oxytocin and Cystitis--Interstitial

This article explicates a theory that oxytocin, a sexually dimorphic neurotransmitter and paracrine hormone, is a plausible mechanism linking early relational trauma with posttraumatic self disorders (e.g., dissociation, somatization, and interpersonal sensitivity), posttraumatic stress disorder, and pelvic visceral dysregulation disorders (e.g., irritable bowel syndrome, chronic pelvic pain, interstitial cystitis, and hyperemesis gravidarum). This posttraumatic oxytocin dysregulation disorders theory is consistent with the historical and contemporary literature. It integrates attention to psychological and physical comorbidities and could account for the increased incidence of these disorders among females. Specific propositions are explored in data from studies of traumatic stress and women's health.

Topics: Cystitis, Interstitial; Dissociative Disorders; Female; Humans; Hyperemesis Gravidarum; Interpersonal Relations; Irritable Bowel Syndrome; Models, Psychological; Models, Theoretical; Oxytocin; Pelvic Pain; Pregnancy; Pregnancy Complications; Psychophysiologic Disorders; Somatoform Disorders; Stress Disorders, Post-Traumatic