oxytocin and Stroke

Topics: Anorexia; Arousal; Brain Mapping; Circadian Rhythm; Corticotropin-Releasing Hormone; Depression; Glucocorticoids; Humans; Hydrocortisone; Hypothalamic Hormones; Hypothalamo-Hypophyseal System; Hypothalamus; Magnetic Resonance Imaging; Models, Neurological; Models, Psychological; Mood Disorders; Neuropsychological Tests; Neurotransmitter Agents; Oxytocin; Paraventricular Hypothalamic Nucleus; Phototherapy; Pituitary-Adrenal System; Prefrontal Cortex; Receptors, Glucocorticoid; Receptors, Neurotransmitter; Sleep Initiation and Maintenance Disorders; Stress, Physiological; Stroke; Thyroid Gland; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Vasopressins

Various molecular mechanisms are activated in neurons during ischemic stroke. Extracellular glutamate secretion into brain tissue causes neurotoxicity and brain damage. Excitatory amino acid transporter 3 (EAAT3) could remove the extracellular glutamate. Neuroprotective activity of oxytocin (OT) in ischemia of various tissues has been reported. This study investigates the neuroprotective effect of OT in an animal model of middle cerebral artery occlusion (MCAO) and the possible role of EAAT3. Transient MCAO was performed as a model of ischemic stroke in male rats and then OT was administrated intra-nasally. Infarct volume was measured by 2, 3, 5-triphenyl tetrazolium chloride staining. Nissl staining method was performed for the evaluation of neuronal cell morphology. Immunohistochemistry assay was performed to analyze the EAAT3 expression in the ischemic region. OT significantly reduced the infarct volume in the cerebral cortex and striatum after ischemia (

Topics: Animals; Brain Ischemia; Disease Models, Animal; Excitatory Amino Acid Transporter 3; Glutamates; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Oxytocin; Rats; Stroke

Pregnancy is a risk factor for stroke in young women, but the effect of delivery on recovery and rehabilitation after stroke has not been elucidated in pregnant patients with stroke. This case report presents a pregnant patient with stroke who recovered successfully after cesarean delivery during rehabilitation. The possible effect of oxytocin is discussed as a factor promoting recovery from stroke. LEVEL OF EVIDENCE: V.

Topics: Adult; Cesarean Section; Female; Humans; Moyamoya Disease; Oxytocics; Oxytocin; Postnatal Care; Pregnancy; Pregnancy Complications; Stroke

Topics: Agnosia; Female; Hemiplegia; Humans; Oxytocin; Stroke

To evaluate whether uterotrophic agents increase the risk of fatal hemorrhagic brain stroke.. Between 1991 and 1992, there were 230 maternal deaths among 2,420,000 pregnant women in Japan and the causes of these deaths was investigated in 1994. Using information provided in this report, we identified 35 women who died from or were assumed to die from hemorrhagic brain stroke. We assumed that 93% of women would have tried vaginal delivery. The risk of fatal hemorrhagic brain stroke after uterotrophic agent use was calculated according to the assumption that 5.0-40% of women received uterotrophic agents.. Use of uterotrophic agents for induction/augmentation of labor was confirmed in five (14.3%) of the 35 women who died from hemorrhagic brain stroke. The incidence of fatal brain stroke after the use of uterotrophic agents was only significantly higher than that for spontaneous hemorrhagic brain stroke if these agents were administered in ≤ 6.0% of women.. Because more than 6.0% of women received uterotrophic agents, these agents are unlikely to increase the risk of fatal hemorrhagic brain stroke.

Topics: Cerebral Hemorrhage; Dinoprost; Dinoprostone; Female; Humans; Japan; Oxytocics; Oxytocin; Pregnancy; Risk Assessment; Stroke

Pre-eclampsia is a serious obstetric complication associated with a high rate of maternal and fetal morbidity and mortality. We report the case of a woman with a medical history of insulin-dependent diabetes mellitus and seizures possibly related to hypoglycemia who was admitted for an emergency cesarian due to severe pre-eclampsia and macrosomic fetus. In the first hour after delivery she experienced loss of consciousness and seizure, with vaginal bleeding and hypovolemic shock. Maximum vigilance is required for a patient with several concomitant diseases and a high-risk pregnancy. All prophylactic measures to lower the risk to mother and fetus should be undertaken. We analyze preanesthetic assessment, differential diagnosis, and choice of anesthesia in relation to this case.

Topics: Adult; Cesarean Section; Diabetes Mellitus, Type 1; Diagnosis, Differential; Embolism, Amniotic Fluid; Emergencies; Epilepsy; Female; Fetal Macrosomia; Humans; Hypoglycemia; Hysterectomy; Infant, Newborn; Oxytocin; Postoperative Complications; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy in Diabetics; Pregnancy, High-Risk; Puerperal Disorders; Shock; Stroke; Uterine Hemorrhage