ozagrel and Acute-Lung-Injury

ozagrel has been researched along with Acute-Lung-Injury* in 1 studies

Other Studies

1 other study(ies) available for ozagrel and Acute-Lung-Injury

Article	Year
A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs. Journal of pharmacological sciences, 2009, Volume: 111, Issue:2 This study examined the effect of ozagrel, a thromboxane A(2) synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA). OA injection into guinea pigs rapidly increased thromboxane A(2) generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in the whole lung. Administration of ozagrel prevented these changes associated with OA injection. Ozagrel is a promising drug candidate for preventing acute lung injury. Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Chemokine CCL2; Eosine Yellowish-(YS); Guinea Pigs; Interleukin-8; Leukocyte Count; Macrophages; Male; Methacrylates; Methylene Blue; Neutrophils; Oleic Acid; Proteins; RNA, Messenger; Staining and Labeling; Thromboxane A2; Time Factors	2009

Article

Year

A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs.

Journal of pharmacological sciences, 2009, Volume: 111, Issue:2

This study examined the effect of ozagrel, a thromboxane A(2) synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA). OA injection into guinea pigs rapidly increased thromboxane A(2) generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in the whole lung. Administration of ozagrel prevented these changes associated with OA injection. Ozagrel is a promising drug candidate for preventing acute lung injury.

Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Chemokine CCL2; Eosine Yellowish-(YS); Guinea Pigs; Interleukin-8; Leukocyte Count; Macrophages; Male; Methacrylates; Methylene Blue; Neutrophils; Oleic Acid; Proteins; RNA, Messenger; Staining and Labeling; Thromboxane A2; Time Factors

2009