oxytocin and Hemolysis

Using the organic template method, we have synthesized mesoporous SBA-15 particles and characterized them by scanning electron microscopy and transmission electron microscopy. The bone metabolism regulating hormone oxytocin (OT) was selected as a model for preparation of drug/SBA-15 complexes. The process of drug loading was studied using X-ray diffraction and nitrogen absorption methods. Optimal drug loading parameters were experimentally investigated. The kinetics of drug release from the carrier was evaluated. Finally, the extractions of SBA-15 particles were tested for cytotoxicity, in vitro hemolysis, and the direct attachment toxicity. Our findings suggest that SBA-15 materials have good biocompatibility. Moreover, we demonstrated that OT/SBA-15 complex can stimulate alkaline phosphatase activity in osteoblast cells. The study provides fundamental information for further in vivo drug-carrier testing.

Topics: Adsorption; Alkaline Phosphatase; Cell Adhesion; Cell Line, Tumor; Chemistry Techniques, Synthetic; Drug Carriers; Drug Liberation; Hemolysis; Humans; Nitrogen; Osteoblasts; Oxytocin; Porosity; Silicon Dioxide

Topics: Birth Weight; Female; Hemolysis; Humans; Infant, Newborn; Jaundice, Neonatal; Labor, Induced; Maternal-Fetal Exchange; Oxytocin; Pregnancy

Topics: Adenosine Triphosphatases; Cell Membrane; Enzyme Activation; Erythrocytes; Hemolysis; Humans; Magnesium; Oxytocin

Topics: Acetylcholine; Animals; Atropine; Calcium; Catecholamines; Cocaine; Dibucaine; Diethylstilbestrol; Epinephrine; Estrogens; Female; Glycerol; Hemolysis; Histamine; In Vitro Techniques; Lidocaine; Muscle Contraction; Norepinephrine; Oxytocin; Phenoxybenzamine; Procaine; Progesterone; Rabbits; Sensory Receptor Cells; Serotonin; Strontium; Tetracaine; Uterus