oxytetracycline--anhydrous and Rodent-Diseases

Topics: Animals; Bacterial Infections; Bacteroides; Clostridium perfringens; Cricetinae; Diarrhea; Disease Outbreaks; Escherichia coli; Mesocricetus; Oxytetracycline; Proteus; Rodent Diseases

The oral infection of laboratory mice with 10(8) colony-forming units of viable Salmonella ochiogu bacteria resulted in clinical salmonellosis and death in 10 out of 45 of the mice (22%). None of the mice treated with oxytetracycline died. Infection in susceptible mice was characterized by septicaemia, respiratory involvement and mild enteritis. The organism was shed in the faeces from the first day after infection until day 30, and cultures from viscera showed systemic dissemination. S. ochiogu was recovered from the faeces of mice treated with oxytetracycline between days 1 and 9 post infection.

Topics: Animals; Feces; Female; Male; Mice; Oxytetracycline; Rodent Diseases; Salmonella; Salmonella Infections, Animal

After receiving once daily intraperitoneal (i.p.) or subcutaneous (s.c.) injections of oxytetracycline (15 mg/100 g bodyweight) for 7 days, laboratory rats had significantly different oxytetracycline serum levels depending on the method of injection. Regardless of injection method, the biological half-life of the antibiotic was 4.25 h and serum antibiotic levels never fell below therapeutic levels for certain rat pathogens during 24 h post-injection. Severe peritonitis and cellulitis were found in rats whether injected s.c. or i.p. and some animals lost bodyweight. It appeared that either injection method would be an effective treatment for certain infectious diseases of laboratory rats but tissue damage, probably from oxytetracycline's acidity, made both methods unattractive.

Topics: Animals; Bacterial Infections; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Oxytetracycline; Rats; Rats, Inbred Strains; Rodent Diseases

In an epidemic outbreak of salmonellosis associated with Salmonella montevideo in 6 mouse colonies, most deaths occurred in BALB/c and ASI mice, although the carrier rate was similar in other mouse strains. The salmonella was eradicated from ASI mice of 4-6 weeks old, and the carrier rate considerably reduced at 12-26 weeks of age, by use of oral oxytetracycline in conjunction with strict hygiene measures. Housing mice on wire grids instead of wood shavings did not affect the efficacy of the treatment.

Topics: Animals; Carrier State; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Oxytetracycline; Rodent Diseases; Salmonella Infections, Animal; Species Specificity

Topics: Abscess; Ampicillin; Animals; Leucomycins; Mice; Mice, Nude; Oxytetracycline; Pasteurella Infections; Rodent Diseases

A colony of nude mice was maintained under controlled standards of care for 12 months, at which time a rapidly escalating liver disease developed in the animals, characterized by jaundice, emaciation, and rapid death. Histologically, the livers had swollen, vacuolated hepatic cells and increased numbers of enlarged Kupffer cells. Mouse hepatitis virus was not isolated from the livers of sick mice. Although the nature of the lesions suggested toxicity, efforts to reproduce the lesions by increased exposure to chemical compounds used for colony husbandry were unsuccessful. A definitive determination of the causative agent was not made.

Topics: Animals; Hepatitis, Animal; Jaundice; Liver; Mice; Mice, Nude; Oxytetracycline; Peracetic Acid; Rodent Diseases

Topics: Animals; Bacillus; Hepatitis, Animal; Mice; Oxytetracycline; Rodent Diseases

Topics: Animals; Lung Diseases; Mice; Oxytetracycline; Pharmacology; Pulmonary Edema; Research; Rodent Diseases; Virus Diseases

Topics: Animals; Disease; Leptospirosis; Oxytetracycline; Rats; Rodent Diseases