oxytetracycline--anhydrous and Pyoderma

The results of a clinical trial using a new preparation of Terracortril ointment and Terracortril cream without preservatives are reported. Apart from oxytetracycline 30 mg/g and 10 mg hydrocortisone alcohol/g, each drug contains polymyxin B 10,000 I.U./g. Of a total of 85 patients with primary and secondary pyodermias, 41 were completely or almost completely cured after application of ointment or cream respectively, 13 were largely, and 31 cases satisfactorily improved (see tables 1 and 2). The bacteriological findings are discussed. No skin irritations such as contact dermatitis were observed.

Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Dosage Forms; Drug Eruptions; Eczema; Female; Humans; Hydrocortisone; Male; Middle Aged; Ointments; Oxytetracycline; Pyoderma; Skin Diseases, Infectious

The remote results of combined therapy of 300 patients with chronic pyoderma were estimated by the data of the 5-year catamneses. The patients were treated with the use of erycycline, a combined drug consisting of two antibiotics made in the USSR. Stable clinical recovery within 5 years was stated in 78.8 per cent of the patients. Significant improvement (single pustules 2-3 years after discontinuation of the treatment) was registered in 13.7 per cent of the patients. Improvement (insignificant relapses within the first 2 years) was stated in 6.3 per cent of the patients. No effect of the combined therapy was stated in 1.2 per cent of the patients. It was shown that the use of erycycline in the combined therapy of the patients with chronic pyoderma provided its high efficacy, favourable immediate and remote results, decreasing the treatment period at the average by 3.8 days and decreasing the number of relapses. It also provided economy. The analysis of the catamneses promoted critical and objective estimation of the treatment results and stability of the therapeutic remission thus facilitating solution of the problem of treatment and prophylaxis of chronic pyoderma.

Topics: Adolescent; Adult; Chronic Disease; Combined Modality Therapy; Drug Combinations; Erythromycin; Female; Humans; Male; Middle Aged; Oxytetracycline; Pyoderma; Staphylococcal Skin Infections; Staphylococcal Toxoid

Topics: Adolescent; Adult; Chronic Disease; Combined Modality Therapy; Drug Combinations; Erythromycin; Female; Humans; Leg Ulcer; Levamisole; Oxytetracycline; Pyoderma; Staphylococcal Infections

Topics: Adolescent; Adult; Animals; Bees; Biological Products; Chronic Disease; Clothing; Drug Combinations; Drug Evaluation; Erythromycin; Female; Humans; Male; Middle Aged; Oxytetracycline; Pyoderma; Recurrence; Time Factors

Topics: Abscess; Adult; Chronic Disease; Drug Combinations; Drug Therapy, Combination; Erythromycin; Female; Folliculitis; Furunculosis; Humans; Male; Middle Aged; Oxytetracycline; Pyoderma; Skin Ulcer; Staphylococcal Infections; Streptococcal Infections

Topics: Adult; Biological Products; Drug Combinations; Drug Therapy, Combination; Erythromycin; Humans; Middle Aged; Oxytetracycline; Pyoderma

Sensitivity to tetracycline, erythromycin and erycycline was studied in 60 strains of Staph. aureus isolated from the foci of chronic pyoderma and nasopharynx of 30 patients suffering from chronic relapsing pyoderma for 2-5 years. The isolates were 2.6 and 3.2 times more sensitive to erycycline than to erythromycin and tetracycline, respectively. This substantiated the advisability of erycycline use in combined therapy of patients with chronic pyoderma. The staphylococcal strains isolated from the nasopharynx were less sensitive to the antibiotics than the strains isolated from the foci of the skin affection which must explain prolonged persistence of staphylococci in the nasopharynx in spite of the antibiotic use in a dose sufficient for elimination of the microorganism affecting the skin. This might be also the cause of pyoderma relapses. It is concluded that the dose of the antibiotic used for sanation of the nasopharynx in patients with chronic pyoderma should be higher than that for elimination of the pustulous process on the skin.

Topics: Adult; Drug Combinations; Drug Resistance, Microbial; Erythromycin; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Nasopharynx; Oxytetracycline; Pyoderma; Skin; Staphylococcal Infections; Staphylococcus aureus

Topics: Acne Vulgaris; Administration, Topical; Adolescent; Alopecia; Anti-Inflammatory Agents; Cheilitis; Child; Child, Preschool; Dermatitis; Dermatitis, Contact; Dermatitis, Exfoliative; Eczema; Eczema, Dyshidrotic; Female; Herpes Zoster; Humans; Hydrocortisone; Infant; Infant, Newborn; Male; Neurodermatitis; Ointments; Oxytetracycline; Pityriasis; Prednisolone; Pyoderma; Skin Diseases

Topics: Adult; Diagnosis, Differential; Facial Dermatoses; Humans; Male; Oxytetracycline; Pyoderma; Vaccinia virus

Topics: Abortion, Septic; Anti-Bacterial Agents; Bile Ducts; Chloramphenicol; Emetine; Escherichia coli Infections; Female; Humans; Kanamycin; Neomycin; Oxytetracycline; Paraplegia; Penicillins; Peritonitis; Pregnancy; Pressure Ulcer; Pseudomonas Infections; Pyelonephritis; Pyoderma; Staphylococcal Infections; Streptococcal Infections; Streptomycin; Tetracycline

Topics: Abscess; Adolescent; Aerosols; Child; Eczema; Herpes Zoster; Humans; Hydrocortisone; Infant; Nebulizers and Vaporizers; Ointments; Oxytetracycline; Pharyngitis; Pyoderma; Varicose Ulcer

Topics: Child; Humans; Infant; Oxytetracycline; Pyoderma

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Erythromycin; Humans; Neomycin; Oxytetracycline; Pyoderma

Topics: Bacteriology; Chlortetracycline; Female; Humans; Mastitis; Mothers; Oxytetracycline; Pyoderma