oxytocin and Abnormalities--Drug-Induced

A matched control study was undertaken in which 156 children were examined between ages 23 and 62 months after births associated with spontaneous labor, oxytocin-induced labor, or prostaglandin E2 (PGE2)--induced labor. Physical development was not adversely affected by labor induction based on height and weight percentiles. The frequency of neurologic or developmental abnormalities not attributable to postdelivery events was the same overall in induced and spontaneous labors (19.2 per 1,000), but those abnormalities occurring after labor induction all followed use of oxytocin. None followed PGE2 despite case-selection criteria which specifically chose PGE2 cases from among those with documented adverse drug-related reactions.

Topics: Abnormalities, Drug-Induced; Adult; Birth Weight; Child Development; Child, Preschool; Congenital Abnormalities; Developmental Disabilities; Female; Follow-Up Studies; Growth; Humans; Infant; Infant, Newborn; Labor, Induced; Male; Nervous System Malformations; Oxytocin; Pregnancy; Prostaglandins E, Synthetic; Speech Disorders

Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Animals; Cyproterone; Estrogens; Female; Gestational Age; Labor, Obstetric; Mice; Oxytocin; Pregnadienes; Pregnancy; Pregnancy, Animal

Topics: Abnormalities, Drug-Induced; Asphyxia Neonatorum; Cesarean Section; Female; Fetal Death; Fetal Distress; Fetal Heart; Humans; Incidence; Infant, Newborn; Oxytocin; Pregnancy; Toxicology