oxytocin and Diabetic-Foot

oxytocin has been researched along with Diabetic-Foot* in 2 studies

Trials

2 trial(s) available for oxytocin and Diabetic-Foot

Article	Year
[Morphological characteristic of wound healing process in patients with diabetic purulent-necrotic foot lesion treated with oxytocin]. Morfologiia (Saint Petersburg, Russia), 2003, Volume: 124, Issue:5 Wound healing was studied in 90 patients with "diabetic foot" receiving complex treatment which included oxytocin (40 patients) or did not use it (50 patients). Intraarterial injection or local application of oxytocin resulted in significant differences of wound process characteristics as compared with those ones in control group. The necrobiotic and necrotic changes in the tissues of skin, subcutaneous adipose tissue and skeletal muscles, located within the purulent-necrotic foci, were less expressed. The number of sludged capillaries, as well as of arterioles and venules with the signs of microthrombosis, was significantly decreased. Simultaneously, the regenerative potential of endotheliocytes, fibroblasts and adventitial cells was increased, showing a significant stimulation of their DNA-synthesizing capacity. The histological findings obtained indicate that the introduction of oxytocin in complex treatment activates the processes of vasculogenesis, proliferation of endotheliocytes anf histiocytes, that, in turn, results in the effective clearance of the wound and optimal granulation tissue formation. Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amputation, Surgical; Combined Modality Therapy; Diabetic Foot; DNA; Female; Humans; Injections, Intra-Arterial; Male; Middle Aged; Necrosis; Oxytocin; Suppuration; Surgical Procedures, Operative; Wound Healing	2003
[The use of oxytocin in the combined treatment of suppurative-necrotic lesions of the feet in diabetic patients]. Vestnik khirurgii imeni I. I. Grekova, 2000, Volume: 159, Issue:3 The results of treatment of 90 patients with diabetes mellitus and pyo-necrotic lesions of the feet were compared. Oxytocin was used in 40 of the patients. It was found that parenteral administration of oxytocin resulted in more favorable course of diabetes mellitus in such patients. The intra-arterial or local use of Oxytocin was found to reliably increase the DNA synthesis by the endothelial cells, fibroblasts and histiocytes, which in its turn creates favorable conditions for the reparative process in the wounds and allows quality of the treatment to be considerably improved. Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Chronic Disease; Combined Modality Therapy; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Foot; DNA; Female; Foot; Humans; Male; Middle Aged; Necrosis; Oxytocin	2000

Article

Year

[Morphological characteristic of wound healing process in patients with diabetic purulent-necrotic foot lesion treated with oxytocin].

Morfologiia (Saint Petersburg, Russia), 2003, Volume: 124, Issue:5

Wound healing was studied in 90 patients with "diabetic foot" receiving complex treatment which included oxytocin (40 patients) or did not use it (50 patients). Intraarterial injection or local application of oxytocin resulted in significant differences of wound process characteristics as compared with those ones in control group. The necrobiotic and necrotic changes in the tissues of skin, subcutaneous adipose tissue and skeletal muscles, located within the purulent-necrotic foci, were less expressed. The number of sludged capillaries, as well as of arterioles and venules with the signs of microthrombosis, was significantly decreased. Simultaneously, the regenerative potential of endotheliocytes, fibroblasts and adventitial cells was increased, showing a significant stimulation of their DNA-synthesizing capacity. The histological findings obtained indicate that the introduction of oxytocin in complex treatment activates the processes of vasculogenesis, proliferation of endotheliocytes anf histiocytes, that, in turn, results in the effective clearance of the wound and optimal granulation tissue formation.

Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amputation, Surgical; Combined Modality Therapy; Diabetic Foot; DNA; Female; Humans; Injections, Intra-Arterial; Male; Middle Aged; Necrosis; Oxytocin; Suppuration; Surgical Procedures, Operative; Wound Healing

2003

[The use of oxytocin in the combined treatment of suppurative-necrotic lesions of the feet in diabetic patients].

Vestnik khirurgii imeni I. I. Grekova, 2000, Volume: 159, Issue:3

The results of treatment of 90 patients with diabetes mellitus and pyo-necrotic lesions of the feet were compared. Oxytocin was used in 40 of the patients. It was found that parenteral administration of oxytocin resulted in more favorable course of diabetes mellitus in such patients. The intra-arterial or local use of Oxytocin was found to reliably increase the DNA synthesis by the endothelial cells, fibroblasts and histiocytes, which in its turn creates favorable conditions for the reparative process in the wounds and allows quality of the treatment to be considerably improved.

Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Chronic Disease; Combined Modality Therapy; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Foot; DNA; Female; Foot; Humans; Male; Middle Aged; Necrosis; Oxytocin

2000