oxytocin and Glucosephosphate-Dehydrogenase-Deficiency

To determine factors associated with extreme hyperbilirubinaemia in neonates at the University Hospital of the West Indies.. A retrospective review of all neonates with hyperbilirubinaemia requiring medical intervention at the University Hospital of the West Indies between 1 January 2006 and 30 June 2007 was performed. Factors associated with extreme hyperbilirubinaemia were determined using multiple logistic regression models.. A total of 170 neonates fulfilled the inclusion criteria for the study and 15 (9%) of them had extreme hyperbilirubinaemia. The majority (97, 57%) were term infants and 103 (61%) were male. Exclusively breastfed neonates were more likely to have extreme hyperbilirubinaemia (OR 2.6, 95% CI 0.01-0.6). Neonates whose mothers received oxytocin during labour (OR 2.7, 95% CI 0.02-0.3) and those who were G6PD-deficient (OR 2.6, 95% CI 0.01-0.5) were more likely to have extreme hyperbilurubinaemia.. Exclusive breastfeeding, oxytocin use in the mother during labour and G6PD deficiency in the infant were found to be factors associated with extreme hyperbilirubinaemia.

Topics: Breast Feeding; Female; Glucosephosphate Dehydrogenase Deficiency; Hospitals, University; Humans; Hyperbilirubinemia; Infant, Newborn; Logistic Models; Male; Oxytocin; Retrospective Studies; Risk Factors; West Indies