p-aminohippuric acid has been researched along with Heart Failure in 12 studies
p-Aminohippuric Acid: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.
p-aminohippurate : A hippurate that is the conjugate base of p-aminohippuric acid, arising from deprotonation of the carboxy group.
p-aminohippuric acid : An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "d-3-Acetoxy-cis-2,3-dihydro-5-]2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride (diltiazem HCl) was orally administered to 9 patients with chronic congestive heart failure (Class IIb to III, NYHA) to examine whether the drug induces sodium retention and aggravates congestive heart failure." | 7.66 | The effect of diltiazem hydrochloride upon sodium diuresis and renal function in chronic congestive heart failure. ( Hoshino, T; Kinoshita, M; Kusukawa, R; Motomura, M; Shimono, Y; Tomonaga, G, 1979) |
| "Methods of effective renal plasma flow measurement by 125I-orthoiodohippurate elimination and para-aminohippurate clearance were compared with and without captopril pretreatment in 10 chronic heart failure patients and in 20 patients after transmural myocardial infarction." | 5.07 | Comparison of two methods of determining renal perfusion with and without captopril pretreatment in groups of patients with left ventricular dysfunction. ( Fenwick, MK; Motwani, JG; Struthers, AD, 1994) |
| "To validate color Doppler ultrasonography of renal arteries for the assessment of renal blood flow (RBF), we compared left and right RBF estimates and their sum (total RBF) by echo-Doppler with data obtained by iodine 123-123I-p-aminohippuric acid (PAH) scintigraphy in 19 patients with heart failure and 7 normal control subjects." | 3.69 | Color Doppler ultrasonography for the assessment of renal blood flow in heart failure. ( Barbano, F; Fusilli, S; Loperfido, F; Russo, A; Vigna, C, 1995) |
| "Acute reversible renal failure with hyperkalemia developed in a 42-year-old woman during treatment of heart failure and hypertension with high doses of enalapril and diuretics." | 3.67 | [Acute reversible kidney insufficiency due to enalapril during diuretic-treated heart insufficiency]. ( Degenhardt, S, 1987) |
| "d-3-Acetoxy-cis-2,3-dihydro-5-]2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride (diltiazem HCl) was orally administered to 9 patients with chronic congestive heart failure (Class IIb to III, NYHA) to examine whether the drug induces sodium retention and aggravates congestive heart failure." | 3.66 | The effect of diltiazem hydrochloride upon sodium diuresis and renal function in chronic congestive heart failure. ( Hoshino, T; Kinoshita, M; Kusukawa, R; Motomura, M; Shimono, Y; Tomonaga, G, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lannemyr, L | 1 |
| Ricksten, SE | 1 |
| Rundqvist, B | 1 |
| Andersson, B | 1 |
| Bartfay, SE | 1 |
| Ljungman, C | 1 |
| Dahlberg, P | 1 |
| Bergh, N | 1 |
| Hjalmarsson, C | 1 |
| Gilljam, T | 1 |
| Bollano, E | 1 |
| Karason, K | 1 |
| Voors, AA | 1 |
| Dahlke, M | 1 |
| Meyer, S | 1 |
| Stepinska, J | 1 |
| Gottlieb, SS | 1 |
| Jones, A | 1 |
| Zhang, Y | 1 |
| Laurent, D | 1 |
| Slart, RH | 1 |
| Navis, GJ | 1 |
| HIMBERT, J | 1 |
| BECK, D | 1 |
| SIEGENTHALER, W | 1 |
| Vigna, C | 1 |
| Russo, A | 1 |
| Barbano, F | 1 |
| Fusilli, S | 1 |
| Loperfido, F | 1 |
| Motwani, JG | 1 |
| Fenwick, MK | 1 |
| Struthers, AD | 1 |
| Freeman, RH | 1 |
| Davis, JO | 1 |
| Williams, GM | 1 |
| DeForrest, JM | 1 |
| Seymour, AA | 1 |
| Rowe, BP | 1 |
| Kinoshita, M | 1 |
| Kusukawa, R | 1 |
| Shimono, Y | 1 |
| Motomura, M | 1 |
| Tomonaga, G | 1 |
| Hoshino, T | 1 |
| Dietz, R | 1 |
| Nagel, F | 1 |
| Osterziel, KJ | 1 |
| Sweet, CS | 1 |
| Ludden, CT | 1 |
| Frederick, CM | 1 |
| Ribeiro, LG | 1 |
| Nussberger, J | 1 |
| Slater, EE | 1 |
| Blaine, EH | 1 |
| Degenhardt, S | 1 |
| Shilo, S | 1 |
| Slotki, IN | 1 |
| Iaina, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Intravenous Levosimendan Compared With Dobutamine on Renal Hemodynamics and Function in Chronic Heart Failure[NCT02133105] | Phase 3 | 33 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| A Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled Study to Evaluate the Renal Hemodynamic Effects of RLX030 and Placebo Infused for 24 Hours in Subjects With Chronic Heart Failure (CHF)[NCT01546532] | Phase 2 | 118 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for p-aminohippuric acid and Heart Failure
| Article | Year |
|---|---|
Differential Effects of Levosimendan and Dobutamine on Glomerular Filtration Rate in Patients With Heart Failure and Renal Impairment:A Randomized Double-Blind Controlled Trial.
Topics: Aged; Cardio-Renal Syndrome; Cardiotonic Agents; Dobutamine; Double-Blind Method; Female; Glomerular | 2018 |
Renal hemodynamic effects of serelaxin in patients with chronic heart failure: a randomized, placebo-controlled study.
Topics: Aged; Creatinine; Double-Blind Method; Female; Glomerular Filtration Rate; Heart Failure; Humans; Ki | 2014 |
Comparison of two methods of determining renal perfusion with and without captopril pretreatment in groups of patients with left ventricular dysfunction.
Topics: Aged; Blood Flow Velocity; Captopril; Cardiac Output, Low; Chronic Disease; Female; Heart Failure; H | 1994 |
9 other studies available for p-aminohippuric acid and Heart Failure
| Article | Year |
|---|---|
[Renal hemodynamics in cardiac insufficiency].
Topics: Heart Failure; Hemodynamics; Ischemia; Kidney; Kidney Diseases; Kidney Function Tests; Mannitol; p-A | 1962 |
[RENAL FUNCTION IN CARDIAC INSUFFICIENCY].
Topics: Heart Failure; Hypertension; Hypertension, Renal; Kidney; Kidney Function Tests; Natriuresis; p-Amin | 1965 |
Color Doppler ultrasonography for the assessment of renal blood flow in heart failure.
Topics: Adult; Aged; Female; Gamma Cameras; Heart Failure; Humans; Iodine Radioisotopes; Male; Middle Aged; | 1995 |
Effects of the oral converting enzyme inhibitor, SQ 14225, in a model of low cardiac output in dogs.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals | 1979 |
The effect of diltiazem hydrochloride upon sodium diuresis and renal function in chronic congestive heart failure.
Topics: Adult; Benzazepines; Blood Pressure; Diltiazem; Diuresis; Female; Glomerular Filtration Rate; Heart | 1979 |
Angiotensin-converting enzyme inhibitors and renal function in heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Blood Pressure; Captopril; Dipeptides; Female; Gl | 1992 |
Hemodynamic effects of synthetic atrial natriuretic factor (ANF) in dogs with acute left ventricular failure.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Coronary Disease; Creatinine; Dogs; Electrolytes | 1985 |
[Acute reversible kidney insufficiency due to enalapril during diuretic-treated heart insufficiency].
Topics: Acute Kidney Injury; Adult; Drug Therapy, Combination; Enalapril; Female; Heart Failure; Humans; Hyp | 1987 |
Improved renal function following acute peritoneal dialysis in patients with intractable congestive heart failure.
Topics: Adult; Aged; Creatinine; Electrolytes; Female; Glomerular Filtration Rate; Heart Failure; Humans; In | 1987 |