p-chloroamphetamine has been researched along with Nerve Degeneration in 9 studies
p-Chloroamphetamine: Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The neurochemical and histological effects of PCA are very similar to those produced by a large dose of methylamphetamine (MA) in that both drugs are toxic to serotonergic nerve terminals and neuronal perikarya in the somatosensory cortex." | 1.27 | Endogenously produced 5,6-dihydroxytryptamine may mediate the neurotoxic effects of para-chloroamphetamine. ( Axt, KJ; Commins, DL; Seiden, LS; Vosmer, G, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| García-García, L | 1 |
| Delgado, M | 1 |
| Al-Sayed, AA | 1 |
| Bascuñana, P | 1 |
| Fernández de la Rosa, R | 1 |
| Bermejo-Bescós, P | 1 |
| Martín-Aragón, S | 1 |
| Pozo, MA | 1 |
| Wilson, MA | 1 |
| Molliver, ME | 2 |
| Murray, TK | 2 |
| Williams, JL | 1 |
| Misra, A | 1 |
| Colado, MI | 2 |
| Green, AR | 2 |
| O'Shea, E | 1 |
| Granados, R | 1 |
| Yamada, J | 1 |
| Sugimoto, Y | 1 |
| Ohkura, M | 1 |
| Inoue, K | 1 |
| Shinozuka, K | 1 |
| Kunitomo, M | 1 |
| Harvey, JA | 1 |
| McMaster, SE | 1 |
| Schmidt, CJ | 1 |
| Black, CK | 1 |
| Taylor, VL | 1 |
| Berger, UV | 1 |
| Grzanna, R | 1 |
| Commins, DL | 1 |
| Axt, KJ | 1 |
| Vosmer, G | 1 |
| Seiden, LS | 1 |
9 other studies available for p-chloroamphetamine and Nerve Degeneration
| Article | Year |
|---|---|
In vivo [¹⁸F] FDG PET imaging reveals that p-chloroamphetamine neurotoxicity is associated with long-term cortical and hippocampal hypometabolism.
Topics: Animals; Autoradiography; Fluoresceins; Fluorodeoxyglucose F18; Glial Fibrillary Acidic Protein; Glu | 2015 |
Microglial response to degeneration of serotonergic axon terminals.
Topics: Animals; Axons; Biomarkers; Facial Nerve; Glial Fibrillary Acidic Protein; Image Processing, Compute | 1994 |
The spin trap reagent PBN attenuates degeneration of 5-HT neurones in rat brain induced by p-chloroamphetamine but not fenfluramine.
Topics: Animals; Body Temperature; Brain; Brain Chemistry; Cyclic N-Oxides; Fenfluramine; Hydroxyindoleaceti | 1996 |
In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine.
Topics: Animals; Biogenic Monoamines; Body Temperature; Brain Chemistry; Fenfluramine; Free Radical Scavenge | 1997 |
Role of 5-HT(2) receptor subtypes in depletion of 5-HT induced by p-chloroamphetamine in the mouse frontal cortex.
Topics: Animals; Body Temperature; Brain Chemistry; Drug Interactions; Fever; Frontal Lobe; Male; Mice; Nerv | 2001 |
Neurotoxic action of para-chloroamphetamine in the rat as revealed by Nissl and silver stains.
Topics: Amphetamines; Animals; Brain; Male; Nerve Degeneration; Neurons; p-Chloroamphetamine; Rats; Staining | 1976 |
L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dopamine; | 1991 |
Unlike systemic administration of p-chloroamphetamine, direct intracerebral injection does not produce degeneration of 5-HT axons.
Topics: 5,7-Dihydroxytryptamine; Animals; Axons; Cerebral Cortex; Immunohistochemistry; Injections; Male; Ne | 1990 |
Endogenously produced 5,6-dihydroxytryptamine may mediate the neurotoxic effects of para-chloroamphetamine.
Topics: 5,6-Dihydroxytryptamine; Amphetamines; Animals; Brain Chemistry; Hippocampus; Hydroxyindoleacetic Ac | 1987 |