oxytetracycline--anhydrous and Vomiting

Topics: Administration, Oral; Adult; Amines; Clinical Trials as Topic; Doxycycline; Follow-Up Studies; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Nausea; Neisseria gonorrhoeae; Oxytetracycline; Penicillins; Time Factors; Urethra; Urethritis; Vomiting

Topics: Acute Disease; Ampicillin; Bacteria; Child; Child, Preschool; Clinical Trials as Topic; Diaper Rash; Diarrhea; Erythema; Haemophilus influenzae; Humans; Mitosporic Fungi; Otitis Media; Oxytetracycline; Penicillin G Benzathine; Penicillin G Procaine; Penicillin V; Streptococcus; Streptococcus pneumoniae; Sulfisoxazole; Urticaria; Vomiting

Seven cases are reported in which drugs of the tetracycline group produced a fall in the glomerular filtration rate. In six patients there was a primary underlying renal disease and renal impairment. All seven patients were made seriously ill by the antibiotic. Two patients required immediate haemodialysis; one died and the other continued on dialysis until transplanted. Another patient initially responded to intravenous fluids and protein restriction but his renal function deteriorated and four months later he began maintenance haemodialysis. Three patients required peritoneal dialysis. The seventh patient responded satisfactorily to conservative management. The medical and medicolegal complications arising from the use of tetracycline in patients with renal disease are discussed. Yet another plea is made that drugs of the tetracycline group other than doxycycline should not be given to patients with chronic renal failure.

Topics: Adult; Aged; Body Weight; Creatinine; Diarrhea; Dietary Proteins; Female; Glomerular Filtration Rate; Humans; Infusions, Parenteral; Kidney Failure, Chronic; Male; Middle Aged; Nausea; Oxytetracycline; Peritoneal Dialysis; Renal Dialysis; Tetracycline; Urea; Vomiting

Topics: Animals; Anura; Atropine; Cat Diseases; Cats; Chloramphenicol; Dog Diseases; Dogs; Ethiopia; Female; Fever; Oxytetracycline; Pain; Paralysis; Poisoning; Prednisolone; Vomiting

Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Animals; Doxycycline; Drug Resistance, Microbial; Follow-Up Studies; Gonorrhea; Humans; Male; Middle Aged; Milk; Nausea; Neisseria gonorrhoeae; Oxytetracycline; Recurrence; Streptomycin; Sulfisoxazole; Urethritis; Vomiting

Topics: Administration, Oral; Adolescent; Adult; Animals; Doxycycline; Drug Resistance, Microbial; Female; Gonorrhea; Humans; Middle Aged; Milk; Nausea; Neisseria gonorrhoeae; Oxytetracycline; Streptomycin; Sulfonamides; Treponema pallidum; Vomiting

Topics: Antacids; Humans; Nausea; Oxytetracycline; Vomiting