oxytetracycline--anhydrous and Papilloma

To compare the effectiveness of lincomycin and oxytetracycline for treatment of digital dermatitis (DD) in dairy cows through gross visual examination, histologic evaluation, and bacteriologic evaluation.. Randomized controlled clinical trial.. 25 cows with DD lesions from a commercial Holstein dairy herd.. Cows with DD lesions were randomly assigned to 1 of 3 groups: topical treatment with 10 g of lincomycin hydrochloride (n = 11), topical treatment with 10 g of oxytetracycline hydrochloride (11), and no treatment (3) on days 1 and 2 (d1). Biopsy specimens were obtained for histologic examination from DD lesions prior to treatment and 28 or 31 days (d30) after treatment for histologic examination. Cows were clinically examined on d1, days 12 or 14 (d14), and d30.. No difference was evident in clinical responses to lincomycin and oxytetracycline, so data were pooled; at d30, 8 of 11 of lincomycin-treated lesions and 7 of 11 oxytetracycline-treated lesions appeared visually healed, respectively. Gross visual examination suggested 73% (16/22) of treated cows were healed at d14 and 68% (15/22) of treated cows were healed on d30. Of the 15 lesions that appeared healed on d30, 7 of 15 were classified histologically as active (ulceration and bacterial invasion; 2/15) or incipient (5/15).. Clinical responses to lincomycin and oxytetracycline did not differ. Agreement was good between gross visual and histologic assessments of DD lesions before treatment; agreement 1 month after treatment was variable. Histologic evaluation could not distinguish incomplete healing from lesion recurrence.

Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Dairying; Dermatitis; Female; Foot Dermatoses; Hoof and Claw; Lincomycin; Oxytetracycline; Papilloma

To evaluate efficacy of topical treatment with oxytetracycline solution among dairy cows with papillomatous digital dermatitis (PDD) lesions on the interdigital cleft, heels, or dewclaw.. Clinical trial.. 70 dairy cows from a single herd.. On the basis of anatomic location of PDD lesions, cows were allocated into 1 of 3 groups (interdigital cleft [n = 14], heels [30], or dewclaw [26]) and treated topically with oxytetracycline solution. Cows were examined 14 and 30 days after initial treatment. During each examination, pain and lesion size scores were recorded.. On the basis of pain and lesion size scores, oxytetracycline appeared significantly less effective among cows with lesions on the interdigital cleft than for cows with lesions on the heels or the dewclaw. Number of cows with signs of pain or visible lesions after treatment was significantly higher for cows with lesions on the interdigital cleft than for cows with lesions on heels or the dewclaw.. Anatomic location of PDD lesions has an effect on the efficacy of topical treatment with oxytetracycline solution in dairy cows affected with PDD. Cows with lesions on the interdigital cleft were less likely to respond to treatment, compared with cows with lesions on the heels or the dewclaw.

Topics: Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Dermatitis; Female; Foot Dermatoses; Hoof and Claw; Oxytetracycline; Papilloma; Treatment Outcome

A field trial was conducted to compare the efficacy of the original and two modified formulations of Victory and oxytetracycline among dairy cows affected with papillomatous digital dermatitis. Seventy-eight cows with papillomatous digital dermatitis lesions were randomly allocated to one of four treatment groups (A, B, C, D). Cows in group A (n = 19) were treated with an oxytetracycline solution; cows in group B (n = 22) were treated with the original formulation of Victory containing soluble copper, peroxide compound, and a cationic agent; cows in group C (n = 17) were treated with a modified formulation of Victory containing reduced soluble copper and peroxide compound but increased levels of cationic agent; and cows in group D (n = 20) were treated with a modified formulation of Victory containing levels of soluble copper and cationic agent equivalent to the original formulation but with reduced concentrations of peroxide compound. Cows were examined 7, 14 and 28 d after initial treatment; during each examination, pain and lesion scores were recorded. The modified nonantibiotic formulation used in cows in group C appeared to be the most effective for treatment of papillomatous digital dermatitis. Proportions of cows with signs of pain were significantly lower among cows in group C, compared with cows in group A. Similarly, pain scores were significantly lower among cows in treatment group C, compared to cows in group A. The 2 low efficacy of oxytetracycline was an unexpected result b and may have clinical implications associated with possible antibiotic resistance in dairy cows affected with papillomatous digital dermatitis.

Topics: Animals; Anti-Bacterial Agents; Cations; Cattle; Cattle Diseases; Copper; Dermatitis; Extremities; Female; Lameness, Animal; Oxytetracycline; Papilloma; Peroxides; Treatment Outcome

To determine whether there would be detectable antibiotic residues in milk obtained from dairy cattle with papillomatous digital dermatitis (PDD) after topical treatment with oxytetracycline.. Randomized controlled clinical trial.. 28 lactating Holstein cows with PDD.. Cows were assigned to 2 treatment groups. Treatment 1 (n = 16) consisted of spraying of PDD lesions with 15 ml of a solution containing 100 mg of oxytetracycline/ml; lesions were sprayed twice daily for 7 days, using a garden sprayer. Treatment 2 (n = 12) consisted of a one-time application of a bandage that consisted of cotton soaked with 20 ml of a solution containing 100 mg of oxytetracycline/ml. Milk samples were obtained before and after treatment and assayed for tetracycline content by use of high-performance liquid chromatography and a commercially available tetracycline screening test.. None of the cows in either treatment group had violative residues of oxytetracycline in milk samples.. Producers treating lactating cows that have PDD, via topical application of oxytetracycline solution at the concentrations reported in this study, have a low risk of causing violative antibiotic residues in milk.

Topics: Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Chromatography, High Pressure Liquid; Dermatitis; Drug Residues; Female; Foot Diseases; Hoof and Claw; Milk; Oxytetracycline; Papilloma; Treatment Outcome

Topics: Administration, Cutaneous; Animal Diseases; Animal Identification Systems; Animals; Animals, Newborn; Anti-Bacterial Agents; Cattle; Disease Outbreaks; Ear; England; Oxytetracycline; Papilloma; Skin Neoplasms

Topics: Anti-Bacterial Agents; Child; Chlortetracycline; Humans; Laryngeal Neoplasms; Larynx; Oxytetracycline; Papilloma; Papillomavirus Infections

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Child; Chlortetracycline; Fibroma; Humans; Infant; Laryngeal Neoplasms; Larynx; Oxytetracycline; Papilloma; Tetracycline

Topics: Humans; Laryngeal Neoplasms; Larynx; Oxytetracycline; Papilloma