p-chloromercuribenzoic acid has been researched along with Menkes Kinky Hair Syndrome in 3 studies
p-Chloromercuribenzoic Acid: An organic mercurial used as a sulfhydryl reagent.
Menkes Kinky Hair Syndrome: An inherited disorder of copper metabolism transmitted as an X-linked trait and characterized by the infantile onset of HYPOTHERMIA, feeding difficulties, hypotonia, SEIZURES, bony deformities, pili torti (twisted hair), and severely impaired intellectual development. Defective copper transport across plasma and endoplasmic reticulum membranes results in copper being unavailable for the synthesis of several copper containing enzymes, including PROTEIN-LYSINE 6-OXIDASE; CERULOPLASMIN; and SUPEROXIDE DISMUTASE. Pathologic changes include defects in arterial elastin, neuronal loss, and gliosis. (From Menkes, Textbook of Child Neurology, 5th ed, p125)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously reported that copper efflux from C6 rat glioma cells was blocked by a brief exposure to sulfhydryl reagents p-chloromercuribenzoate (PCMB) and iodoacetamide as well as dicyclohexylcarbodiimide, suggesting the possible involvement of a Cu-transporting ATPase in the efflux mechanism." | 3.69 | A Menkes P-type ATPase involved in copper homeostasis in the central nervous system of the rat. ( Harris, ED; Qian, Y; Tiffany-Castiglioni, E, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qian, Y | 3 |
| Tiffany-Castiglioni, E | 2 |
| Harris, ED | 3 |
| Majumdar, S | 1 |
| Reddy, MC | 1 |
3 other studies available for p-chloromercuribenzoic acid and Menkes Kinky Hair Syndrome
| Article | Year |
|---|---|
Functional analysis of a genetic defect of copper transport (Menkes disease) in different cell lines.
Topics: Animals; Biological Transport; Cell Line; Chloromercuribenzoates; Copper; Dithiothreitol; Fibroblast | 1996 |
Coincident expression of Menkes gene with copper efflux in human placental cells.
Topics: Base Sequence; Chloromercuribenzoates; Choriocarcinoma; Copper; Cytological Techniques; Female; Gene | 1996 |
A Menkes P-type ATPase involved in copper homeostasis in the central nervous system of the rat.
Topics: Adenosine Triphosphatases; Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Base Sequence; Bra | 1997 |