oxytetracycline--anhydrous and Syphilis

Between 1916 and 1955 the Mayo Clinic became recognized as one of the premier institutions specializing in the treatment of syphilis. First under the direction of John H. Stokes (1916-1924) and later Paul A. O'Leary (1924-1953), its Department of Dermatology and Syphilology, together with the members of the Clinical Cooperative Study Group, oversaw the establishment of standardized methods for the administration of the existing arsenicals and the introduction of new therapies. Malaria therapy, heat therapy, penicillin, and oxytetracycline each represented important advances in the treatment of syphilis and were extensively evaluated. Two important ancillary benefits of syphilis treatment were the development of routine intravenous techniques, which would later prove invaluable for the administration of antibiotics and cancer drugs, and the establishment of large cooperative clinical trials, the first of their kind. Under the leadership of Stokes and O'Leary the department produced a stream of pivotal clinical research that contributed to the effective management of syphilis in the United States.

Topics: Arsenicals; Clinical Trials as Topic; Dermatology; History, 20th Century; Hospitals, Group Practice; Humans; Hyperthermia, Induced; Injections, Intravenous; Malaria; Mercury; Minnesota; Oxytetracycline; Penicillins; Syphilis

Topics: Aged; HIV Seropositivity; Humans; Male; Oxytetracycline; Prednisolone; Syphilis

Topics: Acne Vulgaris; Anti-Bacterial Agents; Gonorrhea; Humans; Oxytetracycline; Penicillin Resistance; Penicillins; Sexually Transmitted Diseases; Syphilis

Topics: Anti-Bacterial Agents; Chloramphenicol; Gonorrhea; Humans; Neomycin; Oxytetracycline; Penicillin Resistance; Penicillins; Skin Diseases, Infectious; Syphilis

Topics: Administration, Oral; Chloramphenicol; Erythromycin; Evaluation Studies as Topic; Humans; Oxytetracycline; Syphilis; Time Factors

Topics: Adult; Aged; Alopecia; Anti-Bacterial Agents; Balanitis; Biopsy; Child; Child, Preschool; Chloramphenicol; Deoxyuridine; Diagnosis, Differential; Diagnostic Errors; Erythromycin; Exanthema; Female; Hemorrhoids; Hernia, Inguinal; Herpes Simplex; Humans; Lymphadenitis; Male; Metronidazole; Middle Aged; Mycoses; Oxytetracycline; Penicillins; Sarcoidosis; Sclerosis; Skin Tests; Stomatitis; Syphilis; Syphilis Serodiagnosis; Syphilis, Latent; Tetracycline

Topics: Adolescent; Adult; Child; Doxycycline; Female; Humans; Lymphogranuloma Venereum; Male; Middle Aged; Oxytetracycline; Syphilis

Topics: Anti-Bacterial Agents; Chloramphenicol; Erythromycin; Humans; Injections, Intramuscular; Injections, Intravenous; Oxytetracycline; Penicillins; Rolitetracycline; Syphilis; Tetracycline

Topics: Erythromycin; Follow-Up Studies; Oxytetracycline; Syphilis; Time Factors

Topics: Chloramphenicol; Erythromycin; Fluorescent Antibody Technique; Follow-Up Studies; Humans; Oxytetracycline; Syphilis; Treponema Immobilization Test

Topics: Female; Humans; Injections, Intravenous; Male; Oxytetracycline; Penicillins; Prognosis; Syphilis

Topics: Anti-Bacterial Agents; Gonorrhea; Humans; Oxytetracycline; Sexually Transmitted Diseases; Skin Diseases, Infectious; Syphilis; Syphilis, Latent

Topics: Adolescent; Adult; Humans; Male; Oxytetracycline; Syphilis; Treponema pallidum

Topics: Anti-Bacterial Agents; Chloramphenicol; Chlortetracycline; Erythromycin; Humans; Oxytetracycline; Streptomycin; Syphilis

Topics: Humans; Injections, Intravenous; Oxytetracycline; Syphilis; Syphilis Serodiagnosis; Syphilis, Latent; Treponema Immobilization Test

Topics: Delayed-Action Preparations; Dosage Forms; Drug Therapy; Humans; Oxytetracycline; Syphilis

Topics: Adult; Aged; Bismuth; Female; Fever; Humans; Male; Middle Aged; Oxytetracycline; Penicillin G Procaine; Penicillins; Syphilis

Topics: Adolescent; Adult; Female; Humans; Injections, Intramuscular; Oxytetracycline; Syphilis

Topics: Aluminum; Child; Chlortetracycline; Ethylenediamines; Humans; Infant; Infant, Newborn; Massachusetts; Neurosyphilis; Oxytetracycline; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillin Resistance; Pharmacology; Procaine; Syphilis; Syphilis Serodiagnosis; Syphilis, Congenital; Syphilis, Latent; Tetracycline

Topics: Diagnosis, Differential; Fluorescent Antibody Technique; Humans; Neurosyphilis; Oxytetracycline; Penicillin G; Pinta; Procaine; Syphilis; Syphilis, Cardiovascular; Syphilis, Latent; Treponema Immobilization Test; Treponemal Infections; Yaws

Topics: Antacids; Bismuth; Chlortetracycline; Hypersensitivity; Mercury; Oxytetracycline; Penicillins; Syphilis; Toxicology

Topics: Chlortetracycline; Communicable Disease Control; Ethylenediamines; Humans; Maine; Neurosyphilis; Oxytetracycline; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillins; Procaine; Syphilis; Syphilis Serodiagnosis; Syphilis, Congenital; Syphilis, Latent; Toxicology

Topics: Anti-Bacterial Agents; Chancre; Dexfenfluramine; Humans; Medical Records; Oxytetracycline; Syphilis

Topics: Injections, Intramuscular; Oxytetracycline; Syphilis

Topics: Humans; Oxytetracycline; Syphilis

Topics: Dermatology; Humans; Oxytetracycline; Skin Diseases; Syphilis

Topics: Granuloma Inguinale; Humans; Oxytetracycline; Syphilis

Topics: Humans; Oxytetracycline; Syphilis

Topics: Anti-Bacterial Agents; Chloramphenicol; Chlortetracycline; Data Collection; Oxytetracycline; Syphilis

Topics: Humans; Oxytetracycline; Syphilis

Topics: Animals; Antacids; Anti-Bacterial Agents; Antidiarrheals; Bismuth; Oxytetracycline; Rabbits; Syphilis

Topics: Animals; Antacids; Antidiarrheals; Arsenicals; Bismuth; Lagomorpha; Oxytetracycline; Rabbits; Syphilis

Topics: Oxytetracycline; Syphilis

Topics: Antitreponemal Agents; Humans; Oxytetracycline; Syphilis

Topics: Antitreponemal Agents; Humans; Oxytetracycline; Syphilis

Topics: Humans; Oxytetracycline; Syphilis

Topics: Animals; Lagomorpha; Leadership; Oxytetracycline; Rabbits; Syphilis

Topics: Epidemics; Humans; Oxytetracycline; Rural Population; Syphilis