oxytocin and Abscess

A 20-year-old woman with a history of pituitary resection complicated by diabetes insipidus was able to fully breastfeed for three months despite apparent hyposecretion of pituitary hormones. This case report adds to the growing body of evidence that control of milk production shifts from endocrine to autocrine control shortly after delivery. Autocrine control allows efficient regulation of milk supply to match the needs of the infant. A recently discovered factor in human milk that inhibits lactose and casein synthesis in vitro is believed to be responsible for local, short term control of milk production. This study suggests that practices which result in infrequent or incomplete removal of milk from the breast lead to decreased milk production and should be abandoned.

Topics: Abscess; Adult; Deamino Arginine Vasopressin; Diabetes Insipidus; Female; Humans; Infant, Newborn; Lactation; Oxytocin; Patient Education as Topic; Pituitary Diseases; Postoperative Complications; Pregnancy; Prolactin

Local use of oxytocin-antibacterial complexes in combination with treatment of diabetes including divided insulinotherapy in patients with postinjection abscesses and non-insulin-dependent diabetes led to compensation of diabetes and earlier sanation of suppurative focus compared with patients treated by local antibiotics only.

Topics: Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Chi-Square Distribution; Data Interpretation, Statistical; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hyperglycemia; Injections; Insulin; Middle Aged; Oxytocin

Topics: Abscess; Adolescent; Adult; Anti-Bacterial Agents; Female; Humans; Lactation; Mastitis; Oxytocin; Postoperative Care; Pregnancy; Suction; Therapeutic Irrigation

Topics: Abscess; Administration, Topical; Adolescent; Adult; Aged; Ampicillin; Drug Combinations; Female; Humans; Injections, Intradermal; Male; Methicillin; Middle Aged; Oxacillin; Oxytocin; Skin Diseases, Infectious; Staphylococcal Infections

The antimicrobial effect of oxytocin in combination with 39 antibacterial drugs was studied in vitro with the use of 30 strains of different test cultures. It was shown that oxytocin had a capacity for potentiating the antibiotic effect on many microbial species. The potentiation ratio depended on the antibiotic and microbial species used and ranged from 2 to 24 times. The combined therapy with oxytocin and antibiotics was tested on animals with experimental staphylococcal sepsis. The survival rate of more than 50 per cent was observed only in the group of animals treated with the combinations of antibiotics and oxytocin, while in the other groups the death rate amounted to 100 per cent. The most favourable combinations of oxytocin and antibiotics were used in the treatment of 260 patients with pyoinflammatory affections of the soft tissues (mastitis, postinfection suppuration, paraproctitis, etc). In the majority of cases, the surgical treatment was replaced by the paracentetic treatment with local application of the combinations of oxytocin and antibiotics. This markedly decreased (by 3-4 times) the periods of temporary disability, provided better cosmetic results of the treatment and lowered consumption of the dressing material.

Topics: Abscess; Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Cellulitis; Drug Synergism; Female; Humans; Mice; Oxytocin; Species Specificity; Staphylococcal Infections