p-aminohippuric acid has been researched along with Aging in 57 studies
p-Aminohippuric Acid: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.
p-aminohippurate : A hippurate that is the conjugate base of p-aminohippuric acid, arising from deprotonation of the carboxy group.
p-aminohippuric acid : An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with prednisolone or dexamethasone is followed by an increase in renal excretion of p-aminohippurate (PAH) and in accumulation of PAH in renal cortical slices, particularly in 5- and 10-day-old rats with immature kidney function." | 1.28 | Stimulation of renal tubular transport of p-aminohippurate in rats of different ages by treatment with adrenocortical steroids. ( Bräunlich, H; Rassbach, H; Vogelsang, S, 1992) |
| "As phenobarbital treatment in young rats enhanced the symptoms of nephrotoxicity and metyrapone treatment in adult rats decreased the symptoms of nephrotoxicity, age-dependent differences in chromate nephrotoxicity may be linked to an increase in the enzymatic reduction of Cr(VI) with age." | 1.28 | Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats. ( Appenroth, D; Bräunlich, H; Friese, KH; Gambaryan, S, 1990) |
| " In rats of all age-groups, the glomerularly filtered PAH proportion increases with increasing dosage (kinetics in decreasing blood level)." | 1.27 | [Dose- and age-dependence of the renal tubular transport of p-aminohippuric acid (PAH) in rats after injection of single doses]. ( Bajanowski, T; Bräunlich, H; Fleck, C; Miosge, W, 1983) |
| "Renal ischemia was induced in female Fischer-344 rats, 3-4 or 37-38 months old, by renal arterial and venous occlusion followed by 0, 1, 24, or 96 hr of reflow." | 1.27 | Age-related differences in susceptibility to renal ischemia in rats. ( Goldstein, RS; Hewitt, WR; Hook, JB; Miura, K; Morgan, DG; Pasino, DA, 1987) |
| "Gentamicin was administered subcutaneously to sexually immature (1400 to 1800 gm) or sexually mature (3800 to 4600 gm) New Zealand White rabbits in a dose of 15 mg/kg twice a day." | 1.27 | Effect of gentamicin on isolated glomeruli and proximal tubules of the rabbit. ( Chonko, A; Cuppage, F; Hodges, G; Karniski, L; Savin, V, 1985) |
| "Cortisone treatment thus accelerates development of adult permeability characteristics in the pulmonary epithelium." | 1.26 | Effect of cortisone on permeability of the neonatal rat lung to drugs. ( Hemberger, JA; Schanker, LS, 1981) |
| " Single administration of potassium dichromate or glycerol is followed by a marked decrease of renal PAH excretion in dependence on the time after the administration as well as on the dosage used." | 1.26 | Stimulation of kidney function in rats of different ages injured by nephrotoxic agents. ( Bräunlich, H; Fleck, C; Stopp, M; Weise, C, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (70.18) | 18.7374 |
| 1990's | 12 (21.05) | 18.2507 |
| 2000's | 5 (8.77) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fleck, C | 8 |
| Sutter, L | 1 |
| Appenroth, D | 3 |
| Koch, B | 1 |
| Meinhold, T | 1 |
| Pitack, M | 1 |
| Gasser, R | 1 |
| UHLMANN, W | 2 |
| ADAMS, JR | 1 |
| BARROWS, CH | 1 |
| BERECH, J | 1 |
| CURTIS, HJ | 1 |
| BRANDT, IK | 1 |
| Stevanovic, RD | 1 |
| Price, DA | 1 |
| Lansang, MC | 1 |
| Fisher, ND | 1 |
| Laffel, LM | 1 |
| Hollenberg, NK | 2 |
| Berg, UB | 1 |
| Rolig, EC | 1 |
| Hook, JB | 9 |
| Bond, JT | 1 |
| Stopp, M | 5 |
| Bräunlich, H | 21 |
| Hably, C | 1 |
| Banki, K | 1 |
| Bartha, J | 2 |
| Otto, R | 1 |
| Bajanowski, T | 1 |
| Miosge, W | 1 |
| Lock, EA | 1 |
| Ishmael, J | 1 |
| Hemberger, JA | 1 |
| Schanker, LS | 1 |
| Weise, C | 2 |
| Yü, TF | 1 |
| Berger, L | 1 |
| Schmidt, M | 1 |
| Fukagawa, NK | 1 |
| Bandini, LG | 1 |
| Lee, MA | 1 |
| Young, JB | 1 |
| Sambasiva, R | 1 |
| Arvind, A | 1 |
| Böhler, J | 1 |
| Glöer, D | 1 |
| Reetze-Bonorden, P | 1 |
| Keller, E | 1 |
| Schollmeyer, PJ | 1 |
| Holdstock, NB | 1 |
| Ousey, JC | 1 |
| Rossdale, PD | 1 |
| Nakajima, N | 1 |
| Sekine, T | 1 |
| Cha, SH | 1 |
| Tojo, A | 1 |
| Hosoyamada, M | 1 |
| Kanai, Y | 1 |
| Yan, K | 1 |
| Awa, S | 1 |
| Endou, H | 1 |
| Savant, IA | 1 |
| Kalis, M | 1 |
| Almoazen, H | 1 |
| Ortiz, SR | 1 |
| AbuTarif, M | 1 |
| Taft, DR | 1 |
| Schernthaner, G | 1 |
| Erd, W | 1 |
| Ludwig, H | 1 |
| Sinzinger, H | 1 |
| Höfer, R | 1 |
| Hewitt, WR | 4 |
| Wagner, PA | 1 |
| Bostwick, EF | 1 |
| Bailie, MD | 1 |
| Davis, DR | 1 |
| Yeary, RA | 1 |
| Noordewier, B | 1 |
| Withrow, CD | 1 |
| Kluwe, WM | 1 |
| McCormack, KM | 1 |
| Hartwich, R | 2 |
| Pegg, DG | 1 |
| Rassbach, H | 1 |
| Vogelsang, S | 1 |
| Pils, W | 1 |
| el Zein, M | 1 |
| Areas, JL | 1 |
| Knapka, J | 1 |
| DiPette, D | 1 |
| Holland, B | 1 |
| al-Karadaghi, P | 1 |
| Preuss, HG | 1 |
| Gambaryan, S | 1 |
| Friese, KH | 1 |
| Galinsky, RE | 1 |
| Eshima, D | 1 |
| Hansen, L | 1 |
| Greene, J | 1 |
| Dillehay, D | 1 |
| Taylor, A | 1 |
| Tarloff, JB | 1 |
| Goldstein, RS | 2 |
| Silver, AC | 1 |
| Dluhy, RG | 1 |
| Hopkins, P | 1 |
| Williams, GH | 1 |
| Williams, RR | 1 |
| Pfeifer, R | 1 |
| Grau, P | 1 |
| Reznik, L | 1 |
| Meléndez, E | 1 |
| Reyes, JL | 1 |
| Escalante, BA | 1 |
| Meléndez, MA | 1 |
| London, GM | 1 |
| Safar, ME | 1 |
| Wabner, CL | 1 |
| Chen, TS | 1 |
| Corman, B | 1 |
| Michel, JB | 1 |
| Günther, KH | 1 |
| Köhler, A | 1 |
| Schmidt, I | 1 |
| Miura, K | 1 |
| Morgan, DG | 1 |
| Pasino, DA | 1 |
| Savin, V | 1 |
| Karniski, L | 1 |
| Cuppage, F | 1 |
| Hodges, G | 1 |
| Chonko, A | 1 |
| Herceg, R | 1 |
| Wüstenberg, PW | 1 |
| Widmeyer, M | 1 |
| Sponholz, F | 1 |
| Schumann, L | 1 |
| Schröder, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of RAS Inhibitors on Albuminuria, Hyperfiltration and Endothelial Dysfunction in a Sickle Cell Disease Population.[NCT01195818] | 53 participants (Actual) | Interventional | 2010-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for p-aminohippuric acid and Aging
| Article | Year |
|---|---|
Renal handling of drugs and amino acids after impairment of kidney or liver function--influences of maturity and protective treatment.
Topics: Absorption; Aging; Amino Acids; Animals; Biological Transport, Active; Cell Membrane; Chemical and D | 1995 |
Perinatal renal pharmacology.
Topics: Aging; Angiotensin II; Anions; Biological Transport, Active; Diuretics; Hemodynamics; Humans; Infant | 1979 |
1 trial available for p-aminohippuric acid and Aging
| Article | Year |
|---|---|
Renin release in response to Renin system blockade: activation of the Renin system in type 1 diabetes mellitus.
Topics: Adult; Aged; Aging; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Ca | 2005 |
54 other studies available for p-aminohippuric acid and Aging
| Article | Year |
|---|---|
Use of gene chip technology for the characterisation of the regulation of renal transport processes and of nephrotoxicity in rats.
Topics: Aging; Animals; Biological Transport; Dexamethasone; Disease Models, Animal; Female; Gene Expression | 2003 |
[A biological test of aging based on a total clearance method with para-aminohippuric acid (PAH)].
Topics: Aging; Kidney Function Tests; Kinetics; p-Aminohippuric Acid | 1956 |
[A biological test of aging based on a total clearance method with para-aminohippuric acid (PAH)].
Topics: Aging; Kidney Function Tests; Kinetics; p-Aminohippuric Acid | 1956 |
[A biological test of aging based on a total clearance method with para-aminohippuric acid (PAH)].
Topics: Aging; Kidney Function Tests; Kinetics; p-Aminohippuric Acid | 1956 |
[A biological test of aging based on a total clearance method with para-aminohippuric acid (PAH)].
Topics: Aging; Kidney Function Tests; Kinetics; p-Aminohippuric Acid | 1956 |
Effect of age on PAH accumulation by kidney slices of female rats.
Topics: Aging; Animals; Female; Kidney; p-Aminohippuric Acid; Rats | 1963 |
THE ROLE OF AGE AND X-IRRADIATION ON KIDNEY FUNCTION IN THE MOUSE.
Topics: Aging; Animals; Hyperplasia; Hypertrophy; Kidney; Kidney Diseases; Kidney Function Tests; Mice; Neph | 1964 |
THE DEVELOPMENT OF THE HIPPURIC ACID-SYNTHESIZING SYSTEM IN THE RAT.
Topics: 4-Aminobenzoic Acid; Adrenalectomy; Aging; Animals; Animals, Newborn; Female; Fetus; Glycine; Hippur | 1964 |
Differences in decline in GFR with age between males and females. Reference data on clearances of inulin and PAH in potential kidney donors.
Topics: Adult; Aged; Aging; Blood Pressure; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; I | 2006 |
In vitro renal transport functions of the progeny of rats with streptozotocin-induced diabetes.
Topics: Aging; Aminoisobutyric Acids; Animals; Biological Transport; Diabetes Mellitus, Experimental; Female | 1982 |
p-Aminohippurate (PAH) transport and Na-K-ATPase activity in rat renal cortical slices during postnatal maturation and drug-induced stimulation.
Topics: Aging; Aminohippuric Acids; Animals; Biological Transport; Cyclopenthiazide; Diuretics; Female; Kidn | 1983 |
Effects of indomethacin and naproxen on renal p-amino-hippurate (PAH) excretion in rats during postnatal development.
Topics: Aging; Aminohippuric Acids; Animals; Diuresis; Female; Glomerular Filtration Rate; Hematocrit; Indom | 1984 |
Stimulation of renal excretion of p-aminohippurate (PAH) after unilateral nephrectomy in adult and ageing rats.
Topics: Aging; Aminohippuric Acids; Animals; Cyclopenthiazide; Female; Kidney; Nephrectomy; p-Aminohippuric | 1981 |
Age differences in cisplatinum nephrotoxicity.
Topics: Aging; Animals; Body Weight; Cisplatin; Female; Injections, Intraperitoneal; Kidney; Lethal Dose 50; | 1984 |
Age-related differences in nephrotoxicity of cadmium.
Topics: Aging; Animals; Animals, Newborn; Cadmium; Dose-Response Relationship, Drug; Kidney; p-Aminohippuric | 1984 |
[Dose- and age-dependence of the renal tubular transport of p-aminohippuric acid (PAH) in rats after injection of single doses].
Topics: Aging; Aminohippuric Acids; Animals; Biological Transport; Dose-Response Relationship, Drug; Injecti | 1983 |
Nephrotoxicity of hexachloro-1,3-butadiene in the mouse: the effect of age, sex, strain, monooxygenase modifiers, and the role of glutathione.
Topics: Acetylcysteine; Acute Kidney Injury; Aging; Animals; Butadienes; Female; Glutathione; Kidney Tubular | 1984 |
Effect of cortisone on permeability of the neonatal rat lung to drugs.
Topics: Aging; Aminohippuric Acids; Animals; Animals, Newborn; Cell Membrane Permeability; Cortisone; Female | 1981 |
Stimulation of kidney function in rats injured by nephrotoxic agents.
Topics: Aging; Animals; Cyclopenthiazide; Glycerol; Kidney; Kidney Diseases; p-Aminohippuric Acid; Potassium | 1980 |
Impaired renal function gout: its association with hypertensive vascular disease and intrinsic renal disease.
Topics: Adolescent; Adult; Aged; Aging; Coronary Disease; Gout; Humans; Hypertension; Inulin; Kidney; Kidney | 1982 |
Renal pharmacokinetics of furosemide in young and adult rats.
Topics: Aging; Animals; Furosemide; Kidney; Kidney Cortex; Kinetics; Male; p-Aminohippuric Acid; Rabbits; Ra | 1980 |
Effects of calcitriol on expression of triiodothyronine-stimulated renal tubular transport of p-aminohippurate in rats of different ages.
Topics: Aging; Animals; Biological Transport; Body Weight; Calcitriol; Culture Techniques; Drug Synergism; F | 1994 |
Effect of age on dopaminergic responses to protein feeding.
Topics: Adult; Aged; Aging; Amines; Amino Acids; Blood Pressure; Body Weight; Carbidopa; Creatinine; Diet, S | 1995 |
Effects of quinidine on renal biochemistry and function in young and old rats.
Topics: Aging; Animals; Blood Urea Nitrogen; Creatinine; In Vitro Techniques; Kidney Cortex; Male; Mitochond | 1994 |
Renal functional reserve in elderly patients.
Topics: Aged; Aged, 80 and over; Aging; Amino Acids; Female; Glomerular Filtration Rate; Glucose; Humans; In | 1993 |
Glomerular filtration rate, effective renal plasma flow, blood pressure and pulse rate in the equine neonate during the first 10 days post partum.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Blood Pressure; Breeding; Female; Glomerular | 1998 |
Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney.
Topics: Aging; Animals; Animals, Newborn; Anion Transport Proteins; Blotting, Northern; Blotting, Western; C | 2000 |
Alternative high-performance liquid chromatographic assay for p-aminohippuric acid (PAH): effect of aging on PAH excretion in the isolated perfused rat kidney.
Topics: Aging; Animals; Calibration; Chromatography, High Pressure Liquid; In Vitro Techniques; Kidney; Kidn | 2001 |
[Study of age and sex dependance in renal clearances with radioisotopes (author's transl)].
Topics: Adolescent; Adult; Aged; Aging; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Middle Age | 1976 |
Transport ontogeny and selective substrate stimulation as models for identification of multiple renal organic anion transport systems.
Topics: 4-Aminobenzoic Acid; Aging; Animals; Animals, Newborn; Anions; Aspirin; Biological Transport, Active | 1977 |
Decreased conjugation of p-aminobenzoic acid in the icteric newborn Gunn rat.
Topics: 4-Aminobenzoic Acid; Aging; Aminobenzoates; Animals; Animals, Newborn; Female; Genotype; Glucuronosy | 1977 |
Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat.
Topics: Aging; Aminohippuric Acids; Animals; Biological Transport; Glomerular Filtration Rate; Inulin; Kidne | 1979 |
Stimulation of kidney function in rats of different ages injured by nephrotoxic agents.
Topics: Aging; Aminohippuric Acids; Animals; Chromates; Cyclopenthiazide; Diuretics; Female; Glycerol; Kidne | 1979 |
Chemical induction of p-aminohippuric acid transport in renal cortical slices from adult and immature rabbits.
Topics: Aging; Aminohippuric Acids; Animals; Biological Transport, Active; Female; In Vitro Techniques; Kidn | 1978 |
Enhancement of p-aminohippurate accumulation in renal cortical slices after repeated administrations of various organic anionic drugs to rats of different ages.
Topics: Aging; Aminohippuric Acids; Animals; Animals, Newborn; Cycloheximide; Cyclopenthiazide; Female; Kidn | 1978 |
Alteration of renal cortical palmitate utilization and p-aminohippurate (PAH) accumulation after penicillin treatment of neonatal rabbits.
Topics: Aging; Aminohippuric Acids; Animals; Animals, Newborn; Esterification; Fatty Acids, Nonesterified; I | 1978 |
Glutathione S-transferases: an evaluation of their role in renal organic anion transport.
Topics: Aging; Ammonium Chloride; Animals; Animals, Newborn; Anions; Biological Transport; Female; Glutathio | 1977 |
Kinetics of p-aminohippurate transport in renal cortical slices from neonatal and adult rats.
Topics: Aging; Aminohippuric Acids; Animals; Animals, Newborn; Biological Transport, Active; Female; In Vitr | 1977 |
Stimulation of renal tubular transport of p-aminohippurate in rats of different ages by treatment with adrenocortical steroids.
Topics: Adrenal Cortex Hormones; Aging; Animals; Dexamethasone; Female; In Vitro Techniques; Kidney Cortex; | 1992 |
Synergistic effect of triiodothyronine and dexamethasone on renal tubular transport of p-aminohippurate in rats of different ages.
Topics: Aging; Animals; Body Weight; Dexamethasone; Diuresis; Drug Synergism; Female; In Vitro Techniques; K | 1992 |
Development of sugar-induced blood pressure elevation after uninephrectomy in a resistant rat strain.
Topics: Aging; Animals; Body Weight; Carbohydrates; Catecholamines; Dietary Carbohydrates; Hypertension; Nep | 1991 |
Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats.
Topics: Aging; Animals; Chromates; Chromium; Cromolyn Sodium; Female; Kidney; Kidney Diseases; Kidney Tubule | 1990 |
Effect of advanced age on p-aminohippurate-induced inhibition of renal tubular secretion in male Fischer 344 rats.
Topics: Aging; Animals; Glomerular Filtration Rate; Iodohippuric Acid; Kidney; Kidney Tubules; Male; Oligope | 1990 |
Intrinsic susceptibility of the kidney to acetaminophen toxicity in middle-aged rats.
Topics: Acetaminophen; Aging; Animals; Glutathione; Kidney; Kidney Diseases; Male; p-Aminohippuric Acid; Rat | 1990 |
Heritable abnormalities of the renin-angiotensin-aldosterone system in essential hypertension.
Topics: Adult; Aging; Blood Pressure; Female; Humans; Hypertension; Lithium; Male; Middle Aged; p-Aminohippu | 1988 |
Renal effects of vanadate in rats of different ages.
Topics: Aging; Animals; Diuresis; Dose-Response Relationship, Drug; Female; Kidney; p-Aminohippuric Acid; Ra | 1989 |
Development of the receptors to prostaglandin E2 in the rat kidney and neonatal renal functions.
Topics: Acetaminophen; Aging; Animals; Dinoprostone; Female; In Vitro Techniques; Indomethacin; Kidney; p-Am | 1989 |
Renal hemodynamics in patients with sustained essential hypertension and in patients with unilateral stenosis of the renal artery.
Topics: Adult; Aging; Blood Pressure; Blood Volume; Female; Hemodynamics; Humans; Hypertension, Renovascular | 1989 |
Aging changes in renal handling of p-aminohippurate.
Topics: Aging; Aminohippuric Acids; Animals; Body Weight; Cerebral Cortex; Kidney; Kinetics; Male; Mice; Mic | 1987 |
Glomerular filtration, renal blood flow, and solute excretion in conscious aging rats.
Topics: Aging; Animals; Calcium; Female; Glomerular Filtration Rate; Hemodynamics; Inulin; Kidney; Metabolic | 1987 |
Relation between renal and hepatic excretion of drugs. VI. Influence of pretreatment with phenol red on renal excretion and accumulation capacity of kidney or liver slices of immature and adult rats.
Topics: Aging; Animals; Female; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Liver; Male; Oxygen; p-A | 1987 |
Relation between renal and hepatic excretion of drugs. II. Age-dependence of phenol red excretion in comparison with those of p-aminohippurate and indocyanine green.
Topics: Aging; Animals; Bile; Bile Ducts; Female; Indocyanine Green; Kidney; Kinetics; Ligation; Liver; Neph | 1986 |
Acceleration of p-aminohippurate excretion in immature rats by dexamethasone treatment.
Topics: Aging; Aminohippuric Acids; Animals; Dexamethasone; Female; Glomerular Filtration Rate; In Vitro Tec | 1986 |
Age-related differences in susceptibility to renal ischemia in rats.
Topics: Aging; Animals; Blood Urea Nitrogen; Body Water; Creatinine; Disease Susceptibility; Female; Hypoxia | 1987 |
Effect of gentamicin on isolated glomeruli and proximal tubules of the rabbit.
Topics: Aging; Animals; Creatinine; Female; Gentamicins; Glomerular Filtration Rate; Kidney Cortex; Kidney G | 1985 |
Influence of an inhibition of thromboxane synthetase by imidazole on kidney function in rats during postnatal development.
Topics: Aging; Animals; Female; Imidazoles; Kidney; Male; Naproxen; Oxidoreductases; p-Aminohippuric Acid; R | 1985 |
[Renal and nephronal function diagnosis in the aged experimental rat].
Topics: Aging; Animals; Female; Glomerular Filtration Rate; Inulin; Kidney Concentrating Ability; Kidney Fun | 1985 |