oxytetracycline--anhydrous and Pneumonia

Respiratory infections are the main indication for antimicrobial use in calves. Optimal treatment duration currently is unknown, but shorter duration would likely decrease selection for antimicrobial resistance.. Determine differences in cure rate and healing time between animals treated with florfenicol and oxytetracycline in a natural outbreak of respiratory disease using reaeration observed on thoracic ultrasound examination as healing criterion.. Commercial farm housing 130, 3 to 9 month old Belgian blue beef calves.. Randomized clinical trial during an outbreak of respiratory disease. Metaphylactic treatment was initiated, randomly treating animals with either florfenicol or oxytetracycline. Ultrasonographic follow-up was done the first day and every other day for a 14-day period. At the individual animal level, treatment was discontinued when reaeration of the lungs occurred. Differences in cure rate and healing time were determined.. Of the 130 animals studied, 67.7% developed a lung consolidation ≥0.5 cm. The mean ultrasonographic healing time was 2.5 days in the florfenicol group compared to 3.1 days in the oxytetracycline group (P = .04). After single treatment, 80.6% and 60.3% had no consolidations in the florfenicol and oxytetracycline groups, respectively (P = .01). A Mycoplasma bovis strain was genetically and phenotypically determined to be susceptible to both antimicrobials.. Ultrasonographic lung reaeration shows potential as a cure criterion to rationalize antimicrobial use for outbreaks of pneumonia. In our study, florfenicol resulted in a faster cure and higher reduction in antimicrobial usage than did oxytetracycline.

Topics: Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Disease Outbreaks; Lung; Oxytetracycline; Pneumonia; Thiamphenicol

The experiment was set up to make a clinical comparison in 140 pneumonic calves of two injectable oxytetracycline formulations with different pharmacokinetic properties: Engemycin 10% DD and Terramycin LA. The animals were examined clinically on the day of admission (day 0) and 1, 2, 3, 6 and 21 days thereafter. Calves were treated on day 0 with either Engemycin 10% DD (n = 70) or Terramycin LA (n = 70) at a dose of 20 mg/kg. If animals were not cured after one single injection, a second or even third injection was given at day 3 and day 6 respectively. No significant differences between the two treatment groups were found with regard to the number of injections needed for a complete cure, the evolution of dyspnoea, or the restoration of appetite. Thus both preparations gave comparable recovery rates. A difference between the two groups existed in the evolution of body temperature during the test period: the return to a normal body temperature occurred more rapidly in the Engemycin 10% DD group. Regarding the tolerance aspects the degree of irritation depended in the preparation used. Calves treated with Engemycin 10% DD showed significantly less swelling of the injection site on day 1 then calves treated with Terramycin LA.

Topics: Animals; Appetite; Biological Availability; Body Temperature; Cattle; Cattle Diseases; Dyspnea; Fever; Injections, Intramuscular; Oxytetracycline; Pneumonia

The prophylactic administration of injectable tilmicosin for pneumonia in weaned beef calves was investigated in 1,806 animals. Comparisons were made among calves receiving an "on-arrival" injection of tilmicosin, calves receiving a single injection of long-acting oxytetracycline, and calves receiving no prophylaxis. Morbidity and mortality attributable to pneumonia, morbidity and mortality attributable to all causes, and case fatality were significantly lower in the group of calves that received tilmicosin, compared with calves that received long-acting oxytetracycline and calves that received no prophylactic antibiotic. Mean time to initial pneumonia treatment was significantly extended in calves that received prophylaxis, compared with those that received no antibiotic on arrival at the feedlot. Calves that received tilmicosin gained significantly more weight than calves that received oxytetracycline. Calves that were not treated for pneumonia during the trial period gained significantly more weight than did those calves that were treated for pneumonia regardless of experimental group. The majority of mortalities were attributable to fibrinous pneumonia (31/34). Important bacterial isolates (Pasteurella spp, Haemophilus somnus, Actinomyces pyogenes) obtained at necropsy did not have resistance to tilmicosin in association with administration of tilmicosin as prophylaxis for pneumonia. However, bacterial resistance to trimethoprim/sulfonamide and to oxytetracycline were commonly found in these postmortem isolates.

Topics: Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Injections; Macrolides; Male; Oxytetracycline; Pneumonia; Respiratory Tract Infections; Tylosin

Topics: Adolescent; Adult; Child; Child, Preschool; Chloramphenicol; Clinical Trials as Topic; Drug Resistance, Microbial; Escherichia coli; Female; Humans; In Vitro Techniques; Infant; Infant, Newborn; Infections; Male; Meningitis; Myelitis; Oleandomycin; Oxytetracycline; Peritonitis; Pneumonia; Postoperative Complications; Proteus; Pseudomonas; Staphylococcal Infections; Staphylococcus; Streptococcus; Streptomycin; Suppuration

Topics: Animals; Anti-Bacterial Agents; Body Temperature; Cattle; Cattle Diseases; Disease Outbreaks; Macrolides; Oxytetracycline; Pneumonia; Tylosin

The treatment of an outbreak of acute pneumonia in 50 four- to eight-month-old Friesian and Friesian cross calves is described. At the first visit (day 0) 16 calves received 20 mg/kg bodyweight of oxytetracycline dihydrate intramuscularly and 15 received 10 mg/kg of the macrolide tilmicosin subcutaneously. The remaining 19 in-contact animals were not considered ill enough to be included in the trial and received 20 mg/kg of oxytetracycline dihydrate. The rectal temperature, demeanour, respiratory rate and respiratory effort of each calf was assessed on days 1, 2, 3, 9, 14, 21 and 28, and calves which had not responded were given repeat injections of the same antibiotic. All the calves recovered from the outbreak and of the 19 calves treated strategically, three required a second injection. Among the calves with clinical pneumonia, fewer treatments (P less than 0.01) were required by those treated with tilmicosin. The rectal temperatures of both groups decreased (P less than 0.05) after the first injection, but on day 3 the decrease was greater (P less than 0.05) in the group treated with tilmicosin. Respiratory rates varied widely but respiratory effort was less (P less than 0.05) on day 2 in the calves treated with tilmicosin. When long-acting antibiotic injections are used to treat enzootic pneumonia it is suggested that a second visit should be made on day 3 to assess the animals' response to treatment.

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Delayed-Action Preparations; Disease Outbreaks; Injections, Intramuscular; Injections, Subcutaneous; Macrolides; Oxytetracycline; Pneumonia; Respiration; Tylosin

Danofloxacin, a novel fluoroquinolone antimicrobial drug was evaluated in the treatment of acute bacterial pneumonia in recently housed beef cattle of approximately 300 kg liveweight. The clinical responses of 67 pneumonic cattle treated with danofloxacin were compared with those of 65 cattle treated with oxytetracycline, both treatments being given by intramuscular injection for either three or five days, depending on clinical response. Both treatments resulted in a rapid fall in group mean rectal temperature and improved the clinical condition of the majority of cases. However, in comparison with oxytetracycline, danofloxacin therapy was characterised by significantly fewer treatment days, a higher response rate, significantly better reduction of pyrexia and fewer cattle requiring re-treatment.

Topics: 4-Quinolones; Acute Disease; Animals; Anti-Infective Agents; Bacterial Infections; Body Temperature; Cattle; Cattle Diseases; Drug Evaluation; Fever; Fluoroquinolones; Housing, Animal; Oxytetracycline; Pneumonia

The pharmacokinetics of oxytetracycline (OTC) were studied in healthy pigs and in pigs endobronchially inoculated with Actinobacillus pleuropneumoniae toxins. In two groups of seven pigs OTC was administered intravenously in a single dose of 10 or 50 mg/kg, respectively. OTC was administered to clinically healthy pigs and 7 days later at 3 h after a challenge with A. pleuropneumoniae toxins. Pneumonia developed in toxin-treated pigs. In the challenged pigs there was a decreased distribution-rate constant (alpha) and a significantly increased elimination-rate constant (beta) (P less than 0.05). Moreover, the apparent volume of distribution (Vd beta) was decreased. The elimination half-lives (t1/2 beta) were approximately 6 h in the healthy pigs and 5 h in the diseased animals. There was no difference in the pharmacokinetic profile of OTC following administration of 50 mg/kg compared to 10 mg/kg.

Topics: Actinobacillus Infections; Animals; Dose-Response Relationship, Drug; Half-Life; Injections, Intravenous; Male; Oxytetracycline; Pneumonia; Swine; Swine Diseases; Tissue Distribution

The serum bactericidal activity test was carried out in two groups of 7 calves each suspected to be suffering from pneumonic pasteurellosis. The diagnosis was based on clinical signs, endoscopic examination and bacteriological investigations. The first group of seven calves received oxytetracycline at a dosage rate of 10 mg kg-1 once a day. A second similar group received penicillin at 30,000 IU kg-1 once a day. Results showed that the correlation between antibiograms, serum bactericidal activity and clinical response may be good for oxytetracyclines and poor for penicillin. The serum bactericidal activity test may be a good method to establish effective dosages for certain antibiotics in the treatment of pneumonic pasteurellosis.

Topics: Animals; Cats; Cattle; Cattle Diseases; Oxytetracycline; Pasteurella; Pasteurella Infections; Penicillins; Pneumonia

The effects of pneumonia on the pharmacokinetics of chloramphenicol, lincomycin, and oxytetracycline were evaluated in two-month-old calves. Pneumonia was induced by injection of Pasteurella haemolytica cultures directly through the thoracic wall into each lung. Six days prior to induction of pneumonia, the antibiotics were administered in a single i.v. dose. The antibiotics were administered again 48 (i.v.), 60 and 72 h (i.m.) following injection of P. haemolytica. The pharmacokinetics of chloramphenicol (25 mg/kg) and lincomycin (10 mg/kg) were not significantly different in calves with pneumonia. The hybrid rate constant beta for oxytetracycline was increased in calves with pneumonia from 0.0034 +/- 0.0003/min to 0.0048 +/- 0.0007/min between 2 h and 8 h. Thus the elimination half-life in serum was shortened from 212.4 +/- 20.3 min to 149.3 +/- 19.5 min. In addition, there was an apparent but not statistically significant decrease in K12 with pneumonia. These findings accentuate the need for observance of 12-h dose intervals with oxytetracycline.

Topics: Animals; Cattle; Cattle Diseases; Chloramphenicol; Kinetics; Lincomycin; Oxytetracycline; Pasteurella Infections; Pneumonia

A method to produce bovine pneumonic pasteurellosis for experimental purposes was studied and the clinical response of experimentally infected calves to selected antimicrobials was characterized. Male Holstein calves stressed with multiple hot and cold water applications followed by intratracheal inoculation of broth cultures of Pasteurella multocida serotype B developed acute clinical illness consistent with pneumonia. Infected, untreated calves consistently developed classic pneumonic pasteurellosis, infected calves treated with either oxytetracycline or sulfadimethoxine recovered from acute clinical disease, and the uninfected controls remained healthy. This disease model offers potential for use in pharmacokinetic and target tissue drug concentration studies and for dosage titration of drugs intended for treatment of bacterial pneumonias.

Topics: Acute Disease; Animals; Animals, Newborn; Cattle; Cattle Diseases; Lung; Male; Oxytetracycline; Pasteurella Infections; Pneumonia; Sulfadimethoxine

Topics: Animals; Drug Resistance, Microbial; Male; Oxytetracycline; Pasteurella; Pasteurella Infections; Pneumonia; Pyrrolidinones; Swine; Swine Diseases

Pneumonia was induced in a group of calves that were then treated with oxytetracycline (OTC). When the plasma pharmacokinetics and tissue concentrations of this group were compared with those of healthy controls, obvious differences were observed. The volume of distribution and the half-life of OTC were increased in the group with pneumonia. Tissue concentrations of OTC (1.48 +/- 0.29 microgram/ml) were greater in the lungs of calves with pneumonia than that in the lungs (1.09 +/- 0.09 microgram/ml) of healthy controls. For the dose of OTC used, the correlation between serum concentration and tissue concentrations at 24 hours was poor. Seemingly, current concepts of antibiotic dosages and dosage intervals may be inadequate because they are based on blood and tissue values of healthy animals.

Topics: Animals; Cattle; Cattle Diseases; Half-Life; Male; Oxytetracycline; Pasteurella Infections; Pneumonia; Tissue Distribution

Two groups of 10, specific pathogen free lambs were injected with a long acting oxytetracycline preparation at a dose rate of 20 mg/kg either 24 hours before or 24 hours after exposure to an aerosol of Pasteurella haemolytica. When compared with the response of similarly infected but untreated lambs, the effect of pretreatment was to postpone the appearance of clinical signs of pneumonia for four days and the deaths of five lambs for five to six days post infection, by which time seven untreated lambs had died. Treatment 24 hours after infection caused a rapid clinical recovery which persisted until six days after infection but two treated lambs died seven days after infection. Lung lesions in the group treated after infection were significantly less extensive than those in the untreated lambs.

Topics: Animals; Lung; Oxytetracycline; Pasteurella Infections; Pneumonia; Sheep; Sheep Diseases; Specific Pathogen-Free Organisms

Topics: Animals; Oxytetracycline; Pneumonia; Swine; Swine Diseases

Topics: Ampicillin; Anti-Bacterial Agents; Floxacillin; Gentamicins; Haemophilus Infections; Haemophilus influenzae; Humans; Klebsiella Infections; Klebsiella pneumoniae; Mycoplasma Infections; Oxytetracycline; Penicillin G; Penicillin Resistance; Pneumonia; Streptococcal Infections

The effects in mice of oral treatment with amoxicillin, ampicillin, and oxytetracycline against an otherwise lethal intranasal infection with Chlamydia trachomatis (mouse pneumonitis) were studied. When treatment was started 30 min after infection and continued once daily thereafter for a total of seven treatments, the mean protective doses of amoxicillin, ampicillin, and oxytetracycline were 9.5, greater than 50, and 31.3 mg/kg, respectively. If 14 oral treatments were given, these values were 1.6 mg/kg for amoxicillin, 12.7 mg/kg for ampicillin, and 12.3 mg/kg for oxytetracycline.

Topics: Administration, Oral; Amoxicillin; Ampicillin; Animals; Chlamydia Infections; Chlamydia trachomatis; Disease Models, Animal; Mice; Oxytetracycline; Pneumonia

Topics: Animals; Anti-Bacterial Agents; Diterpenes; Leucomycins; Mycoplasma; Mycoplasma Infections; Oxytetracycline; Pneumonia; Swine; Swine Diseases

Topics: Adolescent; Adult; Child; Disease Outbreaks; England; Erythromycin; Female; Humans; Male; Mycoplasma Infections; Oxytetracycline; Pneumonia; Pregnancy; Pregnancy Complications, Infectious; Recurrence; Tetracycline

The case of a patient with ornithosis pneumonia associated with a haemolytic anaemia is described. The infection responded to oxytetracycline and the anaemia subsequently resolved.

Topics: Anemia, Hemolytic; Hemolysis; Humans; Male; Middle Aged; Oxytetracycline; Pneumonia; Psittacosis

An outbreak of acute severe pneumonia which affected six to 14-week-old single-suckled calves, resulted in 45/77 requiring treatment. The examination of paired sera from all affected calves revealed that neither an adenovirus, non infectious bovine rhinotracheitis virus nor parainfluenza 3 virus was involved. The acute exudative interstitial pneumonia found at post mortem was typical of pneumonic pasteurellosis.

Topics: Animals; Cattle; Cattle Diseases; Disease Outbreaks; Female; Lung; Oxytetracycline; Parainfluenza Virus 3, Human; Pneumonia

Topics: Female; Hemorrhagic Disorders; Humans; Middle Aged; Oxytetracycline; Pneumonia

Topics: Ampicillin; Animals; Animals, Newborn; Anti-Bacterial Agents; Bronchopneumonia; Chloramphenicol; Corneal Ulcer; Diarrhea; Enteritis; Female; Horse Diseases; Horses; Male; Oxytetracycline; Penicillin Resistance; Penicillins; Pleurisy; Pneumonia; Pneumonia, Aspiration; Pneumonia, Pneumocystis; Postoperative Complications; Salmonella Infections, Animal; Sepsis; Streptococcal Infections; Uterine Diseases

Topics: Animal Nutritional Physiological Phenomena; Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Infectious Bovine Rhinotracheitis; Oxytetracycline; Pasteurella Infections; Pneumonia; Respiratory Tract Infections; Vaccination

Topics: Acute Disease; Adult; Ascorbic Acid; Ascorbic Acid Deficiency; Humans; Oxytetracycline; Penicillins; Pneumonia; Streptomycin

Topics: Animals; Cattle; Cattle Diseases; Oxytetracycline; Pneumonia

Acholeplasma axanthum sp. was isolated from the lung of swine with catarrhal pneumonia. Clinical symptoms of respiratory disease, gross and histological lesions of pneumonia, as well as serological response were produced by intranasal inoculation of ;miniature pigs' with the supernatant of lung suspension containing Acholeplasma axanthum and by a 48 hr. broth culture of the strain.A similar picture of disease was observed in animals held in contact with the animals inoculated with untreated lung suspension. Acholeplasma axanthum was isolated from the nasal cavity, lung and peribronchial lymph nodes 7-41 days after inoculation. No lesions were observed after inoculation of pigs with the supernatant of lung suspension pretreated with oxytetracycline or chloroform, and no successful isolation of Acholeplasma axanthum could be achieved after this treatment.

Topics: Animals; Bronchi; Chloroform; Fever; Hemagglutination Tests; Lung; Lymph Nodes; Mycoplasma; Nasal Mucosa; Oxytetracycline; Pneumonia; Pulmonary Alveoli; Swine; Swine Diseases

Topics: Animals; Autopsy; Chick Embryo; Chlamydia; Chlamydia Infections; Disease Models, Animal; Female; Histological Techniques; Lung; Male; Mice; Oxytetracycline; Pneumonia; Time Factors; Vitelline Membrane

Topics: Anti-Bacterial Agents; Bacteria; Candidiasis; Cross Infection; Enterobacter; Female; Haemophilus influenzae; Humans; Klebsiella pneumoniae; Male; Microbial Sensitivity Tests; Mutation; Mycoplasma Infections; Oxytetracycline; Penicillin Resistance; Penicillins; Pneumonia; Staphylococcal Infections; Staphylococcus; Streptococcus pneumoniae; Streptococcus pyogenes; Streptomycin; Tetracycline

Topics: Adult; Drug Resistance, Microbial; Erythromycin; Female; Fever; Humans; Male; Middle Aged; Mycoplasma; Mycoplasma Infections; Oxytetracycline; Pneumonia

Topics: Adolescent; Adult; Age Factors; Aged; Biopsy; Bronchial Neoplasms; Bronchoscopy; Chloramphenicol; Chronic Disease; Diagnosis, Differential; Female; Humans; Leukocytosis; Male; Middle Aged; Oxytetracycline; Pneumonia; Radiography; Sex Factors; Time Factors; Tuberculosis, Pulmonary

Topics: Drug Synergism; Erythromycin; Humans; Leukemia; Myeloproliferative Disorders; Oxytetracycline; Pharyngitis; Pneumonia; Respiratory Tract Infections; Tonsillitis

Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; Bronchiectasis; Bronchitis; Cephaloridine; Chloramphenicol; Chronic Disease; Cloxacillin; Erythromycin; Humans; Lactose; Methicillin; Oxytetracycline; Penicillin G; Penicillin Resistance; Pneumonia; Pneumonia, Staphylococcal; Pneumonia, Viral; Streptomycin; Tetracycline

Topics: Bronchitis; Cholecystectomy; Doxycycline; Female; Humans; Male; Oxytetracycline; Pneumonia; Postoperative Complications; Rectal Neoplasms; Sigmoid Neoplasms; Urinary Tract Infections

Topics: Adrenocorticotropic Hormone; Blood Cell Count; Blood Transfusion; Bone Marrow Examination; Coombs Test; Edema; Female; Fever; Humans; Infant; Kidney; Liver; Lung; Lymph Nodes; Lymphatic Diseases; Male; Oxytetracycline; Penicillins; Pneumonia; Prednisone; Spleen

Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Bacteria; Chloramphenicol; Chlortetracycline; Depression, Chemical; Enterococcus faecalis; Erythromycin; Erythromycin Ethylsuccinate; Female; Furazolidone; Humans; Male; Middle Aged; Neomycin; Nitrofurantoin; Oleandomycin; Oxytetracycline; Penicillin G; Penicillin Resistance; Penicillins; Pneumonia; Polymyxins; Ristocetin; Staphylococcus; Streptococcus; Streptomycin; Tetracycline; Urine

Topics: Adolescent; Adult; Doxycycline; Female; Humans; Male; Mycoplasma Infections; Oxytetracycline; Pneumonia

Topics: Ampicillin; Child; Child, Preschool; Chloramphenicol; Chlortetracycline; Drug Synergism; Humans; Infant; Nasal Mucosa; Oxytetracycline; Penicillinase; Penicillins; Pneumonia; Time Factors; Whooping Cough

Topics: Bronchitis; Child; Child, Preschool; Female; Humans; Infant; Otitis; Oxytetracycline; Pneumonia; Respiratory Tract Infections; Urinary Tract Infections

Topics: Bronchitis; Child; Child, Preschool; Humans; Infant; Oxytetracycline; Pneumonia; Pyuria; Respiratory Tract Infections

Topics: Bronchography; Caffeine; Child, Preschool; Female; Humans; Infant; Leukocytosis; Lymphocytosis; Male; Oxygen Inhalation Therapy; Oxytetracycline; Penicillins; Petroleum; Pneumonia; Promethazine; Pulmonary Emphysema; Tachycardia; Tetracycline

Topics: Animals; Anti-Bacterial Agents; Bacteria; Dihydrostreptomycin Sulfate; Mycoplasma; Mycoplasma Infections; Oxytetracycline; Penicillin G; Penicillin Resistance; Pneumonia; Swine; Swine Diseases

Topics: Anti-Bacterial Agents; Bacteria; Chloramphenicol; Chlortetracycline; Erythromycin; Erythromycin Ethylsuccinate; Escherichia coli; Klebsiella; Neomycin; Oleandomycin; Oxytetracycline; Penicillin Resistance; Penicillins; Pneumonia; Proteus; Pseudomonas; Saccharomyces; Sputum; Staphylococcus; Streptococcus; Streptococcus pneumoniae; Streptomycin; Tetracycline

Topics: Animals; Oxytetracycline; Pneumonia; Rhinitis; Snakes

Topics: Anti-Bacterial Agents; Austria; Bronchitis; Chloramphenicol; Erythromycin; Humans; Lung Abscess; Morbidity; Mortality; Mouth Mucosa; Oxytetracycline; Penicillin Resistance; Penicillins; Pneumonia; Public Health; Pyelonephritis; Saliva; Streptomycin

Topics: Adolescent; Adult; Aged; Bronchiolitis, Viral; Bronchitis; Child; Child, Preschool; Complement Fixation Tests; Female; Germany, East; Humans; Infant; Infant, Newborn; Laryngitis; Male; Middle Aged; Mycoplasma; Mycoplasma Infections; Oxytetracycline; Pneumonia; Rhinitis; Tracheitis

Topics: Humans; Military Medicine; Oxytetracycline; Pneumonia; USSR

Topics: Anti-Bacterial Agents; Antitubercular Agents; Asthma; Bronchiectasis; Bronchitis; Chloramphenicol; Chlortetracycline; Chymotrypsin; Empyema; Humans; Hydrocortisone; Kanamycin; Oxytetracycline; Penicillins; Peptide Hydrolases; Pleurisy; Pneumonia; Pulmonary Emphysema; Respiratory System; Respiratory Tract Diseases; Tuberculosis; Tuberculosis, Pulmonary

Topics: Bacteriophage Typing; Biomedical Research; Carrier State; Child; Chlortetracycline; Drug Resistance; Drug Resistance, Microbial; Humans; Infant; Meningitis; Mice; Oxytetracycline; Penicillins; Pneumonia; Pneumothorax; Sepsis; Staphylococcal Infections; Staphylococcus; Staphylococcus Phages; Streptomycin; Virulence

Topics: Agricultural Workers' Diseases; Ambroxol; Dust; Farmer's Lung; Gas Poisoning; Humans; Hypersensitivity; Lung Diseases; Nitrogen; Nitrogen Dioxide; Oxygen Inhalation Therapy; Oxytetracycline; Pathology; Penicillins; Pneumonia; Radiography, Thoracic; Silo Filler's Disease; Toxicology; Tuberculin Test

Topics: Acidosis; Cesarean Section; Fatty Liver; Female; Hematemesis; Humans; Hypoproteinemia; Hypotension; Hysterectomy; Jaundice; Liver Diseases; Melena; Oxytetracycline; Pathology; Placenta Previa; Pneumonia; Postpartum Hemorrhage; Postpartum Period; Pregnancy; Pregnancy Complications; Tetracycline; Toxicology

Topics: Child; Humans; Infant; Oxygen Inhalation Therapy; Oxytetracycline; Pneumonia; Positive-Pressure Respiration; Respiration; Respiration, Artificial; Sulfonamides; Tracheotomy; Ventilators, Mechanical

Topics: Asthma; Biomedical Research; Bronchitis; Bronchopneumonia; Child; Chlortetracycline; Double-Blind Method; Drug Therapy; Escherichia coli; Haemophilus influenzae; Humans; Nasopharynx; Oxytetracycline; Pneumonia; Preventive Medicine; Proteus; Pseudomonas; Radiography, Thoracic; Staphylococcus; Streptococcus pneumoniae; Toxicology

Topics: Biomedical Research; Blood; Drug Therapy; Metabolism; Niacinamide; Oxytetracycline; Pharmacology; Pneumonia; Streptomycin

Topics: Bacteriophage Typing; Child; Chloramphenicol; Chlortetracycline; Drug Resistance; Drug Resistance, Microbial; Oxytetracycline; Pneumonia; Staphylococcal Infections; Staphylococcus; Statistics as Topic; Streptomycin

Topics: Animals; Animals, Newborn; Bronchitis; gamma-Globulins; Immunoelectrophoresis; Microscopy, Electron; Oxytetracycline; Plasma Cells; Pneumonia; Rats; Thymectomy; Ultracentrifugation

Topics: Anti-Bacterial Agents; Bacteria; Humans; Methacycline; Oxytetracycline; Pneumococcal Infections; Pneumonia; Pyelonephritis

Topics: Anti-Bacterial Agents; Child; Chlorpromazine; Erythromycin; gamma-Globulins; Infant; Infant, Newborn; Oxytetracycline; Penicillins; Pneumococcal Infections; Pneumonia; Pneumonia, Viral; Staphylococcal Infections; Streptomycin; Tetracycline

Topics: Animals; Epidemics; Humans; Occupational Diseases; Oxytetracycline; Pneumonia; Pneumonia, Viral; Poultry Diseases; Psittacosis; Radiography, Thoracic

Topics: Bronchial Diseases; Bronchopneumonia; Child; Dyspnea; Encephalitis; Foreign Bodies; Gastroenteritis; Humans; Laryngitis; Meningococcal Infections; Osteomyelitis; Otolaryngology; Oxytetracycline; Pediatrics; Pneumonia; Pneumonia, Pneumococcal; Salmonella Infections; Staphylococcal Infections; Whooping Cough

Topics: Arthritis; Chloramphenicol; Humans; Neuritis; Neurologic Manifestations; Oxytetracycline; Paralysis; Pneumonia; Pneumonia, Viral; Polyradiculopathy; Psittacosis

Topics: Bacteriology; Child; Chloramphenicol; Drainage; Empyema; Epidemiology; Erythromycin; Humans; Infant; Lung Abscess; Lung Diseases; Oxytetracycline; Pathology; Penicillins; Pleural Effusion; Pneumonia; Sepsis; Staphylococcal Infections; Streptomycin; Toxicology

Topics: Burns; Candidiasis; Chloramphenicol; Chlortetracycline; Escherichia coli Infections; Humans; Influenza, Human; Klebsiella; Oximetry; Oxygen Inhalation Therapy; Oxytetracycline; Penicillins; Pneumococcal Infections; Pneumonia; Proteus Infections; Pseudomonas Infections; Staphylococcal Infections; Statistics as Topic; Streptococcal Infections; Streptomycin; Sulfanilamide; Sulfanilamides

Topics: Bronchi; Bronchial Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Diagnosis, Differential; Humans; Neoplasms; Oxytetracycline; Pneumonia

Topics: Anti-Bacterial Agents; Chlortetracycline; Erythromycin; Humans; Mycoplasma Infections; Oxytetracycline; Pneumonia; Pneumonia, Mycoplasma; Tetracycline

Topics: Bronchitis; Humans; Influenza, Human; Oxytetracycline; Pneumonia

Topics: Humans; Oxytetracycline; Pneumonia; Purpura, Thrombocytopenic

Topics: Chloramphenicol; Chlortetracycline; Humans; Influenza, Human; Mycoplasma Infections; Oxytetracycline; Penicillins; Pneumonia; Pneumonia, Bacterial; Pneumonia, Mycoplasma

Topics: Anti-Bacterial Agents; Chloramphenicol; Chlortetracycline; Humans; Oxytetracycline; Penicillins; Pneumonia; Pneumonia, Pneumococcal

Topics: Animals; Bacteriology; Brucella; Oxytetracycline; Pneumonia; Rats

Topics: Humans; Measles; Oxytetracycline; Pneumonia

Topics: Aerosols; Child; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Oxytetracycline; Plasma Cells; Pneumonia; Pneumonia, Pneumocystis

Topics: Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Chloramphenicol; Chlortetracycline; Oxytetracycline; Penicillins; Pneumonia; Streptomycin

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Child; Chlortetracycline; Dyspepsia; Gastrointestinal Diseases; Infant; Measles; Oxytetracycline; Pneumonia; Pneumonia, Mycoplasma

Topics: Child; Infant; Oxytetracycline; Pneumonia

Topics: Oxytetracycline; Pneumonia

Topics: Chloramphenicol; Chlortetracycline; Humans; Influenza, Human; Lung Diseases, Interstitial; Oxytetracycline; Pneumonia; Pneumonia, Bacterial; Pneumonia, Mycoplasma

Topics: Animals; Cats; Chlortetracycline; Oxytetracycline; Pneumonia

Topics: Anti-Bacterial Agents; Chlortetracycline; Humans; Incidence; Oxytetracycline; Penicillins; Pneumococcal Infections; Pneumonia; Sulfanilamide; Sulfanilamides; Sulfonamides

Topics: Oxytetracycline; Pneumonia

Topics: Oxytetracycline; Pneumonia; Pneumonia, Pneumococcal

Topics: Humans; Influenza, Human; Lung Diseases, Interstitial; Mycoplasma Infections; Oxytetracycline; Pneumonia; Pneumonia, Mycoplasma; Pneumonia, Viral

Topics: Oxytetracycline; Pneumococcal Vaccines; Pneumonia; Pneumonia, Bacterial; Streptococcus pneumoniae

Topics: Animals; Cats; Chloramphenicol; Chlortetracycline; Mice; Oxytetracycline; Pneumonia

Topics: Oxytetracycline; Pneumonia

Topics: Biomedical Research; Oxytetracycline; Pneumonia; Pneumonia, Viral

Topics: Humans; Influenza, Human; Mycoplasma Infections; Oxytetracycline; Pneumonia; Pneumonia, Bacterial; Pneumonia, Mycoplasma

Topics: Oxytetracycline; Pneumonia