ozagrel and Respiratory-Distress-Syndrome
ozagrel has been researched along with Respiratory-Distress-Syndrome* in 5 studies
Other Studies
5 other study(ies) available for ozagrel and Respiratory-Distress-Syndrome
Article | Year |
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Regulation of blood flow in pulmonary microcirculation by vasoactive arachidonic acid metabolites--analysis in acute lung injury.
Topics: Animals; Arachidonic Acids; Disease Models, Animal; Dogs; Embolism, Fat; Epoprostenol; Female; Hypoxia; Indomethacin; Lung; Lung Injury; Male; Methacrylates; Microcirculation; Oleic Acid; Oleic Acids; Pulmonary Circulation; Pulmonary Embolism; Respiratory Distress Syndrome; Thromboxane A2; Vasoconstriction; Vasodilation | 1994 |
[Effects of ibuprofen and OKY-046 on ventilation perfusion distribution in acute respiratory failure].
Hydrochloric acid was injected into the trachea to produce acute respiratory failure in 18 anesthetized dogs. Six dogs were pretreated with ibuprofen (12.5 mg/kg), six dogs were given OKY-046 (0.5 mg/kg), and the remaining six were taken as controls. Distribution of ventilation-perfusion was evaluated by inert gas elimination technique. Acid aspiration caused a prompt decline in PaO2 with an increased perfusion to shunt and low VA/Q lung regions. Pretreatment with ibuprofen reduced pulmonary blood flow to shunt and low VA/Q regions for the first 2 hours after acid aspiration and attenuated hypoxemia, causing an increase in PVR. However, OKY-046, a thromboxane synthetase inhibitor, did not ameliorate acid-induced VA/Q mismatching and hypoxemia. Topics: Animals; Dogs; Hydrochloric Acid; Ibuprofen; Methacrylates; Plethysmography, Impedance; Pulmonary Circulation; Respiratory Distress Syndrome; Thromboxane-A Synthase; Ventilation-Perfusion Ratio | 1991 |
Role of arachidonic acid metabolites in the pathogenesis of acute lung injury.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Diethylcarbamazine; Disease Models, Animal; Dogs; Ethchlorvynol; Indomethacin; Leukotrienes; Lung; Male; Methacrylates; Neutrophils; Pulmonary Edema; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate; Thromboxanes | 1991 |
Attenuation of permeability lung injury after phorbol myristate acetate by verapamil and OKY-046.
Phorbol myristate acetate (PMA), which produces an experimental model of acute lung injury similar to the adult respiratory distress syndrome, was studied in isolated dog lung lobes perfused at constant pressure in Zone 3 conditions. The effect of 25 to 50 micrograms PMA on pulmonary vascular permeability and resistance was observed in 4 groups of lungs: Group 1, perfused with a plasma/dextran solution; Group 2, perfused with blood; Group 3, blood-perfused and pretreated with verapamil (a calcium channel blocker); and Group 4, blood-perfused and pretreated with OKY-046 (a thromboxane synthetase inhibitor). Permeability changes were assessed by determining capillary filtration coefficient (Kf), isogravimetric capillary pressure (Pci), and in blood-perfused lungs, the protein reflection coefficient (sigma d). An increase in Kf, a decrease in Pci, and a decrease in sigma d, all indicative of an increase in vascular permeability, occurred 1 h after PMA in blood-perfused but not in plasma/dextran-perfused lungs. An increase in pulmonary vascular resistance occurred in both blood- and plasma/dextran-perfused lungs. Verapamil (2 X 10(-5) M) and OKY-046 (7 X 10(-4) M) pretreatment in blood-perfused lungs essentially blocked the PMA-induced change in permeability and significantly attenuated the increased vascular resistance. Total leukocyte and platelet counts fell in all blood-perfused lungs, whether pretreated or not. We conclude that cellular components of blood (platelets and/or leukocytes) are required to produce the permeability injury but not the pulmonary vasoconstriction and that the injury can be attenuated by either a calcium channel blocker or a specific thromboxane synthetase inhibitor. The left ventricular volume change caused by increasing right ventricular volume was measured at normal and elevated pericardial pressures. Topics: Acrylates; Animals; Capillary Permeability; Dogs; Leukocyte Count; Lung; Methacrylates; Perfusion; Phorbols; Platelet Count; Pulmonary Edema; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate; Thromboxane-A Synthase; Time Factors; Vascular Resistance; Verapamil | 1986 |
[Serial changes in plasma thromboxane and complement in ARDS--effect of the thromboxane synthetase inhibitor].
Topics: Acrylates; Adult; Aged; Complement C3; Complement C4; Female; Humans; Methacrylates; Respiratory Distress Syndrome; Thromboxane B2; Thromboxane-A Synthase | 1985 |