oxytetracycline--anhydrous and Urethritis

Topics: Anti-Bacterial Agents; Cephaloridine; Gonorrhea; Humans; Kanamycin; Male; Neisseria gonorrhoeae; Oxytetracycline; Penicillins; Sulfonamides; Tetracycline; Urethritis

Topics: Anti-Infective Agents, Urinary; Drug Combinations; Humans; Male; Oxytetracycline; Rifampin; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Urethritis

An asssessment of the clinical findings and treatment in 400 patients with non-specific urethritis (NSU) is reported, and the effect of treating their contacts is analysed. Three tetracyclines were compared ina randomised trial which showed that low-dose oxytetracycline (250 mg twice a day) was as effective as preparations formulated specifically for twice daily administration (triple tetracycline and sustained-release tetracycline hydrochloride). The question of multiple aetiology was explored by testing statistically whether various clinical features such as age, incubation period, severity of symptoms, and previous infection were related to outcome. No subgrouping of the condition could be found. Clinical relapse proved to be independent of empirical treatment of asymptomatic contacts, which therefore appeared not to confer any benefit on either partner. It is suggested that the infective aspect of NSU is readily controlled, and that other factors, probably psychological, determine relapse.

Topics: Adolescent; Adult; Clinical Trials as Topic; Delayed-Action Preparations; Drug Combinations; Humans; Male; Middle Aged; Oxytetracycline; Tetracyclines; Urethritis

Details are given of a double-blind trial involving 400 cases in which tetracycline 500 mg. four times a day for 7 days was compared with tetracycline 250 mg. four times a day for 14 days and also of the findings in 311 cases treated with Deteclo 300 mg. three times a day for 3 weeks. The treatment in the double-blind trial were equally effective and appeared to be as effective as the long-term Deteclo therapy. When the results of these treatments were compared with those obtained previously with tetracycline 250 mg. four times a day for 4 days and allowance was made for the time at which the latter results have been assessed, it was concluded that neither the treatment used in the double-blind trial nor Deteclo 300 mg. three times a day for 3 weeks offered any advantage over the customary treatment with tetracycline 250 mg, four times a day for 4 days.

Topics: Chlortetracycline; Clinical Trials as Topic; Demeclocycline; Humans; Oxytetracycline; Tetracycline; Tetracyclines; Time Factors; Urethritis

A double-blind trial of oxytetracycline (Imperacin-I.C.I.) and tetracycline hydrochloride in a sustained-release formulation (Tetrabid-Organon) was carried out on 259 men suffering from non-specific urethritis. Patients who had NSU in the preceeding 3 months were excluded from the trial. The response to treatment assessed at 10 days was favourable in ninety patients out of 129 (35 per cent.) who received oxytetracycline and in 89 patients out of 130 (34 per cent.) who received Tetrabid-Organon. Eight patients in each group required re-treatment and the remainder failed to attend for follow-up. At 4 weeks after treatment one (1-3 per cent.) of 74 patients treated with Tetrabid-Organon and twenty (37-7 per cent.) of patients treated with oxytetracycline required further treatment. A large proportion of patients who were free of signs and symptoms at the first follow-up failed to return at 4 weeks, so that the true rates of cure at 4 weeks are difficult to assess. In a field such as venereology, the twice-daily administration of medication offers distinct advantages over a four-times-daily regime. This study suggests that Tetrabid-Organon, a tetracycline designed specifically for twice-daily dosage, is more effective than standard oxytetracycline, given twice daily, in the treatment of NSU. It was satisfying to find that the traditional advice concerning abstention from sexual activity and alcohol consumption during the treatment of NSU has a sound basis. The study showed a close correlation between recurrence of NSU and failure to follow such advice. It would be interesting to investigate the means by which alcohol consumption may act to delay recovery.

Topics: Administration, Oral; Adolescent; Adult; Aged; Alcohol Drinking; Clinical Trials as Topic; Delayed-Action Preparations; Humans; Male; Middle Aged; Oxytetracycline; Sexual Behavior; Tetracycline; Urethritis

Topics: Administration, Oral; Adolescent; Adult; Drug Combinations; Follow-Up Studies; Humans; Male; Middle Aged; Oxytetracycline; Placebos; Recurrence; Streptomycin; Sulfamethoxazole; Sulfonamides; Time Factors; Trimethoprim; Urethritis

Topics: Administration, Oral; Adult; Amines; Clinical Trials as Topic; Doxycycline; Follow-Up Studies; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Nausea; Neisseria gonorrhoeae; Oxytetracycline; Penicillins; Time Factors; Urethra; Urethritis; Vomiting

Topics: Clinical Trials as Topic; Humans; Minocycline; Oxytetracycline; Tetracyclines; Urethritis

Topics: Administration, Oral; Drug Therapy, Combination; Humans; Injections, Intramuscular; Male; Oxytetracycline; Pyrazines; Streptomycin; Sulfonamides; Urethritis

Topics: Humans; Male; Oxytetracycline; Phosphates; Tetracycline; Time Factors; Urethritis

Topics: Clinical Trials as Topic; Humans; Oxytetracycline; Time Factors; Urethritis

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Capsules; Clinical Trials as Topic; Gonorrhea; Humans; Middle Aged; Oxytetracycline; Time Factors; Urethritis

Topics: Adult; Animals; Child; Humans; Mice; Oxytetracycline; Skin Diseases, Infectious; Urethritis

Topics: Gonorrhea; Humans; Injections, Intramuscular; Male; Oxytetracycline; Penicillin G; Penicillin G Procaine; Urethritis

Sexually transmitted diseases (STDs) constitute a major public health concern in developing countries. Their interest lies mainly in their diagnosis and their early treatment. Owing to lack of health education and poor living conditions inherent in underdevelopment, self-medication is common practice in these Third World countries. Therefore, the illegal sale of drugs is an important phenomenon in Africa and Asia.. An investigation, with a view to evaluating the importance of drug sales in the parallel market for the treatment of urethral discharge in Dakar, was carried out in 50 different locations in the working-class districts of the capital from 13 February to 6 March 1997. These drugs, obtained from vendors in the illegal market, were tested and analyzed using the standard physicochemical methods.. The most frequently proposed drugs to treat male urethritis are: ampicillin 250-mg capsules (44%); oxytetracyline 250-mg capsules (24%); and cotrimoxazole 450-mg tablets (12%). In most cases (88%), these drugs were sold unpackaged; 12% were sold in blisters. Furthermore, in 90% of cases, the expiry date was not indicated. The dosage and duration of treatment were correct in only 6% of cases. The physicochemical analysis was based on the external appearance, the identification, and the dosage of the active principle. Of these drugs offered by street vendors, 53.1% had an unusual appearance; they were mainly ampicillin 250 mg (21 of 22 samples) and oxytetracycline 250 mg (6 of 12 samples). Furthermore, all active principles were identified as positive, with the exception of ampicillin 250 mg, for which only one sample of the 22 was positive; the others appeared to be flour, with no trace of the active principle.. Given the extent of these illegal sales of drug and their harmful consequences for the health of the population, adequate measures should be taken to eradicate this blight. For this mission to succeed, public authorities, health professionals and populations should combine their efforts.

Topics: Ampicillin; Anti-Bacterial Agents; Humans; Illicit Drugs; Male; Oxytetracycline; Penicillins; Public Health; Senegal; Sexually Transmitted Diseases; Urethritis

Topics: Adolescent; Adult; Anti-Bacterial Agents; Azithromycin; Humans; Male; Middle Aged; Oxytetracycline; Treatment Outcome; Urethritis

Topics: Humans; Male; Ofloxacin; Oxytetracycline; Urethritis

In a retrospective study, the efficacy of tetracycline therapy was assessed in 48 men with non-gonococcal urethritis who only harbored Ureaplasma urealyticum in their urethras. After 2 weeks of therapy with 2.0 g oxytetracycline per day, U. urealyticum was still found in the urethra of 8 patients (17%). Urethritis was still present in 8 patients (17%) according to clinical criteria and in 11 patients (23%) according to microscopic findings. The persistence of U. urealyticum in the urethra did not correlate with the persistence of urethritis to a statistically significant degree. Therapy compliance, antibiotic resistance in a few cases, reinfections in 2 cases and a special host-parasite relationship are discussed with respect to the treatment failures.

Topics: Adolescent; Adult; Humans; Male; Middle Aged; Mycoplasmatales Infections; Oxytetracycline; Retrospective Studies; Ureaplasma; Urethritis

Of 62 men with non-gonococcal urethritis who entered a study to assess compliance with treatment with oxytetracycline, only 33 could be evaluated. Traditional methods (interview and the absence of oxytetracycline in the urine) showed incomplete compliance in nine. Use of low dose phenobarbitone as a pharmacological marker showed incomplete compliance in a further five patients. In addition, phenobarbitone concentrations gave information on the extent to which individual patients had omitted treatment and provided direct, as opposed to circumstantial, evidence of good compliance by most (18) of those studied. Only three of the 33 patients whose compliance was assessed had evidence of continuing infection at follow up, and there was evidence of incomplete compliance in only one of these patients.

Topics: Adolescent; Adult; Drug Therapy, Combination; Humans; Male; Oxytetracycline; Patient Compliance; Phenobarbital; Urethritis

Four young male chimpanzees were inoculated intra-urethrally with a strain (G37) of Mycoplasma genitalium which had been isolated from the urethra of a patient with non-gonococcal urethritis. Two of the chimpanzees became infected as indicated by persistent recovery of the organisms from the urethra for 13 weeks and by an antibody response measured by both metabolism inhibition and micro-immunofluorescence techniques. The numbers of organisms isolated from both animals increased about 4 weeks after inoculation and antibody development was first detected 1 week later. The infected animals developed a minimal and inconsistently detected urethral polymorphonuclear leucocyte response which was not seen in those that were uninfected, nor in a chimpanzee that had been given medium only. The organisms were not isolated and the cellular response was not observed after treatment of the infected chimpanzees with oxytetracycline. One of the animals that had been infected was re-inoculated with strain G37 six months after successful treatment, but although the titre of serum antibody had diminished to its original level urethral recolonization did not occur. The organisms in the inoculum were not attenuated, however, because they infected another chimpanzee that had not had previous experience of M. genitalium. The results are discussed in relation to the potential of this mycoplasma to produce urethritis in man.

Topics: Animals; Antibodies, Bacterial; Leukocyte Count; Male; Microbial Sensitivity Tests; Mycoplasma; Mycoplasma Infections; Neutrophils; Oxytetracycline; Pan troglodytes; Urethra; Urethritis

Chlamydia trachomatis was reisolated from 11 of 12 men with gonorrhoea who had initially yielded chlamydiae and who had been treated with ampicillin and probenecid (AMP) only, but from none of five such men treated with ampicillin and probenecid followed by tetracycline (AMPT). These results correlated with the absence of postgonococcal urethritis (PGU) in the group treated with AMPT. C trachomatis was isolated or reisolated from 20 of 25 women after treatment with AMP, compared with none of 14 women treated with AMPT. We recommend the addition of a course of tetracycline to the routine single dose treatment for gonorrhoea in men and women.

Topics: Ampicillin; Chlamydia Infections; Chlamydia trachomatis; Drug Combinations; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Oxytetracycline; Probenecid; Urethritis

An investigation of chlamydial infection in sexual contacts of patients with nongonococcal urethritis (NGU) was carried out to determine the clinical signs of infection in the cervix, and their response to chemotherapy, and the incidence of cervical infection in the presence of ectopy and oral contraception. In 202 consecutive female contacts of NGU the isolation rate of Chlamydia trachomatis was 35%. Hypertrophic ectopy and endocervical mucopus were present in 19% and 37% of chlamydia-positive patients respectively and, in all but one, resolved after treatment. Only 14% of those followed up after treatment developed yeast infections. The chlamydial isolation rate was significantly higher in patients with hypertrophic ectopy and endocervical mucopus. Cervical ectopy and oral contraceptives acted additively, each producing a significant effect on the chlamydial isolation rate in the presence of the other but not when present alone.

Topics: Adolescent; Adult; Cervix Uteri; Chlamydia Infections; Chlamydia trachomatis; Contraceptives, Oral; Erythromycin; Female; Humans; Male; Menstruation; Middle Aged; Oxytetracycline; Pregnancy; Pregnancy Complications, Infectious; Urethritis; Uterine Cervical Diseases; Uterine Cervical Erosion

Topics: Humans; Hypersensitivity; Male; Oxytetracycline; Urethritis

We have currently established the spectrum of sensitivity of the isolated strains to various antibiotics before prescribing the appropriate treatment. A microtechnic has been used. The most active antibiotics are: minocyclin, pristinamycin, erythromycin, chloramphenicol, oxytetracyclin, kanamycin, tobramycin, streptomycin, in this order.

Topics: Anti-Bacterial Agents; Culture Media; Erythromycin; Female; Humans; Hydrogen-Ion Concentration; Male; Microbial Sensitivity Tests; Minocycline; Mycoplasma Infections; Oxytetracycline; Ureaplasma; Urethritis

Topics: Drug Resistance, Microbial; Erythromycin; Humans; Male; Microbial Sensitivity Tests; Minocycline; Mycoplasma; Oxytetracycline; Species Specificity; Tetracyclines; Ureaplasma; Urethritis

In a comparative trial minocycline was the best oral tetracycline compound for twice-daily administration in the treatment of non-specific urethritis. A review six months later showed that 29% of patients had needed further treatment, 35% of these more than one month after initial treatment and 12% between three and six months later. The history revealed no evidence of predisposition to non-specific urethritis among patients in whom relapse occurred. Multiple relapses were in the groups of patients who relapsed earliest. These cases proved more resistant to subsequent treatment, but all patients were eventually cured. The records of female contacts showed that 29% were symptomatic, 44% had an abnormal appearance of the cervix, but only 11% had inflammatory changes detected on cytological smear. A previous report was confirmed that there was no apparent benefit from the empirical treatment of contacts; possible reasons for this are given.

Topics: Adolescent; Adult; Female; Humans; Male; Middle Aged; Minocycline; Oxytetracycline; Recurrence; Tetracycline; Tetracyclines; Urethritis

A trial comparing the efficacy of three different tetracyclines, each in two different dosage regimens, in the treatment of non-specific urethritis is described. There was a significant association between the retreatment rate and sexual intercourse. Age, race, duration of symptoms, previous infection, and indulgence in alcohol did not appear to influence the results whereas treatment of sexual contacts before resumption of sexual intercourse significantly reduced the retreatment rate. Single-dose treatment with doxycycline was shown to be ineffective. Treatment with doxycycline for seven days or triple tetracycline for seven days was less effective than triple tetracycline for 21 days or oxytetracyline for seven or 21 days, all of which gave the same success rate.

Topics: Adult; Alcohol Drinking; Coitus; Doxycycline; Drug Administration Schedule; Humans; Male; Middle Aged; Oxytetracycline; Tetracycline; Tetracyclines; Urethritis

Topics: Chlamydia Infections; Chlamydia trachomatis; Erythromycin; Humans; Male; Oxytetracycline; Urethritis

The conclusions, where pertinent, of the 10 papers on the treatment of non-specific urethritis which have appeared in the British Journal of Venereal Diseases between 1971 and now are reviewed. Recent studies purport to argue, but in fact assume, that tetracyclilne treatment for non-specific urethritis is both effective and desirable; current practice agrees with this assumption. To prove effectiveness, studies over much longer follow-up periods would be necessary. These studies should compare results not only of different methods and doses of tetracycline, of different regimens, and of different types of the drug; they should also compare results over a prolonged period with placebos and with other drugs, for instance those outside the antibiotic range and with no suspected side effects. Only then would it be reasonable to hold a firm view on the desirability or the effectiveness of the treatment. With patience and properly conducted experiments results may emerge to justify some view. At the moment the data are ill-assembled although voluminous and fail to support conclusions that have any clarity or force; moreover they are so haphazard that they cannot be compared with one another. Some venereologists are sceptical about treatment, some advocate the administration of one single dose, others say the four- or five-day regimen is preferable, and so on up to those who maintain that the 21-day regimen is the best. The coexistence of such mutually incompatible, firmly-held views may well suggest that the whole system of investigation put together to validate such views is quite inappropriate. That would be a radical thesis, and perhaps none the worse for that. What is not a radical thesis, however, is that at present the whole system of data and argument is in disarray.

Topics: Humans; Oxytetracycline; Tetracycline; Urethritis

Topics: Adult; Dose-Response Relationship, Drug; Doxycycline; Drug Resistance, Microbial; Humans; In Vitro Techniques; Male; Middle Aged; Minocycline; Mycoplasma; Mycoplasma Infections; Oxytetracycline; Prostatitis; Tetracyclines; Ureaplasma; Urethritis

Topics: Antigens, Viral; Antiviral Agents; Female; Herpes Simplex; Humans; Male; Metronidazole; Mycoplasma Infections; Nystatin; Oxytetracycline; Tetracycline; Urethritis

Topics: Adult; Candida albicans; Cervix Uteri; Contraceptive Devices; Family Practice; Female; Humans; London; Male; Methods; Microscopy; Neisseria gonorrhoeae; Oxytetracycline; Rectum; Trichomonas vaginalis; Urethra; Urethritis; Urine; Uterine Cervicitis; Vagina

Topics: Adult; Cervix Mucus; Child; Family Practice; Female; Humans; Leukocytes; Male; Oxytetracycline; Sexually Transmitted Diseases; Tetracycline; Urethritis

Topics: Administration, Oral; Anemia, Hemolytic; Blood-Brain Barrier; Chlortetracycline; Demeclocycline; Doxycycline; Drug Hypersensitivity; Female; Glucosephosphate Dehydrogenase Deficiency; Gonorrhea; Humans; Injections, Intramuscular; Intestinal Absorption; Male; Methacycline; Minocycline; Oxytetracycline; Penicillins; Tetracycline; Urethritis

Topics: Administration, Oral; Adolescent; Adult; Chlortetracycline; Demeclocycline; Drug Combinations; Humans; Male; Middle Aged; Oxytetracycline; Tetracycline; Time Factors; Urethritis

Topics: Arthritis; Arthritis, Reactive; Female; Haemophilus Infections; Humans; Hypersensitivity; Inclusion Bodies; Male; Mycoplasma Infections; Mycoses; Oxytetracycline; Tetracycline; Trichomonas vaginalis; Urethritis; Uveitis

Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Animals; Doxycycline; Drug Resistance, Microbial; Follow-Up Studies; Gonorrhea; Humans; Male; Middle Aged; Milk; Nausea; Neisseria gonorrhoeae; Oxytetracycline; Recurrence; Streptomycin; Sulfisoxazole; Urethritis; Vomiting

Topics: Humans; Injections, Intramuscular; Male; Oxytetracycline; Pyrazines; Streptomycin; Sulfonamides; Tablets; Urethritis

Topics: Acute Disease; Administration, Oral; Bacteriological Techniques; Doxycycline; Follow-Up Studies; Gonorrhea; Humans; Injections, Intramuscular; Male; Microbial Sensitivity Tests; Military Medicine; Neisseria gonorrhoeae; Oxytetracycline; Penicillin G Procaine; Penicillin Resistance; Texas; United States; Urethritis

Topics: Adolescent; Adult; Doxycycline; Gonorrhea; Humans; Male; Oxytetracycline; Urethritis

Topics: Adolescent; Child; Child, Preschool; Humans; Male; Oxytetracycline; Urethral Stricture; Urethritis

Topics: Ampicillin; Australia; Culture Media; Drug Eruptions; Erythromycin; Gonorrhea; Humans; Kanamycin; Kidney; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Oxytetracycline; Penicillin G Benzathine; Penicillin G Procaine; Penicillin Resistance; Probenecid; Streptomycin; Tetracycline; Urethritis

Topics: Humans; Male; Mycoplasma; Oxytetracycline; Prostatitis; Trichomonas; Urethritis; Urine

Topics: Acinetobacter Infections; Adult; Diagnosis, Differential; Gonorrhea; Humans; Male; Oxytetracycline; Penicillin Resistance; Penicillins; Urethritis

Topics: Adolescent; Adult; Gonorrhea; Humans; Male; Middle Aged; Oxytetracycline; Urethritis

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Chlortetracycline; Demeclocycline; Humans; Male; Middle Aged; Oxytetracycline; Penicillins; Streptomycin; Urethritis

Topics: Adult; Delayed-Action Preparations; Gonorrhea; Humans; Male; Oxytetracycline; Penicillin G Benzathine; Penicillin G Procaine; Penicillins; Urethritis

Topics: Drug Therapy; Humans; Inflammation; Male; Oxytetracycline; Urethra; Urethritis

Topics: Epididymitis; Humans; Male; Oxytetracycline; Prostatitis; Urethritis; Vas Deferens

Topics: Humans; Inflammation; Male; Oxytetracycline; Trichomonas; Trichomonas Infections; Urethra; Urethritis; Virus Diseases

Forty cases of gonococcal urethritis were treated with oxytetracycline using various dosage schedules; there were 37 cures and three failures. The most convenient and most effective dosage was found to be 250 mg. oxytetracycline, given as a single intramuscular injection of 5 c.c.A series of 40 patients with non-gono-coccal urethritis was also collected. Two cases of urethritis due to Trichomonas vaginalis and two due to Candida albicans were removed from the series. Of the 36 cases which remained, cure was obtained with the use of oxytetracycline in different dosages in 30 cases; six cases were failures. The dosage which gave the best result in the therapy of non-gonococcal urethritis was 250 mg. oxytetracycline (5 c.c.), given as a single intramuscular injection, plus 250 mg. orally, four times a day for four days.The effectiveness of oxytetracycline in the treatment of urethritis has not decreased.

Topics: Candidiasis; Gonorrhea; Humans; Male; Oxytetracycline; Proteus Infections; Pseudomonas Infections; Staphylococcal Infections; Streptococcal Infections; Trichomonas Infections; Trichomonas vaginalis; Urethritis

Topics: Gonorrhea; Humans; Male; Oxytetracycline; Urethritis

Topics: Gonorrhea; Humans; Injections; Male; Oxytetracycline; Urethritis

Topics: Anti-Bacterial Agents; Injections, Intramuscular; Oxytetracycline; Protein Synthesis Inhibitors; Tetracycline; Urethritis

Topics: Aminobenzoates; Anti-Bacterial Agents; Hyaluronoglucosaminidase; Methylcellulose; Oxytetracycline; Sympathomimetics; Urethritis

Topics: Aminobenzoates; Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Hyaluronoglucosaminidase; Methylcellulose; Oxytetracycline; Sympathomimetics; Urethritis

Topics: Acute Disease; Gonorrhea; Humans; Injections, Intramuscular; Male; Oxytetracycline; Urethritis

Topics: Injections, Intramuscular; Oxytetracycline; Urethritis

Topics: Gonorrhea; Injections, Intramuscular; Oxytetracycline; Urethritis

Topics: Chlortetracycline; Humans; Oxytetracycline; Urethritis

Topics: Oxytetracycline; Urethritis

Topics: Anti-Bacterial Agents; Oxytetracycline; Urethritis

Topics: Humans; Oxytetracycline; Urethritis

Topics: Analgesics; Humans; Oxytetracycline; Penicillins; Streptomycin; Urethritis

Topics: Gonorrhea; Humans; Oxytetracycline; Urethritis

Topics: Arthritis, Reactive; Humans; Lung Neoplasms; Oxytetracycline; Urethritis

Topics: Oxytetracycline; Urethritis

Topics: Oxytetracycline; Urethritis

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Oxytetracycline; Urethritis