oz-439 and Parasitemia

oz-439 has been researched along with Parasitemia* in 3 studies

Trials

1 trial(s) available for oz-439 and Parasitemia

Article	Year
A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum in Healthy Volunteers. Antimicrobial agents and chemotherapy, 2019, 12-20, Volume: 64, Issue:1 Topics: Adamantane; Administration, Oral; Adult; Antimalarials; Drug Combinations; Female; Healthy Volunteers; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Peroxides; Plasmodium falciparum; Pyrimidines; Triazoles; Young Adult	2019

Article

Year

A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum in Healthy Volunteers.

Antimicrobial agents and chemotherapy, 2019, 12-20, Volume: 64, Issue:1

Topics: Adamantane; Administration, Oral; Adult; Antimalarials; Drug Combinations; Female; Healthy Volunteers; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Peroxides; Plasmodium falciparum; Pyrimidines; Triazoles; Young Adult

2019

Other Studies

2 other study(ies) available for oz-439 and Parasitemia

Article	Year
Liver Enzyme Elevations in The American journal of tropical medicine and hygiene, 2020, Volume: 103, Issue:1 Topics: Acrylamides; Adamantane; Adult; Alanine Transaminase; Aminopyridines; Aminoquinolines; Antimalarials; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Erythrocyte Transfusion; Erythrocytes; Female; Ferrous Compounds; Healthy Volunteers; Heterocyclic Compounds, 4 or More Rings; Humans; Indoles; Isoquinolines; Malaria, Falciparum; Male; Metallocenes; Parasitemia; Peroxides; Piperazines; Plasmodium falciparum; Primaquine; Pyrimidines; Quinolines; Spiro Compounds; Sulfones; Triazoles; Young Adult	2020
Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity. Immunity, 2016, 08-16, Volume: 45, Issue:2 Many pathogens, including Plasmodium spp., exploit the interaction of programmed death-1 (PD-1) with PD-1-ligand-1 (PD-L1) to "deactivate" T cell functions, but the role of PD-L2 remains unclear. We studied malarial infections to understand the contribution of PD-L2 to immunity. Here we have shown that higher PD-L2 expression on blood dendritic cells, from Plasmodium falciparum-infected individuals, correlated with lower parasitemia. Mechanistic studies in mice showed that PD-L2 was indispensable for establishing effective CD4(+) T cell immunity against malaria, because it not only inhibited PD-L1 to PD-1 activity but also increased CD3 and inducible co-stimulator (ICOS) expression on T cells. Importantly, administration of soluble multimeric PD-L2 to mice with lethal malaria was sufficient to dramatically improve immunity and survival. These studies show immuno-regulation by PD-L2, which has the potential to be translated into an effective treatment for malaria and other diseases where T cell immunity is ineffective or short-lived due to PD-1-mediated signaling. Topics: Adamantane; Adult; Animals; Antimalarials; B7-H1 Antigen; CD4-Positive T-Lymphocytes; Cells, Cultured; Clinical Trials as Topic; Dendritic Cells; Female; Humans; Immunity, Cellular; Lymphocyte Activation; Malaria, Falciparum; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Parasitemia; Peroxides; Plasmodium falciparum; Programmed Cell Death 1 Ligand 2 Protein; Programmed Cell Death 1 Receptor; Pyrimidines; Triazoles; Young Adult	2016

Article

Year

Liver Enzyme Elevations in

The American journal of tropical medicine and hygiene, 2020, Volume: 103, Issue:1

Topics: Acrylamides; Adamantane; Adult; Alanine Transaminase; Aminopyridines; Aminoquinolines; Antimalarials; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Erythrocyte Transfusion; Erythrocytes; Female; Ferrous Compounds; Healthy Volunteers; Heterocyclic Compounds, 4 or More Rings; Humans; Indoles; Isoquinolines; Malaria, Falciparum; Male; Metallocenes; Parasitemia; Peroxides; Piperazines; Plasmodium falciparum; Primaquine; Pyrimidines; Quinolines; Spiro Compounds; Sulfones; Triazoles; Young Adult

2020

Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity.

Immunity, 2016, 08-16, Volume: 45, Issue:2

Many pathogens, including Plasmodium spp., exploit the interaction of programmed death-1 (PD-1) with PD-1-ligand-1 (PD-L1) to "deactivate" T cell functions, but the role of PD-L2 remains unclear. We studied malarial infections to understand the contribution of PD-L2 to immunity. Here we have shown that higher PD-L2 expression on blood dendritic cells, from Plasmodium falciparum-infected individuals, correlated with lower parasitemia. Mechanistic studies in mice showed that PD-L2 was indispensable for establishing effective CD4(+) T cell immunity against malaria, because it not only inhibited PD-L1 to PD-1 activity but also increased CD3 and inducible co-stimulator (ICOS) expression on T cells. Importantly, administration of soluble multimeric PD-L2 to mice with lethal malaria was sufficient to dramatically improve immunity and survival. These studies show immuno-regulation by PD-L2, which has the potential to be translated into an effective treatment for malaria and other diseases where T cell immunity is ineffective or short-lived due to PD-1-mediated signaling.

Topics: Adamantane; Adult; Animals; Antimalarials; B7-H1 Antigen; CD4-Positive T-Lymphocytes; Cells, Cultured; Clinical Trials as Topic; Dendritic Cells; Female; Humans; Immunity, Cellular; Lymphocyte Activation; Malaria, Falciparum; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Parasitemia; Peroxides; Plasmodium falciparum; Programmed Cell Death 1 Ligand 2 Protein; Programmed Cell Death 1 Receptor; Pyrimidines; Triazoles; Young Adult

2016