oxytetracycline--anhydrous and Tooth-Discoloration

Topics: Absorption; Acne Vulgaris; Bacteria; Bacteriuria; Bronchial Diseases; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Chlortetracycline; Demeclocycline; Drug Eruptions; Humans; Infections; Kidney Diseases; Methacycline; Oxytetracycline; Protein Binding; Tetracycline; Tooth Discoloration

Topics: Adult; Child, Preschool; Female; Fetus; Humans; Infant; Infant, Newborn; Maternal-Fetal Exchange; Oxytetracycline; Pregnancy; Pregnancy Complications, Infectious; Tetracycline; Tooth Abnormalities; Tooth Discoloration; Tooth, Deciduous

Topics: Child, Preschool; Dental Enamel Hypoplasia; Female; Humans; Infant; Male; Oxytetracycline; Sodium Chloride; Tooth; Tooth Discoloration

Topics: Child, Preschool; Dental Enamel Hypoplasia; Female; Humans; Infant; Male; Oxytetracycline; Sodium Fluoride; Tooth Discoloration

Topics: Animals; Bone and Bones; Demeclocycline; Doxycycline; Durapatite; Hydroxyapatites; Male; Mice; Oxytetracycline; Spectrometry, Fluorescence; Tetracycline; Tooth; Tooth Discoloration

The present study was done in order to examine the durability of the tetracycline-induced antimicrobial capacity, and also to assess the reproducibility of the bacterial growth-inhibitory assay used. Standardized enamel and dentin specimens were impregnated in aqueous solutions of tetracycline HCl, oxytetracycline HCl or doxycycline HCl, rinsed in water, and stored dry for 200 days. Another series of specimens was impregnated in solutions of doxycycline HCl and then rinsed in tap water for varying periods up to 35 days. In addition, drug-impregnated specimens were used for reproducibility tests without storage or prolonged rinsing. Impregnated specimens were tested for antimicrobial capacity on agar plates seeded with S. sanguis. After 24 h aerobic incubation in 10% CO2 atmosphere, the plates were inspected and the diameter of the bacterial growth inhibition zones measured. The drug-impregnated enamel and dentin specimens consistently demonstrated growth-inhibitory capacity. The results of the reproducibility tests showed moderate intrasample and day-to-day variation. Two hundred days of dry storage or 35 days soaking in water reduced, but did not eliminate, the bacterial growth-inhibitory capacity of the impregnated dental specimens. The results show that a short-term exposure of dental hard tissues to tetracyclines may result in a long-lasting antibacterial capacity.

Topics: Bacteria; Bacterial Physiological Phenomena; Dental Enamel; Dentin; Doxycycline; Humans; Oxytetracycline; Tetracycline; Time Factors; Tooth Discoloration; Water

Topics: Child, Preschool; Dentin; Humans; Oxytetracycline; Tetracyclines; Tooth Discoloration

Topics: Demeclocycline; Doxycycline; Oxytetracycline; Tetracycline; Tooth Bleaching; Tooth Discoloration

Topics: Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Oxytetracycline; Tetracyclines; Tooth Discoloration; Tooth, Deciduous

The capacity of the tetracyclines to discolour teeth has been widely recognized for over 10 years. This survey examined recent trends in tetracycline usage as shown by deposits of the antibiotic in primary molars extracted from 505 children aged from 3 to 5 years.It was found that 70% of the children had been given the antibiotic during their first three years of life, each having received on average 2.4 courses. This represented an increase of 12% in tetracycline usage in children of this age as compared with a similar series five years ago. There was no evidence of increasing preference by prescribers for oxytetracycline (the analogue least likely to cause dental discoloration). Staining of the permanent incisor teeth frequently occurs if tetracyclines are given to children under 6 years of age and it is predicted that some degree of staining will occur in about 23% of the children in this series.All things considered, there appears to be a strong case for stopping the manufacture of paediatric preparations of tetracycline except for those comprised of oxytetracycline for use in exceptional cases.

Topics: Age Factors; Child, Preschool; Humans; Infant; Odontogenesis; Oxytetracycline; Tetracycline; Tooth Discoloration

Topics: Age Factors; Australia; Child; Child, Preschool; Chlortetracycline; Humans; Oxytetracycline; Tetracycline; Tooth; Tooth Discoloration

Topics: Anti-Infective Agents, Local; Biguanides; Dental Plaque; Dental Prophylaxis; Dextranase; Gingivitis; Humans; Mouthwashes; Oxytetracycline; Periodontal Diseases; Tooth Discoloration; Toothbrushing

Topics: Anti-Infective Agents, Local; Biguanides; Dental Plaque; Dental Prophylaxis; Dextranase; Gingivitis; Humans; Mouthwashes; Oxytetracycline; Periodontal Diseases; Tooth Discoloration; Toothbrushing

Topics: Age Factors; Child, Preschool; Dental Caries; Female; Gestational Age; Humans; Infant; Male; Minerals; Oxytetracycline; Pregnancy; Rolitetracycline; Tetracycline; Tooth Abnormalities; Tooth Calcification; Tooth Discoloration; Tooth, Deciduous

Topics: Age Factors; Child; Child, Preschool; Chlortetracycline; Female; Fluorescence; Humans; Infant; Infant, Newborn; Male; Oxytetracycline; Tetracycline; Tooth Discoloration; Tooth, Deciduous

Topics: Adolescent; Age Factors; Child; Child, Preschool; Chlortetracycline; Dental Caries; Germany, West; Humans; Infant; Oxytetracycline; Tetracycline; Tooth; Tooth Abnormalities; Tooth Discoloration; Tooth, Deciduous

Topics: Adolescent; Child; Child, Preschool; Female; Humans; Maternal-Fetal Exchange; Oxytetracycline; Pregnancy; Tetracycline; Tooth Discoloration

Topics: Adolescent; Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Demeclocycline; Dogs; Female; Humans; Kidney Diseases; Male; Methacycline; Oxytetracycline; Photosensitivity Disorders; Pregnancy; Tetracycline; Tooth Calcification; Tooth Discoloration

Topics: Adolescent; Child; Child, Preschool; Chlortetracycline; Cystic Fibrosis; Dental Caries; Female; Fluorescence; Humans; Incisor; Male; Oxytetracycline; Tetracycline; Tooth Calcification; Tooth Discoloration

Topics: Child; Dental Enamel; Humans; Oxytetracycline; Tooth Discoloration

Topics: Child; Child, Preschool; Chlortetracycline; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; Oxytetracycline; Pregnancy; Tetracycline; Tooth Discoloration; Tooth, Deciduous; Twins; Wounds and Injuries

Topics: Humans; Infant, Newborn; Infant, Premature; Oxytetracycline; Tooth Discoloration

Topics: Anti-Bacterial Agents; Child; Chlortetracycline; Demeclocycline; Female; Humans; Maternal-Fetal Exchange; Oxytetracycline; Pharmacology; Pregnancy; Staining and Labeling; Tetracycline; Tooth; Tooth Discoloration; Tooth, Deciduous; Toxicology

Topics: Anti-Bacterial Agents; Chlortetracycline; Demeclocycline; Oxytetracycline; Rabbits; Research; Rolitetracycline; Staining and Labeling; Tetracycline; Tetracyclines; Tooth Discoloration; Toxicology

Topics: Abnormalities, Drug-Induced; Child, Preschool; Chlortetracycline; Demeclocycline; Female; Humans; Infant; Infant, Newborn; Oxytetracycline; Pregnancy; Tetracycline; Tooth Discoloration