oxytocin and Respiratory-Insufficiency

Previous studies have shown that, oxytocin has anticonvulsant and neuroprotective effects. One of the most important complications of Hypercapnic-hypoxia is drug resistance epilepsy. Effects of chronic intraperitoneal oxytocin treatment on gliosis, neuroinflammation and seizure activity was investigated in a model in which rats were exposed to hypoxia on postnatal day 1 and later challenged to the seizure-inducing pentylenetetrazol Forty pups were included in the study on their first day of birth. 16 pups were exposed to 100% CO

Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Brain; Disease Models, Animal; GABAergic Neurons; Gliosis; Hippocampus; Humans; Hypoxia; Inflammation; Neuroprotective Agents; Oxytocin; Rats; Respiratory Distress Syndrome, Newborn; Respiratory Insufficiency

A case of life-threatening respiratory distress during a Caesarean section under spinal anaesthesia is reported. Possible causes of the event including anaphylactoid reactions and the methods of their diagnosis are discussed. The most likely cause of the episode was felt to be an anaphylactoid reaction to Syntocinon.

Topics: Acute Disease; Adult; Anaphylaxis; Anesthesia, Obstetrical; Anesthesia, Spinal; Cesarean Section; Female; Humans; Intraoperative Complications; Oxytocin; Pregnancy; Respiratory Insufficiency

Cord serum sodium concentrations in two groups of vaginally delivered, singleton term infants were correlated with the incidence of transient neonatal tachypnoea. Hyponatraemia (cord serum sodium less than 130 mmol/l) was seen in 71 of 180 (39%) infants born to mothers who received an intravenous infusion of aqueous glucose solution during labour (study group) compared with 6 of 103 (6%) infants born to mothers who did not receive any intravenous fluid treatment (controls). The incidence of transient neonatal tachypnoea was 4.5 times higher for hyponatraemic infants in the study group (11 of 71) than for normonatraemic infants in the same group (3 of 109) and the control group (3 of 97). The difference was not attributable to other perinatal or neonatal characteristics. Our findings suggest an increased risk of transient neonatal tachypnoea in term infants who suffer from transplacental hyponatraemia after their mothers received intrapartum infusion of aqueous glucose solutions.

Topics: Adult; Female; Fetal Blood; Fluid Therapy; Glucose; Humans; Hyponatremia; Infant, Newborn; Maternal-Fetal Exchange; Obstetric Labor Complications; Oxytocin; Pharmaceutical Vehicles; Pregnancy; Respiratory Insufficiency; Risk; Sodium; Water-Electrolyte Imbalance

The clinical course is described of an infant who accidentally received an adult dose of Syntometrine (synthetic oxytocin + ergometrine) at delivery. The infant soon became ill with convulsions and ventilatory failure, and later with water intoxication. Similar reported cases are reviewed and recommendations are given for the management of future cases.

Topics: Accidents; Drug Combinations; Ergonovine; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Oxytocin; Respiratory Insufficiency; Seizures; Water Intoxication

Twenty-six women received intramuscular or intra-amniotic 15 (S) 15-methyl prostaglandin F2 alpha to induce midtrimester abortion. The median initial injection-abortion interval was 10 hours and 25 minutes. The advantages of intramuscular analogue are somnolence and reduced discomfort during labor. Disadvantages include severe gastrointestinal toxicity in the majority of patients and symptoms of acute respiratory distress in two patients.

Topics: Abortion, Induced; Diarrhea; Female; Humans; Injections, Intramuscular; Oxytocin; Pregnancy; Pregnancy Trimester, Second; Prostaglandins; Respiratory Insufficiency; Time Factors; Vomiting