Compounds > paclitaxel
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paclitaxel and Chromosomal Instability

paclitaxel has been researched along with Chromosomal Instability in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (42.86)29.6817
2010's8 (38.10)24.3611
2020's4 (19.05)2.80

Authors

AuthorsStudies
Bugni, TS; Burkard, ME; Chappell, RJ; Correia-Staudt, K; Esbona, K; Fitzgerald, J; Fowler, AM; Laffin, JJ; Lager, AM; Lasek, A; McGregor, SM; Molini, R; O'Regan, R; Scribano, CM; Tevaarwerk, AJ; Tucker, JB; Wan, J; Weaver, BA; Wisinski, KB; Zasadil, LM; Zhou, AS1
De Sousa, F; Eskat, A; Harry, D; Meraldi, P; Olziersky, AM; Vassal, H; Wilhelm, T1
Bakker, B; Burghel, GJ; Clamp, AR; Desai, S; Donaldson, IJ; Edmondson, R; Foijer, F; Golder, A; Green, CM; Hayes, A; Jayson, GC; Littler, S; Moralli, D; Morgan, RD; Murtuza Baker, S; Neale, B; Nelson, L; Spierings, DCJ; Taylor, SS; Tighe, A; Wardenaar, R; Winter-Roach, B1
Bazrgar, M; Hassani, SN; Masoudi, NS; Mirzaei-Seresht, B; Mollammohammadi, S; Sheidai, M1
Clayton, JE; Fonseca, CL; Malaby, HLH; Marquis, C; Queen, KA; Stumpff, J; Vandal, SE; Wood, L1
Becker, S; El-Balat, A; Raab, M; Rödel, F; Sanhaji, M; Strebhardt, K; Zhou, S1
Castro, C; de León, DC; Gallardo, D; Herrera, LA; López, A; Mendoza, J; Mohar, A; Morales, F; Oñate, LF; Perez, D; Prada, D; Santibáñez, M1
Geng, J; He, X; Liu, T; Liu, X; Liu, Y; Pang, D; Sun, Q; Zhang, X1
D'Assoro, AB; Galanis, E; Gambino, MW; Goetz, MP; Iankov, I; Ingle, JN; Malatino, L; McCubrey, J; Opyrchal, M; Puccia, G; Salisbury, JL1
Bartlett, JM; Boutros, PC; Burnell, M; Chen, BE; D'Costa, A; Levine, MN; Lyttle, N; O'Brien, P; Shepherd, L; Spears, M; Yao, CQ1
Auer, G; Brenton, JD; Chen, JG; Downward, J; East, P; Eklund, AC; Endesfelder, D; Habermann, JK; Hardcastle, T; Howell, M; Kim, SN; Kschischo, M; Lee, A; Li, Q; Ng, C; Nicke, B; Ried, T; Roy, R; Schuett, M; Swanton, C; Szallasi, Z; Wylie, P1
Janssen, A; Kops, GJ; Medema, RH1
Appleton, P; Kroboth, K; Nathke, IS; Patel, S; Radulescu, S; Ridgway, RA; Sansom, OJ; Taylor, S; Woodgett, J1
Cho, MH; Hong, SH; Hwang, SG; Joo, HY; Ju, YJ; Juhn, KM; Kang, CM; Kim, HK; Lee, JK; Lee, KH; Park, ER; Park, GH; Park, IC; Park, JE; Shin, HJ; Woo, SR1
Downward, J; Swanton, C; Tomlinson, I1
Chabalier, C; Lamare, C; Larminat, F; Privat, M; Racca, C; Valette, A1
Hiratsuka, M; Inoue, T; Ito, H; Katoh, M; Kishimoto, I; Nakano, S; Osaki, M; Oshimura, M; Yamada, H; Yamaguchi, S1
Black, EJ; Earnshaw, WC; Gillespie, DA; Scott, MT; Vagnarelli, P; Walker, M; Zachos, G1
Chakrabarti, R; Davila, M; Ghosh, D; Grizzle, WE; Jhala, D1
Altieri, D; Fuks, Z; Kolesnick, R1
Ahmed, AA; Brenton, JD; Chang, J; Downward, J; Elustondo, F; Kelly, G; Marani, M; Nicke, B; Pardo, O; Sahai, E; Swanton, C; Temple, J; Warne, PH1

Reviews

1 review(s) available for paclitaxel and Chromosomal Instability

ArticleYear
Chromosomal instability, colorectal cancer and taxane resistance.
    Cell cycle (Georgetown, Tex.), 2006, Volume: 5, Issue:8

    Topics: Antineoplastic Agents; Aurora Kinase A; Aurora Kinases; Chromosomal Instability; Clinical Trials as Topic; Colorectal Neoplasms; Drug Resistance, Neoplasm; Humans; Microtubules; Mitosis; Neoplasm Metastasis; Paclitaxel; Protein Kinases; Protein Serine-Threonine Kinases; Spindle Apparatus; Taxoids; Vincristine

2006

Trials

2 trial(s) available for paclitaxel and Chromosomal Instability

ArticleYear
Increased expression of mitotic arrest deficient-like 1 (MAD1L1) is associated with poor prognosis and insensitive to Taxol treatment in breast cancer.
    Breast cancer research and treatment, 2013, Volume: 140, Issue:2

    Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle Proteins; Chromosomal Instability; Female; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Nuclear Proteins; Paclitaxel; Prognosis; Tissue Array Analysis

2013
A four gene signature of chromosome instability (CIN4) predicts for benefit from taxanes in the NCIC-CTG MA21 clinical trial.
    Oncotarget, 2016, Aug-02, Volume: 7, Issue:31

    Topics: Adult; Aged; Anthracyclines; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Chromosomal Instability; Cyclophosphamide; Disease-Free Survival; Epirubicin; Female; Fluorouracil; Gene Expression Profiling; Humans; Middle Aged; Paclitaxel; Prognosis; Taxoids

2016

Other Studies

18 other study(ies) available for paclitaxel and Chromosomal Instability

ArticleYear
Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel.
    Science translational medicine, 2021, Sep-08, Volume: 13, Issue:610

    Topics: Breast Neoplasms; Chromosomal Instability; Female; Humans; Paclitaxel

2021
Mild replication stress causes chromosome mis-segregation via premature centriole disengagement.
    Nature communications, 2019, 08-08, Volume: 10, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Carcinogenesis; Cell Line, Tumor; Centrioles; Chromosomal Instability; Chromosome Segregation; DNA Damage; G2 Phase Cell Cycle Checkpoints; Humans; Microtubules; Neoplasms; Paclitaxel; Spindle Apparatus; Stress, Physiological

2019
A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity.
    Nature communications, 2020, 02-13, Volume: 11, Issue:1

    Topics: Biological Specimen Banks; Chromosomal Instability; Drug Resistance, Neoplasm; Exome Sequencing; Female; Gene Expression; Gene Expression Profiling; Histological Techniques; Humans; Imaging, Three-Dimensional; In Situ Hybridization, Fluorescence; In Vitro Techniques; Karyotyping; Mitosis; Models, Biological; Mutation; Ovarian Neoplasms; Paclitaxel; Single-Cell Analysis; Time-Lapse Imaging; Tumor Suppressor Protein p53

2020
Chromosomal instability reducing effect of paclitaxel and lapatinib in mouse embryonic stem cells with chromosomal abnormality.
    Molecular biology reports, 2020, Volume: 47, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Bortezomib; Cell Line; Chromosomal Instability; Lapatinib; Mice; Mouse Embryonic Stem Cells; Nanog Homeobox Protein; Octamer Transcription Factor-3; Paclitaxel; SOXB1 Transcription Factors

2020
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
    Nature communications, 2021, 02-22, Volume: 12, Issue:1

    Topics: Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Proliferation; Centrosome; Chromosomal Instability; Humans; Kinesins; Microtubules; Mitosis; Models, Biological; Neoplasms; Nocodazole; Paclitaxel; Spindle Apparatus

2021
Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability.
    Neoplasia (New York, N.Y.), 2019, Volume: 21, Issue:4

    Topics: Anaphase-Promoting Complex-Cyclosome; Antineoplastic Agents; Apoptosis; Biomarkers; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Chromosomal Instability; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Immunohistochemistry; Mitosis; Ovarian Neoplasms; Paclitaxel; Polo-Like Kinase 1; Prognosis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins

2019
The MAD1 1673 G → A polymorphism alters the function of the mitotic spindle assembly checkpoint and is associated with a worse response to induction chemotherapy and sensitivity to treatment in patients with advanced epithelial ovarian cancer.
    Pharmacogenetics and genomics, 2013, Volume: 23, Issue:4

    Topics: Biomarkers, Pharmacological; Calcium-Binding Proteins; Carcinoma, Ovarian Epithelial; Cell Cycle Proteins; Chromosomal Instability; Female; Genetic Association Studies; Humans; M Phase Cell Cycle Checkpoints; Mad2 Proteins; Microtubules; Neoplasm Staging; Neoplasms, Glandular and Epithelial; Nocodazole; Nuclear Proteins; Ovarian Neoplasms; Paclitaxel; Polymorphism, Single Nucleotide; Repressor Proteins

2013
Inhibition of Cdk2 kinase activity selectively targets the CD44⁺/CD24⁻/Low stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells.
    International journal of oncology, 2014, Volume: 45, Issue:3

    Topics: Apoptosis; CD24 Antigen; Cell Line, Tumor; Chromosomal Instability; Cyclin-Dependent Kinase 2; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Humans; Hyaluronan Receptors; Imidazoles; Indoles; Inflammatory Breast Neoplasms; MCF-7 Cells; Neoplastic Stem Cells; Paclitaxel; Triple Negative Breast Neoplasms

2014
Chromosomal instability determines taxane response.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, May-26, Volume: 106, Issue:21

    Topics: Bridged-Ring Compounds; Cell Survival; Chromosomal Instability; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Microtubules; Neoplasms; Paclitaxel; Polymerase Chain Reaction; Prognosis; Taxoids

2009
Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Nov-10, Volume: 106, Issue:45

    Topics: Apoptosis; Blotting, Western; Calcium-Binding Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Chromosomal Instability; Chromosome Segregation; Colony-Forming Units Assay; Drug Resistance; Fibroblasts; Humans; Mad2 Proteins; Microscopy, Fluorescence; Paclitaxel; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Repressor Proteins; RNA Interference

2009
Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.
    Oncogene, 2010, Dec-09, Volume: 29, Issue:49

    Topics: Adenomatous Polyposis Coli; Adenomatous Polyposis Coli Protein; Animals; Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Transformation, Neoplastic; Chromosomal Instability; Drug Resistance, Neoplasm; Enterocytes; Male; Mice; Mice, Inbred C57BL; Paclitaxel; Protein Serine-Threonine Kinases; Sequence Deletion; Spindle Apparatus; Vinblastine; Vinorelbine; Wnt Proteins

2010
Paclitaxel stimulates chromosomal fusion and instability in cells with dysfunctional telomeres: implication in multinucleation and chemosensitization.
    Biochemical and biophysical research communications, 2011, Jan-14, Volume: 404, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Chromosomal Instability; Chromosomes, Mammalian; Drug Resistance, Neoplasm; Mice; Paclitaxel; Telomere; Tubulin Modulators

2011
BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance.
    Cell cycle (Georgetown, Tex.), 2006, Volume: 5, Issue:9

    Topics: Antineoplastic Agents, Phytogenic; BRCA1 Protein; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Chromosomal Instability; Down-Regulation; Drug Resistance, Neoplasm; Female; Humans; Paclitaxel; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Small Interfering; Spindle Apparatus; Up-Regulation

2006
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
    Oncogene, 2007, Feb-15, Volume: 26, Issue:7

    Topics: Cell Line, Tumor; Chromosomal Instability; Chromosomes, Human; Glioma; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Mitosis; Nocodazole; Paclitaxel; Polyploidy; Sirtuin 2; Sirtuins; Stress, Physiological; Tubulin; Ultraviolet Rays; X-Rays

2007
Chk1 is required for spindle checkpoint function.
    Developmental cell, 2007, Volume: 12, Issue:2

    Topics: Animals; Aurora Kinase B; Aurora Kinases; Biopolymers; Catalysis; Cell Death; Checkpoint Kinase 1; Chickens; Chromosomal Instability; Chromosome Segregation; HCT116 Cells; Humans; Kinetochores; Microtubules; Neoplasms; Paclitaxel; Phosphorylation; Prometaphase; Protein Kinases; Protein Serine-Threonine Kinases; Protein Transport; Spindle Apparatus

2007
Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer.
    Molecular cancer, 2007, Jun-08, Volume: 6

    Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Chromosomal Instability; Fluorescent Antibody Technique; G1 Phase; Humans; Immunoblotting; Immunohistochemistry; Lim Kinases; Male; Paclitaxel; Precancerous Conditions; Prostatic Neoplasms; Protein Kinases; S Phase; Tissue Array Analysis

2007
A CERTain role for ceramide in taxane-induced cell death.
    Cancer cell, 2007, Volume: 11, Issue:6

    Topics: Bridged-Ring Compounds; Cell Death; Ceramides; Chromosomal Instability; Drug Resistance, Neoplasm; Humans; Mitosis; Paclitaxel; Polyploidy; Protein Folding; Protein Serine-Threonine Kinases; RNA, Small Interfering; Spindle Apparatus; Taxoids; Tumor Cells, Cultured

2007
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.
    Cancer cell, 2007, Volume: 11, Issue:6

    Topics: Cell Line, Tumor; Cell Survival; Ceramides; Chromosomal Instability; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Mitosis; Ovarian Neoplasms; Paclitaxel; Polyploidy; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Small Interfering

2007