oxytocin and Cardiac-Output--Low

The aim of the present investigation was to study the structure of reactively modified rat myocardium (experimental heart failure model) during in vitro organotypical culture, including the direct effect of some hypothalamic nonapeptides (oxytocin) and monoamines (dopamine, noradrenalin). Light and electron microscopic methods were used. The major regularities of structural and functional reorganization of myocardium were determined. Multidirectional nature of ultrastructural changes of cardiomyocytes and of cardiac non-muscular cells was found to depend on direct effect of hypothalamic nonapeptides and monoamines upon myocardium. Adaptogenic role of oxytocin in provision of cardiac muscle protection and vitality is discussed.

Topics: Animals; Cardiac Output, Low; Culture Media; Disease Models, Animal; Dopamine; Male; Microscopy, Electron; Myocardium; Myocytes, Cardiac; Norepinephrine; Organ Culture Techniques; Oxytocin; Rats