
Enhanced efficacy of herpes simplex virus mutant HF10 combined with paclitaxel in peritoneal cancer dissemination models.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma; Colonic Neoplasms; Combined Modality Therapy; Genetic Vectors; Mice; Mice, Inbred BALB C; Oncolytic Virotherapy; Paclitaxel; Peritoneal Neoplasms; Simplexvirus | 2007 |
High mobility group box I (HMGB1) release from tumor cells after treatment: implications for development of targeted chemoimmunotherapy.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Nucleus; Colonic Neoplasms; Combined Modality Therapy; HMGB1 Protein; Humans; Immunotherapy; Killer Cells, Lymphokine-Activated; Melanoma; Melphalan; Microscopy, Confocal; Necrosis; Neoplasms; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Pancreatic Neoplasms | 2007 |
Cytoskeleton and motor proteins are required for the transcytosis of Neisseria gonorrhoeae through polarized epithelial cells.
Topics: Actins; Bacterial Adhesion; Cell Adhesion Molecules; Colonic Neoplasms; Cytoskeletal Proteins; Dyneins; Epithelial Cells; Gonorrhea; Humans; Kinesins; Microtubules; Molecular Motor Proteins; Myosins; Neisseria gonorrhoeae; Nocodazole; Paclitaxel; Tumor Cells, Cultured; Vinblastine | 2008 |
Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Adhesion; Cell Line, Tumor; Collagen Type II; Colonic Neoplasms; Female; Fibronectins; Floxuridine; Fluorouracil; Humans; Irinotecan; Laminin; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; Models, Biological; Neoplasm Metastasis; Paclitaxel | 2007 |
The effect of core composition in biodegradable oligomeric micelles as taxane formulations.
Topics: Animals; Chemistry, Pharmaceutical; Colonic Neoplasms; Docetaxel; Drug Stability; Magnetic Resonance Spectroscopy; Mice; Micelles; Paclitaxel; Particle Size; Taxoids | 2008 |
Marked regression of liver metastasis by combined therapy of ultrasound-mediated NF kappaB-decoy transfer and transportal injection of paclitaxel, in mouse.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Chemotherapy, Adjuvant; Colonic Neoplasms; Colorimetry; Down-Regulation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genetic Therapy; Humans; Immunoblotting; Injections, Intravenous; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; NF-kappa B; Oligodeoxyribonucleotides; Oligonucleotide Array Sequence Analysis; Paclitaxel; Portal Vein; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Ultrasonics; Ultrasonography | 2008 |
Comparative cytotoxicity of C-1311 in colon cancer in vitro and in vivo using the hollow fiber assay.
Topics: Aminoacridines; Animals; Antineoplastic Agents; Camptothecin; Capecitabine; Cell Line, Tumor; Cell Proliferation; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Deoxycytidine; Drug Screening Assays, Antitumor; Fluorouracil; HT29 Cells; Humans; In Vitro Techniques; Irinotecan; Mice; Mice, Nude; Organoplatinum Compounds; Oxaliplatin; Paclitaxel | 2007 |
Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity.
Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Agents; Ataxia; Catechols; Cisplatin; Colonic Neoplasms; Drug Evaluation, Preclinical; Female; Humans; Interleukin-6; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neural Conduction; Neuroprotective Agents; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Postural Balance; Rats; Rats, Inbred Strains; Transplantation, Heterologous; Vincristine | 2008 |
Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epothilones; Female; Glioma; Magnetic Resonance Imaging; Mice; Mice, Nude; Microtubules; Neoplasm Proteins; Paclitaxel; Pancreatic Neoplasms; Rats; Rats, Inbred Lew; Tissue Distribution; Xenograft Model Antitumor Assays | 2008 |
Response of human tumor xenografts in athymic nude mice to docetaxel (RP 56976, Taxotere).
Topics: Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Docetaxel; Drugs, Investigational; Female; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Paclitaxel; Taxoids; Transplantation, Heterologous | 1995 |
Isolation, purification, and biological activity of mono- and dihydroxylated paclitaxel metabolites from human feces.
Topics: Animals; Bone Marrow Cells; Chromatography, High Pressure Liquid; Colonic Neoplasms; Feces; Female; Hematopoietic Stem Cells; Humans; Hydroxylation; Ovarian Neoplasms; Paclitaxel; Rats; Spectrometry, Mass, Fast Atom Bombardment; Taxoids; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1995 |
Enhancement by recombinant human interferon alfa of the reversal of multidrug resistance by MRK-16 monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Female; Flow Cytometry; Humans; Interferon alpha-2; Interferon-alpha; Mice; Mice, Nude; Neoplasm Transplantation; Paclitaxel; Recombinant Proteins; Time Factors; Tumor Cells, Cultured; Vincristine | 1995 |
Lack of radiosensitization after paclitaxel treatment of three human carcinoma cell lines.
Topics: Breast Neoplasms; Carcinoma; Cell Cycle; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Flow Cytometry; G2 Phase; Humans; Male; Mitosis; Paclitaxel; Prostatic Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents; Radiotherapy Dosage; Tumor Cells, Cultured | 1995 |
[Effect of the association of antimitotic agents on cell lines of human adenocarcinoma].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carbamates; Colonic Neoplasms; Docetaxel; Humans; Paclitaxel; Pyrazines; Pyridines; Skin Neoplasms; Taxoids; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Vinblastine; Vinorelbine | 1994 |
Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines.
Topics: Adenocarcinoma; Astrocytoma; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Glycerol; HeLa Cells; Humans; Lung Neoplasms; Ovarian Neoplasms; Paclitaxel; Pancreatic Neoplasms; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1993 |
Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase.
Topics: Anaphase; Cell Cycle; Colonic Neoplasms; Drug Screening Assays, Antitumor; G1 Phase; Humans; Nocodazole; Paclitaxel; Spindle Apparatus; Telophase; Tumor Cells, Cultured | 1994 |
Estramustine: a novel radiation enhancer in human carcinoma cells.
Topics: Breast Neoplasms; Cell Cycle; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; Estramustine; Female; Flow Cytometry; Glioma; HeLa Cells; Humans; Male; Microtubules; Neoplasms; Paclitaxel; Prostatic Neoplasms; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Vinblastine | 1994 |
Taxotere inhibits in-vitro growth of human colonic cancer cell lines.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Colonic Neoplasms; DNA, Neoplasm; Docetaxel; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Paclitaxel; Taxoids; Time Factors; Tumor Cells, Cultured | 1994 |
Synthesis of a photoaffinity analog of taxol as an approach to identify the taxol binding site on microtubules.
Topics: Adenocarcinoma; Affinity Labels; Animals; Binding Sites; Binding, Competitive; Cell Line; Colonic Neoplasms; Fluorescent Antibody Technique; Mice; Microtubules; Paclitaxel; Photochemistry; Tumor Cells, Cultured | 1993 |
Preclinical profile of docetaxel (taxotere): efficacy as a single agent and in combination.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Docetaxel; Female; Humans; Leukemia P388; Male; Mammary Neoplasms, Experimental; Melanoma, Experimental; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Paclitaxel; Taxoids | 1995 |
Taxol-dependent transcriptional activation of IL-8 expression in a subset of human ovarian cancer.
Topics: Administration, Topical; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Cell Division; Colonic Neoplasms; Dimethyl Sulfoxide; Female; Humans; Interleukin-8; Ovarian Neoplasms; Paclitaxel; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Schedule-dependent interaction between paclitaxel and doxorubicin in human cancer cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Doxorubicin; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Paclitaxel; Tumor Cells, Cultured | 1995 |
[Modification of the response to paclitaxel of human differentiated colon cancer line after long-term treatment at very low dose].
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Humans; Microtubules; Mitosis; Paclitaxel; Tumor Cells, Cultured | 1996 |
Antitumor efficacy of taxane liposomes on a human ovarian tumor xenograft in nude athymic mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Bridged-Ring Compounds; Carcinoma; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Docetaxel; Drug Carriers; Female; Humans; Liposomes; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Paclitaxel; Taxoids | 1995 |
Schedule-dependent interaction between paclitaxel and 5-fluorouracil in human carcinoma cell lines in vitro.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Death; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Fluorouracil; Humans; Lung Neoplasms; Ovarian Neoplasms; Paclitaxel; Tumor Cells, Cultured | 1996 |
An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo.
Topics: Animals; Apoptosis; Carmustine; Colonic Neoplasms; DNA Fragmentation; Doxorubicin; Etoposide; Mice; Paclitaxel; Photochemotherapy; Protoporphyrins | 1996 |
Resistance to paclitaxel mediated by P-glycoprotein can be modulated by changes in the schedule of administration.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carcinoma; Cell Death; Colonic Neoplasms; Drug Administration Schedule; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Ovarian Neoplasms; Paclitaxel; Tumor Cells, Cultured | 1997 |
Influence of drug exposure parameters on the activity of paclitaxel in multicellular spheroids.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Paclitaxel; Spheroids, Cellular; Tumor Cells, Cultured | 1997 |
Combined action of paclitaxel and cisplatin against wildtype and resistant human ovarian carcinoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cisplatin; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Head and Neck Neoplasms; Humans; Ovarian Neoplasms; Paclitaxel; Tumor Cells, Cultured | 1997 |
Loss of DNA mismatch repair: effects on the rate of mutation to drug resistance.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Carrier Proteins; Cell Survival; Chromosome Mapping; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 3; Cisplatin; Colonic Neoplasms; DNA Repair; Drug Resistance, Multiple; Etoposide; Humans; Mutagenesis; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Paclitaxel; Repetitive Sequences, Nucleic Acid; Tumor Cells, Cultured | 1997 |
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.
Topics: Alkanes; Animals; Antineoplastic Agents, Phytogenic; Binding, Competitive; Carbamates; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Fluorescent Antibody Technique, Indirect; Humans; Lactones; Microscopy, Electron; Microtubules; Ovarian Neoplasms; Paclitaxel; Pyrones; Rats; Tubulin; Tumor Cells, Cultured | 1997 |
Protection against ethanol injury by prostaglandin in a human intestinal cell line: role of microtubules.
Topics: 16,16-Dimethylprostaglandin E2; Anti-Ulcer Agents; Cell Line; Cell Survival; Colchicine; Colon; Colonic Neoplasms; Ethanol; Humans; Microtubules; Paclitaxel; Tumor Cells, Cultured | 1998 |
Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol).
Topics: Alkaloids; Animals; Antineoplastic Agents; Binding Sites; Binding, Competitive; Cattle; Colonic Neoplasms; Diterpenes; Female; Growth Inhibitors; Humans; Microtubules; Ovarian Neoplasms; Paclitaxel; Polymers; Tubulin; Tumor Cells, Cultured | 1998 |
Induction of thymidine phosphorylase activity and enhancement of capecitabine efficacy by taxol/taxotere in human cancer xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colonic Neoplasms; Deoxycytidine; Docetaxel; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Induction; Female; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Taxoids; Thymidine Phosphorylase; Transplantation, Heterologous; Tumor Necrosis Factor-alpha; Up-Regulation | 1998 |
Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Colonic Neoplasms; Dose-Response Relationship, Drug; Genes, p53; Humans; Lymphoma; Mutation; Paclitaxel; Radiation, Ionizing; Tumor Cells, Cultured; Vincristine | 1998 |
Characterization of 2-chloro-N10-substituted phenoxazines for reversing multidrug resistance in cancer cells.
Topics: Adenocarcinoma; Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chlorine; Clone Cells; Colchicine; Colonic Neoplasms; Drug Resistance, Multiple; Humans; KB Cells; Molecular Structure; Oxazines; Paclitaxel; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured; Vinblastine | 1998 |
The effect of combining antitubulin agents on differentiated and undifferentiated human colon cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Differentiation; Cell Division; Cell Survival; Colonic Neoplasms; Docetaxel; Dose-Response Relationship, Drug; Drug Synergism; Humans; Paclitaxel; Taxoids; Time Factors; Tubulin; Tumor Cells, Cultured; Vinblastine; Vinorelbine | 1998 |
Schedule-dependent synergism and antagonism between paclitaxel and methotrexate in human carcinoma cell lines.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Female; Folic Acid Antagonists; Humans; Lung Neoplasms; Methotrexate; Ovarian Neoplasms; Paclitaxel; Tumor Cells, Cultured | 1998 |
A novel taxane with improved tolerability and therapeutic activity in a panel of human tumor xenografts.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Division; Cell Survival; Colonic Neoplasms; Drug Resistance, Multiple; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Prostatic Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1999 |
Effects of paclitaxel on the growth of normal, polyposis, and cancerous human colonic epithelial cells.
Topics: Adenomatous Polyposis Coli; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Colon; Colonic Neoplasms; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Paclitaxel; Tumor Cells, Cultured | 1999 |
Neutrophil F-actin and myosin but not microtubules functionally regulate transepithelial migration induced by interleukin 8 across a cultured intestinal epithelial monolayer.
Topics: Actins; ADP Ribose Transferases; Bacterial Toxins; Calcium; Cell Adhesion; Cells, Cultured; Chelating Agents; Chemotaxis, Leukocyte; Colchicine; Colonic Neoplasms; Cytochalasin B; Cytoskeleton; Diacetyl; Egtazic Acid; Epithelial Cells; Humans; Interleukin-8; Intestinal Mucosa; Microtubules; Myosins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Paclitaxel; Phalloidine; Tumor Cells, Cultured | 1999 |
Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma; CDC2 Protein Kinase; Colonic Neoplasms; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Ecdysterone; Female; G1 Phase; Mice; Mice, Nude; Microtubules; Neoplasm Proteins; Neoplasm Transplantation; Paclitaxel; S Phase; Tumor Cells, Cultured; Vincristine | 1999 |
Paclitaxel and radiotherapy: sequence-dependent efficacy--a preclinical model.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; Flow Cytometry; HT29 Cells; Humans; Paclitaxel; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Schedule-dependent interactions between paclitaxel and etoposide in human carcinoma cell lines in vitro.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Division; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Interactions; Drug Screening Assays, Antitumor; Etoposide; Female; Humans; Lung Neoplasms; Ovarian Neoplasms; Paclitaxel; Time Factors; Tumor Cells, Cultured | 1999 |
Berberine modulates expression of mdr1 gene product and the responses of digestive track cancer cells to Paclitaxel.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Berberine; Carcinoma; Cell Cycle; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorescent Dyes; Genes, MDR; Growth Inhibitors; Humans; Mice; Mouth Neoplasms; Paclitaxel; Rhodamine 123; Stomach Neoplasms; Tumor Cells, Cultured | 1999 |
Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Blotting, Western; Butyrates; Cell Nucleus; Colonic Neoplasms; Cytoplasm; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Paclitaxel; Phenotype; RNA, Catalytic; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Vincristine | 1999 |
Schedule-dependent interactions between vinorelbine and paclitaxel in human carcinoma cell lines in vitro.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Colonic Neoplasms; Drug Administration Schedule; Drug Interactions; Female; Humans; Lung Neoplasms; Ovarian Neoplasms; Paclitaxel; Tumor Cells, Cultured; Vinblastine; Vinorelbine | 1999 |
Enhanced antitumor activity of paclitaxel in combination with the anticarcinoma immunoconjugate BR96-doxorubicin.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasms; Paclitaxel; Rats; Rats, Nude; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
In vivo anti-tumor activity of a novel indolocarbazole compound, J-107088, on murine and human tumors transplanted into mice.
Topics: Animals; Antineoplastic Agents; Body Weight; Breast Neoplasms; Carbazoles; Cisplatin; Colonic Neoplasms; Doxorubicin; Drug Administration Schedule; Female; Glucosides; Humans; Indoles; Leukemia P388; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Mice, Nude; Neoplasms; Paclitaxel; Prostatic Neoplasms; Time Factors | 1999 |
In vitro efficacy of a novel chemoradiopotentiator--taxoltere metro.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Hypoxia; Cell Survival; CHO Cells; Colonic Neoplasms; Cricetinae; Docetaxel; Drug Resistance, Neoplasm; Humans; Paclitaxel; Radiation-Sensitizing Agents; Taxoids; Tumor Cells, Cultured | 2000 |
Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs.
Topics: Antineoplastic Agents; Cell Division; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Doxorubicin; Drug Interactions; Epoxy Compounds; Humans; Microtubules; Mutagens; Paclitaxel; Thiazoles; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vinblastine | 2000 |
Neuroprotective interactions in rats between paclitaxel and cisplatin.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Drug Screening Assays, Antitumor; Female; Ganglia, Spinal; Mice; Mice, Inbred C57BL; Neural Conduction; Paclitaxel; Rats; Rats, Wistar | 1999 |
Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-X Protein; Butyrates; Camptothecin; Caspase 3; Caspases; Cell Survival; Colonic Neoplasms; Drug Interactions; Ganciclovir; Humans; Membrane Proteins; Paclitaxel; Peptide Hydrolases; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Simplexvirus; Staurosporine; Thymidine Kinase; Transfection; Tumor Cells, Cultured | 2000 |
Differential expression of sphingolipids in MRP1 overexpressing HT29 cells.
Topics: Antineoplastic Agents; ATP-Binding Cassette Transporters; Cell Survival; Ceramides; Colchicine; Colonic Neoplasms; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fluoresceins; Galactosylceramides; Glucosylceramides; HT29 Cells; Humans; Immunoblotting; Immunohistochemistry; Microscopy, Confocal; Microtubules; Mitosis; Multidrug Resistance-Associated Proteins; Paclitaxel; Propionates; Quinolines; Signal Transduction; Sphingolipids; Vincristine | 2000 |
Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Cell Cycle Proteins; Colonic Neoplasms; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase Inhibitor p27; Female; Growth Substances; Humans; Immunohistochemistry; Ki-67 Antigen; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; Neoplasm Transplantation; Neovascularization, Pathologic; Oligonucleotides, Antisense; Paclitaxel; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2000 |
Modulation of paclitaxel resistance by annexin IV in human cancer cell lines.
Topics: Annexin A4; Blotting, Western; Colchicine; Colonic Neoplasms; DNA, Complementary; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Neoplastic; Growth Inhibitors; Humans; Lung Neoplasms; Neoplasm Proteins; Nocodazole; Paclitaxel; Recombinant Fusion Proteins; Transfection; Tubulin Modulators; Tumor Cells, Cultured | 2000 |
A novel synthetic DNA minor groove binder, MS-247: antitumor activity and cytotoxic mechanism.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Benzimidazoles; Cell Survival; Cisplatin; Colonic Neoplasms; DNA; Female; Fluorescent Dyes; Humans; Leukemia L1210; Leukemia P388; Macromolecular Substances; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Paclitaxel; Pyrroles; Radiation-Sensitizing Agents | 2000 |
Preclinical oral antitumor activity of BMS-185660, a paclitaxel derivative.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Drug Screening Assays, Antitumor; Female; Humans; Injections, Intravenous; Injections, Subcutaneous; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Paclitaxel; Taxoids | 2000 |
Multiple factors other than p53 influence colon cancer sensitivity to paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Division; Colonic Neoplasms; Exons; Genes, p53; Humans; Immunoblotting; Paclitaxel; Polymorphism, Single-Stranded Conformational; Tumor Cells, Cultured | 2000 |
Caspase-8 activation independent of CD95/CD95-L interaction during paclitaxel-induced apoptosis in human colon cancer cells (HT29-D4).
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Caspase 8; Caspase 9; Caspases; Colonic Neoplasms; Enzyme Activation; Fas Ligand Protein; fas Receptor; HT29 Cells; Humans; Membrane Glycoproteins; Mitochondria; Mitosis; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2 | 2000 |
A case of rapidly growing ovarian squamous cell carcinoma successfully controlled by weekly paclitaxel-carboplatin administration.
Topics: Abdominal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Colonic Neoplasms; Drug Administration Schedule; Female; Humans; Middle Aged; Ovarian Neoplasms; Paclitaxel | 2000 |
Bax induction activates apoptotic cascade via mitochondrial cytochrome c release and Bax overexpression enhances apoptosis induced by chemotherapeutic agents in DLD-1 colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cisplatin; Colonic Neoplasms; Cytochrome c Group; Doxorubicin; Fluorouracil; Humans; In Situ Nick-End Labeling; Kinetics; Mitochondria; Mitomycin; Paclitaxel; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Transfection; Tumor Cells, Cultured | 2000 |
Preclinical antitumor activity of two novel taxanes.
Topics: Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred Strains; Ovarian Neoplasms; Paclitaxel; Rats; Tumor Cells, Cultured | 2001 |
BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Survival; Colonic Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Female; Humans; Infusions, Parenteral; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Ovarian Neoplasms; Paclitaxel; Pancreatic Neoplasms; Sarcoma; Thiazoles; Tubulin; Tumor Cells, Cultured; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2001 |
Thymidine incorporation is highly predictive of colony formation and can be used for high-throughput screening.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Chickens; CHO Cells; Colonic Neoplasms; Colony-Forming Units Assay; Cricetinae; Drug Screening Assays, Antitumor; Etoposide; Humans; Hydroxyurea; Kidney Neoplasms; Lung Neoplasms; Paclitaxel; Sensitivity and Specificity; Thymidine; Tritium; Tumor Cells, Cultured | 2001 |
Endometrial adenocarcinoma arising during estrogenic treatment 17 years after total abdominal hysterectomy and bilateral salpingo-oophorectomy: a case report.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cell Transformation, Neoplastic; Colonic Neoplasms; Endometrial Neoplasms; Endometriosis; Estrogen Replacement Therapy; Female; Follow-Up Studies; Humans; Hysterectomy; Middle Aged; Ovariectomy; Paclitaxel | 2001 |
Expression of protein kinase C beta1 confers resistance to TNFalpha- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; HT29 Cells; Humans; Isoenzymes; Paclitaxel; Protein Kinase C; Protein Kinase C beta; Time Factors; Tumor Necrosis Factor-alpha | 2001 |
Synthesis of a novel C-10 spiro-epoxide of paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Drug Screening Assays, Antitumor; Epoxy Compounds; Female; Humans; Ovarian Neoplasms; Paclitaxel; Tumor Cells, Cultured | 2001 |
Selective tumor sensitization to taxanes with the mAb-drug conjugate cBR96-doxorubicin.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Cycle; Colonic Neoplasms; Docetaxel; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Immunotoxins; Inhibitory Concentration 50; Lewis Blood Group Antigens; Lung Neoplasms; Mice; Mice, Nude; Paclitaxel; Taxoids; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance.
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Bridged-Ring Compounds; Colonic Neoplasms; Doxorubicin; Drug Screening Assays, Antitumor; Female; Flow Cytometry; Fluorescence; Humans; Male; Paclitaxel; Taxoids; Tissue Distribution; Transplantation, Heterologous; Tumor Cells, Cultured | 2001 |
Synergistic interaction between topotecan and microtubule-interfering agents.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; bcl-X Protein; Blotting, Western; Cell Cycle; Colonic Neoplasms; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Enzyme Inhibitors; Formazans; Humans; Microtubules; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Tetrazolium Salts; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured; Vinblastine | 2001 |
[A new method for study of the effect of drugs on cancer cells--31PNMR with perfused cell system].
Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Humans; Magnetic Resonance Spectroscopy; Mouth Neoplasms; Paclitaxel; Phosphorus Isotopes; Tumor Cells, Cultured; Vincristine | 1998 |
[Synthesis and cytotoxicity of the new taxoids].
Topics: Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Female; Humans; KB Cells; Middle Aged; Ovarian Neoplasms; Paclitaxel; Tumor Cells, Cultured | 1998 |
Paclitaxel delivery systems: the use of amino acid linkers in the conjugation of paclitaxel with carboxymethyldextran to create prodrugs.
Topics: Amino Acids; Animals; Antineoplastic Agents, Phytogenic; Body Weight; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dextrans; Drug Carriers; Drug Delivery Systems; Female; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Organ Size; Paclitaxel; Prodrugs; Spectrophotometry, Ultraviolet; Tissue Distribution; Tumor Cells, Cultured | 2002 |
Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue.
Topics: Adenocarcinoma; Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Intraductal, Noninfiltrating; Colonic Neoplasms; Docetaxel; Female; Leukemia, Experimental; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Osteosarcoma; Paclitaxel; Pancreatic Neoplasms; Sarcoma, Experimental; Taxoids | 1991 |
Hypersensitivity reactions from taxol.
Topics: Adult; Aged; Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Colonic Neoplasms; Dexamethasone; Drug Administration Schedule; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Immediate; Leukemia, Myeloid, Acute; Male; Melanoma; Middle Aged; Paclitaxel; Premedication | 1990 |