oxytetracycline--anhydrous and Puerperal-Disorders

Holstein cows (n = 51) that had been diagnosed with toxic puerperal metritis were used to determine the treatment efficacy of various antibiotics. On the day of diagnosis, cows affected with toxic puerperal metritis were assigned randomly to three treatment groups. Cows in groups 1 and 2 received 22,000 IU/kg of procaine penicillin G i.m. for 5 d. In addition, cows in group 2 received an intrauterine infusion of 6 g of oxytetracycline on d 1, 3, and 5. Cows in group 3 received 2.2 mg/kg of ceftiofur sodium i.m. for 5 d. Dependent variables used to determine antibiotic efficacy included milk yield on d 1 through 12, rectal temperature on d 1 through 5, and serum haptoglobin concentration on d 1, 3, and 5. No difference was observed among groups for milk yield on d 1 and 12 or for temperature on d 1 and 5. Serum haptoglobin was elevated to > 10 mg/dl for cows in all groups; however, no difference was observed among groups on d 1 and 5. Because all groups showed a favorable response, this study suggests that there is no difference in treatment efficacy among antibiotics used to treat cows affected with toxic puerperal metritis.

Topics: Animals; Anti-Bacterial Agents; Body Temperature; Cattle; Cattle Diseases; Cephalosporins; Endometritis; Female; Haptoglobins; Metrial Gland; Oxytetracycline; Penicillin G Procaine; Puerperal Disorders

Sixteen dairy cows with chronic puerperal endometritis between 3 and 8 weeks post partum were treated with intra-uterine applied oxytetracycline (OTC) and lugol. OTC was rapidly removed from plasma and was not detectable after 48 hours. The concentration of OTC in milk did not exceed 40 micrograms/kg, and it was still detectable in milk 34 hours after treatment. The concentration of OTC in milk was always lower than the limit of 50 micrograms/kg used by milk-testing stations and the European limit (MRL) of 100 micrograms/kg. Milk from cows treated with lugol did not cause inhibition in the plate test.

Topics: Administration, Topical; Animals; Cattle; Cattle Diseases; Endometritis; Female; Iodine Compounds; Oxytetracycline; Puerperal Disorders; Uterus

Factors associated with foot abscess were evaluated in a cohort of 3,322 suckling pigs reared on a woven-wire floor (wire diameter, 0.5 cm; size of openings, 1 x 3.8 cm). In bivariate analysis, foot abscess was significantly (P < 0.05) associated with postpartum sow illness, number of pigs born alive, and parity, but not with birthweight (P = 0.31) or time spent on wire flooring (P = 0.89). One oxytetracycline treatment (100 mg, IM) at birth or 1 treatment at birth and a second 5 to 7 days later reduced (P < 0.05) the risk of lesions by about half. Multivariate analyses indicated that pigs in large litters (> 10 pigs at birth) born to sows with postpartum illnesses had an increased risk (relative risk [RR], 3.77) of developing foot abscess, compared with pigs in small litters (< or = 10 pigs) born to unaffected sows. For sows without evidence of postpartum illness, pigs in large litters had a slightly increased risk (RR, 1.32) of developing foot abscess, compared with pigs in small litters. Pigs born to multiparous sows also had an increased risk (RR, 1.69) of developing foot abscess, compared with pigs born to primiparous sows. Similar risk estimates were obtained when logistic regression models included location farrowed (crate number) as a fixed effect, and when litter was a random effect in a logistic-binomial regression.

Topics: Abscess; Analysis of Variance; Animals; Animals, Newborn; Animals, Suckling; Cohort Studies; Female; Foot Diseases; Housing, Animal; Incidence; Litter Size; Male; Oxytetracycline; Parity; Puerperal Disorders; Regression Analysis; Risk Factors; Swine; Swine Diseases

A combination of neomycin and metronidazole was compared with oxytetracycline for its activity against the intrauterine flora of 10 cows with retained placenta. In vitro the metronidazole/neomycin combination reduced the numbers of aerobic and obligately anaerobic bacteria much more effectively than did oxytetracycline.

Topics: Animals; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Cattle; Cattle Diseases; Drug Therapy, Combination; Female; Metronidazole; Neomycin; Oxytetracycline; Placenta Diseases; Pregnancy; Puerperal Disorders; Uterine Diseases

Topics: Female; Humans; Oxytetracycline; Pregnancy; Pregnancy Complications, Infectious; Puerperal Disorders

Topics: Animals; Cattle; Cattle Diseases; Female; Oxytetracycline; Pregnancy; Pregnancy, Animal; Puerperal Disorders